PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23106432-1 2012 Human UDP-alpha-D-glucose dehydrogenase (hUGDH) catalyzes the NAD(+)-dependent oxidation of UDP-alpha-D-glucose (UDG) to produce UDP-alpha-D-glucuronic acid. Uridine Diphosphate Glucuronic Acid 129-156 UDP-glucose 6-dehydrogenase Homo sapiens 41-46 23363239-1 2013 Human UDP-alpha-d-glucose 6-dehydrogenase (hUGDH) forms a hexamer that catalyzes the NAD(+)-dependent oxidation of UDP-alpha-d-glucose (UDG) to produce UDP-alpha-d-glucuronic acid. Uridine Diphosphate Glucuronic Acid 152-179 UDP-glucose 6-dehydrogenase Homo sapiens 43-48 21576248-1 2011 UDP-glucose dehydrogenase (UGDH) catalyzes the formation of UDP-glucuronate. Uridine Diphosphate Glucuronic Acid 60-75 UDP-glucose 6-dehydrogenase Homo sapiens 0-25 22525098-1 2012 Human UDP-glucose 6-dehydrogenase (hUGDH) catalyzes the biosynthetic oxidation of UDP-glucose into UDP-glucuronic acid. Uridine Diphosphate Glucuronic Acid 99-118 UDP-glucose 6-dehydrogenase Homo sapiens 6-33 22525098-1 2012 Human UDP-glucose 6-dehydrogenase (hUGDH) catalyzes the biosynthetic oxidation of UDP-glucose into UDP-glucuronic acid. Uridine Diphosphate Glucuronic Acid 99-118 UDP-glucose 6-dehydrogenase Homo sapiens 35-40 21502315-3 2011 Human UDP-glucose 6-dehydrogenase (hUGDH) catalyzes, in two NAD(+)-dependent steps without release of intermediate aldehyde, the biosynthetic oxidation of UDP-glucose (UDP-Glc) to UDP-GlcUA. Uridine Diphosphate Glucuronic Acid 180-189 UDP-glucose 6-dehydrogenase Homo sapiens 6-33 21502315-3 2011 Human UDP-glucose 6-dehydrogenase (hUGDH) catalyzes, in two NAD(+)-dependent steps without release of intermediate aldehyde, the biosynthetic oxidation of UDP-glucose (UDP-Glc) to UDP-GlcUA. Uridine Diphosphate Glucuronic Acid 180-189 UDP-glucose 6-dehydrogenase Homo sapiens 35-40 21502315-4 2011 Here, we present a structural characterization of the hUGDH reaction coordinate using crystal structures of the apoenzyme and ternary complexes of the enzyme bound with UDP-Glc/NADH and UDP-GlcUA/NAD(+). Uridine Diphosphate Glucuronic Acid 186-195 UDP-glucose 6-dehydrogenase Homo sapiens 54-59 22123821-1 2012 Biosynthesis of UDP-glucuronic acid by UDP-glucose 6-dehydrogenase (UGDH) occurs through the four-electron oxidation of the UDP-glucose C6 primary alcohol in two NAD(+)-dependent steps. Uridine Diphosphate Glucuronic Acid 16-35 UDP-glucose 6-dehydrogenase Homo sapiens 39-66 22123821-1 2012 Biosynthesis of UDP-glucuronic acid by UDP-glucose 6-dehydrogenase (UGDH) occurs through the four-electron oxidation of the UDP-glucose C6 primary alcohol in two NAD(+)-dependent steps. Uridine Diphosphate Glucuronic Acid 16-35 UDP-glucose 6-dehydrogenase Homo sapiens 68-72 21602353-5 2011 UDP-glucose dehydrogenase (UGD) is responsible for the NAD-dependent 2-fold oxidation of UDP-glucose (UDP-Glc) to UDP-glucuronic acid (UDP-GlcA), which is a key step in cepacian biosynthesis. Uridine Diphosphate Glucuronic Acid 114-133 UDP-glucose 6-dehydrogenase Homo sapiens 0-25 21602353-5 2011 UDP-glucose dehydrogenase (UGD) is responsible for the NAD-dependent 2-fold oxidation of UDP-glucose (UDP-Glc) to UDP-glucuronic acid (UDP-GlcA), which is a key step in cepacian biosynthesis. Uridine Diphosphate Glucuronic Acid 114-133 UDP-glucose 6-dehydrogenase Homo sapiens 27-30 21602353-5 2011 UDP-glucose dehydrogenase (UGD) is responsible for the NAD-dependent 2-fold oxidation of UDP-glucose (UDP-Glc) to UDP-glucuronic acid (UDP-GlcA), which is a key step in cepacian biosynthesis. Uridine Diphosphate Glucuronic Acid 135-143 UDP-glucose 6-dehydrogenase Homo sapiens 0-25 21602353-5 2011 UDP-glucose dehydrogenase (UGD) is responsible for the NAD-dependent 2-fold oxidation of UDP-glucose (UDP-Glc) to UDP-glucuronic acid (UDP-GlcA), which is a key step in cepacian biosynthesis. Uridine Diphosphate Glucuronic Acid 135-143 UDP-glucose 6-dehydrogenase Homo sapiens 27-30 21576248-1 2011 UDP-glucose dehydrogenase (UGDH) catalyzes the formation of UDP-glucuronate. Uridine Diphosphate Glucuronic Acid 60-75 UDP-glucose 6-dehydrogenase Homo sapiens 27-31 20691680-3 2010 Using UGDH-specific small interference RNA to treat HCT-8 colorectal carcinoma cells, a decrease in both mRNA and protein levels of UGDH, as well as the cellular UDP-glucuronic acid and GAG production was observed. Uridine Diphosphate Glucuronic Acid 162-181 UDP-glucose 6-dehydrogenase Homo sapiens 6-10 21984906-1 2011 BACKGROUND: UDP-glucose dehydrogenase (UGDH) is the sole enzyme that catalyzes the conversion of UDP-glucose to UDP-glucuronic acid. Uridine Diphosphate Glucuronic Acid 112-131 UDP-glucose 6-dehydrogenase Homo sapiens 12-37 21984906-1 2011 BACKGROUND: UDP-glucose dehydrogenase (UGDH) is the sole enzyme that catalyzes the conversion of UDP-glucose to UDP-glucuronic acid. Uridine Diphosphate Glucuronic Acid 112-131 UDP-glucose 6-dehydrogenase Homo sapiens 39-43 20691680-1 2010 UDP-glucose dehydrogenase (UGDH) catalyzes oxidation of UDP-glucose to yield UDP-glucuronic acid, a precursor of hyaluronic acid (HA) and other glycosaminoglycans (GAGs) in extracellular matrix. Uridine Diphosphate Glucuronic Acid 77-96 UDP-glucose 6-dehydrogenase Homo sapiens 0-25 20691680-1 2010 UDP-glucose dehydrogenase (UGDH) catalyzes oxidation of UDP-glucose to yield UDP-glucuronic acid, a precursor of hyaluronic acid (HA) and other glycosaminoglycans (GAGs) in extracellular matrix. Uridine Diphosphate Glucuronic Acid 77-96 UDP-glucose 6-dehydrogenase Homo sapiens 27-31 20863317-7 2010 The inhibition of synthesis of UDP-alpha-D-glucuronic acid using UGDH antagonists might therefore be a useful strategy for therapy. Uridine Diphosphate Glucuronic Acid 31-58 UDP-glucose 6-dehydrogenase Homo sapiens 65-69 20863317-1 2010 Biosynthesis of the glycosaminoglycan precursor UDP-alpha-D-glucuronic acid occurs through a 2-fold oxidation of UDP-alpha-D-glucose that is catalysed by UGDH (UDP-alpha-D-glucose 6-dehydrogenase). Uridine Diphosphate Glucuronic Acid 48-75 UDP-glucose 6-dehydrogenase Homo sapiens 154-158 20863317-1 2010 Biosynthesis of the glycosaminoglycan precursor UDP-alpha-D-glucuronic acid occurs through a 2-fold oxidation of UDP-alpha-D-glucose that is catalysed by UGDH (UDP-alpha-D-glucose 6-dehydrogenase). Uridine Diphosphate Glucuronic Acid 48-75 UDP-glucose 6-dehydrogenase Homo sapiens 160-195 16158268-1 2005 UDP-glucose dehydrogenase (UGDH) catalyzes two oxidations of UDP-glucose to yield UDP-glucuronic acid. Uridine Diphosphate Glucuronic Acid 82-101 UDP-glucose 6-dehydrogenase Homo sapiens 0-25 17209547-1 2007 Human UDP-glucose dehydrogenase (UGDH) is a homohexameric enzyme that catalyzes two successive oxidations of UDP-glucose to yield UDP-glucuronic acid, an essential precursor for matrix polysaccharide and proteoglycan synthesis. Uridine Diphosphate Glucuronic Acid 130-149 UDP-glucose 6-dehydrogenase Homo sapiens 33-37 19676054-1 2010 Uridine diphosphate (UDP)-glucose dehydrogenase (UGDH) catalyzes the oxidation of UDP-glucose to yield UDP-glucuronic acid, a precursor for synthesis of glycosaminoglycans and proteoglycans that promote aggressive prostate cancer (PC) progression. Uridine Diphosphate Glucuronic Acid 103-122 UDP-glucose 6-dehydrogenase Homo sapiens 49-53 19358821-1 2009 UDP-glucose dehydrogenase (UGDH) is an enzyme catalyzing the conversion of UDP-glucose to UDP-glucuronic acid. Uridine Diphosphate Glucuronic Acid 90-109 UDP-glucose 6-dehydrogenase Homo sapiens 0-25 19358821-1 2009 UDP-glucose dehydrogenase (UGDH) is an enzyme catalyzing the conversion of UDP-glucose to UDP-glucuronic acid. Uridine Diphosphate Glucuronic Acid 90-109 UDP-glucose 6-dehydrogenase Homo sapiens 27-31 19244115-1 2009 UDP-glucose dehydrogenase (UGDH) oxidizes UDP-glucose to UDP-glucuronate, an essential precursor for production of hyaluronan (HA), proteoglycans, and xenobiotic glucuronides. Uridine Diphosphate Glucuronic Acid 57-72 UDP-glucose 6-dehydrogenase Homo sapiens 0-25 19244115-1 2009 UDP-glucose dehydrogenase (UGDH) oxidizes UDP-glucose to UDP-glucuronate, an essential precursor for production of hyaluronan (HA), proteoglycans, and xenobiotic glucuronides. Uridine Diphosphate Glucuronic Acid 57-72 UDP-glucose 6-dehydrogenase Homo sapiens 27-31 17209547-1 2007 Human UDP-glucose dehydrogenase (UGDH) is a homohexameric enzyme that catalyzes two successive oxidations of UDP-glucose to yield UDP-glucuronic acid, an essential precursor for matrix polysaccharide and proteoglycan synthesis. Uridine Diphosphate Glucuronic Acid 130-149 UDP-glucose 6-dehydrogenase Homo sapiens 6-31 16495656-1 2006 The enzyme UDP-glucose dehydrogenase (UGDH) catalyzes the conversion of UDP-glucose to UDP-glucuronic acid, which is essential for the biosynthesis of complex carbohydrates such as hyaluronan in many cell types, and is required for detoxification of toxic compounds in the liver. Uridine Diphosphate Glucuronic Acid 87-106 UDP-glucose 6-dehydrogenase Homo sapiens 11-36 16495656-1 2006 The enzyme UDP-glucose dehydrogenase (UGDH) catalyzes the conversion of UDP-glucose to UDP-glucuronic acid, which is essential for the biosynthesis of complex carbohydrates such as hyaluronan in many cell types, and is required for detoxification of toxic compounds in the liver. Uridine Diphosphate Glucuronic Acid 87-106 UDP-glucose 6-dehydrogenase Homo sapiens 38-42 17073734-1 2006 UDP-glucose dehydrogenase (UGDH) catalyzes the synthesis of UDP-glucuronic acid from UDP-glucose resulting in the formation of proteoglycans that are involved in promoting normal cellular growth and migration. Uridine Diphosphate Glucuronic Acid 60-79 UDP-glucose 6-dehydrogenase Homo sapiens 0-25 17073734-1 2006 UDP-glucose dehydrogenase (UGDH) catalyzes the synthesis of UDP-glucuronic acid from UDP-glucose resulting in the formation of proteoglycans that are involved in promoting normal cellular growth and migration. Uridine Diphosphate Glucuronic Acid 60-79 UDP-glucose 6-dehydrogenase Homo sapiens 27-31 16158268-1 2005 UDP-glucose dehydrogenase (UGDH) catalyzes two oxidations of UDP-glucose to yield UDP-glucuronic acid. Uridine Diphosphate Glucuronic Acid 82-101 UDP-glucose 6-dehydrogenase Homo sapiens 27-31 16158268-2 2005 Pathological over-production of extracellular matrix components may be linked to the availability of UDP-glucuronic acid, therefore UGDH is a potential therapeutic target. Uridine Diphosphate Glucuronic Acid 101-120 UDP-glucose 6-dehydrogenase Homo sapiens 132-136 15247292-1 2004 UDP-glucose dehydrogenase (UGDH) is the unique pathway enzyme furnishing in vertebrates UDP-glucuronate for numerous transferases. Uridine Diphosphate Glucuronic Acid 88-103 UDP-glucose 6-dehydrogenase Homo sapiens 0-25 16292757-1 2005 During drug metabolism, UDPglucuronate, a product of the reaction catalyzed by the enzyme UDPglucose dehydrogenase (UGDH), is conjugated with the metabolites to facilitate their elimination. Uridine Diphosphate Glucuronic Acid 24-38 UDP-glucose 6-dehydrogenase Homo sapiens 90-114 16292757-1 2005 During drug metabolism, UDPglucuronate, a product of the reaction catalyzed by the enzyme UDPglucose dehydrogenase (UGDH), is conjugated with the metabolites to facilitate their elimination. Uridine Diphosphate Glucuronic Acid 24-38 UDP-glucose 6-dehydrogenase Homo sapiens 116-120 16002992-1 2005 UDP-glucose dehydrogenase (UGDH) catalyzes the conversion of UDP-glucose to UDP-glucuronic acid, which is required in liver for the excretion of toxic compounds, and for the biosynthesis of complex carbohydrates, such as hyaluronan, in many cell types. Uridine Diphosphate Glucuronic Acid 76-95 UDP-glucose 6-dehydrogenase Homo sapiens 0-25 16002992-1 2005 UDP-glucose dehydrogenase (UGDH) catalyzes the conversion of UDP-glucose to UDP-glucuronic acid, which is required in liver for the excretion of toxic compounds, and for the biosynthesis of complex carbohydrates, such as hyaluronan, in many cell types. Uridine Diphosphate Glucuronic Acid 76-95 UDP-glucose 6-dehydrogenase Homo sapiens 27-31 15247292-1 2004 UDP-glucose dehydrogenase (UGDH) is the unique pathway enzyme furnishing in vertebrates UDP-glucuronate for numerous transferases. Uridine Diphosphate Glucuronic Acid 88-103 UDP-glucose 6-dehydrogenase Homo sapiens 27-31 8220234-4 1993 Following serum stimulation, changes in cellular UDP-glucuronic acid concentrations mirror changes in UDP-GDH activity. Uridine Diphosphate Glucuronic Acid 49-68 UDP-glucose 6-dehydrogenase Homo sapiens 102-109 12682078-1 2003 UDP-glucose dehydrogenase (UGDH) is a key enzyme of the unique pathway for the synthesis of UDP-glucuronate, the substrate for the numerous glucuronosyl transferases, which act on the synthesis of glycosaminoglycans and glucuronidation reaction of xeno- and endobiotics. Uridine Diphosphate Glucuronic Acid 92-107 UDP-glucose 6-dehydrogenase Homo sapiens 0-25 12682078-1 2003 UDP-glucose dehydrogenase (UGDH) is a key enzyme of the unique pathway for the synthesis of UDP-glucuronate, the substrate for the numerous glucuronosyl transferases, which act on the synthesis of glycosaminoglycans and glucuronidation reaction of xeno- and endobiotics. Uridine Diphosphate Glucuronic Acid 92-107 UDP-glucose 6-dehydrogenase Homo sapiens 27-31 10973831-1 2000 UDP-glucose dehydrogenase (GDH) is an unique pathway enzyme, which furnishes in vertebrates the UDP-glucuronic acid for numerous transferases, including those of glycosaminoglycan synthesis and xenobiotics elimination. Uridine Diphosphate Glucuronic Acid 96-115 UDP-glucose 6-dehydrogenase Homo sapiens 0-25 10973831-1 2000 UDP-glucose dehydrogenase (GDH) is an unique pathway enzyme, which furnishes in vertebrates the UDP-glucuronic acid for numerous transferases, including those of glycosaminoglycan synthesis and xenobiotics elimination. Uridine Diphosphate Glucuronic Acid 96-115 UDP-glucose 6-dehydrogenase Homo sapiens 27-30 9737970-10 1998 Preliminary expression studies indicated that proinflammatory cytokines, such as interleukin 1beta, can substantially increase the expression of human UGDH in cultured human fibroblasts, suggesting that glycosaminoglycan biosynthesis may be partly regulated by the availability of activated UDP-glucuronate, as determined by relative Udpgdh expression levels. Uridine Diphosphate Glucuronic Acid 291-306 UDP-glucose 6-dehydrogenase Homo sapiens 151-155 7868856-4 1995 Uridine diphosphoglucose dehydrogenase (UDPGD) activity is responsible for the prior conversion of UDP-glucose to UDP-glucuronate. Uridine Diphosphate Glucuronic Acid 114-129 UDP-glucose 6-dehydrogenase Homo sapiens 0-38 7868856-4 1995 Uridine diphosphoglucose dehydrogenase (UDPGD) activity is responsible for the prior conversion of UDP-glucose to UDP-glucuronate. Uridine Diphosphate Glucuronic Acid 114-129 UDP-glucose 6-dehydrogenase Homo sapiens 40-45 15044486-2 2004 UDP-glucose dehydrogenase (UGDH) catalyzes two oxidations of UDP-glucose to yield UDP-glucuronic acid. Uridine Diphosphate Glucuronic Acid 82-101 UDP-glucose 6-dehydrogenase Homo sapiens 0-25 15044486-2 2004 UDP-glucose dehydrogenase (UGDH) catalyzes two oxidations of UDP-glucose to yield UDP-glucuronic acid. Uridine Diphosphate Glucuronic Acid 82-101 UDP-glucose 6-dehydrogenase Homo sapiens 27-31 15044486-3 2004 Pathological overproduction of extracellular matrix components may be linked to the availability of UDP-glucuronic acid; therefore UGDH is an intriguing therapeutic target. Uridine Diphosphate Glucuronic Acid 100-119 UDP-glucose 6-dehydrogenase Homo sapiens 131-135 9737970-1 1998 The enzyme UDP-glucose dehydrogenase (Udpgdh) (EC 1.1.1.22) converts UDP-glucose to UDP-glucuronate, a critical component of the glycosaminoglycans, hyaluronan, chondroitin sulfate, and heparan sulfate. Uridine Diphosphate Glucuronic Acid 84-99 UDP-glucose 6-dehydrogenase Homo sapiens 11-36 9737970-1 1998 The enzyme UDP-glucose dehydrogenase (Udpgdh) (EC 1.1.1.22) converts UDP-glucose to UDP-glucuronate, a critical component of the glycosaminoglycans, hyaluronan, chondroitin sulfate, and heparan sulfate. Uridine Diphosphate Glucuronic Acid 84-99 UDP-glucose 6-dehydrogenase Homo sapiens 38-44 32768525-3 2020 We examined clinical association of nucleotide sugar pathway gene expression and found that UGDH, encoding UDP-glucose 6-dehydrogenase which catalyzes production of UDP-glucuronate, is associated with worse breast cancer patient survival. Uridine Diphosphate Glucuronic Acid 165-180 UDP-glucose 6-dehydrogenase Homo sapiens 92-96 2287590-3 1990 UDP-glucose dehydrogenase is particularly important in oxidizing UDP-glucose to UDP-glucuronic acid, the building block of hyaluronic acid and chondroitin sulfates. Uridine Diphosphate Glucuronic Acid 80-99 UDP-glucose 6-dehydrogenase Homo sapiens 0-25 34548906-2 2021 UDP-glucose dehydrogenase (UGDH) produces UDP-glucuronate, the essential precursor for glucuronidation, and its expression is elevated in prostate cancer. Uridine Diphosphate Glucuronic Acid 42-57 UDP-glucose 6-dehydrogenase Homo sapiens 0-25 34548906-2 2021 UDP-glucose dehydrogenase (UGDH) produces UDP-glucuronate, the essential precursor for glucuronidation, and its expression is elevated in prostate cancer. Uridine Diphosphate Glucuronic Acid 42-57 UDP-glucose 6-dehydrogenase Homo sapiens 27-31 1023336-1 1976 In the byosinthesis of glycosaminoglycans, UDP-glucose is utilized by two enzymes: UDP-glucose dehydrogenase which produces UDP-glucuronic acid (chondroitin sulphate precursor), and UDP-glucose 4"-epimerase which produces UDP-galactose (keratan sulphate precursor). Uridine Diphosphate Glucuronic Acid 124-143 UDP-glucose 6-dehydrogenase Homo sapiens 83-108 1023336-9 1976 Under our experimental conditions, UDP-glucose 4"-epimerase present in the cells epimerizes UDP-galactose (added in the incubation mixture) to UDP-glucose which can bo oxidized by the excess of UDP-glucose dehydrogenase to UDP-glucuronic acid with a consequent NADH formation. Uridine Diphosphate Glucuronic Acid 223-242 UDP-glucose 6-dehydrogenase Homo sapiens 194-219 33572239-1 2021 UDP-glucose-dehydrogenase (UGDH) synthesizes UDP-glucuronic acid. Uridine Diphosphate Glucuronic Acid 45-64 UDP-glucose 6-dehydrogenase Homo sapiens 0-25 33572239-1 2021 UDP-glucose-dehydrogenase (UGDH) synthesizes UDP-glucuronic acid. Uridine Diphosphate Glucuronic Acid 45-64 UDP-glucose 6-dehydrogenase Homo sapiens 27-31 8471533-2 1993 Uridine diphosphoglucose dehydrogenase (UDPGD) activity is the irreversible, rate-limiting step in the production of UDP-glucuronate, an essential monosaccharide in the synthesis of HA. Uridine Diphosphate Glucuronic Acid 117-132 UDP-glucose 6-dehydrogenase Homo sapiens 0-38 8471533-2 1993 Uridine diphosphoglucose dehydrogenase (UDPGD) activity is the irreversible, rate-limiting step in the production of UDP-glucuronate, an essential monosaccharide in the synthesis of HA. Uridine Diphosphate Glucuronic Acid 117-132 UDP-glucose 6-dehydrogenase Homo sapiens 40-45 32749901-3 2021 The enzyme uridine diphosphate (UDP)-glucose dehydrogenase (UGDH) produces UDP-glucuronate, an essential precursor for new glycosaminoglycan synthesis that is tightly controlled at multiple levels. Uridine Diphosphate Glucuronic Acid 75-90 UDP-glucose 6-dehydrogenase Homo sapiens 11-58 32749901-3 2021 The enzyme uridine diphosphate (UDP)-glucose dehydrogenase (UGDH) produces UDP-glucuronate, an essential precursor for new glycosaminoglycan synthesis that is tightly controlled at multiple levels. Uridine Diphosphate Glucuronic Acid 75-90 UDP-glucose 6-dehydrogenase Homo sapiens 60-64 32768525-3 2020 We examined clinical association of nucleotide sugar pathway gene expression and found that UGDH, encoding UDP-glucose 6-dehydrogenase which catalyzes production of UDP-glucuronate, is associated with worse breast cancer patient survival. Uridine Diphosphate Glucuronic Acid 165-180 UDP-glucose 6-dehydrogenase Homo sapiens 107-134 32175296-1 2020 UDP-glucose dehydrogenase (UGDH) encodes an oxidoreductase that converts two successive oxidations of UDP-glucose to produce UDP-glucuronic acid, a key component in the synthesis of several polysaccharides such as glycosaminoglycan and the disaccharide hyaluronic acid. Uridine Diphosphate Glucuronic Acid 125-144 UDP-glucose 6-dehydrogenase Homo sapiens 0-25 31932306-4 2020 The synthesis of UDP-glucuronic acid can alter the NAD+:NADH ratio via the enzyme UDP-glucose dehydrogenase, which oxidizes the alcohol group at C6 to the COO- group. Uridine Diphosphate Glucuronic Acid 17-36 UDP-glucose 6-dehydrogenase Homo sapiens 82-107 32175296-1 2020 UDP-glucose dehydrogenase (UGDH) encodes an oxidoreductase that converts two successive oxidations of UDP-glucose to produce UDP-glucuronic acid, a key component in the synthesis of several polysaccharides such as glycosaminoglycan and the disaccharide hyaluronic acid. Uridine Diphosphate Glucuronic Acid 125-144 UDP-glucose 6-dehydrogenase Homo sapiens 27-31 32001716-3 2020 UGDH encodes an oxidoreductase that converts UDP-glucose to UDP-glucuronic acid, a key component of specific proteoglycans and glycolipids. Uridine Diphosphate Glucuronic Acid 60-79 UDP-glucose 6-dehydrogenase Homo sapiens 0-4 31243371-6 2019 Phosphorylated UGDH interacts with Hu antigen R (HuR) and converts UDP-glucose to UDP-glucuronic acid, which attenuates the UDP-glucose-mediated inhibition of the association of HuR with SNAI1 mRNA and therefore enhances the stability of SNAI1 mRNA. Uridine Diphosphate Glucuronic Acid 82-101 UDP-glucose 6-dehydrogenase Homo sapiens 15-19 31189734-1 2019 UDP-glucose dehydrogenase (UGDH), an oxidoreductase, catalyzes the NAD+-dependent four-electron oxidation of UDP-glucose to UDP-glucuronic acid. Uridine Diphosphate Glucuronic Acid 124-143 UDP-glucose 6-dehydrogenase Homo sapiens 0-25 31189734-1 2019 UDP-glucose dehydrogenase (UGDH), an oxidoreductase, catalyzes the NAD+-dependent four-electron oxidation of UDP-glucose to UDP-glucuronic acid. Uridine Diphosphate Glucuronic Acid 124-143 UDP-glucose 6-dehydrogenase Homo sapiens 27-31 26582015-0 2016 Selective oxidation of UDP-glucose to UDP-glucuronic acid using permeabilized Schizosaccharomyces pombe expressing human UDP-glucose 6-dehydrogenase. Uridine Diphosphate Glucuronic Acid 38-57 UDP-glucose 6-dehydrogenase Homo sapiens 121-148 30774864-3 2019 We have previously reported in vitro that the oxidative metabolites of 6TP, specifically 6-thiouric acid (6TU, K i 7 muM), are potent inhibitors of UDP-glucose dehydrogenase (UDPGDH), an enzyme that is responsible for the formation of UDP-glucuronic acid (UDPGA), an essential substrate that is used in detoxification processes in the liver. Uridine Diphosphate Glucuronic Acid 235-254 UDP-glucose 6-dehydrogenase Homo sapiens 148-173 30774864-3 2019 We have previously reported in vitro that the oxidative metabolites of 6TP, specifically 6-thiouric acid (6TU, K i 7 muM), are potent inhibitors of UDP-glucose dehydrogenase (UDPGDH), an enzyme that is responsible for the formation of UDP-glucuronic acid (UDPGA), an essential substrate that is used in detoxification processes in the liver. Uridine Diphosphate Glucuronic Acid 235-254 UDP-glucose 6-dehydrogenase Homo sapiens 175-181 30457329-1 2018 Human UDP-glucose dehydrogenase (hUGDH) oxidizes UDP-glucose to UDP-glucuronic acid, an essential substrate in the phase II metabolism of drugs. Uridine Diphosphate Glucuronic Acid 64-83 UDP-glucose 6-dehydrogenase Homo sapiens 6-31 30457329-1 2018 Human UDP-glucose dehydrogenase (hUGDH) oxidizes UDP-glucose to UDP-glucuronic acid, an essential substrate in the phase II metabolism of drugs. Uridine Diphosphate Glucuronic Acid 64-83 UDP-glucose 6-dehydrogenase Homo sapiens 33-38 29479058-1 2018 UDP-glucose 6-dehydrogenase (UGDH) produces UDP-alpha-D-glucuronic acid, the precursors for glycosaminoglycans (GAGs) and proteoglycans of the extracellular matrix. Uridine Diphosphate Glucuronic Acid 44-71 UDP-glucose 6-dehydrogenase Homo sapiens 29-33 29324279-4 2018 None have investigated the effects of inhibition towards UDP-Glucose Dehydrogenase (UDPGDH), an oxidative enzyme responsible for UDP-glucuronic acid (UDPGA) formation or UDP-Glucuronosyl transferase (UGT1A1), which is responsible for the conjugation of bilirubin with UDPGA for excretion. Uridine Diphosphate Glucuronic Acid 129-148 UDP-glucose 6-dehydrogenase Homo sapiens 84-90 27307252-2 2016 UDP-glucose dehydrogenase (UGDH) catalyzes the NAD(+)-dependent oxidation of UDP-glucose to UDP-glucuronate, an essential precursor for androgen inactivation by the prostate glucuronidation enzymes UGT2B15 and UGT2B17. Uridine Diphosphate Glucuronic Acid 92-107 UDP-glucose 6-dehydrogenase Homo sapiens 0-25 27307252-2 2016 UDP-glucose dehydrogenase (UGDH) catalyzes the NAD(+)-dependent oxidation of UDP-glucose to UDP-glucuronate, an essential precursor for androgen inactivation by the prostate glucuronidation enzymes UGT2B15 and UGT2B17. Uridine Diphosphate Glucuronic Acid 92-107 UDP-glucose 6-dehydrogenase Homo sapiens 27-31 27307252-3 2016 UGDH expression is androgen stimulated, which increases the production of UDP-glucuronate and fuels UGT-catalyzed glucuronidation. Uridine Diphosphate Glucuronic Acid 74-89 UDP-glucose 6-dehydrogenase Homo sapiens 0-4 27241161-5 2016 The system was first tested using resting yeast cells coexpressing UGDH and human UGT1A6, 7-hydroxycoumarin as the substrate, in a reaction medium containing 8% glucose, serving as a source of UDP-glucuronic acid. Uridine Diphosphate Glucuronic Acid 193-212 UDP-glucose 6-dehydrogenase Homo sapiens 67-71 27198584-1 2016 The enzyme UDP-glucose dehydrogenase (UGDH) catalyzes the reaction of UDP-glucose to UDP-glucuronate through two successive NAD(+)-dependent oxidation steps. Uridine Diphosphate Glucuronic Acid 85-100 UDP-glucose 6-dehydrogenase Homo sapiens 11-36 27198584-1 2016 The enzyme UDP-glucose dehydrogenase (UGDH) catalyzes the reaction of UDP-glucose to UDP-glucuronate through two successive NAD(+)-dependent oxidation steps. Uridine Diphosphate Glucuronic Acid 85-100 UDP-glucose 6-dehydrogenase Homo sapiens 38-42 26190959-3 2014 In a mimic of the natural biosynthetic route, UDP-glucose is converted to UDP-glucuronic acid by hUGDH, followed by subsequent formation of UDP-xylose by hUXS. Uridine Diphosphate Glucuronic Acid 74-93 UDP-glucose 6-dehydrogenase Homo sapiens 97-102