PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18551038-3 2008 Response to the antifolate methotrexate (MTX) may be modified in 677TT individuals because MTHFR converts nonmethylated folates, used for thymidine and purine synthesis, to 5-methyltetrahydrofolate, used in homocysteine remethylation to methionine. purine 152-158 methylenetetrahydrofolate reductase Mus musculus 91-96