PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30680760-0 2019 Structure-activity study of fluorine or chlorine-substituted cinnamic acid derivatives with tertiary amine side chain in acetylcholinesterase and butyrylcholinesterase inhibition. Amines 101-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-141 31351393-2 2019 Here we describe the synthesis and multitarget biological profiling of a new class of compounds designed by molecular hybridization of an NMDA receptor antagonist fluorobenzohomoadamantanamine with the potent acetylcholinesterase (AChE) inhibitor 6-chlorotacrine, using two different linker lengths and linkage positions, to preserve or not the memantine-like polycyclic unsubstituted primary amine. Amines 187-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 209-229 31351393-2 2019 Here we describe the synthesis and multitarget biological profiling of a new class of compounds designed by molecular hybridization of an NMDA receptor antagonist fluorobenzohomoadamantanamine with the potent acetylcholinesterase (AChE) inhibitor 6-chlorotacrine, using two different linker lengths and linkage positions, to preserve or not the memantine-like polycyclic unsubstituted primary amine. Amines 187-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 231-235 31444085-3 2019 The results revealed that the tertiary amines and methylene chain length significantly affected the eeAChE inhibitory potency, in particular, compound TM-14 showed the best eeAChE inhibitory activity with IC50 value of 2.9 muM, in addition, both kinetic analysis of AChE inhibition and docking study displayed that TM-14 could simultaneously bind to the catalytic active site and peripheral anionic site of AChE. Amines 39-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 32008906-0 2020 Design, synthesis and evaluation of new 4-arylthiazole-2-amine derivatives as acetylcholinesterase inhibitors. Amines 40-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 32008906-1 2020 A series of new 4-arylthiazole-2-amine derivatives as acetylcholinesterase inhibitors (AChEIs) were designed and synthesized, Furthermore, their inhibitory activities against acetylcholinesterase in vitro were tested by Ellman spectrophotometry, and the results of inhibitory activity test showed that most of them had a certain acetylcholinesterase inhibitory activity in vitro. Amines 16-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 32008906-1 2020 A series of new 4-arylthiazole-2-amine derivatives as acetylcholinesterase inhibitors (AChEIs) were designed and synthesized, Furthermore, their inhibitory activities against acetylcholinesterase in vitro were tested by Ellman spectrophotometry, and the results of inhibitory activity test showed that most of them had a certain acetylcholinesterase inhibitory activity in vitro. Amines 16-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 175-195 32008906-1 2020 A series of new 4-arylthiazole-2-amine derivatives as acetylcholinesterase inhibitors (AChEIs) were designed and synthesized, Furthermore, their inhibitory activities against acetylcholinesterase in vitro were tested by Ellman spectrophotometry, and the results of inhibitory activity test showed that most of them had a certain acetylcholinesterase inhibitory activity in vitro. Amines 16-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 175-195 30680760-2 2019 The results show that almost all the derivatives containing tertiary amine side chain (compounds 4a-9d) exhibit moderate or potent activity in AChE inhibition. Amines 69-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 27951489-3 2017 The alteration of carbon chain linking tertiary amine groups and ferulic acid scaffold markedly influenced the inhibition activity against AChE. Amines 48-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 29934672-1 2018 Chalcones containing tertiary amine side-chains have potent activity as acetylcholinesterase (AChE) inhibitors. Amines 30-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 29934672-1 2018 Chalcones containing tertiary amine side-chains have potent activity as acetylcholinesterase (AChE) inhibitors. Amines 30-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 29934672-2 2018 However, the effects of the location of the tertiary amine groups as well as of other groups on AChE and butyrylcholinesterase (BChE) activity have not been reported. Amines 53-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 30033646-0 2018 Schiff bases and their amines: Synthesis and discovery of carbonic anhydrase and acetylcholinesterase enzymes inhibitors. Amines 23-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 25047936-0 2014 Amine substitution of quinazolinones leads to selective nanomolar AChE inhibitors with "inverted" binding mode. Amines 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 20452769-3 2010 Compounds 25-31 having a secondary amine moiety connected to the phenyl ring via eight CH(2) units spacer were found to be the most potent inhibitors with IC(50) value lower than 220nM and 48nM against AChE and BChE, respectively. Amines 35-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 202-206 14611850-1 2003 Cage amines 1-4 are potent peripheral anionic site-bound reversible inhibitors of both acetylcholinesterase and butyrylcholinesterase. Amines 5-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 14611850-3 2003 For both enzymes, the -log K(i) values linearly correlate with the difference of substituted phenyl radius of cage amines (-log K(i)=5.4+3.4Deltagamma for acetylcholinesterase, -log K(i)=5.9+3.2Deltagamma for butyrylcholinesterase). Amines 115-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-175 7744305-0 1995 A possible interaction between acetylcholinesterase and dopamine molecules during autoxidation of the amine. Amines 59-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 32754990-4 2020 For all new synthesized compounds, the position of tertiary amine side chain obviously influenced the activity of inhibiting AChE. Amines 60-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 34216669-0 2021 In silico, theoretical biointerface analysis and in vitro kinetic analysis of amine compounds interaction with acetylcholinesterase and butyrylcholinesterase. Amines 78-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 34216669-6 2021 Binding energy calculated through MMGBSA method identified the non-covalent interactions (electrostatic and Van der Waals interactions) have contributed to the stable binding of the amine compounds with the AChE/BChE. Amines 182-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 207-211 34216669-7 2021 Biointerface between amine compounds and AChE/BChE were visualized through Hirshfeld surface analysis. Amines 21-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 3746817-6 1986 Increasing lipophilicity of the amine segment correlated with reactivator potency, as did electron-withdrawing groups on the aryl moiety, presumably due to increased binding to hydrophobic sites surrounding the AChE active site. Amines 32-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 211-215