PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26593027-1 2012 Monoamine oxidase (MAO), which exists in two isozymic forms, MAO A and MAO B, is an important flavoenzyme responsible for the metabolism of amine neurotransmitters such as dopamine, serotonin, and norepinephrine. Amines 4-9 monoamine oxidase B Homo sapiens 71-76 24607445-3 2014 More recently, the understanding that: a) potentiation of indirectly-acting sympathomimetic amines is caused by inhibitors of MAO-A but not by inhibitors of MAO-B, and b) that reversible inhibitors of MAO-A cause minimal tyramine potentiation, has led to their re-introduction to clinical use for treatment of depression (reversible MAO-A inhibitors and new dose form MAO-B inhibitor) and treatment of Parkinson"s disease (MAO-B inhibitors). Amines 92-98 monoamine oxidase B Homo sapiens 368-373 23116392-1 2013 Flavin-containing monoamine oxidases (MAO A and MAO B) located on the outer membrane of mitochondria oxidise amines and generate hydrogen peroxide. Amines 109-115 monoamine oxidase B Homo sapiens 48-53 22974659-1 2012 Monoamine oxidase B (MAO-B) plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Amines 100-106 monoamine oxidase B Homo sapiens 0-19 22974659-1 2012 Monoamine oxidase B (MAO-B) plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Amines 100-106 monoamine oxidase B Homo sapiens 21-26 23417310-2 2013 The detailed molecular mechanism proposed for the MAO-catalyzed oxidation of amines has been controversial with the basic assumption that both MAO A and MAO B follow the same pathway for the C-H bond cleavage step. Amines 77-83 monoamine oxidase B Homo sapiens 153-158 20123154-3 2010 Making the phenylethylamine scaffold rigid by fixing the amine chain in an extended six-membered ring conformation increased MAO-B (but not MAO-A) inhibitory activity relative to the more flexible alpha-methylated derivative. Amines 22-27 monoamine oxidase B Homo sapiens 125-130 22765918-0 2012 Modulations of brain amines and dopaminergic behavior by a novel, reversible and selective MAO-B inhibitor. Amines 21-27 monoamine oxidase B Homo sapiens 91-96 22365943-4 2012 Patients who lack both MAOA and MAOB have the most extreme laboratory values (urine, blood, and CSF serotonin 4-6 times normal, with elevated O-methylated amine metabolites and reduced deaminated metabolites) in addition to severe intellectual deficiency and behavioral problems. Amines 155-160 monoamine oxidase B Homo sapiens 32-36 21359973-1 2011 Monoamine oxidase (MAO) A and MAO B are a crucial pair of isoenzymes, which oxidatively deaminate monoamine neurotransmitters and dietary amines with a production of hydrogen peroxide. Amines 138-144 monoamine oxidase B Homo sapiens 30-35 20832472-4 2010 Incubation of MAO-B with 2-phenylethylamine, an endogenous trace amine and MAO-B substrate, resulted in a progressive loss of enzyme activity, increased enzyme mass, distinct spectral changes and, as was observed with tranylcypromine, a parallel increase in high affinity binding of [(3)H]2-BFI. Amines 38-43 monoamine oxidase B Homo sapiens 14-19 20832472-4 2010 Incubation of MAO-B with 2-phenylethylamine, an endogenous trace amine and MAO-B substrate, resulted in a progressive loss of enzyme activity, increased enzyme mass, distinct spectral changes and, as was observed with tranylcypromine, a parallel increase in high affinity binding of [(3)H]2-BFI. Amines 38-43 monoamine oxidase B Homo sapiens 75-80 20832472-8 2010 High affinity I(2) sites may form in vivo due to inactivation of a portion of MAO-B during amine oxidation, while the low affinity I(2) site on active enzyme is a target for novel MAO-B inhibitor drugs. Amines 91-96 monoamine oxidase B Homo sapiens 78-83 20832472-8 2010 High affinity I(2) sites may form in vivo due to inactivation of a portion of MAO-B during amine oxidation, while the low affinity I(2) site on active enzyme is a target for novel MAO-B inhibitor drugs. Amines 91-96 monoamine oxidase B Homo sapiens 180-185 20485326-1 2010 Monoamine oxidases (MAO-A and MAO-B) have a key role in the degradation of amine neurotransmitters, such as dopamine, norepinephrine and serotonin. Amines 4-9 monoamine oxidase B Homo sapiens 30-35 20022119-2 2010 The enzyme monoamine oxidase, type B (MAO-B), is expressed in platelets, and metabolizes endogenous amines. Amines 100-106 monoamine oxidase B Homo sapiens 11-36 20022119-2 2010 The enzyme monoamine oxidase, type B (MAO-B), is expressed in platelets, and metabolizes endogenous amines. Amines 100-106 monoamine oxidase B Homo sapiens 38-43 22475561-2 2012 It is worth noting that most of the small amine moieties substituted on the piperidine ring proved to be potent and selective inhibitors of MAO-B rather than of MAO-A. Amines 42-47 monoamine oxidase B Homo sapiens 140-145 21697081-1 2011 Monoamine oxidases (MAO-A, MAO-B) metabolize biogenic amines and have been implicated in neuronal apoptosis. Amines 54-60 monoamine oxidase B Homo sapiens 27-32 21354322-2 2011 zMAO oxidizes the neurotransmitter amines (serotonin, dopamine and tyramine) with k(cat) values that exceed those of hMAO A or of hMAO B. Amines 35-41 monoamine oxidase B Homo sapiens 130-136 20679667-5 2010 Affected males in this family showed an inherited hemizygous deletion restricted to NDP and two immediately telomeric genes, monoamine oxidase-B (MAO-B) and monoamine oxidase-A (MAO-A), which encode closely related enzymes that metabolize biogenic amines including serotonin, dopamine, and norepinephrine. Amines 248-254 monoamine oxidase B Homo sapiens 125-144 20679667-5 2010 Affected males in this family showed an inherited hemizygous deletion restricted to NDP and two immediately telomeric genes, monoamine oxidase-B (MAO-B) and monoamine oxidase-A (MAO-A), which encode closely related enzymes that metabolize biogenic amines including serotonin, dopamine, and norepinephrine. Amines 248-254 monoamine oxidase B Homo sapiens 146-151 17401536-2 2007 The results presented here provide additional new insights into the interactions that take place on activation of the amine substrate by the aromatic cage residues in MAO-B catalysis and have relevance to the MAO-A catalytic mechanism. Amines 118-123 monoamine oxidase B Homo sapiens 167-172 19401466-1 2009 Monoamine oxidase (MAO) B deaminates a number of biogenic and dietary amines and plays an important role in many biological processes. Amines 70-76 monoamine oxidase B Homo sapiens 0-25 18313306-2 2008 The two stereocenters present in this compound provide an opportunity to examine the enantioselectivity and diastereoselectivity of the MAO-B-catalyzed ring alpha-carbon oxidation of cyclic tertiary amines to give the corresponding conjugated iminiumyl metabolites. Amines 199-205 monoamine oxidase B Homo sapiens 136-141 17573034-1 2007 Due to their pharmacological importance in the oxidation of amine neurotransmitters, the membrane-bound flavoenzymes monoamine oxidase A and monoamine oxidase B have attracted numerous investigations and, as a result, two different mechanisms; the single electron transfer and the polar nucleophilic mechanisms, have been proposed to describe their catalytic mechanisms. Amines 60-65 monoamine oxidase B Homo sapiens 141-160 15279562-1 2004 Monoamine oxidases A and B (MAO A and MAO B) are mitochondrial outer membrane-bound flavoproteins that catalyze the oxidative deamination of neurotransmitters and biogenic amines. Amines 172-178 monoamine oxidase B Homo sapiens 38-43 15717295-2 2005 Monoamine oxidases A and B (MAO-A and MAO-B) degrade biogenic amines such as dopamine and serotonin and thereby control the levels of these neurotransmitters in the central nervous system. Amines 62-68 monoamine oxidase B Homo sapiens 38-43 9603903-1 1998 Mitochondrial monoamine oxidases A and B (MAO A and MAO B) are ubiquitous homodimeric FAD-containing oxidases that catalyze the oxidation of biogenic amines. Amines 150-156 monoamine oxidase B Homo sapiens 52-57 9724550-1 1998 Monoamine oxidase B (MAO B) is an integral protein of the outer mitochondrial membrane that is involved in the deamination of vasoactive and neuroactive amines. Amines 153-159 monoamine oxidase B Homo sapiens 0-19 9724550-1 1998 Monoamine oxidase B (MAO B) is an integral protein of the outer mitochondrial membrane that is involved in the deamination of vasoactive and neuroactive amines. Amines 153-159 monoamine oxidase B Homo sapiens 21-26 9724550-2 1998 The oxidation of these amine substrates requires the cofactor FAD, which is covalently bound to Cys-397 of human MAO B. Amines 23-28 monoamine oxidase B Homo sapiens 113-118 11797065-1 2001 RATIONALE AND OBJECTIVE: Sufficiently high doses of beta-phenylethylamine (beta-PEA), a trace amine that is rapidly metabolized by monoamine oxidase-type B (MAO-B), can produce effects comparable to those of cocaine or methamphetamine (MA). Amines 68-73 monoamine oxidase B Homo sapiens 131-155 11797065-1 2001 RATIONALE AND OBJECTIVE: Sufficiently high doses of beta-phenylethylamine (beta-PEA), a trace amine that is rapidly metabolized by monoamine oxidase-type B (MAO-B), can produce effects comparable to those of cocaine or methamphetamine (MA). Amines 68-73 monoamine oxidase B Homo sapiens 157-162 11259630-1 2001 The human monoamine oxidase (MAO) B plays a major role in the degradation of biogenic and dietary amines such as phenylethylamine, benzylamine, dopamine, and tyramine. Amines 98-104 monoamine oxidase B Homo sapiens 10-35 9547937-1 1998 Both 1-methyl-3-pyrrolines and 2-methylisoindolines are substrates for MAO-B with Vmax/Km values ranging from 200 to 2000 min-1 mM-1 at 37 degrees C. These compounds represent new classes of cyclic tertiary amine substrates for this flavoenzyme. Amines 207-212 monoamine oxidase B Homo sapiens 71-76 9564606-2 1998 In comparative studies with other, structurally similar acetylenic inhibitors of MAO, pargyline, an MAO-B > MAO-A inhibitor used in doses of 90 mg/day for three or more weeks, produced elevations in these trace amines which were similar to those found with the highest dose of selegiline studied. Amines 214-220 monoamine oxidase B Homo sapiens 100-105 9564606-0 1998 Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (clorgyline) or MAO-B (selegiline and pargyline). Amines 19-24 monoamine oxidase B Homo sapiens 109-114 9564616-1 1998 The rate of oxidation by monoamine oxidase (MAO) of a particular amine in a given cell depends on the levels of MAO-A and MAO-B expressed in the mitochondrial outer membranes, on the amine concentration and the oxygen concentration. Amines 29-34 monoamine oxidase B Homo sapiens 122-127 9564616-1 1998 The rate of oxidation by monoamine oxidase (MAO) of a particular amine in a given cell depends on the levels of MAO-A and MAO-B expressed in the mitochondrial outer membranes, on the amine concentration and the oxygen concentration. Amines 65-70 monoamine oxidase B Homo sapiens 122-127 9564606-6 1998 Overall, trace amine elevations in individuals receiving the highest dose of deprenyl or receiving pargyline were approximately three to five-fold lower than the elevations observed in individuals lacking the genes for both MAO-A and MAO-B, suggesting that these drug doses yield incomplete inhibition of MAO-A and MAO-B. Amines 15-20 monoamine oxidase B Homo sapiens 315-320 9503563-1 1997 MAO A and MAO B follow the same chemical mechanism to oxidise primary, secondary, and tertiary amines, but they are distinguished by differences in their substrate and inhibitor specificities and in their kinetic behaviour. Amines 95-101 monoamine oxidase B Homo sapiens 10-15 9313858-1 1997 The MAO-B catalyzed alpha-carbon oxidation of amines has been proposed to proceed via either a single electron transfer (SET) or hydrogen atom transfer (HAT) pathway. Amines 46-52 monoamine oxidase B Homo sapiens 4-9 8870990-1 1996 The monoamine oxidase B (MAO-B) catalyzed oxidation of amines has been proposed to proceed via a polar pathway, an initial single-electron transfer pathway and an initial hydrogen atom transfer pathway. Amines 55-61 monoamine oxidase B Homo sapiens 4-23 8870990-1 1996 The monoamine oxidase B (MAO-B) catalyzed oxidation of amines has been proposed to proceed via a polar pathway, an initial single-electron transfer pathway and an initial hydrogen atom transfer pathway. Amines 55-61 monoamine oxidase B Homo sapiens 25-30 7626622-1 1995 Monoamine oxidase B (MAO B), an integral protein of the outer mitochondrial membrane, catalyzes the oxidative deamination of various neuroactive and vasoactive amines. Amines 160-166 monoamine oxidase B Homo sapiens 0-19 8678123-1 1996 The monoamine oxidases (MAO-A and MAO-B) are the enzymes primarily responsible for the degradation of amine neurotransmitters, such as dopamine, norepinephrine, and serotonin. Amines 8-13 monoamine oxidase B Homo sapiens 34-39 8613523-9 1996 The differences in neurochemical profiles indicate that, under normal conditions, MAO-A is considerably more important than MAO-B in the metabolism of biogenic amines, a factor likely to contribute to the different clinical phenotypes. Amines 160-166 monoamine oxidase B Homo sapiens 124-129 7626622-1 1995 Monoamine oxidase B (MAO B), an integral protein of the outer mitochondrial membrane, catalyzes the oxidative deamination of various neuroactive and vasoactive amines. Amines 160-166 monoamine oxidase B Homo sapiens 21-26 7626622-2 1995 A covalently bound FAD cofactor at Cys-397 of human MAO B is required for the oxidation of the amine substrates. Amines 95-100 monoamine oxidase B Homo sapiens 52-57 7840641-1 1995 Monoamine oxidase B (MAO B), an integral protein of the outer mitochondrial membrane, catalyzes the oxidative deamination of neuroactive and vasoactive amines. Amines 152-158 monoamine oxidase B Homo sapiens 0-19 7840641-1 1995 Monoamine oxidase B (MAO B), an integral protein of the outer mitochondrial membrane, catalyzes the oxidative deamination of neuroactive and vasoactive amines. Amines 152-158 monoamine oxidase B Homo sapiens 21-26 7931238-4 1994 The kinetic behaviour of the parent amines as MAO A and MAO B inhibitors and substrates was determined. Amines 36-42 monoamine oxidase B Homo sapiens 56-61 8390270-1 1993 The "cheese effect", potentiation of sympathomimetic action of indirectly acting amines such as tyramine, the main side effect of irreversible non-selective and selective monoamine oxidase (MAO) A inhibitors, has largely been eliminated in the new generation of reversible selective MAO-A and B and irreversible MAO-B inhibitors. Amines 81-87 monoamine oxidase B Homo sapiens 312-317 8259692-3 1993 This is attributed to a primary amine metabolite which inhibits MAO B in vitro, but which is not detected in human plasma in vivo. Amines 32-37 monoamine oxidase B Homo sapiens 64-69 8259692-4 1993 A secondary amine metabolite, also present in rat but not human plasma, inhibitors MAO B in vivo but not in vitro. Amines 12-17 monoamine oxidase B Homo sapiens 83-88 8246228-1 1993 3-[4-[(3-Chlorophenyl)methoxy]phenyl]-5-[(methylamino)methyl]- 2-oxazolidinone (1) is a secondary amine known to be a potent time-dependent irreversible inactivator of monoamine oxidase B (MAO-B). Amines 98-103 monoamine oxidase B Homo sapiens 168-187 8246228-1 1993 3-[4-[(3-Chlorophenyl)methoxy]phenyl]-5-[(methylamino)methyl]- 2-oxazolidinone (1) is a secondary amine known to be a potent time-dependent irreversible inactivator of monoamine oxidase B (MAO-B). Amines 98-103 monoamine oxidase B Homo sapiens 189-194 34977548-3 2022 Some monoamine oxidase (MAO)-B inhibitors have a sympathomimetic amine, which can be attributed to OH. Amines 65-70 monoamine oxidase B Homo sapiens 5-30 2023912-1 1991 Monoamine oxidases A and B [MAOA and MAOB; amine:oxygen oxidoreductase (deaminating) (flavin-containing), EC 1.4.3.4] play important roles in the metabolism of neuroactive, vasoactive amines and the Parkinsonism-producing neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Amines 184-190 monoamine oxidase B Homo sapiens 37-41 2239154-6 1990 The present results clearly indicate that MAO-B activity is expressed in fibrillary astrocytes in or around senile plaques, suggesting that these astrocytes metabolize exogenous amines in senile plaques. Amines 178-184 monoamine oxidase B Homo sapiens 42-47 1759390-8 1991 The data obtained suggest that the product(s) of oxidative deamination of biogenic amines (probably the aldehydes) catalyzed by both types of MAO (MAO-A and MAO-B) are able to regulate the energy functions of mitochondria. Amines 83-89 monoamine oxidase B Homo sapiens 142-145 1759390-8 1991 The data obtained suggest that the product(s) of oxidative deamination of biogenic amines (probably the aldehydes) catalyzed by both types of MAO (MAO-A and MAO-B) are able to regulate the energy functions of mitochondria. Amines 83-89 monoamine oxidase B Homo sapiens 157-162 35472505-1 2022 Monoamine oxidases A and B (MAO-A and MAO-B) play important roles in biogenic amine metabolism, oxidative stress, and chronic inflammation. Amines 78-83 monoamine oxidase B Homo sapiens 38-43 3335842-3 1988 BP-N-methylbutylamine had a much higher affinity to MAO-A than an amine substrate, kynuramine, and it was a more potent inhibitor of MAO-A than of MAO-B. Amines 16-21 monoamine oxidase B Homo sapiens 147-152 2568664-2 1989 It is now apparent that MAO-B is capable of oxidizing inert non-polar amines such as MPTP (N-methyl-4-phenyl-1,2,3,6, tetrahydropyridine) and milacemide (2-n-pentylaminoacetamide) into neuroactive substances giving rise to Parkinson inducing dopaminergic neurotoxin, MPP+ and inhibitory amino acid neurotransmitter, glycine respectively. Amines 70-76 monoamine oxidase B Homo sapiens 24-29 32093545-1 2021 The human Monoamine oxidase B (hMAO B) is an important flavoenzyme that metabolizes several biogenic amine neurotransmitters, regulates their concentration in the living cells and is involved in different neurological disorders and diseases. Amines 14-19 monoamine oxidase B Homo sapiens 31-37 33279529-1 2021 Monoamine oxidases (MAO-A and MAO-B) are the two flavin adenine dinucleotide (FAD) enzymes that play an important role in neurotransmitter homeostasis and in protection against biogenic amines. Amines 186-192 monoamine oxidase B Homo sapiens 30-35 31303592-2 2019 In this research paper, ligand based virtual screening has been performed in order to predict the inhibitors for monoamine oxidase (MAO-B), an enzyme specifically involved in the metabolism of non-hydroxylated amines such as benzylamine and beta-phenylethylamine (PEA), thus, could be the target to treat various neurodegenerative disorders like Parkinson"s disease. Amines 210-216 monoamine oxidase B Homo sapiens 132-137 32942081-1 2020 Monoamine oxidases (MAO-A and MAO-B) are mammalian flavoenzyme, which catalyze the oxidative deamination of several neurotransmitters like norepinephrine, dopamine, tyramine, serotonin, and some other amines. Amines 201-207 monoamine oxidase B Homo sapiens 30-35 33081086-1 2020 Monoamine oxidase B (MAOB) is expressed in the mitochondrial membrane and has a key role in degrading various neurologically active amines such as benzylamine, phenethylamine and dopamine with the help of Flavin adenine dinucleotide (FAD) cofactor. Amines 132-138 monoamine oxidase B Homo sapiens 0-19 33081086-1 2020 Monoamine oxidase B (MAOB) is expressed in the mitochondrial membrane and has a key role in degrading various neurologically active amines such as benzylamine, phenethylamine and dopamine with the help of Flavin adenine dinucleotide (FAD) cofactor. Amines 132-138 monoamine oxidase B Homo sapiens 21-25 30964996-2 2019 Human monoamine oxidase B (MAO-B) catalyzes the oxidation of amines and is inhibited for the treatment of both Parkinson"s disease and depression. Amines 61-67 monoamine oxidase B Homo sapiens 6-25 30964996-2 2019 Human monoamine oxidase B (MAO-B) catalyzes the oxidation of amines and is inhibited for the treatment of both Parkinson"s disease and depression. Amines 61-67 monoamine oxidase B Homo sapiens 27-32 27575476-1 2016 Monoamine oxidase (MAO) catalyzes the oxidation of monoamines and its two isoforms, MAO-A and MAO-B, break down neurotransmitter amines. Amines 55-61 monoamine oxidase B Homo sapiens 94-99 27010708-3 2016 Recently, we demonstrated that the rate-limiting step of MAO B catalyzed conversion of amines into imines represents the hydride anion transfer from the substrate alpha-CH2 group to the N5 atom of the flavin cofactor moiety. Amines 87-93 monoamine oxidase B Homo sapiens 57-62 26087676-0 2015 Catalytic Amine Oxidation under Ambient Aerobic Conditions: Mimicry of Monoamine Oxidase B. Amines 10-15 monoamine oxidase B Homo sapiens 71-90 29569037-2 2018 Neuronal and glial MAO-B inhibition contributes to more stable levels of dopamine and other biogenic amines in the synaptic cleft. Amines 101-107 monoamine oxidase B Homo sapiens 19-24 26891670-4 2016 The need to inhibit MAO B to combat decreased brain amines continues to drive the search for new drugs. Amines 52-58 monoamine oxidase B Homo sapiens 20-25 26091526-3 2015 The choice of these amines relies on their importance to address MAO B catalytic mechanisms so as to help us to answer questions such as why BA is a better substrate than NBA or how para-substitution affects substrate"s reactivity. Amines 20-26 monoamine oxidase B Homo sapiens 65-70