PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32974315-13 2020 In all scenarios, among the tested mediators the most pronounced anti-inflammatory effect of MP was observed for IL-8. Methylprednisolone 93-95 C-X-C motif chemokine ligand 8 Homo sapiens 113-117 33767939-3 2021 The aim of this study was to investigate the therapeutic effects of the combination of erythropoietin and methylprednisolone in the treatment of ischemia-reperfusion injury to the spinal cord and to analyze its effects on the levels of interleukin-1 beta (IL-1beta), interleukin-1 receptor antagonist (IL-1RA), and interleukin-8 (IL-8). Methylprednisolone 106-124 C-X-C motif chemokine ligand 8 Homo sapiens 315-328 33767939-3 2021 The aim of this study was to investigate the therapeutic effects of the combination of erythropoietin and methylprednisolone in the treatment of ischemia-reperfusion injury to the spinal cord and to analyze its effects on the levels of interleukin-1 beta (IL-1beta), interleukin-1 receptor antagonist (IL-1RA), and interleukin-8 (IL-8). Methylprednisolone 106-124 C-X-C motif chemokine ligand 8 Homo sapiens 330-334 32554157-15 2020 Methylprednisolone administration in six patients had no significant influence on the studied surface receptors but led to lower IL-8 and higher IL-10 plasma concentrations. Methylprednisolone 0-18 C-X-C motif chemokine ligand 8 Homo sapiens 129-133 7614647-0 1995 Methylprednisolone inhibits increase of interleukin 8 and 6 during open heart surgery. Methylprednisolone 0-18 C-X-C motif chemokine ligand 8 Homo sapiens 40-53 7614647-3 1995 This prospective study was conducted to investigate whether methylprednisolone (MP) pretreatment (30 mg.kg-1 before CPB and before declamping of aorta) influenced the production of IL-8 and 6 in the peripheral circulation in 27 patients undergoing elective coronary artery bypass surgery. Methylprednisolone 60-78 C-X-C motif chemokine ligand 8 Homo sapiens 181-185 7614647-3 1995 This prospective study was conducted to investigate whether methylprednisolone (MP) pretreatment (30 mg.kg-1 before CPB and before declamping of aorta) influenced the production of IL-8 and 6 in the peripheral circulation in 27 patients undergoing elective coronary artery bypass surgery. Methylprednisolone 80-82 C-X-C motif chemokine ligand 8 Homo sapiens 181-185 8214944-4 1993 Therefore, we conducted a prospective study in order to investigate whether methylprednisolone (MP) pretreatment (30 mg/kg) could influence the appearance of IL-8 (a recently discovered cytokine with potent neutrophil-chemotactic activity) in the peripheral circulation. Methylprednisolone 76-94 C-X-C motif chemokine ligand 8 Homo sapiens 158-162 8214944-4 1993 Therefore, we conducted a prospective study in order to investigate whether methylprednisolone (MP) pretreatment (30 mg/kg) could influence the appearance of IL-8 (a recently discovered cytokine with potent neutrophil-chemotactic activity) in the peripheral circulation. Methylprednisolone 96-98 C-X-C motif chemokine ligand 8 Homo sapiens 158-162 30261896-11 2018 In the CSF, methylprednisolone enhanced the interleukin-8 release (p < 0.001) but did not affect postoperative changes in CSF levels of tumor necrosis factor alpha. Methylprednisolone 12-30 C-X-C motif chemokine ligand 8 Homo sapiens 44-57 32037273-11 2020 Methylprednisolone reduced the proinflammatory cytokines interleukin-6 and interleukin-8 and increased the anti-inflammatory cytokine interleukin-10 postoperatively. Methylprednisolone 0-18 C-X-C motif chemokine ligand 8 Homo sapiens 75-88 32292492-7 2020 Methylprednisolone group, compared to Cytosorb and Control had significantly lower levels of TNF-alpha (until the end of surgery, p < 0.001), IL-6 (until 48 h after surgery, p < 0.001), and IL-8 (until 24 h after surgery, p < 0.016). Methylprednisolone 0-18 C-X-C motif chemokine ligand 8 Homo sapiens 190-194 21835900-8 2012 Treatment with methylprednisolone, compared with placebo, was associated with a statistically significant reduction in plasma IL-6 and IL-8, a significant increase in plasma IL-10, and a significant reduction in postoperative IL-1ra and IL-6, but not IL-8 in BAL fluid obtained 1 day after surgery. Methylprednisolone 15-33 C-X-C motif chemokine ligand 8 Homo sapiens 135-139 24396446-9 2014 The following parameters were found to be reduced following the use of methylprednisolone: Interleukin (IL)-6 immediately following surgery and on postoperative days (PODs) 1 and 3; IL-8 immediately following surgery; and PaO2/FiO2 on POD 3. Methylprednisolone 71-89 C-X-C motif chemokine ligand 8 Homo sapiens 182-186 28003224-5 2017 We found that a corticosteroid (methylprednisolone) and an anti-VEGF agent (bevacizumab) prevented mCRP-induced ARPE-19 barrier disruption and IL-8 production. Methylprednisolone 32-50 C-X-C motif chemokine ligand 8 Homo sapiens 143-147 23602068-9 2013 Methylprednisolone significantly lowered concentrations of proinflammatory cytokines IL-6 and IL-8 and raised levels of anti-inflammatory IL-10. Methylprednisolone 0-18 C-X-C motif chemokine ligand 8 Homo sapiens 94-98 21835900-8 2012 Treatment with methylprednisolone, compared with placebo, was associated with a statistically significant reduction in plasma IL-6 and IL-8, a significant increase in plasma IL-10, and a significant reduction in postoperative IL-1ra and IL-6, but not IL-8 in BAL fluid obtained 1 day after surgery. Methylprednisolone 15-33 C-X-C motif chemokine ligand 8 Homo sapiens 251-255 22289755-6 2012 Compared with the HSP serum group, the levels of IL-8, TNF-alpha, and NO in the HSP serum plus methylprednisolone group decreased significantly (P<0.05). Methylprednisolone 95-113 C-X-C motif chemokine ligand 8 Homo sapiens 49-53 18768046-11 2008 Lung tissue homogenate in the methylprednisolone group had lower levels of TNF-alpha (P < 0.05), IL-1beta (P < 0.05), and IL-8 (P < 0.05) in both the collapsed and the ventilated lungs. Methylprednisolone 30-48 C-X-C motif chemokine ligand 8 Homo sapiens 128-132 20941359-8 2010 Two of these genes, CEACAM1 and MMP8, possibly inhibited by methylprednisolone through IL8, were both found to be over-expressed in non-responsive patients. Methylprednisolone 60-78 C-X-C motif chemokine ligand 8 Homo sapiens 87-90 15696082-4 2005 OBJECTIVE: We sought to investigate the effect of a 2-week course of oral corticosteroid (methylprednisolone, 40 mg/d) on the expression of CXC chemokines (IL-8 and IFN-gamma-inducible protein 10 [IP-10]) and CC chemokines (eotaxin and monocyte chemotactic proteins [MCPs] 1-4) in endoscopic biopsy specimens of 13 patients with moderate-to-severe asthma. Methylprednisolone 90-108 C-X-C motif chemokine ligand 8 Homo sapiens 156-160 17588396-8 2007 Methylprednisolone attenuated postoperative tumor necrosis factor-alpha, interleukin 6, interleukin 8, and C-reactive protein levels while increasing interleukin 10 release. Methylprednisolone 0-18 C-X-C motif chemokine ligand 8 Homo sapiens 88-101 15298427-12 2004 CONCLUSION: In this study, we have found that preoperative administration of methylprednisolone has decreased TNF-alpha, IL-6 and IL-8 release, and increased the perfusing IL-10 levels after CPB. Methylprednisolone 77-95 C-X-C motif chemokine ligand 8 Homo sapiens 130-134 14728888-0 2003 [Interleukin-8 gene expression before and after the pulse treatment with methylprednisolone in primary nephrotic syndrome of children]. Methylprednisolone 73-91 C-X-C motif chemokine ligand 8 Homo sapiens 1-14 15298427-0 2004 Methylprednisolone prevents inflammatory reaction occurring during cardiopulmonary bypass: effects on TNF-alpha, IL-6, IL-8, IL-10. Methylprednisolone 0-18 C-X-C motif chemokine ligand 8 Homo sapiens 119-123 14728888-3 2003 The purpose of the study was to evaluate the serum concentration and mRNA expression of IL-8 before and after the methylprednisolone pulse therapy (MPT) in PNS. Methylprednisolone 114-132 C-X-C motif chemokine ligand 8 Homo sapiens 88-92 14728888-21 2003 Methylprednisolone pulse therapy in PNS was able to inhibit the protein production and PBMC mRNA expression of IL-8, so the therapeutic mechanism of MPT in PNS might be associated with the inhibition of IL-8 expression. Methylprednisolone 0-18 C-X-C motif chemokine ligand 8 Homo sapiens 111-115 14728888-21 2003 Methylprednisolone pulse therapy in PNS was able to inhibit the protein production and PBMC mRNA expression of IL-8, so the therapeutic mechanism of MPT in PNS might be associated with the inhibition of IL-8 expression. Methylprednisolone 0-18 C-X-C motif chemokine ligand 8 Homo sapiens 203-207 12842763-11 2003 These results indicate that methylprednisolone significantly reduces the production of IL-8 in an isolated CPB system. Methylprednisolone 28-46 C-X-C motif chemokine ligand 8 Homo sapiens 87-91 11749774-12 2001 After administration of methylprednisolone or aprotinin, leukocyte CD11b expression, plasma IL-6, IL-8, C-reactive protein levels, and MPO activity decreased by different extent. Methylprednisolone 24-42 C-X-C motif chemokine ligand 8 Homo sapiens 98-102 10230950-8 1999 MEASUREMENTS AND MAIN RESULTS: After CPB, the concentration of the proinflammatory cytokines, interleukin-6 and interleukin-8, was significantly less in the methylprednisolone group. Methylprednisolone 157-175 C-X-C motif chemokine ligand 8 Homo sapiens 112-125 11688002-16 2001 IL-8 levels in control patients were significantly higher compared with patients treated with aprotinin and patients treated with methylprednisolone 1 hour after CPB (p < 0.05). Methylprednisolone 130-148 C-X-C motif chemokine ligand 8 Homo sapiens 0-4 11688002-17 2001 CONCLUSION: This study showed that methylprednisolone suppresses TNF-alpha, IL-6, and IL-8 release; however, aprotinin attenuates IL-8 release alone. Methylprednisolone 35-53 C-X-C motif chemokine ligand 8 Homo sapiens 86-90 11087880-12 2000 In the patients who received methylprednisolone, interleukin-8 concentrations decreased by 50 percent, and this decrease correlated with the duration of neuralgia and with the extent of global pain relief (P<0.001 for both comparisons). Methylprednisolone 29-47 C-X-C motif chemokine ligand 8 Homo sapiens 49-62 9517777-4 1998 RESULTS: Nitric oxide production was partly (< or = 50%) inhibited and IL-8 almost completely suppressed (> 80%) by dexamethasone and methylprednisolone. Methylprednisolone 140-158 C-X-C motif chemokine ligand 8 Homo sapiens 74-78 10199534-13 1999 CONCLUSIONS: Methylprednisolone reduces the production of IL-6 and IL-8 but not that of IL-10 and IL-1ra. Methylprednisolone 13-31 C-X-C motif chemokine ligand 8 Homo sapiens 67-71 9517777-7 1998 CONCLUSION: Dexamethasone and methylprednisolone are inhibitors of human chondrocyte nitric oxide production, although to a lesser extent than for IL-8 production. Methylprednisolone 30-48 C-X-C motif chemokine ligand 8 Homo sapiens 147-151 9513367-3 1998 In patients without methylprednisolone treatment, IL-8 levels in BALF were 362 +/- 67 pg/ml on 0-POD and 948 +/- 359 pg/ml on 1-POD, and were approximately 10 times higher than those in plasma levels. Methylprednisolone 20-38 C-X-C motif chemokine ligand 8 Homo sapiens 50-54 9513367-6 1998 The patients with preoperative methylprednisolone treatment had significantly lower IL-8 levels in BALF and plasma compared with the patients without the treatment. Methylprednisolone 31-49 C-X-C motif chemokine ligand 8 Homo sapiens 84-88