PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33898165-3	2021	Through a single-crystal study on a model compound, the double Schiff base formation is found to follow syn addition, a kinetically favored product, suggesting that reactivity of the amine and carbonyls dictate the order and geometry of the framework building.	Amines	183-188	synemin	Homo sapiens	104-107	
34424694-0	2021	A Diastereodivergent and Enantioselective Approach to syn- and anti-Diamines: Development of 2-Azatrienes for Cu-Catalyzed Reductive Couplings with Imines That Furnish Allylic Amines.	Amines	176-182	synemin	Homo sapiens	54-57	
34264662-5	2021	By choosing an appropriate combination of chiral palladium and amine catalysts, we could obtain either syn or anti coupling products, and this method therefore provides highly diastereo- and enantioselective access to complementary diastereomers of chiral aldehydes with alpha,beta-vicinal stereocenters.	Amines	63-68	synemin	Homo sapiens	103-106	
30183792-2	2018	The reaction at room temperature under neat conditions (no solvent) with quinuclidine as an amine nucleophile, in the presence of benzyl alcohol as an additive, afforded a product, gamma-(aziridin-2-yl)-beta-hydroxy-alpha-methylene butanoate, in 97% yield with a diastereomeric ratio of anti and syn as 86 : 14.	Amines	92-97	synemin	Homo sapiens	296-299	
31979160-3	2020	The free amine (-NH2) groups at the tail of the CYS-SAM enabled the immobilization of anti-alpha-Syn-antibody, which concurrently allowed the formation of immunocomplex by covalent bonding with alpha-Syn-antigen.	Amines	9-14	synemin	Homo sapiens	97-100	
32198909-3	2020	The photoirradiation of the optically active double helices complexed with chiral amines proceeded in a diastereo- (anti or syn) and enantiodifferentiating way to afford the chiral anti-photodimer with up to 98% enantiomeric excess when (R)-phenylethylamine was used as a chiral double-helix inducer.	Amines	82-88	synemin	Homo sapiens	124-127	
24428414-2	2014	With this method, both syn- and anti-1,2-difunctionalized compounds were obtained from the same set of reactants by using the appropriate amine catalyst.	Amines	138-143	synemin	Homo sapiens	23-26	
27682640-2	2016	Branched homoallylic amines are readily prepared in a syn-selective manner with high regio-, diastereo- and enantioselectivity.	Amines	21-27	synemin	Homo sapiens	54-57	
27355860-2	2016	syn-Selective aldol reactions realized by using either tertiary amines or a dizinc aldol catalyst constitute two parallel routes to the de novo synthesis of orthogonally protected biologically relevant 2-keto-d- and l-gluconic acids.	Amines	64-70	synemin	Homo sapiens	0-3	
24954727-2	2014	Key elements include an asymmetric organocatalytic sequence proceeding by a regiospecific secondary-amine-catalyzed syn Michael addition followed by an intramolecular aldol reaction.	Amines	100-105	synemin	Homo sapiens	116-119	
23723888-2	2013	The major conformational difference arises in the relative orientation of the pyrazole ring amine and dioxole substituents which are anti in A and syn in B.	Amines	92-97	synemin	Homo sapiens	147-150	
24195476-1	2013	By capitalizing on the different reactivity of nitrile N-oxides with isocyanides and amine, alpha-oximinoamidines, a so far elusive class of compounds, have been synthesized in a straightforward way by reacting isocyanides, syn-chlorooximes, and amines in a multicomponent fashion.	Amines	85-90	synemin	Homo sapiens	162-165	
24195476-1	2013	By capitalizing on the different reactivity of nitrile N-oxides with isocyanides and amine, alpha-oximinoamidines, a so far elusive class of compounds, have been synthesized in a straightforward way by reacting isocyanides, syn-chlorooximes, and amines in a multicomponent fashion.	Amines	246-252	synemin	Homo sapiens	162-165	
23478288-1	2013	A reagent-controlled, diastereo- and enantioselective synthesis of anti- and syn-beta-hydroxy-alpha-phenyl carboxylates has been achieved by the proper choice of solvent, temperature, alkoxy group, and amine for the diisopinocampheylboron-mediated asymmetric enolization-aldolization of phenylacetates.	Amines	202-207	synemin	Homo sapiens	54-57	
23790080-2	2013	The subtle interplay between the corresponding acetoxypyranone conformation and steric bulk of tertiary amine bases causes syn-acetoxypyranones to undergo [5 + 2] cycloaddition appreciably faster than anti-acetoxypyranones.	Amines	104-109	synemin	Homo sapiens	123-126	
23425209-2	2013	In the presence of a phosphine scavenger, Ni(COD)2, the phosphine-ligated syn-dinickel complexes copolymerized alpha-olefins and ethylene in the presence of amines to afford 0.2-1.3% alpha-olefin incorporation and copolymerized amino olefins and ethylene with a similar range of incorporation (0.1-0.8%).	Amines	157-163	synemin	Homo sapiens	74-77	
23723843-1	2013	In the title compound, C13H19N3S, the methyl-amine substituent is coplanar with the thia-diazole ring to which it is attached [C-N-C-S torsion angle = 175.9 (2) ] and the amine H atom is syn to the thia-diazole S atom.	Amines	45-50	synemin	Homo sapiens	187-190	
22064936-3	2011	The hy-droxy and amine groups are almost syn which enables the formation of inter-molecular hy-droxy-OH N(thia-diazo-yl) and amine-H O(sulfon-yl) hydrogen bonds leading to a supra-molecular chain aligned along the a axis.	Amines	17-22	synemin	Homo sapiens	41-44	
22395306-4	2012	3-Monosubstituted secondary amine 7c was proved to be the best catalyst, affording high yields (up to 95%), good to excellent enantioselectivities (up to 99%) and diastereoselectivities (syn/anti up to 99:1) under the optimized conditions.	Amines	28-33	synemin	Homo sapiens	187-190	
22719553-3	2012	In each mol-ecule, there is a twist in the link between the approximately syn carbonyl and amine groups [the N-C-C-O torsion angles range from 19.73 (19) to -21.2 (2) ].	Amines	91-96	synemin	Homo sapiens	74-77	
22324784-5	2012	X-ray crystallography of the syn isomer of complex 2 demonstrated that it has a distorted trigonal bipyramidal geometry with the nitrido group and the two sulfur atoms defining the equatorial plane, the phosphorus atom of the monophosphine and the protonated amine nitrogen of the tridentate ligand spanning the two reciprocal trans positions along the axis perpendicular to the trigonal plane.	Amines	259-264	synemin	Homo sapiens	29-32	
22315965-1	2012	A concise and highly stereoselective total synthesis of manzacidin B and its congeners has been developed following chelation-controlled syn-epoxidation and Lewis acid catalyzed intramolecular regioselective epoxide ring opening to generate the quarternary amine center.	Amines	257-262	synemin	Homo sapiens	43-46	
17078716-1	2006	[Structure: see text] Syn-configured aldol products of mandelic acid esters and aldehydes were synthesized by the catalytic use of amines in the presence of titanium(IV) tert-butoxide.	Amines	131-137	synemin	Homo sapiens	22-25	
20397160-3	2010	Moreover, the judicious selection of commercially available secondary amine catalysts allows selective access to the desired stereoisomer of the N-tert-butoxycarbonyl (Boc) or N-carbobenzyloxy (Cbz) Mannich adducts, with high control over the syn or anti relative configuration and almost perfect enantioselectivity.	Amines	70-75	synemin	Homo sapiens	243-246	
18215050-0	2008	Highly enantioselective direct syn- and anti-aldol reactions of dihydroxyacetones catalyzed by chiral primary amine catalysts.	Amines	110-115	synemin	Homo sapiens	31-34	
21264400-0	2011	Highly enantioselective synthesis of syn-aldols of cyclohexanones via chiral primary amine catalyzed asymmetric transfer aldol reactions in ionic liquid.	Amines	85-90	synemin	Homo sapiens	24-27	
21523067-3	2011	Pairs of mol-ecules assemble in the crystal structure, forming centrosymmetric hydrogen-bonded dimers via pairs of N-H N hydrogen bonds through the syn H atom of the amine group.	Amines	166-171	synemin	Homo sapiens	148-151	
21069994-8	2010	Finally, empirical models are proposed that are consistent with the observed stereochemical course of these coupling reactions en route to chiral homoallylic amines possessing di- or trisubstituted alkenes and anti- or syn- relative stereochemistry at the allylic and homoallylic positions.	Amines	158-164	synemin	Homo sapiens	219-222	
20831256-4	2010	The product pyrimidines can be readily transformed into the corresponding free syn- and anti-amines.	Amines	93-99	synemin	Homo sapiens	79-82	
20521772-2	2010	To achieve this end, chiral primary amines have been explored and the primary-tertiary diamine-Bronsted acid salts are found to promote the cross-aldol reactions of aldehydes with high activity and syn selectivity.	Amines	36-42	synemin	Homo sapiens	198-201	
20464574-3	2010	This hypothesis derived from the results of the biochemical studies, mainly generated from our laboratory, on the possible metabolic shifts of tyrosine toward an activation of decarboxylase enzyme activity with an increased synthesis of traces amines, i.e. tyr, oct and syn, and an unphysiological synthesis of noradrenalin and dopamine.	Amines	244-250	synemin	Homo sapiens	224-227	
19642691-3	2009	Oxidation of the homoallylic amines 3-(N-benzylamino)methylcyclohex-1-ene and 3-(N,N-dibenzylamino)methylcyclohex-1-ene gave, in both cases, the corresponding N-protected 1,2-anti-2,3-syn-3-aminomethylcyclohexane-1,2-diol with high levels of diastereoselectivity (>or=90:10 dr).	Amines	29-35	synemin	Homo sapiens	184-187	
16608325-2	2006	The syn-oriented 2-OH takes over the catalytic role of the external water or amine molecule previously observed in 2-deoxy ester aminolysis.	Amines	77-82	synemin	Homo sapiens	4-7	
14995172-2	2004	On addition of simple amine bases, such as 1,8-bis(dimethylamino)naphthalene (7), complex 5 rapidly generates the triene 6 via a beta-H elimination process whose stereochemistry is demonstrated to be syn.	Amines	22-27	synemin	Homo sapiens	200-203	
15471472-4	2004	Both syn and anti adducts were separately N-deprotected, and the resulting amines reacted with an activated ester derived from the acid (20) to afford the final targets (5).	Amines	75-81	synemin	Homo sapiens	5-8	
11670433-2	1998	All have the syn,anti configuration about the two meridional amine centers of the cis-coordinated cyclen ligand (syn(NH(3)),anti(X)- and syn(X),anti(NH(3))-isomers for X = OH(2), Cl, N(3), OH; designated as 1-X and 2-X respectively) but a syn,syn intermediate is proposed for a number of the reactions.	Amines	61-66	synemin	Homo sapiens	13-16	
11457008-1	2001	The achiral syn folded (face-to-face conformation) host molecule of the ethane-bridged bis(zinc porphyrin) transforms into the corresponding chiral extended anti bis-ligated species in the presence of enantiopure amine guests.	Amines	213-218	synemin	Homo sapiens	12-15