PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20100815-6 2010 When the P450 activities were measured at the whole-cell level, some of the blue colonies, but not the white colonies, possessed apparent oxidation activity toward coumarin and 7-ethoxycoumarin, which are typical human P450 substrates that produce fluorescent products. 7-ethoxycoumarin 177-193 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 219-223 20100815-6 2010 When the P450 activities were measured at the whole-cell level, some of the blue colonies, but not the white colonies, possessed apparent oxidation activity toward coumarin and 7-ethoxycoumarin, which are typical human P450 substrates that produce fluorescent products. 7-ethoxycoumarin 177-193 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 9-13 18669587-0 2008 Generation of human metabolites of 7-ethoxycoumarin by bacterial cytochrome P450 BM3. 7-ethoxycoumarin 35-51 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 76-80 18669587-3 2008 In this report, we show that the oxidation of 7-ethoxycoumarin, a typical human P450 substrate, is catalyzed by both wild-type and mutant forms of CYP102A1. 7-ethoxycoumarin 46-62 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 80-84 11181500-6 2001 Negative correlations between 7-ethoxycoumarin O-deethylation and cell line chemosensitivity to a group of topoisomerase inhibitors were also seen, again suggesting P450-dependent drug inactivation. 7-ethoxycoumarin 30-46 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 165-169 11181500-3 2001 Cell line-specific P450 enzyme patterns were observed using three other P450 substrates, 7-ethoxycoumarin, coumarin, and 7-ethoxyresorufin, each of which was metabolized at a low rate. 7-ethoxycoumarin 89-105 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 19-23 9633999-1 1998 The human cytochrome P450 2B6 metabolizes, among numerous other substrates, diazepam, 7-ethoxycoumarin, testosterone, and phenanthrene. 7-ethoxycoumarin 86-102 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 10-29 10027632-0 1999 Highly sensitive high-performance liquid chromatographic assay for coumarin 7-hydroxylation and 7-ethoxycoumarin O-deethylation by human liver cytochrome P450 enzymes. 7-ethoxycoumarin 96-112 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 154-158 10027632-1 1999 A highly sensitive method for the determination of coumarin 7-hydroxylation and 7-ethoxycoumarin O-deethylation by human cytochrome P450 (P450 or CYP) enzymes was developed using high-performance liquid chromatography (HPLC). 7-ethoxycoumarin 80-96 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 132-136 10027632-1 1999 A highly sensitive method for the determination of coumarin 7-hydroxylation and 7-ethoxycoumarin O-deethylation by human cytochrome P450 (P450 or CYP) enzymes was developed using high-performance liquid chromatography (HPLC). 7-ethoxycoumarin 80-96 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 138-149 10027632-3 1999 With this high sensitivity, the kinetics of coumarin 7-hydroxylation and 7-ethoxycoumarin O-deethylation catalyzed by human liver microsomal and recombinant P450 enzymes were determined more precisely. 7-ethoxycoumarin 73-89 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 157-161 8794884-5 1996 P450-dependent activities (7-ethoxycoumarin O-deethylation and O-dealkylation of alkoxyresorufins) decreased progressively after lead injection to 56-69% of control levels within 20 hr. 7-ethoxycoumarin 27-43 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 0-4 8460938-7 1993 The monooxygenase activities of the purified human brain P450s were demonstrated with various substrates (aminopyrine, morphine, aniline, 7-ethoxycoumarin, and nifedipine) as examined in reconstituted systems consisting of purified human brain P450, purified rat brain NADPH cytochrome P450 reductase, deoxycholate, phospholipid, and NADPH. 7-ethoxycoumarin 138-154 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 57-61