PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35013145-6 2022 APP-CTFs accumulation also resulted in mitophagy failure, as validated by increased LC3-II and p62 and inconsistent PTEN-induced kinase 1 (PINK1)/E3 ubiquitin ligase (Parkin) recruitment to mitochondria and failed fusion of mitochondria and lysosomes. app-ctfs 0-8 mitochondrial E3 ubiquitin protein ligase 1 Homo sapiens 146-165