PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19457084-7 2009 Likewise, treatment of HO-1 over-expressing cells with the HO-1 inhibitor, tin mesoporphyrin, the iron chelator deferoxamine or antagonist of CO-dependent cGMP activation, methylene blue, mitigated the HO-1-induced reduction in alpha-synuclein levels. Cyclic GMP 155-159 heme oxygenase 1 Homo sapiens 23-27 24361900-8 2014 We finally show that the effects of the NO-donor are reproduced by a permeable analog of cGMP and that a soluble guanylate cyclase specific inhibitor blocked both the induction of HO-1 by NO and the nuclear translocation of Nrf2. Cyclic GMP 89-93 heme oxygenase 1 Homo sapiens 180-184 22864061-8 2012 In conclusion, these studies demonstrate that sildenafil stimulates the expression of HO-1 and iNOS via the ROS-Nrf2 and sGC-cGMP pathway, respectively. Cyclic GMP 125-129 heme oxygenase 1 Homo sapiens 86-90 22864061-9 2012 The ability of sildenafil to block the catabolism of cGMP while stimulating the synthesis of sGC-stimulatory gaseous monoxides through the induction of HO-1 and iNOS provides a potent mechanism by which cGMP-dependent vascular actions of this drug are amplified. Cyclic GMP 203-207 heme oxygenase 1 Homo sapiens 152-156 17138185-0 2006 Heme oxygenase-1 mediates cytoprotection against nitric oxide-induced cytotoxicity via the cGMP pathway in human pulp cells. Cyclic GMP 91-95 heme oxygenase 1 Homo sapiens 0-16 18923065-8 2009 The ability of YC-1 to sensitize sGC to gaseous monoxides and simultaneously stimulate their production through the induction of HO-1 and iNOS provides a potent mechanism by which the cGMP-dependent and -independent biological actions of this agent are amplified. Cyclic GMP 184-188 heme oxygenase 1 Homo sapiens 129-133 17924972-9 2007 The inductive effects of SP on HO-1 and CCL20 were enhanced by HO-1 inducer hemin and the membrane-permeable guanosine 3",5"-monophosphate (cGMP) analogue 8-bromo-cGMP. Cyclic GMP 109-138 heme oxygenase 1 Homo sapiens 31-35 17924972-9 2007 The inductive effects of SP on HO-1 and CCL20 were enhanced by HO-1 inducer hemin and the membrane-permeable guanosine 3",5"-monophosphate (cGMP) analogue 8-bromo-cGMP. Cyclic GMP 140-144 heme oxygenase 1 Homo sapiens 31-35 17138185-1 2006 OBJECTIVE: This study examined the effects of exogenous nitric oxide (NO) on human pulp cells and the involvement of cyclic 3",5"-monophosphate (cGMP) in pulpal protection induced by heme oxygenase-1 (HO-1) against NO-induced cytotoxicity. Cyclic GMP 145-149 heme oxygenase 1 Homo sapiens 183-199 17138185-6 2006 Pretreatment with a membrane-permeable cGMP analog, 8-bromo-cGMP, restored cell death and enhanced the HO-1 protein expression induced by SNAP. Cyclic GMP 39-43 heme oxygenase 1 Homo sapiens 103-107 17138185-8 2006 CONCLUSION: These findings of a link between HO-1, regulated via the cGMP system and NO-induced cytotoxicity in human pulp cells, suggest a protective role for HO-1 in pulpal inflammation. Cyclic GMP 69-73 heme oxygenase 1 Homo sapiens 45-49 17138185-8 2006 CONCLUSION: These findings of a link between HO-1, regulated via the cGMP system and NO-induced cytotoxicity in human pulp cells, suggest a protective role for HO-1 in pulpal inflammation. Cyclic GMP 69-73 heme oxygenase 1 Homo sapiens 160-164 12709582-0 2003 Influence of heme and heme oxygenase-1 transfection of pulmonary microvascular endothelium on oxidant generation and cGMP. Cyclic GMP 117-121 heme oxygenase 1 Homo sapiens 22-38 15681695-5 2005 Increased HO-1 expression in VSMCs leads to increased production of CO and its second messenger cGMP, which are important regulators of vascular tone and paracrine interactions in the vasculature. Cyclic GMP 96-100 heme oxygenase 1 Homo sapiens 10-14 15591777-9 2004 CO appears to mediate the suppressive effect of HO-1, at least in part, through downregulating transcriptional activation of the iNOS gene via a cGMP-dependent pathway. Cyclic GMP 145-149 heme oxygenase 1 Homo sapiens 48-52 12709582-3 2003 Culture of PMEC with low serum heme decreased cGMP and the detection of peroxide with 10 microM 2",7"-dichlorofluorescin diacetate and increased HO-1 further decreased cGMP without altering the peroxide detection under these conditions. Cyclic GMP 168-172 heme oxygenase 1 Homo sapiens 145-149 11208917-3 2001 We have also shown that reactive iron (Fe3+) and cGMP staining spatially resemble that of HO-1; which, in turn, colocalizes in motor neurons with transcription factors: Fas-associated protein containing death domain (FADD), tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and p53. Cyclic GMP 49-53 heme oxygenase 1 Homo sapiens 90-94 21207851-1 2003 AIM: To explore the effects of heme- heme oxygenase-1 (HO-1)-carbon monoxide(CO)-cyclic GMP (cGMP)on aortic vascular reactivity in endotoxemic rats and its molecular mechanism. Cyclic GMP 81-91 heme oxygenase 1 Homo sapiens 55-59 21207851-1 2003 AIM: To explore the effects of heme- heme oxygenase-1 (HO-1)-carbon monoxide(CO)-cyclic GMP (cGMP)on aortic vascular reactivity in endotoxemic rats and its molecular mechanism. Cyclic GMP 93-97 heme oxygenase 1 Homo sapiens 55-59 12376366-0 2002 Modulation of cGMP by human HO-1 retrovirus gene transfer in pulmonary microvessel endothelial cells. Cyclic GMP 14-18 heme oxygenase 1 Homo sapiens 28-32 12376366-3 2002 Pulmonary cells that expressed hHO-1 exhibited a fourfold increase in HO activity associated with decreases in the steady-state levels of heme and cGMP without changes in soluble GC (sGC) and endothelial nitric oxide synthase (NOS) proteins or basal nitrite production. Cyclic GMP 147-151 heme oxygenase 1 Homo sapiens 31-36 12376366-6 2002 In the presence of exogenous heme, CO and cGMP levels in hHO-1-expressing cells exceeded the corresponding levels in pulmonary endothelial cells. Cyclic GMP 42-46 heme oxygenase 1 Homo sapiens 57-62 11950143-11 2001 In the case of severe tissue injury, such as compression injury, HO-1 is induced and colocalizes with cGMP and pro-apoptotic oncogenes. Cyclic GMP 102-106 heme oxygenase 1 Homo sapiens 65-69 11208917-11 2001 Tissue Fe3+ and cGMP staining were increased and prominently mapped below the site of injury, where cGMP colocalized with HO-1 in the nucleus of the motor neurons. Cyclic GMP 16-20 heme oxygenase 1 Homo sapiens 122-126 11208917-11 2001 Tissue Fe3+ and cGMP staining were increased and prominently mapped below the site of injury, where cGMP colocalized with HO-1 in the nucleus of the motor neurons. Cyclic GMP 100-104 heme oxygenase 1 Homo sapiens 122-126 10807735-0 2000 Heme oxygenase-1 is a cGMP-inducible endothelial protein and mediates the cytoprotective action of nitric oxide. Cyclic GMP 22-26 heme oxygenase 1 Homo sapiens 0-16 10906077-6 2000 Treatments of isolated tubules with either sodium arsenite, known to induce HO-1, or hematin, an HO substrate, resulted in 4.4- and 1.8-fold, respectively, increases in cGMP levels. Cyclic GMP 169-173 heme oxygenase 1 Homo sapiens 76-80 10906077-9 2000 These findings, demonstrating for the first time a link between HO-1 activity in Sertoli cells and sGC-dependent cGMP production in seminiferous tubules, suggest a functional role of CO in the human testis. Cyclic GMP 113-117 heme oxygenase 1 Homo sapiens 64-68 10807735-9 2000 Our results show for the first time that HO-1 is a cGMP-sensitive endothelial gene and establish conclusively a causal relationship between HO-1 induction and endothelial protection by the NO/cGMP system. Cyclic GMP 51-55 heme oxygenase 1 Homo sapiens 41-45 10807735-9 2000 Our results show for the first time that HO-1 is a cGMP-sensitive endothelial gene and establish conclusively a causal relationship between HO-1 induction and endothelial protection by the NO/cGMP system. Cyclic GMP 51-55 heme oxygenase 1 Homo sapiens 140-144 10807735-9 2000 Our results show for the first time that HO-1 is a cGMP-sensitive endothelial gene and establish conclusively a causal relationship between HO-1 induction and endothelial protection by the NO/cGMP system. Cyclic GMP 192-196 heme oxygenase 1 Homo sapiens 41-45 10807735-9 2000 Our results show for the first time that HO-1 is a cGMP-sensitive endothelial gene and establish conclusively a causal relationship between HO-1 induction and endothelial protection by the NO/cGMP system. Cyclic GMP 192-196 heme oxygenase 1 Homo sapiens 140-144 10872747-13 2000 The increase in HO-1 mRNA was inhibited by actinomycin D and cycloheximide, but not by NAC, and was not mimicked by the lipophilic cGMP analogue, 8-bromo-cGMP, suggesting that NO-mediated induction required de novo RNA and protein synthesis and was unrelated to cGMP and redox signaling. Cyclic GMP 154-158 heme oxygenase 1 Homo sapiens 16-20 9884071-7 1998 Guanosine 3",5"-monophosphate (cyclic GMP) content was also greatly enhanced in aortas expressing high levels of HO-1. Cyclic GMP 0-29 heme oxygenase 1 Homo sapiens 113-117 7525927-0 1994 Induction of heart heme oxygenase-1 (HSP32) by hyperthermia: possible role in stress-mediated elevation of cyclic 3":5"-guanosine monophosphate. Cyclic GMP 107-143 heme oxygenase 1 Homo sapiens 19-35 7525927-0 1994 Induction of heart heme oxygenase-1 (HSP32) by hyperthermia: possible role in stress-mediated elevation of cyclic 3":5"-guanosine monophosphate. Cyclic GMP 107-143 heme oxygenase 1 Homo sapiens 37-42 33287596-6 2021 Heme oxygenase-1 (HO-1) induction offers protection via inhibition of NADPH oxidase and promotion of cGMP generation. Cyclic GMP 101-105 heme oxygenase 1 Homo sapiens 0-16 19912946-0 1993 Heme Oxygenase, a Likely Regulator of cGMP Production in the Brain: Induction in Vivo of HO-1 Compensates for Depression in NO Synthase Activity. Cyclic GMP 38-42 heme oxygenase 1 Homo sapiens 89-93 33287596-6 2021 Heme oxygenase-1 (HO-1) induction offers protection via inhibition of NADPH oxidase and promotion of cGMP generation. Cyclic GMP 101-105 heme oxygenase 1 Homo sapiens 18-22 29753142-0 2018 Heme Oxygenase-1 inhibits spring viremia of carp virus replication through carbon monoxide mediated cyclic GMP/Protein kinase G signaling pathway. Cyclic GMP 100-110 heme oxygenase 1 Homo sapiens 0-16 29753142-10 2018 Collectively, these findings suggest potential drug or therapy that induced the Nrf2/HO-1/CO/cGMP/PKG signaling pathway as a promising strategy for treating SVC. Cyclic GMP 93-97 heme oxygenase 1 Homo sapiens 85-92 27908781-8 2017 Collectively, our findings identify a HO-1-BV/BR-NO-cGMP/PKG cascade as a novel pathway underlying the host cell antiviral effect. Cyclic GMP 52-56 heme oxygenase 1 Homo sapiens 38-42 29165873-11 2018 The inhibition of hypoxia-induced HIF-1alpha and ET-1 expression by andrographolide is likely associated with HO-1/CO/cGMP/MKP-5 pathways, which is involved in inhibiting hypoxia-induced p38 MAPK activation. Cyclic GMP 118-122 heme oxygenase 1 Homo sapiens 110-117