PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24919794-0 2014 Quinazoline analog HMJ-30 inhibits angiogenesis: involvement of endothelial cell apoptosis through ROS-JNK-mediated death receptor 5 signaling. 6-fluoro-2-(3-fluorophenyl)-4-(cyanoanilino)quinazoline 19-25 TNF receptor superfamily member 10b Homo sapiens 116-132 24919794-8 2014 We investigated the upstream of the death receptor pathway and further observed that the levels of death receptor 5 (DR5) and phosphorylated c-Jun N-terminal kinase (JNK) signals were upregulated in HUVECs following HMJ-30 challenge, which was confirmed by a JNK-specific inhibitor (SP600125). 6-fluoro-2-(3-fluorophenyl)-4-(cyanoanilino)quinazoline 216-222 TNF receptor superfamily member 10b Homo sapiens 99-115 24919794-8 2014 We investigated the upstream of the death receptor pathway and further observed that the levels of death receptor 5 (DR5) and phosphorylated c-Jun N-terminal kinase (JNK) signals were upregulated in HUVECs following HMJ-30 challenge, which was confirmed by a JNK-specific inhibitor (SP600125). 6-fluoro-2-(3-fluorophenyl)-4-(cyanoanilino)quinazoline 216-222 TNF receptor superfamily member 10b Homo sapiens 117-120 24919794-9 2014 Hence, HMJ-30-induced endothelial cell apoptosis involved the ROS/JNK-regulated DR5 pathway. 6-fluoro-2-(3-fluorophenyl)-4-(cyanoanilino)quinazoline 7-13 TNF receptor superfamily member 10b Homo sapiens 80-83