PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28414290-0 2017 [The effect of isatin on protein-protein interactions between cytochrome b5 and cytochromes P450]. Isatin 15-21 cytochrome b5 type A Homo sapiens 62-75 28414290-4 2017 The aim of this study was to investigate a possible effect of isatin on interaction of human CYP with cytochrome b5 (CYB5A). Isatin 62-68 cytochrome b5 type A Homo sapiens 102-115 28414290-4 2017 The aim of this study was to investigate a possible effect of isatin on interaction of human CYP with cytochrome b5 (CYB5A). Isatin 62-68 cytochrome b5 type A Homo sapiens 117-122 28414290-6 2017 The SPR-based experiments have shown that a high concentration of isatin (270 mM) increases Kd values for complexes CYB5A/CYP3A5 and CYB5A/CYP3A4 (twofold and threefold, respectively), but has no influence on complex formation between CYB5A and other CYP (including indol-metabolizing CYP2C19 and CYP2E1). Isatin 66-72 cytochrome b5 type A Homo sapiens 116-121 28414290-6 2017 The SPR-based experiments have shown that a high concentration of isatin (270 mM) increases Kd values for complexes CYB5A/CYP3A5 and CYB5A/CYP3A4 (twofold and threefold, respectively), but has no influence on complex formation between CYB5A and other CYP (including indol-metabolizing CYP2C19 and CYP2E1). Isatin 66-72 cytochrome b5 type A Homo sapiens 133-138 28414290-6 2017 The SPR-based experiments have shown that a high concentration of isatin (270 mM) increases Kd values for complexes CYB5A/CYP3A5 and CYB5A/CYP3A4 (twofold and threefold, respectively), but has no influence on complex formation between CYB5A and other CYP (including indol-metabolizing CYP2C19 and CYP2E1). Isatin 66-72 cytochrome b5 type A Homo sapiens 133-138 28414290-7 2017 Isatin injection to the optical biosensor chip with the preformed molecular complex CYB5A/CYP3A4 caused a 30%-increase in its dissociation rate. Isatin 0-6 cytochrome b5 type A Homo sapiens 84-89 28414290-8 2017 Molecular docking manipulations have shown that isatin can influence interaction of CYP3A5 or CYP3A4 with CYB5A acting at the contact region of CYB5A/CYP. Isatin 48-54 cytochrome b5 type A Homo sapiens 106-111 28414290-8 2017 Molecular docking manipulations have shown that isatin can influence interaction of CYP3A5 or CYP3A4 with CYB5A acting at the contact region of CYB5A/CYP. Isatin 48-54 cytochrome b5 type A Homo sapiens 144-149