PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1005491-9	1976	This discrepancy may be explained by high doses of L-DOPA causing inhibiton of catechol-O-methyl transferase (COMT), which is suggested by the observation that the forebrain homovanillic acid (HVA): 3,4-dihydroxyphenylacetic acid (DOPAC) ratio was significantly lower after the high dose of L-DOPA than in untreated mice.	3,4-Dihydroxyphenylacetic Acid	199-229	catechol-O-methyltransferase	Mus musculus	79-108	
11849292-7	2002	In contrast, when COMT-deficient mice are challenged with l-dihydroxyphenylalanine, they show an extensive accumulation of 3,4-dihydroxyphenylacetic acid and dihydroxyphenylglycol and even dopamine, revealing an important role for COMT under such situations.	3,4-Dihydroxyphenylacetic Acid	123-153	catechol-O-methyltransferase	Mus musculus	18-22	
1005491-9	1976	This discrepancy may be explained by high doses of L-DOPA causing inhibiton of catechol-O-methyl transferase (COMT), which is suggested by the observation that the forebrain homovanillic acid (HVA): 3,4-dihydroxyphenylacetic acid (DOPAC) ratio was significantly lower after the high dose of L-DOPA than in untreated mice.	3,4-Dihydroxyphenylacetic Acid	199-229	catechol-O-methyltransferase	Mus musculus	110-114	
1005491-9	1976	This discrepancy may be explained by high doses of L-DOPA causing inhibiton of catechol-O-methyl transferase (COMT), which is suggested by the observation that the forebrain homovanillic acid (HVA): 3,4-dihydroxyphenylacetic acid (DOPAC) ratio was significantly lower after the high dose of L-DOPA than in untreated mice.	3,4-Dihydroxyphenylacetic Acid	231-236	catechol-O-methyltransferase	Mus musculus	79-108	
1005491-9	1976	This discrepancy may be explained by high doses of L-DOPA causing inhibiton of catechol-O-methyl transferase (COMT), which is suggested by the observation that the forebrain homovanillic acid (HVA): 3,4-dihydroxyphenylacetic acid (DOPAC) ratio was significantly lower after the high dose of L-DOPA than in untreated mice.	3,4-Dihydroxyphenylacetic Acid	231-236	catechol-O-methyltransferase	Mus musculus	110-114	
20617305-12	2010	CONCLUSION: A lack of S-COMT has a notable, albeit small, brain-area and sex-dependent effect on the O-methylation of dopamine and 3,4-dihydroxyphenylacetic acid in the mouse brain.	3,4-Dihydroxyphenylacetic Acid	131-161	catechol-O-methyltransferase	Mus musculus	24-28	
5560896-3	1971	After drug treatments which normally increase the concentration of HVA several-fold, inhibition of catechol-O-methyltransferase (COMT) by tropolone greatly reduced the concentration of HVA but resulted in only a small increase in the concentration of DOPAC in the striatum of the mouse.3.	3,4-Dihydroxyphenylacetic Acid	251-256	catechol-O-methyltransferase	Mus musculus	129-133	
22414866-9	2012	Taken together these results suggest that inhibition of the DA metabolizing enzymes monoamine oxidase A (MAO) or catechol-O-methyl transferase (COMT) may take place at lower doses of MPTP treatment; conversely, higher doses of MPTP may cause decreases in DA, DOPAC and HVA through another mechanism.	3,4-Dihydroxyphenylacetic Acid	259-264	catechol-O-methyltransferase	Mus musculus	113-142	
22414866-9	2012	Taken together these results suggest that inhibition of the DA metabolizing enzymes monoamine oxidase A (MAO) or catechol-O-methyl transferase (COMT) may take place at lower doses of MPTP treatment; conversely, higher doses of MPTP may cause decreases in DA, DOPAC and HVA through another mechanism.	3,4-Dihydroxyphenylacetic Acid	259-264	catechol-O-methyltransferase	Mus musculus	144-148