PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
14990704-2	2004	Roscovitine (Rosco) is a purine derivative that inhibits cyclin-dependent kinase 1 (cdk1), cdk2, cdk5, cdk7, and cdk9, which are key regulators of the cell cycle and transcription.	purine	25-31	cyclin dependent kinase 5	Homo sapiens	97-101	
15308730-4	2004	In contrast, roscovitine and other purine PCIs inhibit with high potency only CDK1, CDK2, CDK5, and CDK7, and they specifically inhibit the expression of viral but not cellular genes.	purine	35-41	cyclin dependent kinase 5	Homo sapiens	90-94	
16407256-1	2006	A detailed analysis is presented of the dynamics of human CDK5 in complexes with the protein activator p25 and the purine-like inhibitor roscovitine.	purine	115-121	cyclin dependent kinase 5	Homo sapiens	58-62	
10465404-3	1999	Optimal inhibitory activity against CDK5, CDK1 and CDK2, with IC50 values of 0.16, 0.45 and 0.65 microM, respectively, was obtained with compound 21 containing a (2R)-pyrrolidin-2-yl-methanol substituent at the C-2 and a 3-iodobenzylamino group at the C-6 of the purine.	purine	263-269	cyclin dependent kinase 5	Homo sapiens	36-40	
21641213-0	2011	Novel purine-based fluoroaryl-1,2,3-triazoles as neuroprotecting agents: synthesis, neuronal cell culture investigations, and CDK5 docking studies.	purine	6-12	cyclin dependent kinase 5	Homo sapiens	126-130	
30023695-0	2017	A Simple Isomerization of the Purine Scaffold of a Kinase Inhibitor, Roscovitine, Affords a Four- to Seven-Fold Enhancement of Its Affinity for Four CDKs.	purine	30-36	cyclin dependent kinase 5	Homo sapiens	149-153	
30023695-2	2017	Roscovitine is an antitumor purine inhibitor of cyclin-dependent kinase CDK5, for which it displays submicromolar affinity.	purine	28-34	cyclin dependent kinase 5	Homo sapiens	72-76	
26207228-2	2015	It is a broad-range purine inhibitor, which inhibits CDK1, CDK2, CDK5 and CDK7, but is a poor inhibitor for CDK4 and CDK6.	purine	20-26	cyclin dependent kinase 5	Homo sapiens	65-69