PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11181500-6	2001	Negative correlations between 7-ethoxycoumarin O-deethylation and cell line chemosensitivity to a group of topoisomerase inhibitors were also seen, again suggesting P450-dependent drug inactivation.	7-ethoxycoumarin	30-46	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	165-169	
11181500-3	2001	Cell line-specific P450 enzyme patterns were observed using three other P450 substrates, 7-ethoxycoumarin, coumarin, and 7-ethoxyresorufin, each of which was metabolized at a low rate.	7-ethoxycoumarin	89-105	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	19-23	
10027632-0	1999	Highly sensitive high-performance liquid chromatographic assay for coumarin 7-hydroxylation and 7-ethoxycoumarin O-deethylation by human liver cytochrome P450 enzymes.	7-ethoxycoumarin	96-112	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	154-158	
10027632-1	1999	A highly sensitive method for the determination of coumarin 7-hydroxylation and 7-ethoxycoumarin O-deethylation by human cytochrome P450 (P450 or CYP) enzymes was developed using high-performance liquid chromatography (HPLC).	7-ethoxycoumarin	80-96	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	132-136	
10027632-1	1999	A highly sensitive method for the determination of coumarin 7-hydroxylation and 7-ethoxycoumarin O-deethylation by human cytochrome P450 (P450 or CYP) enzymes was developed using high-performance liquid chromatography (HPLC).	7-ethoxycoumarin	80-96	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	138-149	
10027632-3	1999	With this high sensitivity, the kinetics of coumarin 7-hydroxylation and 7-ethoxycoumarin O-deethylation catalyzed by human liver microsomal and recombinant P450 enzymes were determined more precisely.	7-ethoxycoumarin	73-89	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	157-161	
9633999-1	1998	The human cytochrome P450 2B6 metabolizes, among numerous other substrates, diazepam, 7-ethoxycoumarin, testosterone, and phenanthrene.	7-ethoxycoumarin	86-102	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	10-29	
8460938-7	1993	The monooxygenase activities of the purified human brain P450s were demonstrated with various substrates (aminopyrine, morphine, aniline, 7-ethoxycoumarin, and nifedipine) as examined in reconstituted systems consisting of purified human brain P450, purified rat brain NADPH cytochrome P450 reductase, deoxycholate, phospholipid, and NADPH.	7-ethoxycoumarin	138-154	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	57-61	
20100815-6	2010	When the P450 activities were measured at the whole-cell level, some of the blue colonies, but not the white colonies, possessed apparent oxidation activity toward coumarin and 7-ethoxycoumarin, which are typical human P450 substrates that produce fluorescent products.	7-ethoxycoumarin	177-193	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	9-13	
20100815-6	2010	When the P450 activities were measured at the whole-cell level, some of the blue colonies, but not the white colonies, possessed apparent oxidation activity toward coumarin and 7-ethoxycoumarin, which are typical human P450 substrates that produce fluorescent products.	7-ethoxycoumarin	177-193	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	219-223	
18669587-0	2008	Generation of human metabolites of 7-ethoxycoumarin by bacterial cytochrome P450 BM3.	7-ethoxycoumarin	35-51	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	76-80	
18669587-3	2008	In this report, we show that the oxidation of 7-ethoxycoumarin, a typical human P450 substrate, is catalyzed by both wild-type and mutant forms of CYP102A1.	7-ethoxycoumarin	46-62	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	80-84	
8794884-5	1996	P450-dependent activities (7-ethoxycoumarin O-deethylation and O-dealkylation of alkoxyresorufins) decreased progressively after lead injection to 56-69% of control levels within 20 hr.	7-ethoxycoumarin	27-43	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	0-4