PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 6846038-0 1983 Studies on biogenic amine metabolizing enzymes (DBH, COMT, MAO) and pathogenesis of affective illness. Amines 20-25 catechol-O-methyltransferase Homo sapiens 53-57 6132322-3 1983 Two other enzymes of biogenic amine metabolism, catechol-o-methyl transferase and Dopa-decarboxylase, were essentially the same in both groups. Amines 30-35 catechol-O-methyltransferase Homo sapiens 48-77 6846042-0 1983 Studies on biogenic amine metabolizing enzymes (DBH, COMT, MAO) and pathogenesis of affective illness. Amines 20-25 catechol-O-methyltransferase Homo sapiens 53-57 6846043-0 1983 Studies on biogenic amine metabolizing enzymes (DBH, COMT, MAO) and pathogenesis of affective illness. Amines 20-25 catechol-O-methyltransferase Homo sapiens 53-57 17894650-5 2007 The purpose of this article is to review the current knowledge on the enzyme catechol-O-methyltransferase (COMT) and the role of COMT inhibitors in PD as a new therapeutic approach to PD involving conversion of levodopa to dopamine at the target region in the brain and facilitation of the continuous action of this amine at the receptor sites. Amines 226-231 catechol-O-methyltransferase Homo sapiens 77-105 27998194-7 2017 In the aging brain, then one of the two enzymes involved in degrading synaptic amines, catechol-O-methyl transferase, increasingly catalyzes methylation processes. Amines 79-85 catechol-O-methyltransferase Homo sapiens 87-116 24532984-11 2013 In PD, polymorphisms of the COMT, MAO, DAT, NET, and 5- HTT genes may change the levels of biogenic amines and their metabolic products. Amines 100-106 catechol-O-methyltransferase Homo sapiens 28-32 7405611-8 1980 Ranking the mean COMT-values leads to the following order: matched controls (< neurotic depression < unipolar depression < bipolar depression, which would be in good agreement with theoretical expectations based on the amine hypothesis of depression. Amines 228-233 catechol-O-methyltransferase Homo sapiens 17-21 17945417-1 2007 Catechol-O-methyltransferase (COMT) is an enzyme that degrades various biogenic amines, which have been hypothesized to be associated with personality traits. Amines 80-86 catechol-O-methyltransferase Homo sapiens 0-28 17945417-1 2007 Catechol-O-methyltransferase (COMT) is an enzyme that degrades various biogenic amines, which have been hypothesized to be associated with personality traits. Amines 80-86 catechol-O-methyltransferase Homo sapiens 30-34 17894650-5 2007 The purpose of this article is to review the current knowledge on the enzyme catechol-O-methyltransferase (COMT) and the role of COMT inhibitors in PD as a new therapeutic approach to PD involving conversion of levodopa to dopamine at the target region in the brain and facilitation of the continuous action of this amine at the receptor sites. Amines 226-231 catechol-O-methyltransferase Homo sapiens 107-111 17894650-5 2007 The purpose of this article is to review the current knowledge on the enzyme catechol-O-methyltransferase (COMT) and the role of COMT inhibitors in PD as a new therapeutic approach to PD involving conversion of levodopa to dopamine at the target region in the brain and facilitation of the continuous action of this amine at the receptor sites. Amines 226-231 catechol-O-methyltransferase Homo sapiens 129-133 9661138-2 1998 However, it is well recognized now that under in vitro conditions, dopamine newly synthesised in tubular epithelial cells undergoes extensive deamination to 3,4-dihydroxyphenylacetic acid (DOPAC) by monoamine oxidase (MAO); a small amount of the amine is converted to homovanillic acid by both MAO and catechol-O-methyltransferase (COMT) and a minor amount is methylated to 3-methoxytyramine. Amines 70-75 catechol-O-methyltransferase Homo sapiens 302-330 16584839-1 2006 Catechol-O-methyltransferase (COMT) and monoamine oxidase A (MAOA) are both involved in the degradation of various biogenic amines which have been hypothesized to have a relationship with personality traits. Amines 124-130 catechol-O-methyltransferase Homo sapiens 0-28 16584839-1 2006 Catechol-O-methyltransferase (COMT) and monoamine oxidase A (MAOA) are both involved in the degradation of various biogenic amines which have been hypothesized to have a relationship with personality traits. Amines 124-130 catechol-O-methyltransferase Homo sapiens 30-34 15900225-1 2005 OBJECTIVES: Catechol-O-methyltransferase plays a central role in the metabolism of biogenic amines such as norepinephrine, dopamine and serotonin. Amines 92-98 catechol-O-methyltransferase Homo sapiens 12-40 9661138-2 1998 However, it is well recognized now that under in vitro conditions, dopamine newly synthesised in tubular epithelial cells undergoes extensive deamination to 3,4-dihydroxyphenylacetic acid (DOPAC) by monoamine oxidase (MAO); a small amount of the amine is converted to homovanillic acid by both MAO and catechol-O-methyltransferase (COMT) and a minor amount is methylated to 3-methoxytyramine. Amines 70-75 catechol-O-methyltransferase Homo sapiens 332-336 8510765-4 1993 Uptake of noradrenaline was manifested after 30 minutes as a 6-fold increase in the cell content of the amine following inhibition of catechol-O-methyl transferase, either alone or in conjunction with inhibition of monoamine oxidase. Amines 104-109 catechol-O-methyltransferase Homo sapiens 134-163 8369108-5 1993 On the one hand inhibition of COMT alone may also slow the metabolisation of biogenic amines in glial cells and may consequently induce synthesis of neurotrophic factors in glial cells. Amines 86-92 catechol-O-methyltransferase Homo sapiens 30-34