PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31178977-1 2019 Monoamine oxidases (MAO) with 2 isoforms, A and B, located at the outer mitochondrial membrane are flavoenzyme membranes with a major role in the metabolism of monoaminergic neurotransmitters and biogenic amines in the central nervous system and peripheral tissues, respectively. Amines 205-211 monoamine oxidase A Homo sapiens 0-49 32942081-1 2020 Monoamine oxidases (MAO-A and MAO-B) are mammalian flavoenzyme, which catalyze the oxidative deamination of several neurotransmitters like norepinephrine, dopamine, tyramine, serotonin, and some other amines. Amines 201-207 monoamine oxidase A Homo sapiens 20-25 31680079-1 2019 Monoamine oxidase A (MAO-A), an enzyme found on outer mitochondrial membrane, catalyzes the oxidative deamination of biogenic amines. Amines 126-132 monoamine oxidase A Homo sapiens 0-19 31680079-1 2019 Monoamine oxidase A (MAO-A), an enzyme found on outer mitochondrial membrane, catalyzes the oxidative deamination of biogenic amines. Amines 126-132 monoamine oxidase A Homo sapiens 21-26 28722111-1 2017 Monoamine oxidase A (MAOA) is a mitochondrial enzyme that catalyzes oxidative deamination of neurotransmitters and dietary amines and produces H2 O2 . Amines 123-129 monoamine oxidase A Homo sapiens 0-19 30336354-9 2019 Finally, the downstream effects of increased MAO-A levels are dependent on the availability of amine substrates and in the presence of exogenous substrate, cell viability is dramatically reduced. Amines 95-100 monoamine oxidase A Homo sapiens 45-50 29516165-2 2018 While inhibition of MAO activity in the periphery removes protection from biogenic amines and so is undesirable, inhibition in the brain gives vital antidepressant and behavioural advantages that make MAO a major pharmaceutical target for inhibitor design. Amines 83-89 monoamine oxidase A Homo sapiens 20-25 28722111-1 2017 Monoamine oxidase A (MAOA) is a mitochondrial enzyme that catalyzes oxidative deamination of neurotransmitters and dietary amines and produces H2 O2 . Amines 123-129 monoamine oxidase A Homo sapiens 21-25 25220264-1 2014 Monoamine oxidases (MAOs) A and B are flavoenzymes responsible for the metabolism of biogenic amines such as dopamine, serotonin and noradrenaline. Amines 94-100 monoamine oxidase A Homo sapiens 0-33 27734680-1 2016 Monoamine oxidases (MAOs) A and B are flavoenzymes responsible for the metabolism of biogenic amines, such as dopamine, serotonin, and noradrenaline (NA), which is why they have been extensively implicated in the etiology and course of various neurodegenerative disorders and, accordingly, used as primary pharmacological targets to treat these debilitating cognitive diseases. Amines 94-100 monoamine oxidase A Homo sapiens 0-33 25541744-3 2015 MAO-A is related with metabolism of amine neurotransmitters in the brain whereas MAO-B is concerned with aging related neurodegenerative disorders. Amines 36-41 monoamine oxidase A Homo sapiens 0-5 26227907-1 2016 Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the metabolism of several biological amines such as dopamine, norepinephrine, and serotonin, which are important neurochemicals in the pathogenesis of major psychiatric illnesses. Amines 102-108 monoamine oxidase A Homo sapiens 0-19 26227907-1 2016 Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the metabolism of several biological amines such as dopamine, norepinephrine, and serotonin, which are important neurochemicals in the pathogenesis of major psychiatric illnesses. Amines 102-108 monoamine oxidase A Homo sapiens 21-25 22473857-1 2012 BACKGROUND: Amine catabolism by monoamine oxidase A (MAOA) contributes to oxidative stress, which plays a role in prostate cancer (PCa) development and progression. Amines 12-17 monoamine oxidase A Homo sapiens 32-51 24607445-3 2014 More recently, the understanding that: a) potentiation of indirectly-acting sympathomimetic amines is caused by inhibitors of MAO-A but not by inhibitors of MAO-B, and b) that reversible inhibitors of MAO-A cause minimal tyramine potentiation, has led to their re-introduction to clinical use for treatment of depression (reversible MAO-A inhibitors and new dose form MAO-B inhibitor) and treatment of Parkinson"s disease (MAO-B inhibitors). Amines 92-98 monoamine oxidase A Homo sapiens 126-131 24607445-3 2014 More recently, the understanding that: a) potentiation of indirectly-acting sympathomimetic amines is caused by inhibitors of MAO-A but not by inhibitors of MAO-B, and b) that reversible inhibitors of MAO-A cause minimal tyramine potentiation, has led to their re-introduction to clinical use for treatment of depression (reversible MAO-A inhibitors and new dose form MAO-B inhibitor) and treatment of Parkinson"s disease (MAO-B inhibitors). Amines 92-98 monoamine oxidase A Homo sapiens 201-206 24607445-3 2014 More recently, the understanding that: a) potentiation of indirectly-acting sympathomimetic amines is caused by inhibitors of MAO-A but not by inhibitors of MAO-B, and b) that reversible inhibitors of MAO-A cause minimal tyramine potentiation, has led to their re-introduction to clinical use for treatment of depression (reversible MAO-A inhibitors and new dose form MAO-B inhibitor) and treatment of Parkinson"s disease (MAO-B inhibitors). Amines 92-98 monoamine oxidase A Homo sapiens 201-206 24865426-1 2014 Tumors from patients with high-grade aggressive prostate cancer (PCa) exhibit increased expression of monoamine oxidase A (MAOA), a mitochondrial enzyme that degrades monoamine neurotransmitters and dietary amines. Amines 207-213 monoamine oxidase A Homo sapiens 102-121 24865426-1 2014 Tumors from patients with high-grade aggressive prostate cancer (PCa) exhibit increased expression of monoamine oxidase A (MAOA), a mitochondrial enzyme that degrades monoamine neurotransmitters and dietary amines. Amines 207-213 monoamine oxidase A Homo sapiens 123-127 24652311-3 2014 Monoamine oxidase A (MAOA), a mitochondrial enzyme involved in the degradation of amines, has been reported to be associated with aggression, impulsivity, depression, and mood changes. Amines 82-88 monoamine oxidase A Homo sapiens 0-19 24652311-3 2014 Monoamine oxidase A (MAOA), a mitochondrial enzyme involved in the degradation of amines, has been reported to be associated with aggression, impulsivity, depression, and mood changes. Amines 82-88 monoamine oxidase A Homo sapiens 21-25 24530494-4 2014 For the MAO inhibition, amides were not active, and among the amines, compound 14 was totally MAO A selective, while amines 15 and 16 were quite MAO A selective. Amines 117-123 monoamine oxidase A Homo sapiens 145-150 23417310-2 2013 The detailed molecular mechanism proposed for the MAO-catalyzed oxidation of amines has been controversial with the basic assumption that both MAO A and MAO B follow the same pathway for the C-H bond cleavage step. Amines 77-83 monoamine oxidase A Homo sapiens 143-148 23116392-1 2013 Flavin-containing monoamine oxidases (MAO A and MAO B) located on the outer membrane of mitochondria oxidise amines and generate hydrogen peroxide. Amines 109-115 monoamine oxidase A Homo sapiens 38-43 22473857-1 2012 BACKGROUND: Amine catabolism by monoamine oxidase A (MAOA) contributes to oxidative stress, which plays a role in prostate cancer (PCa) development and progression. Amines 12-17 monoamine oxidase A Homo sapiens 53-57 26593027-1 2012 Monoamine oxidase (MAO), which exists in two isozymic forms, MAO A and MAO B, is an important flavoenzyme responsible for the metabolism of amine neurotransmitters such as dopamine, serotonin, and norepinephrine. Amines 4-9 monoamine oxidase A Homo sapiens 61-66 26593027-9 2012 Thus, we offer here theoretical evidence that the amine is most likely to be present in the active site in its protonated form, which is similar to the conclusion from experimental studies of MAO A (Jones et al. Amines 50-55 monoamine oxidase A Homo sapiens 192-197 21697081-1 2011 Monoamine oxidases (MAO-A, MAO-B) metabolize biogenic amines and have been implicated in neuronal apoptosis. Amines 54-60 monoamine oxidase A Homo sapiens 20-25 21628600-2 2012 Pharmacologic inhibition of monoamine oxidase type A (MAO-A), but not MAO-B, poses a risk of the "cheese effect," a hypertensive response to excess dietary tyramine, a biogenic sympathomimetic amine. Amines 32-37 monoamine oxidase A Homo sapiens 54-59 20679667-5 2010 Affected males in this family showed an inherited hemizygous deletion restricted to NDP and two immediately telomeric genes, monoamine oxidase-B (MAO-B) and monoamine oxidase-A (MAO-A), which encode closely related enzymes that metabolize biogenic amines including serotonin, dopamine, and norepinephrine. Amines 248-254 monoamine oxidase A Homo sapiens 157-176 21359973-1 2011 Monoamine oxidase (MAO) A and MAO B are a crucial pair of isoenzymes, which oxidatively deaminate monoamine neurotransmitters and dietary amines with a production of hydrogen peroxide. Amines 138-144 monoamine oxidase A Homo sapiens 0-25 20679667-5 2010 Affected males in this family showed an inherited hemizygous deletion restricted to NDP and two immediately telomeric genes, monoamine oxidase-B (MAO-B) and monoamine oxidase-A (MAO-A), which encode closely related enzymes that metabolize biogenic amines including serotonin, dopamine, and norepinephrine. Amines 248-254 monoamine oxidase A Homo sapiens 178-183 18501009-1 2008 BACKGROUND: Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in degrading several different biological amines, including serotonin. Amines 116-122 monoamine oxidase A Homo sapiens 12-31 19214141-1 2009 OBJECTIVE: Monoamine oxidase-A (MAO-A) is a key mitochondrial enzyme that metabolizes biogenic amine neurotransmitters such as dopamine and serotonin. Amines 15-20 monoamine oxidase A Homo sapiens 32-37 20485326-1 2010 Monoamine oxidases (MAO-A and MAO-B) have a key role in the degradation of amine neurotransmitters, such as dopamine, norepinephrine and serotonin. Amines 4-9 monoamine oxidase A Homo sapiens 20-25 20421737-1 2010 Monoamine oxidase A (MAO A) is an enzyme that catalyzes the oxidation of neurotransmitter amines. Amines 90-96 monoamine oxidase A Homo sapiens 0-19 20421737-1 2010 Monoamine oxidase A (MAO A) is an enzyme that catalyzes the oxidation of neurotransmitter amines. Amines 90-96 monoamine oxidase A Homo sapiens 21-26 18501009-1 2008 BACKGROUND: Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in degrading several different biological amines, including serotonin. Amines 116-122 monoamine oxidase A Homo sapiens 33-37 18177231-2 2008 Patients produce little IKAP, the gene product of the affected mutated gene, and have low levels of monoamine oxidase A (MAO A), whose reduced presence appears to result in an increased accumulation of biogenic amines, which is a trigger for hypertensive crises. Amines 211-217 monoamine oxidase A Homo sapiens 100-119 18463263-4 2008 Here, we hypothesized that in healthy adult males the gene product of MAO A in the brain, rather than the gene per se, would be associated with regulating the concentration of brain amines involved in trait aggression. Amines 182-188 monoamine oxidase A Homo sapiens 70-75 18177231-2 2008 Patients produce little IKAP, the gene product of the affected mutated gene, and have low levels of monoamine oxidase A (MAO A), whose reduced presence appears to result in an increased accumulation of biogenic amines, which is a trigger for hypertensive crises. Amines 211-217 monoamine oxidase A Homo sapiens 121-126 17554106-2 2007 Medications that inhibit monoamine oxidase type A can augment the pressor effects of sympathomimetic amines, increasing the potential for hypertensive crisis. Amines 101-107 monoamine oxidase A Homo sapiens 25-49 17573034-0 2007 Structural insights into the mechanism of amine oxidation by monoamine oxidases A and B. Amines 42-47 monoamine oxidase A Homo sapiens 61-87 17573034-1 2007 Due to their pharmacological importance in the oxidation of amine neurotransmitters, the membrane-bound flavoenzymes monoamine oxidase A and monoamine oxidase B have attracted numerous investigations and, as a result, two different mechanisms; the single electron transfer and the polar nucleophilic mechanisms, have been proposed to describe their catalytic mechanisms. Amines 60-65 monoamine oxidase A Homo sapiens 117-136 18388730-1 2008 Monoamine oxidase A (MAOA) enzymatically degrades biogenic amines such as norepinephrine, dopamine, and serotonin, and plays a key role in the regulation of their neurotransmission. Amines 59-65 monoamine oxidase A Homo sapiens 0-19 18388730-1 2008 Monoamine oxidase A (MAOA) enzymatically degrades biogenic amines such as norepinephrine, dopamine, and serotonin, and plays a key role in the regulation of their neurotransmission. Amines 59-65 monoamine oxidase A Homo sapiens 21-25 17885758-10 2008 In conclusion, it seems plausible to say that MAOA-dependent metabolism of the biological amines may be partly related to high-activated MAO-A, allele 3, in the occurrence of FS among Turkish population. Amines 90-96 monoamine oxidase A Homo sapiens 46-50 17885758-10 2008 In conclusion, it seems plausible to say that MAOA-dependent metabolism of the biological amines may be partly related to high-activated MAO-A, allele 3, in the occurrence of FS among Turkish population. Amines 90-96 monoamine oxidase A Homo sapiens 137-142 17721552-8 2007 CONCLUSIONS AND IMPLICATIONS: MB is a potent reversible inhibitor of MAO A with implications for gut uptake of amines when administered orally. Amines 111-117 monoamine oxidase A Homo sapiens 69-74 17561096-1 2007 The degradation of biogenic amines by monoamine oxidase A (MAO-A) generates reactive oxygen species (ROS) which participate in serotonin and tyramine signaling. Amines 28-34 monoamine oxidase A Homo sapiens 38-57 17561096-1 2007 The degradation of biogenic amines by monoamine oxidase A (MAO-A) generates reactive oxygen species (ROS) which participate in serotonin and tyramine signaling. Amines 28-34 monoamine oxidase A Homo sapiens 59-64 16584839-1 2006 Catechol-O-methyltransferase (COMT) and monoamine oxidase A (MAOA) are both involved in the degradation of various biogenic amines which have been hypothesized to have a relationship with personality traits. Amines 124-130 monoamine oxidase A Homo sapiens 40-59 17417058-1 2007 OBJECTIVE: Monoamine oxidase A is a mitochondrial enzyme involved in the degradation of certain neurotransmitter amines: serotonin and norepinephrine. Amines 113-119 monoamine oxidase A Homo sapiens 11-30 17401535-2 2007 The pH dependence of the kinetic parameters for kynuramine oxidation by purified human MAO-A and for phenylethylamine oxidation by MAO-B in granulocytes at pH values from 5 to 10 was consistent with the protonated amine being used. Amines 53-58 monoamine oxidase A Homo sapiens 87-92 17401536-2 2007 The results presented here provide additional new insights into the interactions that take place on activation of the amine substrate by the aromatic cage residues in MAO-B catalysis and have relevance to the MAO-A catalytic mechanism. Amines 118-123 monoamine oxidase A Homo sapiens 209-214 16896926-1 2006 Monoamine oxidase A (MAOA) catalyses the oxidative deamination of biogenic amines including neurotransmitters, mainly norepinephrine and serotonin in the brain and peripheral tissues. Amines 75-81 monoamine oxidase A Homo sapiens 0-19 16896926-1 2006 Monoamine oxidase A (MAOA) catalyses the oxidative deamination of biogenic amines including neurotransmitters, mainly norepinephrine and serotonin in the brain and peripheral tissues. Amines 75-81 monoamine oxidase A Homo sapiens 21-25 17328795-3 2007 Monoamine oxidase A (MAO-A) encodes an enzyme that degrades biogenic amines, including neurotransmitters such as norepinephrine, dopamine and serotonin. Amines 69-75 monoamine oxidase A Homo sapiens 0-19 17328795-3 2007 Monoamine oxidase A (MAO-A) encodes an enzyme that degrades biogenic amines, including neurotransmitters such as norepinephrine, dopamine and serotonin. Amines 69-75 monoamine oxidase A Homo sapiens 21-26 16584839-1 2006 Catechol-O-methyltransferase (COMT) and monoamine oxidase A (MAOA) are both involved in the degradation of various biogenic amines which have been hypothesized to have a relationship with personality traits. Amines 124-130 monoamine oxidase A Homo sapiens 61-65 16110245-1 2005 Monoamine oxidase A (MAOA), a mitochondrial outer membrane enzyme, degrades biogenic amines including norepinephrine, dopamine and serotonin, which have been implicated in the expression of personality traits. Amines 85-91 monoamine oxidase A Homo sapiens 0-19 15717295-2 2005 Monoamine oxidases A and B (MAO-A and MAO-B) degrade biogenic amines such as dopamine and serotonin and thereby control the levels of these neurotransmitters in the central nervous system. Amines 62-68 monoamine oxidase A Homo sapiens 0-26 15717295-2 2005 Monoamine oxidases A and B (MAO-A and MAO-B) degrade biogenic amines such as dopamine and serotonin and thereby control the levels of these neurotransmitters in the central nervous system. Amines 62-68 monoamine oxidase A Homo sapiens 28-33 15956990-1 2005 Monoamine oxidase A (MAOA), a mitochondrial enzyme involved in the degradation of biogenic amines, may be implicated in the pathogenesis of major depressive disorder (MDD) and be related to the therapeutic effects of antidepressants. Amines 91-97 monoamine oxidase A Homo sapiens 0-19 15956990-1 2005 Monoamine oxidase A (MAOA), a mitochondrial enzyme involved in the degradation of biogenic amines, may be implicated in the pathogenesis of major depressive disorder (MDD) and be related to the therapeutic effects of antidepressants. Amines 91-97 monoamine oxidase A Homo sapiens 21-25 15946989-5 2005 MAO-A is the primary enzyme metabolizing catecholamines and dietary amines, and its role in skeletal muscle remains largely unexplored. Amines 49-55 monoamine oxidase A Homo sapiens 0-5 16110245-1 2005 Monoamine oxidase A (MAOA), a mitochondrial outer membrane enzyme, degrades biogenic amines including norepinephrine, dopamine and serotonin, which have been implicated in the expression of personality traits. Amines 85-91 monoamine oxidase A Homo sapiens 21-25 15564894-1 2004 Monoamine oxidase A (MAOA) has been suggested to be involved in human behaviour and physiology due to its key role in the metabolism of several different biological amines including the neurotransmitters serotonin, norepinephrin and dopamine.Recently, a 30 bp repeat in the MAOA gene promoter (uMAOA) has been demonstrated to be polymorphic and to affect transcriptional activity. Amines 165-171 monoamine oxidase A Homo sapiens 0-19 15564894-1 2004 Monoamine oxidase A (MAOA) has been suggested to be involved in human behaviour and physiology due to its key role in the metabolism of several different biological amines including the neurotransmitters serotonin, norepinephrin and dopamine.Recently, a 30 bp repeat in the MAOA gene promoter (uMAOA) has been demonstrated to be polymorphic and to affect transcriptional activity. Amines 165-171 monoamine oxidase A Homo sapiens 21-25 15349769-1 2004 Monoamine oxidase A (MAOA) is the X-linked gene responsible for deamination and subsequent degradation of several neurotransmitters and other amines. Amines 142-148 monoamine oxidase A Homo sapiens 0-19 15349769-1 2004 Monoamine oxidase A (MAOA) is the X-linked gene responsible for deamination and subsequent degradation of several neurotransmitters and other amines. Amines 142-148 monoamine oxidase A Homo sapiens 21-25 15279562-1 2004 Monoamine oxidases A and B (MAO A and MAO B) are mitochondrial outer membrane-bound flavoproteins that catalyze the oxidative deamination of neurotransmitters and biogenic amines. Amines 172-178 monoamine oxidase A Homo sapiens 0-26 15279562-1 2004 Monoamine oxidases A and B (MAO A and MAO B) are mitochondrial outer membrane-bound flavoproteins that catalyze the oxidative deamination of neurotransmitters and biogenic amines. Amines 172-178 monoamine oxidase A Homo sapiens 28-33 15024015-1 2004 Monoamine oxidases (MAO) A and B catalyze the oxidative deamination of many biogenic and dietary amines. Amines 97-103 monoamine oxidase A Homo sapiens 0-26 14697899-6 2004 The consequence of these findings were the development of reversible MAO-A inhibitors (RIMA), moclobemide and brofaromin, as antidepressants and possible anti-Parkinson activity, with limited tyramine potentiation, since the amine can displace the inhibitor from its binding site on the enzyme. Amines 195-200 monoamine oxidase A Homo sapiens 69-74 14697882-1 2004 Monoamine oxidases A and B (MAO A and B) are the major enzymes in mammals that catalyze the oxidative deamination or oxidation of neurotransmitters, peripheral vasoactive amines, and xenobiotics (e.g. MPTP). Amines 171-177 monoamine oxidase A Homo sapiens 0-26 14697882-1 2004 Monoamine oxidases A and B (MAO A and B) are the major enzymes in mammals that catalyze the oxidative deamination or oxidation of neurotransmitters, peripheral vasoactive amines, and xenobiotics (e.g. MPTP). Amines 171-177 monoamine oxidase A Homo sapiens 28-39 11956220-1 2002 Monoamine oxidases (MAO) A and B deaminate a number of biogenic amines. Amines 64-70 monoamine oxidase A Homo sapiens 0-32 12445480-1 2002 Monoamine oxidase A (MAO A) catalyses the oxidation of both neurotransmitter and ingested amines. Amines 90-96 monoamine oxidase A Homo sapiens 0-19 12445480-1 2002 Monoamine oxidase A (MAO A) catalyses the oxidation of both neurotransmitter and ingested amines. Amines 90-96 monoamine oxidase A Homo sapiens 21-26 11732903-9 2001 The Y444F MAO A mutant also exhibits similar QSAR properties on the binding of phenylalkyl side chain amine analogues as WT enzyme: log K(i) = (4.37 +/- 0.51)E(S) + 1.21 +/- 0.77. Amines 102-107 monoamine oxidase A Homo sapiens 10-15 12140786-1 2002 Monoamine oxidase A (MAO A) is located on the X chromosome and metabolizes biogenic amines including dopamine, norepinephrine and serotonin. Amines 84-90 monoamine oxidase A Homo sapiens 0-19 12140786-1 2002 Monoamine oxidase A (MAO A) is located on the X chromosome and metabolizes biogenic amines including dopamine, norepinephrine and serotonin. Amines 84-90 monoamine oxidase A Homo sapiens 21-26 11106506-7 2000 The binding affinities of a series of para-substituted phenethylamine analogues to MAO A show an increase in affinity of the deprotonated amine with increasing van der Waals volume of the substituent. Amines 64-69 monoamine oxidase A Homo sapiens 83-88 10564737-2 1999 Monoamine oxidase A (MAO-A) is a key enzyme in the catabolism of biogenic amines and is expressed in brain noradrenergic neurons. Amines 74-80 monoamine oxidase A Homo sapiens 0-19 10564737-2 1999 Monoamine oxidase A (MAO-A) is a key enzyme in the catabolism of biogenic amines and is expressed in brain noradrenergic neurons. Amines 74-80 monoamine oxidase A Homo sapiens 21-26 10521274-1 1999 Monoamine oxidase A (MAO A) plays a central role in the oxidation of amine neurotransmitters. Amines 4-9 monoamine oxidase A Homo sapiens 21-26 9564603-5 1998 The results demonstrate that the characteristic abnormalities in the excretion of biogenic amines and their metabolites were faithfully present in every one of 12 independent samples obtained from the MAO-A deficient males over the two-week study period. Amines 91-97 monoamine oxidase A Homo sapiens 201-206 9564616-1 1998 The rate of oxidation by monoamine oxidase (MAO) of a particular amine in a given cell depends on the levels of MAO-A and MAO-B expressed in the mitochondrial outer membranes, on the amine concentration and the oxygen concentration. Amines 29-34 monoamine oxidase A Homo sapiens 112-117 9564616-1 1998 The rate of oxidation by monoamine oxidase (MAO) of a particular amine in a given cell depends on the levels of MAO-A and MAO-B expressed in the mitochondrial outer membranes, on the amine concentration and the oxygen concentration. Amines 65-70 monoamine oxidase A Homo sapiens 112-117 10498294-1 1999 Monoamine oxidase (MAO) A and B are mitochondrial enzymes involved in the oxidative deamination of endogenous and exogenous amines. Amines 124-130 monoamine oxidase A Homo sapiens 0-31 9603903-1 1998 Mitochondrial monoamine oxidases A and B (MAO A and MAO B) are ubiquitous homodimeric FAD-containing oxidases that catalyze the oxidation of biogenic amines. Amines 150-156 monoamine oxidase A Homo sapiens 42-47 9564606-2 1998 In comparative studies with other, structurally similar acetylenic inhibitors of MAO, pargyline, an MAO-B > MAO-A inhibitor used in doses of 90 mg/day for three or more weeks, produced elevations in these trace amines which were similar to those found with the highest dose of selegiline studied. Amines 214-220 monoamine oxidase A Homo sapiens 111-116 9564606-6 1998 Overall, trace amine elevations in individuals receiving the highest dose of deprenyl or receiving pargyline were approximately three to five-fold lower than the elevations observed in individuals lacking the genes for both MAO-A and MAO-B, suggesting that these drug doses yield incomplete inhibition of MAO-A and MAO-B. Amines 15-20 monoamine oxidase A Homo sapiens 305-310 9564606-0 1998 Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (clorgyline) or MAO-B (selegiline and pargyline). Amines 19-24 monoamine oxidase A Homo sapiens 87-92 8613523-6 1996 In MAO-A-deficient subjects, there is a marked decrease in deaminated catecholamine metabolites and a concomitant marked elevation of O-methylated amine metabolites. Amines 78-83 monoamine oxidase A Homo sapiens 3-8 9503563-1 1997 MAO A and MAO B follow the same chemical mechanism to oxidise primary, secondary, and tertiary amines, but they are distinguished by differences in their substrate and inhibitor specificities and in their kinetic behaviour. Amines 95-101 monoamine oxidase A Homo sapiens 0-5 8941389-2 1996 We have attempted to adapt this metabolic pathway to the preparation of amine-containing prodrugs that may target the central nervous system which is rich in monoamine oxidase A and B. Amines 72-77 monoamine oxidase A Homo sapiens 158-183 9112832-3 1997 Superimposition of norepinephrine and gauche forms of serotonin and mociobemide suggest that the phenyl ring, electronegative group attached to the aromatic ring and the amine terminal group may serve as the recognition elements for binding to monoamine oxidase-A (MAO-A). Amines 170-175 monoamine oxidase A Homo sapiens 244-263 9112832-3 1997 Superimposition of norepinephrine and gauche forms of serotonin and mociobemide suggest that the phenyl ring, electronegative group attached to the aromatic ring and the amine terminal group may serve as the recognition elements for binding to monoamine oxidase-A (MAO-A). Amines 170-175 monoamine oxidase A Homo sapiens 265-270 8678123-1 1996 The monoamine oxidases (MAO-A and MAO-B) are the enzymes primarily responsible for the degradation of amine neurotransmitters, such as dopamine, norepinephrine, and serotonin. Amines 8-13 monoamine oxidase A Homo sapiens 24-29 8613523-9 1996 The differences in neurochemical profiles indicate that, under normal conditions, MAO-A is considerably more important than MAO-B in the metabolism of biogenic amines, a factor likely to contribute to the different clinical phenotypes. Amines 160-166 monoamine oxidase A Homo sapiens 82-87 8592154-1 1996 Monoamine oxidase (MAO) A and B play important roles in the metabolism of neurotransmitters and dietary amines. Amines 104-110 monoamine oxidase A Homo sapiens 0-25 7931241-6 1994 In the case of the initial, non-covalent, inhibition all these compounds were competitive inhibitors of MAO-A, with respect to the amine substrate, and the affinity for inhibitor binding increased with carbon chain length. Amines 131-136 monoamine oxidase A Homo sapiens 104-109 7931238-4 1994 The kinetic behaviour of the parent amines as MAO A and MAO B inhibitors and substrates was determined. Amines 36-42 monoamine oxidase A Homo sapiens 46-51 1546120-1 1992 Monoamine oxidases A and B (MAO-A and B) catalyze the oxidative catabolism of biogenic amines and xenobiotics. Amines 87-93 monoamine oxidase A Homo sapiens 0-26 8390270-1 1993 The "cheese effect", potentiation of sympathomimetic action of indirectly acting amines such as tyramine, the main side effect of irreversible non-selective and selective monoamine oxidase (MAO) A inhibitors, has largely been eliminated in the new generation of reversible selective MAO-A and B and irreversible MAO-B inhibitors. Amines 81-87 monoamine oxidase A Homo sapiens 171-196 8390270-1 1993 The "cheese effect", potentiation of sympathomimetic action of indirectly acting amines such as tyramine, the main side effect of irreversible non-selective and selective monoamine oxidase (MAO) A inhibitors, has largely been eliminated in the new generation of reversible selective MAO-A and B and irreversible MAO-B inhibitors. Amines 81-87 monoamine oxidase A Homo sapiens 283-288 8461277-1 1993 Monoamine oxidase (MAO) A and B play an important role in regulating levels of biogenic amines. Amines 88-94 monoamine oxidase A Homo sapiens 0-31 1432104-1 1992 Monoamine oxidase A and B (MAO A and B) play important roles in the metabolism of biogenic and dietary amines and are encoded by two genes derived from a common ancestral gene. Amines 103-109 monoamine oxidase A Homo sapiens 0-25 1432104-1 1992 Monoamine oxidase A and B (MAO A and B) play important roles in the metabolism of biogenic and dietary amines and are encoded by two genes derived from a common ancestral gene. Amines 103-109 monoamine oxidase A Homo sapiens 27-38 1546120-1 1992 Monoamine oxidases A and B (MAO-A and B) catalyze the oxidative catabolism of biogenic amines and xenobiotics. Amines 87-93 monoamine oxidase A Homo sapiens 28-39 1759390-7 1991 In deprenyl pretreated mitochondria the potency of MAO-A-dependent effects of these amines was: serotonin greater than tyramine much greater than much greater than 2-phenylethylamine. Amines 84-90 monoamine oxidase A Homo sapiens 51-56 1759390-8 1991 The data obtained suggest that the product(s) of oxidative deamination of biogenic amines (probably the aldehydes) catalyzed by both types of MAO (MAO-A and MAO-B) are able to regulate the energy functions of mitochondria. Amines 83-89 monoamine oxidase A Homo sapiens 147-152 2021654-2 1991 In this study, with use of purified monoamine oxidase A, steady-state data for the inhibition by D-amphetamine of the oxidation of primary amines indicate the possibility of a ternary complex mechanism for monoamine oxidase A also. Amines 139-145 monoamine oxidase A Homo sapiens 36-55 2021654-2 1991 In this study, with use of purified monoamine oxidase A, steady-state data for the inhibition by D-amphetamine of the oxidation of primary amines indicate the possibility of a ternary complex mechanism for monoamine oxidase A also. Amines 139-145 monoamine oxidase A Homo sapiens 206-225 2023912-1 1991 Monoamine oxidases A and B [MAOA and MAOB; amine:oxygen oxidoreductase (deaminating) (flavin-containing), EC 1.4.3.4] play important roles in the metabolism of neuroactive, vasoactive amines and the Parkinsonism-producing neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Amines 184-190 monoamine oxidase A Homo sapiens 0-26 2023912-1 1991 Monoamine oxidases A and B [MAOA and MAOB; amine:oxygen oxidoreductase (deaminating) (flavin-containing), EC 1.4.3.4] play important roles in the metabolism of neuroactive, vasoactive amines and the Parkinsonism-producing neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Amines 184-190 monoamine oxidase A Homo sapiens 28-32 2619973-3 1989 The ability of moclobemide to potentiate the pharmacological actions of amine substrates for MAO-A in in vitro preparations is very weak, unless the drug is "activated" by prior incubation with the tissues. Amines 72-77 monoamine oxidase A Homo sapiens 93-98 2398352-1 1990 Monoamine oxidase (MAO) A and B play important roles in the metabolism of biogenic amines. Amines 83-89 monoamine oxidase A Homo sapiens 0-25 34167949-3 2021 Here we report that monoamine oxidase A (MAOA), a mitochondrial enzyme that degrades monoamine neurotransmitters and dietary amines, reciprocally interacts with AR in PC. Amines 125-131 monoamine oxidase A Homo sapiens 20-39 34167949-3 2021 Here we report that monoamine oxidase A (MAOA), a mitochondrial enzyme that degrades monoamine neurotransmitters and dietary amines, reciprocally interacts with AR in PC. Amines 125-131 monoamine oxidase A Homo sapiens 41-45 35472505-1 2022 Monoamine oxidases A and B (MAO-A and MAO-B) play important roles in biogenic amine metabolism, oxidative stress, and chronic inflammation. Amines 78-83 monoamine oxidase A Homo sapiens 0-26 35472505-1 2022 Monoamine oxidases A and B (MAO-A and MAO-B) play important roles in biogenic amine metabolism, oxidative stress, and chronic inflammation. Amines 78-83 monoamine oxidase A Homo sapiens 28-33 2496202-1 1989 Monoamine oxidase (MAO) A and B are important enzymes that metabolize biogenic amines throughout the body. Amines 79-85 monoamine oxidase A Homo sapiens 0-31 2744764-1 1989 Monoamine oxidase A and B (MAO A and B) are the central enzymes that catalyze oxidative deamination of biogenic amines throughout the body. Amines 112-118 monoamine oxidase A Homo sapiens 0-25 2744764-1 1989 Monoamine oxidase A and B (MAO A and B) are the central enzymes that catalyze oxidative deamination of biogenic amines throughout the body. Amines 112-118 monoamine oxidase A Homo sapiens 27-38 3335842-3 1988 BP-N-methylbutylamine had a much higher affinity to MAO-A than an amine substrate, kynuramine, and it was a more potent inhibitor of MAO-A than of MAO-B. Amines 16-21 monoamine oxidase A Homo sapiens 52-57 2451963-19 1988 The results demonstrate that inhibition of MAO-A and -B both within amine neurones and elsewhere in the brain is essential for the development of the 5-HT behavioural syndrome. Amines 68-73 monoamine oxidase A Homo sapiens 43-55 3335842-3 1988 BP-N-methylbutylamine had a much higher affinity to MAO-A than an amine substrate, kynuramine, and it was a more potent inhibitor of MAO-A than of MAO-B. Amines 16-21 monoamine oxidase A Homo sapiens 133-138 6335034-0 1984 Oxidation of the neurotoxic amine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by monoamine oxidases A and B and suicide inactivation of the enzymes by MPTP. Amines 28-33 monoamine oxidase A Homo sapiens 89-115 6203542-6 1984 These data, which suggest that MAO-A inhibition by clorgyline in vivo is more closely associated with changes in the noradrenergic than the serotonergic or dopaminergic systems in nonhuman primates, are in general agreement with the effects of clorgyline on CSF and urinary biogenic amine metabolites in man. Amines 159-164 monoamine oxidase A Homo sapiens 31-36 33279529-1 2021 Monoamine oxidases (MAO-A and MAO-B) are the two flavin adenine dinucleotide (FAD) enzymes that play an important role in neurotransmitter homeostasis and in protection against biogenic amines. Amines 186-192 monoamine oxidase A Homo sapiens 20-25