PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16978022-5 2006 Docking studies of hydroxylated heterocyclic amines in the models of NAT1 and NAT2 probed the differences exhibited by these two proteins with mutagenic agents. Amines 45-51 N-acetyltransferase 1 Homo sapiens 69-73 28628859-1 2017 The human arylamine N-acetyltransferase 1 (NAT1) enzyme plays a vital role in determining the duration of action of amine-containing drugs such as para-aminobenzoic acid (PABA) by influencing the balance between detoxification and metabolic activation of these drugs. Amines 14-19 N-acetyltransferase 1 Homo sapiens 43-47 19273964-1 2009 PURPOSE: Polymorphic cytochrome P-450 1A2, N-acetyltransferase 1, and 2 are important enzymes involved in the biotransformation of aromatic and heterocyclic amines known as carcinogens for colorectal cancer. Amines 157-163 N-acetyltransferase 1 Homo sapiens 43-71 24319536-2 2013 Cytochrome P450 2E1 (CYP2E1), NAD(P)H quinone oxidoreductase1 (NQO1), and N-Acetyltransferase1 (NAT1), are drug-metabolizing enzymes (DMEs) involved in the metabolism of carcinogens, such as arylamines and heterocyclic amines, implicated in bladder cancer. Amines 195-201 N-acetyltransferase 1 Homo sapiens 74-94 24319536-2 2013 Cytochrome P450 2E1 (CYP2E1), NAD(P)H quinone oxidoreductase1 (NQO1), and N-Acetyltransferase1 (NAT1), are drug-metabolizing enzymes (DMEs) involved in the metabolism of carcinogens, such as arylamines and heterocyclic amines, implicated in bladder cancer. Amines 195-201 N-acetyltransferase 1 Homo sapiens 96-100 20041842-1 2010 Human arylamine N-acetyltransferase 1 (NAT1) is a phase II xenobiotic-metabolizing enzyme (XME) involved in the biotransformation of many aromatic and heterocyclic amines. Amines 164-170 N-acetyltransferase 1 Homo sapiens 6-37 20041842-1 2010 Human arylamine N-acetyltransferase 1 (NAT1) is a phase II xenobiotic-metabolizing enzyme (XME) involved in the biotransformation of many aromatic and heterocyclic amines. Amines 164-170 N-acetyltransferase 1 Homo sapiens 39-43 18022202-0 2008 Modification by N-acetyltransferase 1 genotype on the association between dietary heterocyclic amines and colon cancer in a multiethnic study. Amines 95-101 N-acetyltransferase 1 Homo sapiens 16-37 18069763-1 2007 AIM: To evaluate the effect of inflammatory cytokines on arylamine N-acetyltransferase 1 (NAT1), which is a phase-II enzyme involved in the biotransformation of aromatic and heterocyclic amines found in food, drugs and the environment. Amines 187-193 N-acetyltransferase 1 Homo sapiens 57-88 18069763-1 2007 AIM: To evaluate the effect of inflammatory cytokines on arylamine N-acetyltransferase 1 (NAT1), which is a phase-II enzyme involved in the biotransformation of aromatic and heterocyclic amines found in food, drugs and the environment. Amines 187-193 N-acetyltransferase 1 Homo sapiens 90-94 16680433-2 2006 N-acetyltransferase 1 (NAT1) participates in the catabolism of folates and the acetylation of aromatic and heterocyclic amines. Amines 120-126 N-acetyltransferase 1 Homo sapiens 0-21 16680433-2 2006 N-acetyltransferase 1 (NAT1) participates in the catabolism of folates and the acetylation of aromatic and heterocyclic amines. Amines 120-126 N-acetyltransferase 1 Homo sapiens 23-27 11505221-1 2001 N-acetyltransferase 1 (NAT1) catalyses the activation and/or deactivation of aromatic and heterocyclic amine carcinogens. Amines 103-108 N-acetyltransferase 1 Homo sapiens 0-21 16708048-10 2006 CONCLUSIONS: In conclusion, we demonstrated that NAT1, SULT1A1 and SULT1A3 are present in human prostate and that both enzyme classes significantly contribute to the activation of N-hydroxylated heterocyclic amines to DNA-damaging species in this tissue. Amines 208-214 N-acetyltransferase 1 Homo sapiens 49-53 15959877-2 2005 N-acetyltransferase 1 is involved in acetylation of aromatic and heterocyclic amines and the catabolism of folates. Amines 78-84 N-acetyltransferase 1 Homo sapiens 0-21 12351146-4 2002 The high frequency of the NAT1 and NAT2 acetylation polymorphisms in human populations together with ubiquitous exposure to aromatic and heterocyclic amines suggest that NAT1 and NAT2 acetylator genotypes are important modifiers of human cancer susceptibility. Amines 150-156 N-acetyltransferase 1 Homo sapiens 26-30 12351146-4 2002 The high frequency of the NAT1 and NAT2 acetylation polymorphisms in human populations together with ubiquitous exposure to aromatic and heterocyclic amines suggest that NAT1 and NAT2 acetylator genotypes are important modifiers of human cancer susceptibility. Amines 150-156 N-acetyltransferase 1 Homo sapiens 170-174 16847422-2 2006 As part of our evaluation of the role of aromatic and heterocyclic amines, which are metabolized by N-acetyltransferase (NAT) enzymes, in the etiology of non-Hodgkin lymphoma (NHL), we examined NHL risk in relation to genetic variation in NAT1 and NAT2 and exposure to cigarette smoke and dietary heterocyclic amines and mutagens. Amines 67-73 N-acetyltransferase 1 Homo sapiens 239-243 11505221-1 2001 N-acetyltransferase 1 (NAT1) catalyses the activation and/or deactivation of aromatic and heterocyclic amine carcinogens. Amines 103-108 N-acetyltransferase 1 Homo sapiens 23-27 11505221-10 2001 The results of these studies suggest an important role for the NAT1 genetic polymorphism in metabolism of aromatic and heterocyclic amine carcinogens. Amines 132-137 N-acetyltransferase 1 Homo sapiens 63-67 10090301-1 1999 N-Acetyltransferase 1 (NAT1), encoded by the polymorphic NAT1 gene, has been shown to be one of the major enzymes in human breast tissue that activates aromatic and heterocyclic amines. Amines 178-184 N-acetyltransferase 1 Homo sapiens 0-21 10090301-1 1999 N-Acetyltransferase 1 (NAT1), encoded by the polymorphic NAT1 gene, has been shown to be one of the major enzymes in human breast tissue that activates aromatic and heterocyclic amines. Amines 178-184 N-acetyltransferase 1 Homo sapiens 23-27 10090301-1 1999 N-Acetyltransferase 1 (NAT1), encoded by the polymorphic NAT1 gene, has been shown to be one of the major enzymes in human breast tissue that activates aromatic and heterocyclic amines. Amines 178-184 N-acetyltransferase 1 Homo sapiens 57-61