PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26482777-5 2016 The CYP1B1 Leu432Val polymorphism (Leu/Val) was analyzed using the polymerase chain reaction-restriction fragment length polymorphism method. leu432val 11-20 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 4-10 29285838-1 2018 OBJECTIVES: The aim of this study was to examine if the Arg48Gly, Ala119Ser, Leu432Val, and Asn453Ser polymorphisms in the CYP1B1 estrogen-metabolizing gene are associated with menopausal symptom experience in healthy Slovak women aged 40-60 years. leu432val 77-86 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 123-129 24453031-0 2014 The CYP1B1 Leu432Val polymorphism and risk of urinary system cancers. leu432val 11-20 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 4-10 24695682-2 2014 Smokers homozygous for the C-allele (*1/*1) at the CYP1B1 Leu432Val polymorphism have shown increased CYP1B1 expression, compared to smokers homozygous for the G-allele *3/*3. leu432val 58-67 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 51-57 24695682-2 2014 Smokers homozygous for the C-allele (*1/*1) at the CYP1B1 Leu432Val polymorphism have shown increased CYP1B1 expression, compared to smokers homozygous for the G-allele *3/*3. leu432val 58-67 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 102-108 24695682-10 2014 Homozygous carriers of the C-allele (*1/*1) at the CYP1B1 Leu432Val polymorphism show a higher response to environmental factors, such as carcinogenic BaP, than homozygous carriers of the G-allele *3/*3. leu432val 58-67 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 51-57 24453031-2 2014 The CYP1B1 Leu432Val polymorphism leads to leucine to valine substitution at codon 432. leu432val 11-20 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 4-10 24453031-3 2014 A lot of studies have shown that the CYP1B1 Leu432Val polymorphism was associated with urinary system cancers, especially prostate cancer. leu432val 44-53 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 37-43 24453031-5 2014 In this meta-analysis, by searching online databases and references of related reviews, we identified 17 eligible studies to assess the relationship between CYP1B1 Leu432Val polymorphism and urinary system cancers, including 7,783 cancer cases and 7,238 controls. leu432val 164-173 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 157-163 24453031-6 2014 By pooling all eligible studies, we found that the CYP1B1 Leu432Val polymorphism was not associated with overall urinary system cancers. leu432val 58-67 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 51-57 24453031-9 2014 In conclusion, based on 17 eligible studies, we found that the CYP1B1 Leu432Val polymorphism was associated with an increased risk of prostate cancer, while no association of bladder cancer was observed. leu432val 70-79 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 63-69 22327650-0 2012 Association of the CYP1B1 Leu432Val polymorphism with the risk of prostate cancer: a meta-analysis. leu432val 26-35 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 19-25 22504876-0 2012 Prostate cancer risk and aggressiveness associated with the CYP1B1 4326C/G (Leu432Val) polymorphism: a meta-analysis of 2788 cases and 2968 controls. leu432val 76-85 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 60-66 22327650-3 2012 The objective of this meta-analysis was to quantitatively summarize the association between CYP1B1 Leu432Val polymorphism and prostate cancer. leu432val 99-108 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 92-98 22327650-10 2012 In conclusion, this meta-analysis provides evidence that CYP1B1 Leu432Val polymorphism is not associated with prostate cancer risk overall with the exception in Asians. leu432val 64-73 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 57-63 18483560-0 2008 Leu432Val polymorphism in CYP1B1 as a susceptible factor towards predisposition to primary open-angle glaucoma. leu432val 0-9 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 26-32 22190224-0 2012 CYP1B1 Leu432Val polymorphism and colorectal cancer risk among Caucasians: a meta-analysis. leu432val 7-16 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-6 20395011-0 2010 The CYP1B1 Leu432Val polymorphism contributes to lung cancer risk: evidence from 6501 subjects. leu432val 11-20 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 4-10 22190224-1 2012 Studies investigating the association between cytochrome P450 1B1 (CYP1B1) Leu432Val (432 C/G, rs1056836) polymorphism and colorectal cancer (CRC) risk report conflicting results. leu432val 75-84 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 46-65 22190224-1 2012 Studies investigating the association between cytochrome P450 1B1 (CYP1B1) Leu432Val (432 C/G, rs1056836) polymorphism and colorectal cancer (CRC) risk report conflicting results. leu432val 75-84 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 67-73 18841557-3 2008 RESULTS: The Arg46Stop mutation in MYOC gene and Leu432Val in CYP1B1 gene were identified in all patients. leu432val 49-58 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 62-68 18841557-5 2008 CONCLUSION: Author identified digenic mutations, Arg46Stop in MYOC gene and Leu432Val in CYP1B1 gene, in a Chinese PACG family. leu432val 76-85 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 89-95 18483560-7 2008 Allelic variants of Leu432Val were cloned by site-directed mutagenesis of normal CYP1B1 cDNA, which were used for transfection of retinal pigment epithelium (RPE) cells. leu432val 20-29 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 81-87 18483560-9 2008 RESULTS: The c.1666G allele of the Leu432Val in CYP1B1 showed a statistically significant higher representation among POAG patients compared to controls (p=0.0001; Odds ratio=6.027; 95% CI: 3.863-9.401) suggesting it to be a potential risk allele toward disease predisposition. leu432val 35-44 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 48-54 17562158-3 2007 The genetic distribution of four different CYP1B1 polymorphisms at Ala119Ser, Leu432Val, Asp(449)(C>T), Asn453Ser were analyzed by polymerase chain reaction (PCR) and restriction fragment length polymorphism of PCR products. leu432val 78-87 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 43-49 12398325-6 2002 It was interesting that a significant positive correlation between CYP1B1 mRNA and 1-hydroxypyrene was observed in subjects with the Leu/Leu type of CYP1B1 Leu432Val polymorphism (R=0.33, P=0.02, n=38) and a non-significant correlation in subjects with the Leu/Val and Val/Val types (R=-0.36, P=0.25, n=12), although the number of subjects in this strata analysis was small. leu432val 156-165 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 67-73 14656940-3 2004 We evaluated the association between the CYP1B1 Leu432Val and CYP1B1 Asn453Ser polymorphisms and the COMT Val158Met polymorphism and invasive endometrial cancer risk in a case-control study nested within the Nurses" Health Study (n = 222 cases, 666 controls). leu432val 48-57 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 41-47 15896461-3 2005 A matched case-control study of 227 patients with lung cancer was conducted to detect CYP1B1 Leu432Val, GSTP1 Ile105Val and hOGG1 Ser326Cys polymorphisms. leu432val 93-102 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 86-92 12398325-6 2002 It was interesting that a significant positive correlation between CYP1B1 mRNA and 1-hydroxypyrene was observed in subjects with the Leu/Leu type of CYP1B1 Leu432Val polymorphism (R=0.33, P=0.02, n=38) and a non-significant correlation in subjects with the Leu/Val and Val/Val types (R=-0.36, P=0.25, n=12), although the number of subjects in this strata analysis was small. leu432val 156-165 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 149-155