PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1349158-6 1992 Tyrosine hydroxylase inhibition by means of alpha-methyl-para-tyrosine (alpha-MT; 250 mg/kg, IP) caused a drastic reduction (greater than 80%) in dialysate 3,4-dihydroxyphenyl acetic acid (DOPAC) output but did not affect the 5-HT output per se over 3 h post-injection. 3,4-Dihydroxyphenylacetic Acid 156-187 tyrosine hydroxylase Rattus norvegicus 0-20 1349158-6 1992 Tyrosine hydroxylase inhibition by means of alpha-methyl-para-tyrosine (alpha-MT; 250 mg/kg, IP) caused a drastic reduction (greater than 80%) in dialysate 3,4-dihydroxyphenyl acetic acid (DOPAC) output but did not affect the 5-HT output per se over 3 h post-injection. 3,4-Dihydroxyphenylacetic Acid 189-194 tyrosine hydroxylase Rattus norvegicus 0-20 30296469-5 2019 The dopamine level was also increased in the amygdala at 24 h. No change was observed in the striatum at any time point, but levels of the dopamine metabolite DOPAC were markedly reduced at 24 and 48 h. Tyrosine hydroxylase expression is induced downstream of dopamine activity, and it is the rate limiting enzyme in dopamine synthesis. 3,4-Dihydroxyphenylacetic Acid 159-164 tyrosine hydroxylase Rattus norvegicus 203-223 11334998-2 2001 In the present study, these findings were extended for human and rat cells by showing that the induced TH+ cells also produce dopamine and its metabolite 3,4-dihydroxyphenylacetic acid (DOPAC). 3,4-Dihydroxyphenylacetic Acid 154-184 tyrosine hydroxylase Rattus norvegicus 103-105 11334998-2 2001 In the present study, these findings were extended for human and rat cells by showing that the induced TH+ cells also produce dopamine and its metabolite 3,4-dihydroxyphenylacetic acid (DOPAC). 3,4-Dihydroxyphenylacetic Acid 186-191 tyrosine hydroxylase Rattus norvegicus 103-105