PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19317795-7 2009 Melatonin administration in NIDDM patients resulted in a significant increase in the morning melatonin concentration and SOD-1 activity, and a reduction in the MDA level and Cp oxidase activity. Melatonin 0-9 superoxide dismutase 1 Homo sapiens 121-126 20070490-8 2010 The results demonstrated that the mice intranasally inoculated with RSV resulted in oxidative stress changes by increasing NO, MDA and .-OH levels, and decreasing GSH and SOD activities, whereas administration of melatonin significantly reversed all these effects. Melatonin 213-222 superoxide dismutase 1 Homo sapiens 171-174 18363674-5 2008 Melatonin administration resulted in a significant increase in the morning melatonin concentration, SOD-1 and CAT activities, and a reduction in the MDA level. Melatonin 0-9 superoxide dismutase 1 Homo sapiens 100-105 12587715-6 2002 Melatonin cannot only scavenges oxygen free radicals like super oxide radical (O2-), hydroxyl radical (*OH), peroxyl radical (LOO*) and peroxynitrite anion (ONOO-), but can also enhance the antioxidative potential of the cell by stimulating the synthesis of antioxidative enzymes like super oxide dismutase (SOD), glutathione peroxidase (GPX), and also the enzymes that are involved in the synthesis of glutathione. Melatonin 0-9 superoxide dismutase 1 Homo sapiens 285-306 18853657-11 2008 After 15 days of melatonin administration lower MDA concentration and higher SOD-1 activity: in NT group (0.250 +/- 0.03, p < 0.01 and 2757 +/- 299, NS, respectively) and in K group (0.264 +/- 0.03, NS and 3065 +/- 529, p < 0.02, respectively) were measured. Melatonin 17-26 superoxide dismutase 1 Homo sapiens 77-82 17286747-6 2007 Melatonin supplementation resulted in a significant increase in melatonin concentration, SOD-1 and GR activities and a decrease in the MDA level in both examined groups. Melatonin 0-9 superoxide dismutase 1 Homo sapiens 89-94 15754650-6 2004 Genomic action of melatonin appears in its ability to stimulate antioxidant genes expression, and its direct cellular action appears in increasing of these enzymes activity, among which very important place takes zinc-enzyme-superoxide dismutase (SOD). Melatonin 18-27 superoxide dismutase 1 Homo sapiens 213-245 15754650-6 2004 Genomic action of melatonin appears in its ability to stimulate antioxidant genes expression, and its direct cellular action appears in increasing of these enzymes activity, among which very important place takes zinc-enzyme-superoxide dismutase (SOD). Melatonin 18-27 superoxide dismutase 1 Homo sapiens 247-250 15258361-10 2004 Melatonin has no significant effect on the GSH-Px and CAT activity but, it caused a significant decrease in SOD activity (p<0.05). Melatonin 0-9 superoxide dismutase 1 Homo sapiens 108-111 12587715-6 2002 Melatonin cannot only scavenges oxygen free radicals like super oxide radical (O2-), hydroxyl radical (*OH), peroxyl radical (LOO*) and peroxynitrite anion (ONOO-), but can also enhance the antioxidative potential of the cell by stimulating the synthesis of antioxidative enzymes like super oxide dismutase (SOD), glutathione peroxidase (GPX), and also the enzymes that are involved in the synthesis of glutathione. Melatonin 0-9 superoxide dismutase 1 Homo sapiens 308-311 11828555-7 2002 A statistically significant negative correlation between melatonin and SOD (r=-0.421, p=0.014) and a positive correlation between age and Fe (r=0.325, p=0.049) were found only in the Alzheimer disease group. Melatonin 57-66 superoxide dismutase 1 Homo sapiens 71-74 33869202-9 2021 Meanwhile, the global gene expressing in cumulus cells was also modulated by melatonin, especially the genes related to antioxidants (SOD1, GPX1, GPX3, GPX4, PRDX2, and PRDX5), lipid metabolism (FABP3, FABP5, ACACB, TECR, etc. Melatonin 77-86 superoxide dismutase 1 Homo sapiens 134-138 34197883-6 2021 Thus, in addition to their classical antioxidative properties usually associated with mitochondrial effects, it is known that MEL and vitamin D modulate the expression and activity of Cu/Zn-dependent SOD isoforms, MTs and CP; function as copper chelators and regulate genomic and non-genomic mechanisms related to the zinc transport. Melatonin 126-129 superoxide dismutase 1 Homo sapiens 200-203 34355546-7 2022 Our findings indicated that melatonin is used as a complementary treatment to reduce the levels of TNF-alpha and IL-1beta cytokines, MDA, and NO levels in COVID-19 patients and significantly increase SOD level, however, the levels of IL-10 cytokine possesses no considerable changes. Melatonin 28-37 superoxide dismutase 1 Homo sapiens 200-203 35331482-3 2022 Present study aimed to investigate the effect of melatonin supplementation on oxidative stress and antioxidant biomarkers such as malondialdehyde (MDA), increased total antioxidant capacity (TAC), superoxide dismutase (SOD), and Glutathione peroxidase (GPx). Melatonin 49-58 superoxide dismutase 1 Homo sapiens 219-222 35126170-10 2021 There was a reduction in SOD and SOD/O2- ratio in the placental extravillous layer, and melatonin restored the concentrations of this enzyme. Melatonin 88-97 superoxide dismutase 1 Homo sapiens 25-28 35126170-10 2021 There was a reduction in SOD and SOD/O2- ratio in the placental extravillous layer, and melatonin restored the concentrations of this enzyme. Melatonin 88-97 superoxide dismutase 1 Homo sapiens 33-36 31825530-4 2020 RESULTS: All melatonin treatments reduced chilling injury symptoms, reduced electrolyte leakage, malondialdehyde (MDA) content, H2 O2 and superoxide anion (O2 - ), and increased proline content and the activity of superoxide dismutase (SOD), catalase (CAT) and gamma-aminobutyric acid (GABA), and reduced the activities of phospholipase D (PLD) and lipoxygenase (LOX) compared to the control. Melatonin 13-22 superoxide dismutase 1 Homo sapiens 214-234 32758663-6 2020 Melatonin relieved H2O2-induced oxidative stress by significantly reducing intracellular ROS, MDA and 8-OHdG levels and increasing SOD and GSH-Px activities. Melatonin 0-9 superoxide dismutase 1 Homo sapiens 131-134 32172204-7 2020 Melatonin increased nitric oxide and antioxidant mRNAs (SOD1, GPX1, and CAT) and downregulated reactive oxygen species (ROS) level in HUVECs, which may subsequently delay endothelial senescence and promote HUVEC proliferation and repair after injury. Melatonin 0-9 superoxide dismutase 1 Homo sapiens 56-60 33488926-9 2020 Melatonin improved significantly the enzyme activity and protein expression of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) (P < 0.05), thereby activating the antioxidant defense system of SSCs. Melatonin 0-9 superoxide dismutase 1 Homo sapiens 79-99 33488926-9 2020 Melatonin improved significantly the enzyme activity and protein expression of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) (P < 0.05), thereby activating the antioxidant defense system of SSCs. Melatonin 0-9 superoxide dismutase 1 Homo sapiens 101-104 31825530-6 2020 The results indicate that melatonin reduces chilling injury of sapota fruit through maintaining membrane integrity, SOD and CAT activities, and reducing PLD and LOX activities. Melatonin 26-35 superoxide dismutase 1 Homo sapiens 116-119 31825530-4 2020 RESULTS: All melatonin treatments reduced chilling injury symptoms, reduced electrolyte leakage, malondialdehyde (MDA) content, H2 O2 and superoxide anion (O2 - ), and increased proline content and the activity of superoxide dismutase (SOD), catalase (CAT) and gamma-aminobutyric acid (GABA), and reduced the activities of phospholipase D (PLD) and lipoxygenase (LOX) compared to the control. Melatonin 13-22 superoxide dismutase 1 Homo sapiens 236-239 32256092-6 2020 Results: Supplementation with melatonin in adjunct to NSPT significantly increased the serum levels of TAC, SOD, CAT, and GPx in the intervention group (P = 0.02, 0.008, 0.004 and 0.004, respectively). Melatonin 30-39 superoxide dismutase 1 Homo sapiens 108-111 30646765-7 2019 Melatonin supplementation caused a significant decrease in markers of oxidative stress and a significant increase in melatonin concentration and the activities of SOD-1 and GSH-Px in athletes. Melatonin 0-9 superoxide dismutase 1 Homo sapiens 163-168 31735743-7 2020 Mechanism study showed that melatonin significantly reduced the levels of proapoptotic genes p53, Caspase3, and Caspase9 while it upregulated antiapoptotic factors Bcl-2 and Bcl2l1, and antioxidant genes superoxide dismutase 1 and catalase compared with the epirubicin group. Melatonin 28-37 superoxide dismutase 1 Homo sapiens 204-226 31408847-6 2019 Treatment of porcine embryo with melatonin significantly increased formation rates of blastocysts and their total cell numbers, and also upregulated the expression of Nrf2/ARE signaling and apoptosis-related genes (MT2, Nrf2, UCHL, HO-1, SOD1, and Bcl-2). Melatonin 33-42 superoxide dismutase 1 Homo sapiens 238-242 27477115-8 2016 Moreover, the expression of BCL-2, CYP17A1, CYP19A1, SOD1, and GPX4 were up-regulated by 0.01ng/mL melatonin or combined with IIK7, but decreased for the mRNA levels of BAX, P53, and CASPASE-3, as compared with control or groups treated with Luzindole or 4P-PDOT in the presence of melatonin. Melatonin 99-108 superoxide dismutase 1 Homo sapiens 53-57 29136773-8 2018 In leishmaniasis, melatonin arrests parasite replication accompanied by releasing mitochondrial Ca2+ into the cytosol, increasing the level of mitochondrial nitrites as well as reducing superoxide dismutase (SOD) activity. Melatonin 18-27 superoxide dismutase 1 Homo sapiens 186-206 29136773-8 2018 In leishmaniasis, melatonin arrests parasite replication accompanied by releasing mitochondrial Ca2+ into the cytosol, increasing the level of mitochondrial nitrites as well as reducing superoxide dismutase (SOD) activity. Melatonin 18-27 superoxide dismutase 1 Homo sapiens 208-211 27477115-8 2016 Moreover, the expression of BCL-2, CYP17A1, CYP19A1, SOD1, and GPX4 were up-regulated by 0.01ng/mL melatonin or combined with IIK7, but decreased for the mRNA levels of BAX, P53, and CASPASE-3, as compared with control or groups treated with Luzindole or 4P-PDOT in the presence of melatonin. Melatonin 282-291 superoxide dismutase 1 Homo sapiens 53-57 27391761-6 2016 Treatment with 1.0 ng/mL of melatonin also significantly elevated MT2, SOD1, and GPX4 while lowering FASL, CHOP, and GRP78 mRNA abundance compared to the untreated control. Melatonin 28-37 superoxide dismutase 1 Homo sapiens 71-75 25545035-4 2015 The melatonin influences were evaluated by spectrophotometric [hemolysis degree, catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR), glucose-6-phosphate dehydrogenase (G6PDH), and superoxide dismutase (SOD) activities] and chromatographic methods [glutathione (GSH) and malondialdehyde (MDA) levels]. Melatonin 4-13 superoxide dismutase 1 Homo sapiens 235-255 25393080-10 2015 At 5 days, the melatonin/hypothermia group had greater increase in melatonin (P<0.001) and decline in NO (P<0.001), but less decline in SOD (P=0.004). Melatonin 15-24 superoxide dismutase 1 Homo sapiens 142-145 25545035-4 2015 The melatonin influences were evaluated by spectrophotometric [hemolysis degree, catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR), glucose-6-phosphate dehydrogenase (G6PDH), and superoxide dismutase (SOD) activities] and chromatographic methods [glutathione (GSH) and malondialdehyde (MDA) levels]. Melatonin 4-13 superoxide dismutase 1 Homo sapiens 257-260 24374373-9 2014 The results showed that melatonin significantly reduced ROS accumulation and increased SOD expression. Melatonin 24-33 superoxide dismutase 1 Homo sapiens 87-90 25594499-3 2015 Melatonin has been reported to serve as an indirect antioxidant via the stimulation and induction of antioxidant enzymes as superoxide dismutase (SOD) and glutathione peroxidase (Gpx) in several tissues. Melatonin 0-9 superoxide dismutase 1 Homo sapiens 124-144 25594499-3 2015 Melatonin has been reported to serve as an indirect antioxidant via the stimulation and induction of antioxidant enzymes as superoxide dismutase (SOD) and glutathione peroxidase (Gpx) in several tissues. Melatonin 0-9 superoxide dismutase 1 Homo sapiens 146-149 24659586-9 2014 In biopsies of patients suffering idiopathic infertility, melatonin testicular concentrations were negatively correlated with MAC number per mm(2) and TNFalpha, IL1beta and COX2 expression, but positively correlated with the expression of the anti-oxidant enzymes SOD1, peroxiredoxin 1 and catalase. Melatonin 58-67 superoxide dismutase 1 Homo sapiens 264-268 24374373-12 2014 The addition of luzindole and SOD inhibitors abrogated the protective effect of melatonin associated with increased levels of ROS and MMPs. Melatonin 80-89 superoxide dismutase 1 Homo sapiens 30-33 23517928-8 2013 Melatonin caused statistically significant increase of SOD, GPx (p<0.0001 and p=0.004065, respectively) and decrease of MDA in erythrocytes of SPMS patients (p=0.00019). Melatonin 0-9 superoxide dismutase 1 Homo sapiens 55-58 23748038-10 2013 Histochemistry and Western blot data of spinal cord from melatonin treated mice revealed upregulation of human SOD1 compared to untreated mice. Melatonin 57-66 superoxide dismutase 1 Homo sapiens 111-115 23748038-11 2013 In addition, real-time PCR revealed a dose dependent upregulation of human SOD1 in melatonin treated animals. Melatonin 83-92 superoxide dismutase 1 Homo sapiens 75-79 23748038-13 2013 This is probably due to melatonin"s effect on upregulating gene expression of human toxic SOD1. Melatonin 24-33 superoxide dismutase 1 Homo sapiens 90-94 23998285-8 2013 At daytime, melatonin 1 and 10 mg reduced the levels of MDA and increased SOD, IL-6, IL-10, and DHA (p < 0.05). Melatonin 12-21 superoxide dismutase 1 Homo sapiens 74-77 23517928-9 2013 Correlation analysis of Spearman showed positive correlation between SOD and (expanded disability status scale) EDSS scale both before (r=0.64, p=0.00756) and after (r=0.634, p=0.00834) melatonin treatment. Melatonin 186-195 superoxide dismutase 1 Homo sapiens 69-72 23110400-0 2013 Melatonin enhances antioxidative enzyme gene expression (CAT, GPx, SOD), prevents their UVR-induced depletion, and protects against the formation of DNA damage (8-hydroxy-2"-deoxyguanosine) in ex vivo human skin. Melatonin 0-9 superoxide dismutase 1 Homo sapiens 67-70 21392093-2 2011 Melatonin treatment protected primary cultured normal and GCD2 corneal fibroblasts from paraquat (PQ)-induced oxidative stress and caused increased expression levels of Cu/Zn-superoxide dismutase (SOD1) and glutathione reductase (GR) in both types of cells. Melatonin 0-9 superoxide dismutase 1 Homo sapiens 197-201 21392093-5 2011 In addition, the selective melatonin receptor antagonist luzindole blocked melatonin-induced expression of SOD1 and GR. Melatonin 27-36 superoxide dismutase 1 Homo sapiens 107-111 21397009-4 2011 Melatonin, testosterone, dihydrotestosterone, estradiol, and vitamin D induced a sustained activation over time of SOD1 in intact mitochondria, showing a bell-shaped enzyme activation dose response with a threshold at 50nM and a maximum effect at 1muM concentration. Melatonin 0-9 superoxide dismutase 1 Homo sapiens 115-119 20660044-1 2010 INTRODUCTION: A trial of melatonin treatment in children with septo-optic dysplasia (SOD) and sleep disruption is accepted clinical practice in many centers. Melatonin 25-34 superoxide dismutase 1 Homo sapiens 62-89