PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29456505-1 2018 Trace amines (TAs), endogenous amino acid metabolites that are structurally similar to the biogenic amines, are endogenous ligands for trace amine-associated receptor 1 (TAAR1), a GPCR that modulates dopaminergic, serotonergic, and glutamatergic activity. Amines 6-12 trace amine-associated receptor 1 Mus musculus 135-168 31503202-6 2019 These results suggest that the sensory gating in mice may be modulated through TAAR1-dependent processes, indicating potential contribution of TAAR1 and trace amines in general to the neuropharmacology of cognitive processes. Amines 159-165 trace amine-associated receptor 1 Mus musculus 79-84 29545750-1 2018 The trace amine-associated receptor 1 (TAAR1) is expressed by dopaminergic neurons, but the precise influence of trace amines upon their functional activity remains to be fully characterized. Amines 119-125 trace amine-associated receptor 1 Mus musculus 4-37 29545750-1 2018 The trace amine-associated receptor 1 (TAAR1) is expressed by dopaminergic neurons, but the precise influence of trace amines upon their functional activity remains to be fully characterized. Amines 119-125 trace amine-associated receptor 1 Mus musculus 39-44 30954024-1 2019 Trace amine-associated receptor 1 (TAAR1) is a G-protein coupled receptor with affinity for the trace amines. Amines 102-108 trace amine-associated receptor 1 Mus musculus 0-33 30954024-1 2019 Trace amine-associated receptor 1 (TAAR1) is a G-protein coupled receptor with affinity for the trace amines. Amines 102-108 trace amine-associated receptor 1 Mus musculus 35-40 29593543-4 2018 In addition to classical trace amines, TAAR1 can also be activated by the thyroid hormone derivative 3-iodothyronamine (3-T1AM). Amines 31-37 trace amine-associated receptor 1 Mus musculus 39-44 29456505-1 2018 Trace amines (TAs), endogenous amino acid metabolites that are structurally similar to the biogenic amines, are endogenous ligands for trace amine-associated receptor 1 (TAAR1), a GPCR that modulates dopaminergic, serotonergic, and glutamatergic activity. Amines 100-106 trace amine-associated receptor 1 Mus musculus 170-175 29456505-1 2018 Trace amines (TAs), endogenous amino acid metabolites that are structurally similar to the biogenic amines, are endogenous ligands for trace amine-associated receptor 1 (TAAR1), a GPCR that modulates dopaminergic, serotonergic, and glutamatergic activity. Amines 6-12 trace amine-associated receptor 1 Mus musculus 170-175 29456505-1 2018 Trace amines (TAs), endogenous amino acid metabolites that are structurally similar to the biogenic amines, are endogenous ligands for trace amine-associated receptor 1 (TAAR1), a GPCR that modulates dopaminergic, serotonergic, and glutamatergic activity. Amines 100-106 trace amine-associated receptor 1 Mus musculus 135-168 21525407-1 2011 The trace amine-associated receptor 1 (TAAR1), activated by endogenous metabolites of amino acids like the trace amines p-tyramine and beta-phenylethylamine, has proven to be an important modulator of the dopaminergic system and is considered a promising target for the treatment of neuropsychiatric disorders. Amines 113-119 trace amine-associated receptor 1 Mus musculus 4-37 27731647-1 2016 The trace amine-associated receptor 1 (TAAR1) is a G-protein-coupled receptors (GPCR) potently activated by a variety of molecules besides trace amines (TAs), including thyroid hormone-derivatives like 3-iodothyronamine (T1AM), catechol-O-methyltransferase products like 3-methoxytyramine, and amphetamine-related compounds. Amines 145-151 trace amine-associated receptor 1 Mus musculus 4-37 27731647-1 2016 The trace amine-associated receptor 1 (TAAR1) is a G-protein-coupled receptors (GPCR) potently activated by a variety of molecules besides trace amines (TAs), including thyroid hormone-derivatives like 3-iodothyronamine (T1AM), catechol-O-methyltransferase products like 3-methoxytyramine, and amphetamine-related compounds. Amines 145-151 trace amine-associated receptor 1 Mus musculus 39-44 26010728-1 2015 Trace amine associated receptor 1 (TAAR1) is a G protein coupled receptor (GPCR) expressed in brain and periphery activated by a wide spectrum of agonists that include, but are not limited to, trace amines (TAs), amphetamine-like psychostimulants, and endogenous thyronamines such as thyronamine (T0AM) and 3-iodothyronamine (T1AM). Amines 199-205 trace amine-associated receptor 1 Mus musculus 0-33 26010728-1 2015 Trace amine associated receptor 1 (TAAR1) is a G protein coupled receptor (GPCR) expressed in brain and periphery activated by a wide spectrum of agonists that include, but are not limited to, trace amines (TAs), amphetamine-like psychostimulants, and endogenous thyronamines such as thyronamine (T0AM) and 3-iodothyronamine (T1AM). Amines 199-205 trace amine-associated receptor 1 Mus musculus 35-40 21525407-1 2011 The trace amine-associated receptor 1 (TAAR1), activated by endogenous metabolites of amino acids like the trace amines p-tyramine and beta-phenylethylamine, has proven to be an important modulator of the dopaminergic system and is considered a promising target for the treatment of neuropsychiatric disorders. Amines 113-119 trace amine-associated receptor 1 Mus musculus 39-44 19725810-4 2009 In HEK (human embryonic kidney)-293/CRE-bla cells, mouse TAAR1 showed a robust response to trace amines as measured using either a cAMP assay or a beta-lactamase reporter assay, whereas human TAAR1 showed a weaker, but still measurable, response. Amines 97-103 trace amine-associated receptor 1 Mus musculus 57-62 20559446-2 2010 To date the best characterized subtype is TAAR1, which activates the G(s) protein/adenylyl cyclase pathway upon stimulation by trace amines and psychoactive substances like MDMA or LSD. Amines 133-139 trace amine-associated receptor 1 Mus musculus 42-47 19482011-6 2009 TAAR1 activation by the common biogenic amines, the trace amine beta-phenylethylamine and methamphetamine alters the monoamine transporter function in both mouse and rhesus monkey brain synaptosomes, suggesting a modulatory role for this receptor in the presynaptic regulation of monoaminergic activity. Amines 40-46 trace amine-associated receptor 1 Mus musculus 0-5 19482011-6 2009 TAAR1 activation by the common biogenic amines, the trace amine beta-phenylethylamine and methamphetamine alters the monoamine transporter function in both mouse and rhesus monkey brain synaptosomes, suggesting a modulatory role for this receptor in the presynaptic regulation of monoaminergic activity. Amines 40-45 trace amine-associated receptor 1 Mus musculus 0-5 19325074-6 2009 This receptor encoded by the human TAAR1 gene is also present in rat and mouse genomes (Taar1) and has been shown to be activated by endogenous trace amine ligands, including p-tyramine and beta-phenylethylamine. Amines 150-155 trace amine-associated receptor 1 Mus musculus 88-93 18585080-2 2008 The TAAR that is best characterized, TAAR1, is particularly interesting because it can be activated by a variety of monoaminergic compounds including trace amines, amphetamines and dopamine metabolites. Amines 156-162 trace amine-associated receptor 1 Mus musculus 37-42 18182557-4 2008 We confirmed that TAAR1 was activated by trace amines and demonstrated that TAAR1 activation by beta-PEA significantly inhibited uptake and induced efflux of [3H]dopamine, [3H]norepinephrine, and [3H]serotonin in transfected cells. Amines 47-53 trace amine-associated receptor 1 Mus musculus 18-23 18083911-1 2008 The recent identification of the trace amine-associated receptor (TAAR)1 provides an opportunity to dissociate the effects of trace amines on the dopamine transporter from receptor-mediated effects. Amines 132-138 trace amine-associated receptor 1 Mus musculus 33-72 34298937-2 2021 TAAR family generally consists of nine types of receptors (TAAR1-9), which can detect biogenic amines. Amines 95-101 trace amine-associated receptor 1 Mus musculus 59-66 35431833-3 2022 It has been documented that all TAARs, apart from TAAR1, function as olfactory receptors involved in sensing innate odors encoded by volatile amines. Amines 142-148 trace amine-associated receptor 1 Mus musculus 50-55