PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32200384-5 2020 RESULTS: In the current study, we discover that dihydrotanshinone I (DTS I), extracted from Radix Salviae, can obviously inhibit mTOR phosphorylation and increase autophagy via increasing AMPK phosphorylation. dhts 48-67 mechanistic target of rapamycin kinase Homo sapiens 129-133 30003065-4 2018 Therefore, the present study investigated the anti-cancer effect of DHTS in terms of cell cycle regulation and the regulation of the AMP-activated protein kinase (AMPK)/Akt/mTOR signaling pathway in SK-HEP-1 human hepatocellular carcinoma cells. dhts 68-72 mechanistic target of rapamycin kinase Homo sapiens 173-177 30003065-11 2018 In addition, DHTS downregulated the Akt/mTOR and MAPK signaling pathways. dhts 13-17 mechanistic target of rapamycin kinase Homo sapiens 40-44 30003065-12 2018 Conclusions: Our results suggest that the anti-proliferative activity of DHTS might be associated with the induction of G0/G1 phase cell cycle arrest and regulation of AMPK/Akt/mTOR and MAPK signaling pathways in SK-HEP-1 cells. dhts 73-77 mechanistic target of rapamycin kinase Homo sapiens 177-181 26282490-10 2015 These results show that DHTS inhibited HIF-1alpha protein synthesis by downregulating the mTOR/p70S6K/4E-BP1 and MEK/ERK pathways. dhts 24-28 mechanistic target of rapamycin kinase Homo sapiens 90-94