PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8648025-11 1996 However, methylprednisolone inhibited the lipopolysaccharide-stimulated production of IL-10 (2.34 +/- 0.49 ng/ml IL-10 with lipopolysaccharide alone to 1.11 +/- 0.38 ng/ml in the additional presence of 10(-6) mol/L methylprednisolone; p < 0.05). Methylprednisolone 9-27 interleukin 10 Homo sapiens 86-91 8648025-11 1996 However, methylprednisolone inhibited the lipopolysaccharide-stimulated production of IL-10 (2.34 +/- 0.49 ng/ml IL-10 with lipopolysaccharide alone to 1.11 +/- 0.38 ng/ml in the additional presence of 10(-6) mol/L methylprednisolone; p < 0.05). Methylprednisolone 9-27 interleukin 10 Homo sapiens 113-118 8648025-11 1996 However, methylprednisolone inhibited the lipopolysaccharide-stimulated production of IL-10 (2.34 +/- 0.49 ng/ml IL-10 with lipopolysaccharide alone to 1.11 +/- 0.38 ng/ml in the additional presence of 10(-6) mol/L methylprednisolone; p < 0.05). Methylprednisolone 215-233 interleukin 10 Homo sapiens 86-91 32554157-15 2020 Methylprednisolone administration in six patients had no significant influence on the studied surface receptors but led to lower IL-8 and higher IL-10 plasma concentrations. Methylprednisolone 0-18 interleukin 10 Homo sapiens 145-150 32037273-11 2020 Methylprednisolone reduced the proinflammatory cytokines interleukin-6 and interleukin-8 and increased the anti-inflammatory cytokine interleukin-10 postoperatively. Methylprednisolone 0-18 interleukin 10 Homo sapiens 134-148 32292492-9 2020 IL-10 concentration (until the end of surgery) and CD163 expression on monocytes (until 48 h after surgery) were the highest in the Methylprednisolone group (p < 0.016, for all measurements between three groups). Methylprednisolone 132-150 interleukin 10 Homo sapiens 0-5 32517881-10 2020 High-dose intravenous methylprednisolone treatment significantly reduced the levels of ET-1 and interleukin (IL)-6 in blood, but significantly increased the serum concentrations of IL-10 in NMOSD patients. Methylprednisolone 22-40 interleukin 10 Homo sapiens 181-186 23602068-9 2013 Methylprednisolone significantly lowered concentrations of proinflammatory cytokines IL-6 and IL-8 and raised levels of anti-inflammatory IL-10. Methylprednisolone 0-18 interleukin 10 Homo sapiens 138-143 31646767-5 2019 Methylprednisolone plasma exposure following a single 10 mg/kg intravenous dose inhibited IL-6 and stimulated IL-10 production when compared with placebo. Methylprednisolone 0-18 interleukin 10 Homo sapiens 110-115 26334856-9 2015 CONCLUSIONS: This study demonstrates that methylprednisolone is effective for ensuring better myocardial protection during cardiac surgery by suppressing the inflammatory response via decreasing the levels of IL-6 and by increasing anti-inflammatory activity through IL-10. Methylprednisolone 42-60 interleukin 10 Homo sapiens 267-272 31172717-9 2019 Similarly, BIS and oral methylprednisolone significantly reduced eosinophils, T helper 2 cells, eosinophil cationic protein, interleukin (IL)-5, and expression of matrix metalloproteinases 2 and 9, and significantly increased type 1 regulatory T cells, IL-10, transforming growth factor-beta, and tissue inhibitor of metalloproteinases 1 and 2 in nasal polyps to a greater extent than BNS. Methylprednisolone 24-42 interleukin 10 Homo sapiens 253-258 25557228-9 2015 Pro-inflammatory cytokine IL-6 was lower (P = 0.01), and anti-inflammatory cytokine IL-10 was higher (P = 0.001) in the methylprednisolone group. Methylprednisolone 120-138 interleukin 10 Homo sapiens 84-89 24792332-0 2015 The in vitro addition of methotrexate and/or methylprednisolone determines peripheral reduction in Th17 and expansion of conventional Treg and of IL-10 producing Th17 lymphocytes in patients with early rheumatoid arthritis. Methylprednisolone 45-63 interleukin 10 Homo sapiens 146-151 17588396-8 2007 Methylprednisolone attenuated postoperative tumor necrosis factor-alpha, interleukin 6, interleukin 8, and C-reactive protein levels while increasing interleukin 10 release. Methylprednisolone 0-18 interleukin 10 Homo sapiens 150-164 21835900-8 2012 Treatment with methylprednisolone, compared with placebo, was associated with a statistically significant reduction in plasma IL-6 and IL-8, a significant increase in plasma IL-10, and a significant reduction in postoperative IL-1ra and IL-6, but not IL-8 in BAL fluid obtained 1 day after surgery. Methylprednisolone 15-33 interleukin 10 Homo sapiens 174-179 22529517-2 2012 The level of IL-10 is elevated by cardiac surgery when cardiopulmonary bypass (CPB) and methylprednisolone are used. Methylprednisolone 88-106 interleukin 10 Homo sapiens 13-18 18657352-0 2008 Effect of treatment with methylprednisolone on the serum levels of IL-12, IL-10 and CCL2 chemokine in patients with multiple sclerosis in relapse. Methylprednisolone 25-43 interleukin 10 Homo sapiens 74-79 18403020-1 2008 In the present report we have determined the molecular mechanisms, which govern the expression of the human IL-10 gene when induced by the glucocorticoid Methyl-Prednisolone (MP). Methylprednisolone 154-173 interleukin 10 Homo sapiens 108-113 18403020-1 2008 In the present report we have determined the molecular mechanisms, which govern the expression of the human IL-10 gene when induced by the glucocorticoid Methyl-Prednisolone (MP). Methylprednisolone 175-177 interleukin 10 Homo sapiens 108-113 23682327-0 2013 Comparison between preoperative administration of methylprednisolone with its administration before and during congenital heart surgery on serum levels of IL-6 and IL-10. Methylprednisolone 50-68 interleukin 10 Homo sapiens 164-169 23682327-2 2013 OBJECTIVES: This study was performed to compare effectiveness of preoperative and intraoperative methylprednisolone (MP) to preoperative methylprednisolone alone in post bypass inflammatory (IL-6) and anti-inflammatory (IL-10) factors. Methylprednisolone 97-115 interleukin 10 Homo sapiens 220-225 23682327-2 2013 OBJECTIVES: This study was performed to compare effectiveness of preoperative and intraoperative methylprednisolone (MP) to preoperative methylprednisolone alone in post bypass inflammatory (IL-6) and anti-inflammatory (IL-10) factors. Methylprednisolone 117-119 interleukin 10 Homo sapiens 220-225 11957164-7 2002 MEASUREMENTS AND MAIN RESULTS: Patients who received methylprednisolone had a significant reduction in circulating interleukin (IL)-6 at 60 minutes after CPB (p < 0.05) and on the morning of the 1st (p < 0.01) and 3rd (p < 0.05) postoperative days and a significant increase in circulating IL-10 at 60 minutes after CPB (p < 0.01) compared with the placebo group. Methylprednisolone 53-71 interleukin 10 Homo sapiens 299-304 15652760-0 2005 Liposomal methylprednisolone differentially regulates the expression of TNF and IL-10 in human alveolar macrophages. Methylprednisolone 10-28 interleukin 10 Homo sapiens 80-85 15298427-0 2004 Methylprednisolone prevents inflammatory reaction occurring during cardiopulmonary bypass: effects on TNF-alpha, IL-6, IL-8, IL-10. Methylprednisolone 0-18 interleukin 10 Homo sapiens 125-130 15298427-12 2004 CONCLUSION: In this study, we have found that preoperative administration of methylprednisolone has decreased TNF-alpha, IL-6 and IL-8 release, and increased the perfusing IL-10 levels after CPB. Methylprednisolone 77-95 interleukin 10 Homo sapiens 172-177 9630160-8 1998 In vitro experiments employing normal PBMC showed that methylprednisolone (MP) upregulated IL-10 expression as determined by measuring mRNA levels, flow cytometry of intracytoplasmic protein concentration, and the amount of secreted protein. Methylprednisolone 55-73 interleukin 10 Homo sapiens 91-96 9630160-8 1998 In vitro experiments employing normal PBMC showed that methylprednisolone (MP) upregulated IL-10 expression as determined by measuring mRNA levels, flow cytometry of intracytoplasmic protein concentration, and the amount of secreted protein. Methylprednisolone 75-77 interleukin 10 Homo sapiens 91-96