PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
227861-3	1979	Coumermycin, novobiocin, nalidixic acid, and oxolinic acid are known to be inhibitors of Escherichia coli gyrase, to inhibit E. coli DNA replication, to abolish colicin E1 replication, and to depress the supercoiling of phage lambda DNA, the last two via inhibition of the DNA gyrase.	coumermycin	0-11	DNA topoisomerase II alpha	Homo sapiens	273-283	
2846489-4	1988	Coumermycin, an inhibitor of DNA-gyrase, was highly concentrated (11.3 to 16.6-fold) within the neutrophils.	coumermycin	0-11	DNA topoisomerase II alpha	Homo sapiens	29-39	
17132020-1	2006	Novobiocin is a member of the coumermycin family of antibiotics and is a well-established inhibitor of DNA gyrase.	coumermycin	30-41	DNA topoisomerase II alpha	Homo sapiens	103-113	
23129443-7	2012	The target of AMM has been proved to be the DNA gyrase B subunit and its binding mode to DNA gyrase is different from those of novobiocin and coumermycin, the known DNA gyrase inhibitors.	coumermycin	142-153	DNA topoisomerase II alpha	Homo sapiens	44-54	
226966-1	1979	We have used the antibiotics coumermycin A1, novobiocin, and oxolinic acid, which are specific inhibitors of DNA gyrase, to study the coupled transcription and translation of several bacterial and plasmid genes in a DNA-directed cell-free system.	coumermycin	29-43	DNA topoisomerase II alpha	Homo sapiens	109-119	
23859777-1	2013	Recent studies have shown that novobiocin (NB), a member of the coumermycin (CA) family of antibiotics with demonstrated DNA gyrase inhibitory activity, inhibits Heat shock protein 90 (HSP90) by binding weakly to a putative ATP-binding site within its C-terminus.	coumermycin	64-75	DNA topoisomerase II alpha	Homo sapiens	121-131	
17132020-8	2006	Thus, we have established the first set of compounds that clearly differentiate between the C-terminus of Hsp90 and DNA gyrase, converted a well-established gyrase inhibitor into a selective Hsp90 inhibitor, and confirmed essential structure-activity relationships for the coumermycin family of antibiotics.	coumermycin	273-284	DNA topoisomerase II alpha	Homo sapiens	116-126