PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21772997-4 2011 Binding studies show that RPA-C binds pyrimidine- and purine-rich sequences similarly. purine 54-60 replication protein A1 Homo sapiens 26-29 19187036-4 2009 Moreover, hRPA binds to a 26-mer purine-rich quadruplex-forming sequence with an affinity indistinguishable from that for binding to the complementary pyrimidine-rich sequence. purine 33-39 replication protein A1 Homo sapiens 10-14 15938633-6 2005 However, RPA hyperphosphorylation results in a decreased affinity for purine-rich ssDNA and duplex DNA substrates. purine 70-76 replication protein A1 Homo sapiens 9-12 11009611-6 2000 Use of fork and overhang substrates containing 8 nt pyrimidine or purine arms demonstrates that hRPA binding to DNA involves a particular molecular polarity in which initial hRPA binding occurs on the 5" side of a ssDNA substrate, and then extends in the 3" direction to create a stably bound hRPA. purine 66-72 replication protein A1 Homo sapiens 96-100