PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34365685-0 2021 Melatonin induces Nrf2-HO-1 reprogramming and corrections in hepatic core clock oscillations in Non-alcoholic fatty liver disease. Melatonin 0-9 heme oxygenase 1 Homo sapiens 23-27 21073519-0 2011 Melatonin synergistically increases resveratrol-induced heme oxygenase-1 expression through the inhibition of ubiquitin-dependent proteasome pathway: a possible role in neuroprotection. Melatonin 0-9 heme oxygenase 1 Homo sapiens 56-72 21073519-4 2011 We assessed whether the co-administration of melatonin and RSV shows synergistic effects in terms of their neuroprotective properties through HO-1. Melatonin 45-54 heme oxygenase 1 Homo sapiens 142-146 21073519-6 2011 Melatonin + RSV showed a synergistic increase in the expression levels of HO-1 protein but not in the HO-1 mRNA level compared to either melatonin or RSV alone, which is mediated by the activation of PI3K-Akt pathway. Melatonin 0-9 heme oxygenase 1 Homo sapiens 74-78 21073519-8 2011 The blockade of HO-1 induction by shRNA attenuated HO-1 induction by melatonin + RSV and hindered the neuroprotective effects against oxidative stress induced by H(2) O(2) . Melatonin 69-78 heme oxygenase 1 Homo sapiens 16-20 21073519-8 2011 The blockade of HO-1 induction by shRNA attenuated HO-1 induction by melatonin + RSV and hindered the neuroprotective effects against oxidative stress induced by H(2) O(2) . Melatonin 69-78 heme oxygenase 1 Homo sapiens 51-55 21073519-9 2011 The treatment of MG132 + RSV mimicked the effects of melatonin + RSV, and melatonin + RSV inhibited ubiquitination of HO-1. Melatonin 74-83 heme oxygenase 1 Homo sapiens 118-122 21073519-10 2011 These data suggest that melatonin potentiates the neuroprotective effect of RSV against oxidative injury, by enhancing HO-1 induction through inhibiting ubiquitination-dependent proteasome pathway, which may provide an effective means to treat neurodegenerative disorders. Melatonin 24-33 heme oxygenase 1 Homo sapiens 119-123 34867473-11 2021 Moreover, melatonin can repair the endothelial damage from preeclampsia at the placenta level, increasing PIGF, Nrf-2, HO-1 production and reducing critical markers of vascular injury during the pregnancy. Melatonin 10-19 heme oxygenase 1 Homo sapiens 119-123 34146326-10 2021 Interestingly, melatonin not only markedly decreased the protein levels of TRPV1 and CGRP, but also enhanced the expression of Nrf2, quinone oxidoreductase-1 (NQO-1), and heme oxygenase-1 (HO-1). Melatonin 15-24 heme oxygenase 1 Homo sapiens 171-187 34146326-10 2021 Interestingly, melatonin not only markedly decreased the protein levels of TRPV1 and CGRP, but also enhanced the expression of Nrf2, quinone oxidoreductase-1 (NQO-1), and heme oxygenase-1 (HO-1). Melatonin 15-24 heme oxygenase 1 Homo sapiens 189-193 22946793-10 2013 Moreover, the protective role of melatonin against damage to endothelial tight junction integrity was addressed by ZO-1 expression, paralleled with the restored heme oxygenase-1 levels during OGD. Melatonin 33-42 heme oxygenase 1 Homo sapiens 161-177 22728708-10 2012 Interestingly, HO-1 expression was differently affected following treatment with various melatonin formulations. Melatonin 89-98 heme oxygenase 1 Homo sapiens 15-19 21062351-9 2011 The capacity of melatonin to modulate Nrf2 pathway was associated with increased heme oxygenase-1 (HO-1) expression, which strengthens antioxidant defense. Melatonin 16-25 heme oxygenase 1 Homo sapiens 81-97 32500379-9 2020 Therapies with anti-viral properties that raise HO-1 include certain anesthetics (sevoflurane or isoflurane), hemin, estrogen, statins, curcumin, resveratrol, and melatonin. Melatonin 163-172 heme oxygenase 1 Homo sapiens 48-52 35603834-9 2022 Ferroptosis inhibitors such as ferrostatin-1, liproxstatin-1, quercetin, and melatonin could prevent mitochondrial lipid peroxidation, up-regulate antioxidant/GSH levels and abrogate iron overload-induced apoptosis through activation of Nrf2 and HO-1 signaling pathways. Melatonin 77-86 heme oxygenase 1 Homo sapiens 246-250 32850957-0 2020 Melatonin Inhibits Oxidative Stress and Apoptosis in Cryopreserved Ovarian Tissues via Nrf2/HO-1 Signaling Pathway. Melatonin 0-9 heme oxygenase 1 Homo sapiens 92-96 32084418-11 2020 The results showed that agomelatine and melatonin decreased neuronal injury and promoted the Nrf2-HO-1 signalling pathway. Melatonin 40-49 heme oxygenase 1 Homo sapiens 98-102 31772710-0 2019 Melatonin Reduces Androgen Production and Upregulates Heme Oxygenase-1 Expression in Granulosa Cells from PCOS Patients with Hypoestrogenia and Hyperandrogenia. Melatonin 0-9 heme oxygenase 1 Homo sapiens 54-70 32096202-12 2020 Melatonin reduced the ROS, MDA, 4-HNE, and 8-OHdG contents but further enhanced the levels of the nuclear factor E2-related factor-2 (Nrf2) and heme oxygenase (HO-1). Melatonin 0-9 heme oxygenase 1 Homo sapiens 160-164 32096202-13 2020 Melatonin-increased viability and melatonin-decreased LDH release were also mediated by the blockage of NF-kappaB or reversed by Nrf2 or HO-1 knockdown. Melatonin 0-9 heme oxygenase 1 Homo sapiens 137-141 32096202-13 2020 Melatonin-increased viability and melatonin-decreased LDH release were also mediated by the blockage of NF-kappaB or reversed by Nrf2 or HO-1 knockdown. Melatonin 34-43 heme oxygenase 1 Homo sapiens 137-141 32096202-16 2020 CONCLUSIONS: Melatonin protected SH SY5Y cells from OGD/R induced oxidative stress, inflammation, apoptosis, and autophagy by blocking NF-kappaB signaling and activating Nrf2/HO-1, Akt, and mTOR/p70S6K/4E-BP-1 pathways, thereby indicating that melatonin is a potential and novel therapeutic drug for ischemic stroke. Melatonin 13-22 heme oxygenase 1 Homo sapiens 175-179 25904702-6 2015 Our results demonstrated that pretreatment of hASCs with melatonin, 100 muM for 3 h, significantly increased their proliferation and their expression of prosurvival P-Erk1/2 and P-Akt, and of antioxidative enzymes catalase and heme oxygenase (HO)-1. Melatonin 57-66 heme oxygenase 1 Homo sapiens 227-248 26681403-11 2016 In contrast, Nrf2 and HO-1 expression were markedly increased (P = 0.0001, P = 0.0049, respectively) after smokers took melatonin orally. Melatonin 120-129 heme oxygenase 1 Homo sapiens 22-26 25033992-6 2014 Thereafter, we introduce some information covering melatonin-related signaling pathways, including heme oxygenase-1 (HO-1), toll-like receptor (TLR), c-Jun N-terminal kinase (JNK), and so on. Melatonin 51-60 heme oxygenase 1 Homo sapiens 99-115 25033992-6 2014 Thereafter, we introduce some information covering melatonin-related signaling pathways, including heme oxygenase-1 (HO-1), toll-like receptor (TLR), c-Jun N-terminal kinase (JNK), and so on. Melatonin 51-60 heme oxygenase 1 Homo sapiens 117-121