PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31077207-9	2019	Melatonin treatment (1-10 muM) suppresses 400 muM PA-induced cell viability decrease, cell apoptosis, Caspase 3 activation, and BAX, CHOP, and GRP78 expression.	Melatonin	0-9	caspase 3	Mus musculus	102-111	
31480317-7	2019	Melatonin treatment inhibited caspase-3 activation and apoptotic cell death.	Melatonin	0-9	caspase 3	Mus musculus	30-39	
31131920-6	2019	Increased lipid peroxidation, ROS, apoptosis, caspase-3 and caspase-9 activities in the kidney and testes of the DTX group were diminished by treatment with MEL and Se.	Melatonin	157-160	caspase 3	Mus musculus	46-55	
25858697-8	2015	Furthermore, melatonin decreased Abeta1-42 -induced apoptosis through decreasing the overexpression of caspase-9, caspase-3, and PARP-1 level.	Melatonin	13-22	caspase 3	Mus musculus	114-123	
29259391-0	2017	Melatonin partially protects 661W cells from H2O2-induced death by inhibiting Fas/FasL-caspase-3.	Melatonin	0-9	caspase 3	Mus musculus	87-96	
29872034-8	2018	Increased levels of SOD2, Bax, and cleaved caspase-3 following SAH were reduced in the SAH + melatonin-treated group; reduced levels of Sirt3 and Bcl-2 following SAH were increased in the SAH + melatonin-treated group.	Melatonin	93-102	caspase 3	Mus musculus	43-52	
28994117-5	2018	Western blot was used to detect the expression of melatonin on apoptosis-related factors caspase-3 and Bcl-2, as well as the expressions of GSK-3beta and PP2A to further determine the mechanisms of melatonin on the expression of p-tau protein.	Melatonin	50-59	caspase 3	Mus musculus	89-98	
28994117-6	2018	KEY FINDINGS: Melatonin significantly ameliorated the cognitive function and mitochondrial damage in AD mice, reduced the expression levels of GSK-3beta, caspase-3, Abeta1-42 , BACE1, p-tau protein and increased the expressions of PP2A and Bcl-2.	Melatonin	14-23	caspase 3	Mus musculus	154-163	
29259391-15	2017	Finally, MEL treatment partially prevented the activation of caspase-3 caused by H2O2.	Melatonin	9-12	caspase 3	Mus musculus	61-70	
29259391-17	2017	MEL can prevent photoreceptor cell death induced by H2O2 via the inhibition of the proapoptotic pathway Fas/FasL-caspase-3.	Melatonin	0-3	caspase 3	Mus musculus	113-122	
28469767-7	2017	Melatonin treatment also could reduce malondialdehyde (MDA) level, MDA5, Gp91phox, Caspase3 and Bax expression, and increase total antioxidant activity (TAC), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and Bcl-2 expression by up-regulating SIRT1 signaling.	Melatonin	0-9	caspase 3	Mus musculus	83-91	
25858697-9	2015	Additionally, the evaluation of immunohistochemical analysis of caspase-3, Fluorojade-B, and Nissl staining indicated that melatonin prevented neurodegeneration in Abeta1-42-treated mice.	Melatonin	123-132	caspase 3	Mus musculus	64-73	
19664004-3	2009	In particular, melatonin (10(-4)-10(-6) m) fully prevented myotube death induced by tert-butylhydroperoxide (t-BHP; 10 microm-24 hr) as assessed by acid phosphatase, caspase-3 activities and cellular morphological changes.	Melatonin	15-24	caspase 3	Mus musculus	166-175	
23772689-6	2013	Mechanistic studies revealed that melatonin treatment upregulates gene expression of the antioxidant enzyme, superoxide dismutase (SOD), and the anti-apoptotic factor bcl-2 while downregulating the expression of pro-apoptotic genes p53 and caspase-3.	Melatonin	34-43	caspase 3	Mus musculus	240-249	
23537713-0	2013	Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis.	Melatonin	0-9	caspase 3	Mus musculus	46-55	
23537713-6	2013	Melatonin inhibited Rip2/caspase-1 pathway activation, blocked the release of mitochondrial cytochrome c, and reduced the overexpression and activation of caspase-3.	Melatonin	0-9	caspase 3	Mus musculus	155-164	
26205951-10	2015	At this time, radiation-induces activation of ATM-dependent p53 apoptotic proteins-ATM, p53, p21, Bax, cytochrome C, active caspase-3 and caspases-9 expression, which were significantly reversed in melatonin pre-treated mice.	Melatonin	198-207	caspase 3	Mus musculus	124-148	
25401971-11	2015	Moreover, melatonin lowered the oxidative stress kinase p-JNK which suppressed various apoptotic markers, that is, cytochrome C, caspase-9, caspase-3 and PARP-1, and prevent neurodegeneration.	Melatonin	10-19	caspase 3	Mus musculus	140-149	
21812816-8	2012	Furthermore, melatonin treatment mitigated apoptotic rate, maintained DeltaPsim, diminished cytochrome c release from mitochondria, down-regulated Bax/Bcl-2 ratio and caspase-3 levels, and consequently inhibited the important steps of irradiation-induced activation of mitochondrial pathway of apoptosis.	Melatonin	13-22	caspase 3	Mus musculus	167-176	
17910606-3	2007	Melatonin remarkably prevents hepatocyte apoptosis in mice induced during malaria as indicated by caspase 3 and TUNEL assays as well as transmission electron microscopy (TEM) of the liver tissue.	Melatonin	0-9	caspase 3	Mus musculus	98-107	
16337883-8	2006	In addition, transgenic mice administered melatonin (10 mg/kg) showed a significant reduction in upregulated expression of Bax, caspase-3 and Par-4, indicating inhibited triggering of neuronal apoptosis.	Melatonin	42-51	caspase 3	Mus musculus	128-137	
17602819-12	2007	Additional experiment showed that melatonin significantly attenuated GalN/LPS-induced hepatic apoptosis, measured by inhibition of caspase-3 activities and attenuation of DNA laddering.	Melatonin	34-43	caspase 3	Mus musculus	131-140	
32705396-7	2020	Additionally, the Bax/Bcl-2 ratio and the levels of cleaved caspase-3 and p53 were markedly lower in the cells cultured in thrombin + melatonin-CM than in the cells cultured in thrombin-CM.	Melatonin	134-143	caspase 3	Mus musculus	60-69	
15854745-4	2005	Several previous studies have demonstrated the involvement of ROS in Abeta-induced neurotoxicity, and ROS generated by Abeta have been reported to lead to the activation of nuclear factor-kappa B (NF-kappaB), a transcription factor; pre-treatment with melatonin in the present study reduced the level of Abeta-induced intracellular ROS generation, inhibited NF-kappaB activation, and suppressed the Abeta-induced increase in caspase-3 enzyme activity.	Melatonin	252-261	caspase 3	Mus musculus	425-434	
15009507-0	2004	Melatonin reduces disseminate neuronal death after mild focal ischemia in mice via inhibition of caspase-3 and is suitable as an add-on treatment to tissue-plasminogen activator.	Melatonin	0-9	caspase 3	Mus musculus	97-106	
34122726-7	2021	The antiapoptotic effect of melatonin on CI-AKI was revealed by decreasing the ratio of Bax/Bcl2 and the cleaved caspase3 level and by reducing the number of apoptosis-positive tubular cells.	Melatonin	28-37	caspase 3	Mus musculus	113-121	
35367536-4	2022	Moreover, melatonin administration protected kidney tissue by significantly upregulating the levels of PPARalpha reduced by cisplatin injection, resulting in increased FAO pathway-associated genes (PGC-1a, Acadm, Acat1, Acsm2, Acsm3, Bdh2, Echs and Pecr) as well as reducing protein levels of caspase-3, -9 and Bax.	Melatonin	10-19	caspase 3	Mus musculus	293-306	
35367536-5	2022	Melatonin not only partially modulated FAO via PPARalpha signaling, but also decreased cisplatin-induced apoptosis by inhibiting the caspase-3, -9 and Bax pathways.	Melatonin	0-9	caspase 3	Mus musculus	133-146	
16098092-10	2005	Co-treatment with melatonin restored phosphorylated Akt levels, increased Bcl-X(L) expression and reduced caspase-3 activity.	Melatonin	18-27	caspase 3	Mus musculus	106-115	
11589755-7	2001	Furthermore, we found that the *OH-induced increment of caspase-3 activity in thymocytes was completely abolished by melatonin preincubation.	Melatonin	117-126	caspase 3	Mus musculus	56-65	
33453677-10	2021	In Diabetic + Exercise + Melatonin mice, tumor necrosis factor-alpha, Caspase-3 was significantly down-regulated compared to the Diabetic group (p < 0.05).	Melatonin	25-34	caspase 3	Mus musculus	70-79	
33426650-5	2021	Additionally, elevated cleaved caspase-3 and Bax protein levels and reduced Bcl-2 protein levels in response to hypoxia-ischemia were diminished after melatonin treatment.	Melatonin	151-160	caspase 3	Mus musculus	31-40