PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10877005-0	2000	Fluvoxamine but not citalopram increases serum melatonin in healthy subjects-- an indication that cytochrome P450 CYP1A2 and CYP2C19 hydroxylate melatonin.	Melatonin	47-56	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	98-113	
17003850-1	2006	The metabolism of melatonin to 6-sulphatoxymelatonin (aMT6S) and N-acetylserotonin (NAS) is catalyzed by cytochrome-P450 (CYP) isozymes CYP1A2 and CYP2C19 respectively.	Melatonin	18-27	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	105-120	
17003850-1	2006	The metabolism of melatonin to 6-sulphatoxymelatonin (aMT6S) and N-acetylserotonin (NAS) is catalyzed by cytochrome-P450 (CYP) isozymes CYP1A2 and CYP2C19 respectively.	Melatonin	18-27	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	122-125	
11270913-3	2001	Because fluvoxamine is an inhibitor of several cytochrome P450 (CYP) enzymes, the authors studied the biotransformation of melatonin and the effects of fluvoxamine on the metabolism of melatonin in vitro using human liver microsomes and recombinant human CYP isoenzymes.	Melatonin	185-194	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	64-67	
10877005-0	2000	Fluvoxamine but not citalopram increases serum melatonin in healthy subjects-- an indication that cytochrome P450 CYP1A2 and CYP2C19 hydroxylate melatonin.	Melatonin	145-154	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	98-113	
10231734-0	1999	Involvement of cytochrome P-450 isozymes in melatonin metabolism and clinical implications.	Melatonin	44-53	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	15-31	
32888176-1	2021	BACKGROUND: Cytochrome P450 (CYP) enzymes are involved in the metabolism of many important endogenous substrates (steroids, melatonin), drugs and toxic xenobiotics.	Melatonin	124-133	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	12-27	
31658882-1	2020	As an important member of cytochrome P450 (CYP) enzymes, human CYP1A2 is associated with the metabolism of caffeine and melatonin and the activation of precarcinogens.	Melatonin	120-129	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	26-41	
31658882-1	2020	As an important member of cytochrome P450 (CYP) enzymes, human CYP1A2 is associated with the metabolism of caffeine and melatonin and the activation of precarcinogens.	Melatonin	120-129	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	43-46