PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26797706-6 2016 Since C/EBPbeta has been associated with the activation of PPARgamma and the consensus site of ERK/GSK-3beta, PPARgamma and beta-catenin were detected by immunofluorescence staining after pretreatment of melatonin. Melatonin 204-213 mitogen-activated protein kinase 1 Homo sapiens 95-98 26797706-11 2016 In summary, melatonin inhibited the cAMP synthesis through ROS reduction and the phosphorylation of the ERK/GSK-3beta site which is known to be responsible for C/EBPbeta activation for adipogenic differentiation in hMSCs. Melatonin 12-21 mitogen-activated protein kinase 1 Homo sapiens 104-107 26672764-8 2016 Melatonin also increased the berberine-mediated inhibition of the phosphorylated Akt and ERK. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 89-92 26639427-6 2016 Notably, melatonin/memantine combination decreased brain injury and DNA fragmentation significantly, which was associated with reduced p38 and ERK-1/2 phosphorylation. Melatonin 9-18 mitogen-activated protein kinase 1 Homo sapiens 135-138 26639427-9 2016 Here, we provide evidence that melatonin/memantine combination protects brain from traumatic injury, which was associated with decreased DNA fragmentation, p38 phosphorylation and iNOS activity. Melatonin 31-40 mitogen-activated protein kinase 1 Homo sapiens 156-159 26672764-0 2016 Melatonin inhibits AP-2beta/hTERT, NF-kappaB/COX-2 and Akt/ERK and activates caspase/Cyto C signaling to enhance the antitumor activity of berberine in lung cancer cells. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 59-62 26672764-9 2016 Collectively, our results demonstrated that melatonin enhanced the antitumor activity of berberine by activating caspase/Cyto C and inhibiting AP-2beta/hTERT, NF-kappaB/COX-2 and Akt/ERK signaling pathways. Melatonin 44-53 mitogen-activated protein kinase 1 Homo sapiens 183-186 25388990-0 2015 Melatonin attenuates neutrophil inflammation and mucus secretion in cigarette smoke-induced chronic obstructive pulmonary diseases via the suppression of Erk-Sp1 signaling. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 154-157 26645893-7 2015 Our results demonstrate that p38 and JNK inhibitors (SB203580 and SP600125, respectively) prevented melatonin-induced apoptosis; thus, the propensity of p38 MAPK and JNK to promote apoptosis could be at least partly due to the inhibition of NF-x03BA;B p65 activation by p38 and JNK. Melatonin 100-109 mitogen-activated protein kinase 1 Homo sapiens 157-161 25281200-6 2015 Furthermore, melatonin pretreatment significantly modulated the expression of phospho-P38MAPK and phospho-ERK1/2 in Hy/SD-induced MSCs and the protective effects of melatonin were partially reversed by ERK1/2 inhibitor but not p38 inhibitor, suggesting that melatonin inhibited Hy/SD-induced MSCs cell death through the MAPK signaling pathway in part. Melatonin 13-22 mitogen-activated protein kinase 1 Homo sapiens 227-230 25281200-6 2015 Furthermore, melatonin pretreatment significantly modulated the expression of phospho-P38MAPK and phospho-ERK1/2 in Hy/SD-induced MSCs and the protective effects of melatonin were partially reversed by ERK1/2 inhibitor but not p38 inhibitor, suggesting that melatonin inhibited Hy/SD-induced MSCs cell death through the MAPK signaling pathway in part. Melatonin 165-174 mitogen-activated protein kinase 1 Homo sapiens 227-230 25281200-6 2015 Furthermore, melatonin pretreatment significantly modulated the expression of phospho-P38MAPK and phospho-ERK1/2 in Hy/SD-induced MSCs and the protective effects of melatonin were partially reversed by ERK1/2 inhibitor but not p38 inhibitor, suggesting that melatonin inhibited Hy/SD-induced MSCs cell death through the MAPK signaling pathway in part. Melatonin 165-174 mitogen-activated protein kinase 1 Homo sapiens 227-230 25388990-8 2015 Melatonin inhibited Erk phosphorylation and Sp1 expression induced by CS and LPS treatment. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 20-23 25388990-11 2015 Melatonin reduced Erk phosphorylation and Sp1 expression in CSC-stimulated H292 cells. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 18-21 25388990-12 2015 In addition, cotreatment of melatonin and Erk inhibitors significantly limited the proinflammatory mediators with greater reductions in Erk phosphorylation and Sp1 expression than that observed in H292 cells treated with Erk inhibitor alone. Melatonin 28-37 mitogen-activated protein kinase 1 Homo sapiens 136-139 25388990-12 2015 In addition, cotreatment of melatonin and Erk inhibitors significantly limited the proinflammatory mediators with greater reductions in Erk phosphorylation and Sp1 expression than that observed in H292 cells treated with Erk inhibitor alone. Melatonin 28-37 mitogen-activated protein kinase 1 Homo sapiens 136-139 25388990-13 2015 Taken together, melatonin effectively inhibited the neutrophil airway inflammation induced by CS and LPS treatment, which was closely related to downregulation of Erk phosphorylation. Melatonin 16-25 mitogen-activated protein kinase 1 Homo sapiens 163-166 24942200-0 2014 Melatonin promotes the acquisition of neural identity through extracellular-signal-regulated kinases 1/2 activation. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 62-104 26645893-6 2015 Moreover, MAPK pathways (p38, JNK and ERK) were activated by melatonin treatment, which also significantly increased caspase-3 cleavage and Bax protein expression and decreased Bcl-2 protein expression in a time-dependent manner. Melatonin 61-70 mitogen-activated protein kinase 1 Homo sapiens 10-14 26645893-6 2015 Moreover, MAPK pathways (p38, JNK and ERK) were activated by melatonin treatment, which also significantly increased caspase-3 cleavage and Bax protein expression and decreased Bcl-2 protein expression in a time-dependent manner. Melatonin 61-70 mitogen-activated protein kinase 1 Homo sapiens 38-41 25431168-8 2015 Furthermore, melatonin activated p38, extracellular signal-regulated kinase (ERK), and nuclear factor-kappaB (NF-kappaB) in hDPSCs. Melatonin 13-22 mitogen-activated protein kinase 1 Homo sapiens 33-36 25431168-8 2015 Furthermore, melatonin activated p38, extracellular signal-regulated kinase (ERK), and nuclear factor-kappaB (NF-kappaB) in hDPSCs. Melatonin 13-22 mitogen-activated protein kinase 1 Homo sapiens 38-75 25431168-8 2015 Furthermore, melatonin activated p38, extracellular signal-regulated kinase (ERK), and nuclear factor-kappaB (NF-kappaB) in hDPSCs. Melatonin 13-22 mitogen-activated protein kinase 1 Homo sapiens 77-80 25431168-9 2015 Melatonin-induced hepatic differentiation was attenuated by inhibitors of BMP, p38, ERK, and NF-kappaB. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 79-82 25431168-9 2015 Melatonin-induced hepatic differentiation was attenuated by inhibitors of BMP, p38, ERK, and NF-kappaB. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 84-87 25431168-11 2015 For the first time, this study demonstrates that melatonin promotes hepatic differentiation of hDPSCs by modulating the BMP, p38, ERK, and NF-kappaB pathway. Melatonin 49-58 mitogen-activated protein kinase 1 Homo sapiens 125-128 25431168-11 2015 For the first time, this study demonstrates that melatonin promotes hepatic differentiation of hDPSCs by modulating the BMP, p38, ERK, and NF-kappaB pathway. Melatonin 49-58 mitogen-activated protein kinase 1 Homo sapiens 130-133 24724723-3 2014 In this study, using HEK293 cells stably expressing the human MT1 receptor, melatonin induced a concentration-dependent activation of extracellular signal-regulated kinase 1 and 2 (ERK1/2). Melatonin 76-85 mitogen-activated protein kinase 1 Homo sapiens 134-179 25123138-0 2014 Melatonin suppresses hypoxia-induced migration of HUVECs via inhibition of ERK/Rac1 activation. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 75-78 25123138-6 2014 Furthermore, the anti-Rac1 effect of melatonin in HUVECs appeared to be associated with its inhibition of ERK phosphorylation, but not that of the PI3k/Akt signaling pathway. Melatonin 37-46 mitogen-activated protein kinase 1 Homo sapiens 106-109 25123138-7 2014 Taken together, our work indicates that melatonin exerts an anti-migratory effect on hypoxic HUVECs by blocking ERK/Rac1 activation and subsequent HIF-1alpha upregulation. Melatonin 40-49 mitogen-activated protein kinase 1 Homo sapiens 112-115 23397952-12 2013 In conclusion, the model proposed by these findings is that the MT1/MT2 receptors, which are under the positive control of melatonin, trigger an ERK-dependent signalling cascade that interferes with the anti-apoptotic protein cFLIP modulating the cell life/death balance of human leucocytes. Melatonin 123-132 mitogen-activated protein kinase 1 Homo sapiens 145-148 24720799-5 2014 Melatonin markedly decreased the phosphorylation of MAPKs, including ERK1/2, JNK, and p-38, induced by EGF stimulation. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 86-90 25562159-10 2014 When the Het-1A monolayer was pretreated with melatonin and PD98059 before the acid incubation, the permeability and the expression and phosphorylation of MLCK and ERK decreased. Melatonin 46-55 mitogen-activated protein kinase 1 Homo sapiens 164-167 22506987-7 2012 Melatonin treatment also resulted in reduced expression of phosphorylated Janus kinase and enhanced expression of extracellular mitogen-activated protein kinase (ERK) and signal transducer and activator of transcription (STAT) 3. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 114-160 22506987-7 2012 Melatonin treatment also resulted in reduced expression of phosphorylated Janus kinase and enhanced expression of extracellular mitogen-activated protein kinase (ERK) and signal transducer and activator of transcription (STAT) 3. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 162-165 22348531-6 2012 Transfection with an ERK-, IkappaB-, or c/EBPbeta-specific siRNA or pretreatment with an ERK-, p38 MAPK-, or p300-selective inhibitor considerably abrogated the melatonin-mediated inhibition of proinflammatory mediators. Melatonin 161-170 mitogen-activated protein kinase 1 Homo sapiens 21-24 22348531-6 2012 Transfection with an ERK-, IkappaB-, or c/EBPbeta-specific siRNA or pretreatment with an ERK-, p38 MAPK-, or p300-selective inhibitor considerably abrogated the melatonin-mediated inhibition of proinflammatory mediators. Melatonin 161-170 mitogen-activated protein kinase 1 Homo sapiens 89-92 22348531-8 2012 Collectively, these results indicate that melatonin suppresses proinflammatory mediators by simultaneously targeting the multiple signaling such as ERK/p38 MAPK, c/EBPbeta, NF-kappaB, and p300, in LPS-stimulated VSM cell line CRL1999, and suggest that melatonin is a potential candidate compound for the treatment of proinflammatory disorders. Melatonin 42-51 mitogen-activated protein kinase 1 Homo sapiens 148-151 22348531-8 2012 Collectively, these results indicate that melatonin suppresses proinflammatory mediators by simultaneously targeting the multiple signaling such as ERK/p38 MAPK, c/EBPbeta, NF-kappaB, and p300, in LPS-stimulated VSM cell line CRL1999, and suggest that melatonin is a potential candidate compound for the treatment of proinflammatory disorders. Melatonin 252-261 mitogen-activated protein kinase 1 Homo sapiens 148-151 22050627-0 2012 Melatonin synergistically enhances cisplatin-induced apoptosis via the dephosphorylation of ERK/p90 ribosomal S6 kinase/heat shock protein 27 in SK-OV-3 cells. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 92-95 21988060-0 2012 Prevention of ERK activation involves melatonin-induced G(1) and G(2) /M phase arrest in the human osteoblastic cell line hFOB 1.19. Melatonin 38-47 mitogen-activated protein kinase 1 Homo sapiens 14-17 21988060-1 2012 Melatonin regulates mitogen-activated protein kinase (MAPK) and Akt signaling pathways. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 54-58 21988060-4 2012 Here, we demonstrate that melatonin significantly inhibited phosphorylation of ERK but not p38, JNK, or Akt in a human osteoblastic cell line 1.19 (hFOB), as measured by western blot. Melatonin 26-35 mitogen-activated protein kinase 1 Homo sapiens 79-82 21988060-8 2012 Coimmunoprecipitation further confirmed that there was an interaction between phosphorylation of ERK and cyclin D1, CDK4, cyclin B1, or CDK1, which was weaken in the presence of melatonin or PD98059. Melatonin 178-187 mitogen-activated protein kinase 1 Homo sapiens 97-100 21988060-9 2012 These results suggest that the prevention of ERK activation is involved in melatonin-induced G(1) and G(2) /M phase arrest, and this inhibitory effect is potentially via the ERK, but not p38, JNK, or Akt, pathway. Melatonin 75-84 mitogen-activated protein kinase 1 Homo sapiens 45-48 21988060-9 2012 These results suggest that the prevention of ERK activation is involved in melatonin-induced G(1) and G(2) /M phase arrest, and this inhibitory effect is potentially via the ERK, but not p38, JNK, or Akt, pathway. Melatonin 75-84 mitogen-activated protein kinase 1 Homo sapiens 175-178 22507555-7 2012 Melatonin blocked H(2) O(2) -induced phosphorylation of PI3K/Akt, p38, ERK, JNK, and MAPK, as well as activation of NF-kappaB, which was reversed by sirtinol and SIRT1 siRNA. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 71-74 22507555-7 2012 Melatonin blocked H(2) O(2) -induced phosphorylation of PI3K/Akt, p38, ERK, JNK, and MAPK, as well as activation of NF-kappaB, which was reversed by sirtinol and SIRT1 siRNA. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 85-89 22050627-7 2012 Importantly, melatonin synergistically inhibited the phosphorylation of extracellular signal-regulated kinase (ERK) along with dephosphorylation of 90-kDa ribosomal S6 kinase (p90RSK) and heat shock protein 27 (HSP27) induced by cisplatin. Melatonin 13-22 mitogen-activated protein kinase 1 Homo sapiens 72-109 22050627-7 2012 Importantly, melatonin synergistically inhibited the phosphorylation of extracellular signal-regulated kinase (ERK) along with dephosphorylation of 90-kDa ribosomal S6 kinase (p90RSK) and heat shock protein 27 (HSP27) induced by cisplatin. Melatonin 13-22 mitogen-activated protein kinase 1 Homo sapiens 111-114 22050627-9 2012 Taken together, our findings demonstrate that melatonin enhances cisplatin-induced apoptosis via the inactivation of ERK/p90RSK/HSP27 cascade in SK-OV-3 cells as a potent synergist to cisplatin treatment. Melatonin 46-55 mitogen-activated protein kinase 1 Homo sapiens 117-120 23243457-8 2012 Overall, these findings support the scientific evidences that melatonin facilitates gap junctional intercellular communication in H(2)O(2)-treated HaCaT keratinocyte cells via inhibition of connexin 26/43 and ERK as a potent chemopreventive agent. Melatonin 62-71 mitogen-activated protein kinase 1 Homo sapiens 209-212 23243457-5 2012 Of note, melatonin attenuated the phosphorylation of extracellular signal-regulated protein kinases (ERKs) more than p38 MAPK or JNK in H(2)O(2)-treated HaCaT cells. Melatonin 9-18 mitogen-activated protein kinase 1 Homo sapiens 101-105 21311676-7 2010 Treatment with mitogen-activated protein kinase (MAPK) inhibitors, PD98059 (ERK inhibitor), SP600125 (JNK inhibitor) and SB202190 (p38 inhibitor), confirmed that the melatonin-induced apoptosis was p21-dependent, but ERK-independent. Melatonin 166-175 mitogen-activated protein kinase 1 Homo sapiens 217-220 21718361-9 2011 Both melatonin concentrations increased the expression of phosphorylated p38, ERK, and JNK. Melatonin 5-14 mitogen-activated protein kinase 1 Homo sapiens 78-81 21718361-12 2011 Results obtained provide evidence that the melatonin effects on cell viability and proliferation in HepG2 cells are partially mediated through the MT1 membrane receptor, which seems to be related also with melatonin modulation of cAMP and ERK activation. Melatonin 43-52 mitogen-activated protein kinase 1 Homo sapiens 239-242 21718361-12 2011 Results obtained provide evidence that the melatonin effects on cell viability and proliferation in HepG2 cells are partially mediated through the MT1 membrane receptor, which seems to be related also with melatonin modulation of cAMP and ERK activation. Melatonin 206-215 mitogen-activated protein kinase 1 Homo sapiens 239-242 21311676-7 2010 Treatment with mitogen-activated protein kinase (MAPK) inhibitors, PD98059 (ERK inhibitor), SP600125 (JNK inhibitor) and SB202190 (p38 inhibitor), confirmed that the melatonin-induced apoptosis was p21-dependent, but ERK-independent. Melatonin 166-175 mitogen-activated protein kinase 1 Homo sapiens 49-53 21311676-7 2010 Treatment with mitogen-activated protein kinase (MAPK) inhibitors, PD98059 (ERK inhibitor), SP600125 (JNK inhibitor) and SB202190 (p38 inhibitor), confirmed that the melatonin-induced apoptosis was p21-dependent, but ERK-independent. Melatonin 166-175 mitogen-activated protein kinase 1 Homo sapiens 76-79 21497337-0 2011 Melatonin protects human spermatozoa from apoptosis via melatonin receptor- and extracellular signal-regulated kinase-mediated pathways. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 80-117 21497337-10 2011 In addition, we found that the survival-promoting pathway extracellular signal-regulated kinase (ERK) is likely to have a role in the protective actions of melatonin in ejaculated human spermatozoa. Melatonin 156-165 mitogen-activated protein kinase 1 Homo sapiens 58-95 21497337-10 2011 In addition, we found that the survival-promoting pathway extracellular signal-regulated kinase (ERK) is likely to have a role in the protective actions of melatonin in ejaculated human spermatozoa. Melatonin 156-165 mitogen-activated protein kinase 1 Homo sapiens 97-100 21497337-11 2011 Finally, we confirmed these results further by demonstrating that melatonin prevention of H2O2-induced DNA fragmentation is dependent on both MT1 receptor and ERK signaling. Melatonin 66-75 mitogen-activated protein kinase 1 Homo sapiens 159-162 21167057-10 2010 Furthermore, melatonin repressed the phosphorylation of p38 MAPK in MCF-7/Her2.1 cells and blocked stromal-derived factor-1 (SDF-1) induced p38 phosphorylation in MCF-7/CXCR4 cells. Melatonin 13-22 mitogen-activated protein kinase 1 Homo sapiens 56-59 20050989-11 2010 Based on these findings, melatonin is able to minimize the negative effects of nicotine by blocking the activation of ERK and the other signalling pathways in which this enzyme is involved. Melatonin 25-34 mitogen-activated protein kinase 1 Homo sapiens 118-121 21167057-0 2010 Inhibition of breast cancer cell invasion by melatonin is mediated through regulation of the p38 mitogen-activated protein kinase signaling pathway. Melatonin 45-54 mitogen-activated protein kinase 1 Homo sapiens 93-96 21167057-10 2010 Furthermore, melatonin repressed the phosphorylation of p38 MAPK in MCF-7/Her2.1 cells and blocked stromal-derived factor-1 (SDF-1) induced p38 phosphorylation in MCF-7/CXCR4 cells. Melatonin 13-22 mitogen-activated protein kinase 1 Homo sapiens 140-143 21167057-11 2010 SB230580, a p38 inhibitor, was able to mimic, while transfection of the cells with a constitutively-active MKK6b construct blocked melatonin"s effect on cell invasion, suggesting that the anti-invasive action of melatonin is mediated through the p38 pathway. Melatonin 131-140 mitogen-activated protein kinase 1 Homo sapiens 246-249 21167057-12 2010 CONCLUSIONS: Melatonin exerts an inhibitory effect on breast cancer cell invasion through down-regulation of the p38 pathway, and inhibition of MMP-2 and MMP-9 expression and activity. Melatonin 13-22 mitogen-activated protein kinase 1 Homo sapiens 113-116 19522739-0 2009 Melatonin induces apoptotic death in LNCaP cells via p38 and JNK pathways: therapeutic implications for prostate cancer. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 53-56 19522739-6 2009 Moreover, melatonin markedly activated c-JUN N-terminal kinase (JNK) and p38 kinase, whereas extracellular signal-regulated kinase (ERK) was not responsive to melatonin. Melatonin 10-19 mitogen-activated protein kinase 1 Homo sapiens 73-76 19522739-7 2009 Treatment with MAPK inhibitors, PD98059 (ERK inhibitor), SP600125 (JNK inhibitor) and SB202190 (p38 inhibitor), confirmed that melatonin-induced apoptosis was JNK- and p38-dependent, but ERK-independent. Melatonin 127-136 mitogen-activated protein kinase 1 Homo sapiens 15-19 19522739-7 2009 Treatment with MAPK inhibitors, PD98059 (ERK inhibitor), SP600125 (JNK inhibitor) and SB202190 (p38 inhibitor), confirmed that melatonin-induced apoptosis was JNK- and p38-dependent, but ERK-independent. Melatonin 127-136 mitogen-activated protein kinase 1 Homo sapiens 41-44 19538337-9 2009 Melatonin upregulated the expression levels of P21 and P27 dose-dependently (24 hr), induced the phosphorylation of extracellular signal-regulated protein kinase (ERK) time-dependently (10 microm), but did not affect phosphorylation of P38 in RA-FLSs. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 116-161 19522739-7 2009 Treatment with MAPK inhibitors, PD98059 (ERK inhibitor), SP600125 (JNK inhibitor) and SB202190 (p38 inhibitor), confirmed that melatonin-induced apoptosis was JNK- and p38-dependent, but ERK-independent. Melatonin 127-136 mitogen-activated protein kinase 1 Homo sapiens 96-99 19522739-7 2009 Treatment with MAPK inhibitors, PD98059 (ERK inhibitor), SP600125 (JNK inhibitor) and SB202190 (p38 inhibitor), confirmed that melatonin-induced apoptosis was JNK- and p38-dependent, but ERK-independent. Melatonin 127-136 mitogen-activated protein kinase 1 Homo sapiens 168-171 19522739-7 2009 Treatment with MAPK inhibitors, PD98059 (ERK inhibitor), SP600125 (JNK inhibitor) and SB202190 (p38 inhibitor), confirmed that melatonin-induced apoptosis was JNK- and p38-dependent, but ERK-independent. Melatonin 127-136 mitogen-activated protein kinase 1 Homo sapiens 187-190 19522739-10 2009 Together, these results strongly suggest that JNK and p38 activation directly participate in apoptosis induced by melatonin. Melatonin 114-123 mitogen-activated protein kinase 1 Homo sapiens 54-57 19538337-9 2009 Melatonin upregulated the expression levels of P21 and P27 dose-dependently (24 hr), induced the phosphorylation of extracellular signal-regulated protein kinase (ERK) time-dependently (10 microm), but did not affect phosphorylation of P38 in RA-FLSs. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 163-166 19538337-10 2009 In addition, the expression of P21 and P27 triggered by melatonin was inhibited by the pretreatment of the ERK inhibitor, PD98059 (10 microm). Melatonin 56-65 mitogen-activated protein kinase 1 Homo sapiens 107-110 19538337-12 2009 Taken together, these results suggest that melatonin exerts the inhibitory effect of the proliferation of RA-FLSs through the activation of P21 and P27 mediated by ERK. Melatonin 43-52 mitogen-activated protein kinase 1 Homo sapiens 164-167 18930812-0 2009 ERK MAPK activation mediates the antiapoptotic signaling of melatonin in UVB-stressed U937 cells. Melatonin 60-69 mitogen-activated protein kinase 1 Homo sapiens 0-3 18930812-4 2009 The aim of this study was to investigate whether the extracellular signal-regulated kinase (ERK), which controls the balance between survival and death-promoting genes throughout the MAPK pathway, is involved in the antiapoptotic signaling of melatonin. Melatonin 243-252 mitogen-activated protein kinase 1 Homo sapiens 53-90 18930812-4 2009 The aim of this study was to investigate whether the extracellular signal-regulated kinase (ERK), which controls the balance between survival and death-promoting genes throughout the MAPK pathway, is involved in the antiapoptotic signaling of melatonin. Melatonin 243-252 mitogen-activated protein kinase 1 Homo sapiens 92-95 18930812-7 2009 Moreover, melatonin increased the phosphorylative activation of ERK 1/2 independently from the presence of UVB stress, and decreased the UVB-mediated activation of the stress kinases p38 MAPK and JNK. Melatonin 10-19 mitogen-activated protein kinase 1 Homo sapiens 183-186 18930812-9 2009 Using these inhibitors, a cross-talk effect between stress and survival-promoting kinases was tentatively identified, and confirmed the hierarchical role of ERK MAPK phosphorylation in the signaling of melatonin. Melatonin 202-211 mitogen-activated protein kinase 1 Homo sapiens 157-160 18930812-10 2009 In conclusion, melatonin sustains the activation of the survival-promoting pathway ERK MAPK which is required to antagonize UVB-induced apoptosis of U937 cells. Melatonin 15-24 mitogen-activated protein kinase 1 Homo sapiens 83-86 34866924-9 2021 Thus, melatonin has shown regulatory effects against the TBI-induced autophagic dysfunction, regulation of mitogen-activated protein kinases, such as ERK, activation of the NLRP-3 inflammasome, and release of the inflammatory cytokines. Melatonin 6-15 mitogen-activated protein kinase 1 Homo sapiens 150-153 18435720-0 2008 Melatonin prevents oxidized low-density lipoprotein-induced increase of myosin light chain kinase activation and expression in HUVEC through ERK/MAPK signal transduction. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 141-144 18435720-0 2008 Melatonin prevents oxidized low-density lipoprotein-induced increase of myosin light chain kinase activation and expression in HUVEC through ERK/MAPK signal transduction. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 145-149 18435720-3 2008 The purpose of this study was to test whether melatonin prevents ox-LDL-induced increase of myosin light chain kinase (MLCK) activation and expression in human umbilical vein endothelial cells (HUVECs) through extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) signal transduction. Melatonin 46-55 mitogen-activated protein kinase 1 Homo sapiens 210-247 18435720-3 2008 The purpose of this study was to test whether melatonin prevents ox-LDL-induced increase of myosin light chain kinase (MLCK) activation and expression in human umbilical vein endothelial cells (HUVECs) through extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) signal transduction. Melatonin 46-55 mitogen-activated protein kinase 1 Homo sapiens 249-252 18435720-3 2008 The purpose of this study was to test whether melatonin prevents ox-LDL-induced increase of myosin light chain kinase (MLCK) activation and expression in human umbilical vein endothelial cells (HUVECs) through extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) signal transduction. Melatonin 46-55 mitogen-activated protein kinase 1 Homo sapiens 288-292 18435720-8 2008 These results indicate for the first time that hypercholesterolemia may be associated with MLCK expression and the activity which can be reduced by melatonin through ERK/MAPK signal transduction. Melatonin 148-157 mitogen-activated protein kinase 1 Homo sapiens 166-169 18435720-8 2008 These results indicate for the first time that hypercholesterolemia may be associated with MLCK expression and the activity which can be reduced by melatonin through ERK/MAPK signal transduction. Melatonin 148-157 mitogen-activated protein kinase 1 Homo sapiens 170-174 18078456-10 2008 High concentrations of melatonin inhibited both NF-kappaB expression and its binding ability to DNA, possibly through inactivation of ERK/Akt /PKC pathways. Melatonin 23-32 mitogen-activated protein kinase 1 Homo sapiens 134-137 18078456-11 2008 Taken together, high concentrations of melatonin markedly reduced HUVEC proliferation; the antiproliferative action of melatonin was closely correlated with following pathway: melatonin receptors/ERK/PI3K/Akt/PKC/ NF-kappaB. Melatonin 39-48 mitogen-activated protein kinase 1 Homo sapiens 196-199 18078456-11 2008 Taken together, high concentrations of melatonin markedly reduced HUVEC proliferation; the antiproliferative action of melatonin was closely correlated with following pathway: melatonin receptors/ERK/PI3K/Akt/PKC/ NF-kappaB. Melatonin 119-128 mitogen-activated protein kinase 1 Homo sapiens 196-199 35183254-10 2022 Furthermore, the phosphorylation of mitogen-activated protein kinase (MAPK) p38/ERK signaling was significantly increased in DPSCs treated with 100 muM melatonin, and their inhibitors significantly decreased osteogenic differentiation. Melatonin 152-161 mitogen-activated protein kinase 1 Homo sapiens 80-83 34188711-0 2021 Melatonin inhibits gallbladder cancer cell migration and invasion via ERK-mediated induction of epithelial-to-mesenchymal transition. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 70-73 34188711-7 2021 Following treatment of the cells with the ERK activator, tert-Butylhydroquinone, the anti-invasive effects of melatonin were reversed by rescuing epithelial-to-mesenchymal transition in GBC cells. Melatonin 110-119 mitogen-activated protein kinase 1 Homo sapiens 42-45 34188711-8 2021 Taken together, these results suggest that melatonin inhibits GBC invasiveness by blocking the ERK signaling pathway. Melatonin 43-52 mitogen-activated protein kinase 1 Homo sapiens 95-98 35183254-12 2022 CONCLUSIONS: These results suggest that melatonin promotes the proliferation and osteogenic differentiation of DPSCs by regulating COX-2/NF-kappaB and p38/ERK MAPK signaling pathways. Melatonin 40-49 mitogen-activated protein kinase 1 Homo sapiens 155-158 29766567-6 2018 Moreover, melatonin increased and decreased the activation of extracellular signal-regulated kinase (ERK) 1/2 and c-Jun N-terminal kinase (JNK) 1/2, respectively, in a dose-dependent manner in U2OS and HOS cells while exerting no evident influence on the level and activation of p38, Akt, FAK, steroid receptor coactivator, or Raf. Melatonin 10-19 mitogen-activated protein kinase 1 Homo sapiens 279-282 32934681-0 2020 Melatonin promotes Schwann cell dedifferentiation and proliferation through the Ras/Raf/ERK and MAPK pathways, and glial cell-derived neurotrophic factor expression. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 88-91 32934681-8 2020 In conclusion, melatonin induced Schwann cell dedifferentiation and proliferation via the Ras/Raf/ERK, MAPK and GDNF/PKC pathways. Melatonin 15-24 mitogen-activated protein kinase 1 Homo sapiens 98-101 32088216-0 2020 Melatonin induces mitochondrial apoptosis in osteoblasts by regulating the STIM1/cytosolic calcium elevation/ERK pathway. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 109-112 32088216-12 2020 SIGNIFICANCE: Melatonin induces mitochondrial apoptosis in osteoblasts by regulating the STIM1/cytosolic calcium elevation/ERK pathway. Melatonin 14-23 mitogen-activated protein kinase 1 Homo sapiens 123-126 32052470-5 2020 The underlying mechanism suggests that both extracellular signal-regulated kinase 1/2 (ERK1/2) and Akt signaling are involved in the processes of thrombopoiesis facilitated by MT. Melatonin 176-178 mitogen-activated protein kinase 1 Homo sapiens 44-85 32179814-7 2020 Besides, melatonin prevented the positive actions that docetaxel exerts on the expression of other factors related to angiogenesis like JAG1, ANPEP, IGF-1, CXCL6, AKT1, ERK1, ERK2, MMP14 and NOS3 and neutralized the stimulating actions of vinorelbine on the expression of FIGF, FGFR3, CXCL6, CCL2, ERK1, ERK2, AKT1, NOS3 and MMP14. Melatonin 9-18 mitogen-activated protein kinase 1 Homo sapiens 175-179 32179814-7 2020 Besides, melatonin prevented the positive actions that docetaxel exerts on the expression of other factors related to angiogenesis like JAG1, ANPEP, IGF-1, CXCL6, AKT1, ERK1, ERK2, MMP14 and NOS3 and neutralized the stimulating actions of vinorelbine on the expression of FIGF, FGFR3, CXCL6, CCL2, ERK1, ERK2, AKT1, NOS3 and MMP14. Melatonin 9-18 mitogen-activated protein kinase 1 Homo sapiens 304-308 30648758-4 2019 We found that melatonin dose-dependently inhibits tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-1beta expression through the PI3K/AKT, ERK, and NF-kappaB signaling pathways. Melatonin 14-23 mitogen-activated protein kinase 1 Homo sapiens 150-153 30648758-8 2019 Our results indicate that melatonin ameliorates RA by inhibiting TNF-alpha and IL-1beta production through downregulation of the PI3K/AKT, ERK, NF-kappaB signaling pathways, as well as miR-3150a-3p overexpression. Melatonin 26-35 mitogen-activated protein kinase 1 Homo sapiens 139-142 30593827-9 2019 Pretreated AF-MSCs with non-selective MT1/MT2 receptors antagonist, luzindole and selective MT2 receptor antagonist, 4-P-PDOT diminished melatonin-induced increase in dopaminergic neuronal markers and phosphorylated ERK but did not diminish increase in phosphorylated CaMKII by melatonin. Melatonin 137-146 mitogen-activated protein kinase 1 Homo sapiens 216-219 32080899-11 2020 The plasticity of ERK activation by MT2 is highlighted by the switch to a beta-arrestin1/2-dependent mode in the absence of Gq/11 proteins and by the switch to a Gi/o mode when engaged into MT1 /MT2 heterodimers, revealing a new mechanism underlying tissue-specific responses to melatonin. Melatonin 279-288 mitogen-activated protein kinase 1 Homo sapiens 18-21 31986953-0 2020 Melatonin receptor protects cardiomyocyte against oxidative stress-induced apoptosis through the MAPK-ERK signaling pathway. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 97-101 31986953-0 2020 Melatonin receptor protects cardiomyocyte against oxidative stress-induced apoptosis through the MAPK-ERK signaling pathway. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 102-105 31986953-6 2020 Finally, we found that melatonin receptor activation triggered an elevation in the activity and expression of ERK pathway and blockade of ERK pathway would abolish the beneficial effects exerted by melatonin receptors activation on cardiomyocyte survival under oxidative stress.Conclusions: Our data suggest that melatonin receptor could attenuate oxidative stress injury in cardiomyocyte through regulation of the ERK signaling pathway. Melatonin 23-32 mitogen-activated protein kinase 1 Homo sapiens 110-113 31986953-6 2020 Finally, we found that melatonin receptor activation triggered an elevation in the activity and expression of ERK pathway and blockade of ERK pathway would abolish the beneficial effects exerted by melatonin receptors activation on cardiomyocyte survival under oxidative stress.Conclusions: Our data suggest that melatonin receptor could attenuate oxidative stress injury in cardiomyocyte through regulation of the ERK signaling pathway. Melatonin 198-207 mitogen-activated protein kinase 1 Homo sapiens 110-113 31986953-6 2020 Finally, we found that melatonin receptor activation triggered an elevation in the activity and expression of ERK pathway and blockade of ERK pathway would abolish the beneficial effects exerted by melatonin receptors activation on cardiomyocyte survival under oxidative stress.Conclusions: Our data suggest that melatonin receptor could attenuate oxidative stress injury in cardiomyocyte through regulation of the ERK signaling pathway. Melatonin 198-207 mitogen-activated protein kinase 1 Homo sapiens 138-141 31986953-6 2020 Finally, we found that melatonin receptor activation triggered an elevation in the activity and expression of ERK pathway and blockade of ERK pathway would abolish the beneficial effects exerted by melatonin receptors activation on cardiomyocyte survival under oxidative stress.Conclusions: Our data suggest that melatonin receptor could attenuate oxidative stress injury in cardiomyocyte through regulation of the ERK signaling pathway. Melatonin 198-207 mitogen-activated protein kinase 1 Homo sapiens 138-141 31986953-6 2020 Finally, we found that melatonin receptor activation triggered an elevation in the activity and expression of ERK pathway and blockade of ERK pathway would abolish the beneficial effects exerted by melatonin receptors activation on cardiomyocyte survival under oxidative stress.Conclusions: Our data suggest that melatonin receptor could attenuate oxidative stress injury in cardiomyocyte through regulation of the ERK signaling pathway. Melatonin 198-207 mitogen-activated protein kinase 1 Homo sapiens 110-113 31986953-6 2020 Finally, we found that melatonin receptor activation triggered an elevation in the activity and expression of ERK pathway and blockade of ERK pathway would abolish the beneficial effects exerted by melatonin receptors activation on cardiomyocyte survival under oxidative stress.Conclusions: Our data suggest that melatonin receptor could attenuate oxidative stress injury in cardiomyocyte through regulation of the ERK signaling pathway. Melatonin 198-207 mitogen-activated protein kinase 1 Homo sapiens 138-141 31986953-6 2020 Finally, we found that melatonin receptor activation triggered an elevation in the activity and expression of ERK pathway and blockade of ERK pathway would abolish the beneficial effects exerted by melatonin receptors activation on cardiomyocyte survival under oxidative stress.Conclusions: Our data suggest that melatonin receptor could attenuate oxidative stress injury in cardiomyocyte through regulation of the ERK signaling pathway. Melatonin 198-207 mitogen-activated protein kinase 1 Homo sapiens 138-141 31535369-0 2020 Melatonin attenuates ER stress and mitochondrial damage in septic cardiomyopathy: A new mechanism involving BAP31 upregulation and MAPK-ERK pathway. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 136-139 31535369-9 2020 Further, we found that BAP31 transcription was repressed by LPS whereas melatonin could restore BAP31 expression; this effect was dependent on the MAPK-ERK pathway. Melatonin 72-81 mitogen-activated protein kinase 1 Homo sapiens 152-155 31535369-10 2020 Inhibition of the ERK pathway and/or knockdown of BAP31 could attenuate the beneficial effects of melatonin on mitochondrial function and ER homeostasis under LPS stress. Melatonin 98-107 mitogen-activated protein kinase 1 Homo sapiens 18-21 31535369-12 2020 Melatonin could stabilize BAP31 via the ERK pathway and thus contribute to the preservation of cardiac function in septic cardiomyopathy. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 40-43 32392192-9 2020 Melatonin treatment decreased the phosphorylated extracellular signal-regulated kinases (p-ERK) activation while increasing the activation of caspase-3, 8, and 9. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 91-94 32392192-13 2020 In conclusion, melatonin can induce apoptosis of 3T3-L1 preadipocytes via p-ERK decrease. Melatonin 15-24 mitogen-activated protein kinase 1 Homo sapiens 76-79 31906951-4 2020 The regulatory effects of melatonin coupling with melatonin receptor 2 (MT2) on the production of reactive oxygen species (ROS), the activation of PKCdelta and ERK, and the hypermethylation of the Muc2 promoter as induced by rVvpM were examined. Melatonin 26-35 mitogen-activated protein kinase 1 Homo sapiens 160-163 31906951-8 2020 Melatonin inhibited the ROS-mediated phosphorylation of PKCdelta and ERK responsible for region-specific hypermethylation in the Muc2 promoter in rVvpM-treated HT29-MTX cells. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 69-72 31885798-10 2019 Moreover, melatonin significantly elevated the activity of the ERK signaling pathway. Melatonin 10-19 mitogen-activated protein kinase 1 Homo sapiens 63-66 31354524-11 2019 Melatonin also counteracted the stimulatory effect of radiation on CXCL6, CCL2, ERK1, ERK2, and AKT1 mRNA expression and increased the inhibitory effect of radiation on NOS3 expression. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 86-90 31354524-14 2019 Antiangiogenic effect of melatonin could be mediated through AKT and ERK pathways, proteins involved in vascular endothelial (VE) cell growth, cell proliferation, survival, migration, and angiogenesis. Melatonin 25-34 mitogen-activated protein kinase 1 Homo sapiens 69-72 30444523-4 2019 The results revealed a novel molecular mechanism of melatonin promotion of self-renewal of NSCs in which a chain reaction in the ERK and TGF-beta/Smad pathways promotes self-renewal and transcription of nestin. Melatonin 52-61 mitogen-activated protein kinase 1 Homo sapiens 129-132 30593827-11 2019 These findings suggest that melatonin promotes dopaminergic neuronal differentiation of AF-MSCs possibly via the induction in ERK and CaMKII pathways through melatonin receptor-dependent and -independent mechanisms, respectively. Melatonin 28-37 mitogen-activated protein kinase 1 Homo sapiens 126-129 30421542-0 2019 Melatonin reduces lung cancer stemness through inhibiting of PLC, ERK, p38, beta-catenin, and Twist pathways. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 66-69 30421542-5 2019 These effects of melatonin were reversed when the cell lines were incubated with phospholipase C (PLC), ERK/p38, and a beta-catenin activator. Melatonin 17-26 mitogen-activated protein kinase 1 Homo sapiens 104-107 30421542-6 2019 Transfection with Twist siRNA augmented the inhibitory effects of melatonin, indicating that melatonin suppresses lung cancer stemness by inhibiting the PLC, ERK/p38, beta-catenin, and Twist signaling pathways. Melatonin 93-102 mitogen-activated protein kinase 1 Homo sapiens 158-161 30388852-8 2018 Interestingly, ERK-mediated phosphorylation was a prerequisite for the melatonin-induced decline in BimEL, and melatonin only promoted the ubiquitination of phosphorylated BimEL, and did not affect the activities of the lysosome or the proteasome. Melatonin 71-80 mitogen-activated protein kinase 1 Homo sapiens 15-18 29338098-0 2018 Increase in motility and invasiveness of MCF7 cancer cells induced by nicotine is abolished by melatonin through inhibition of ERK phosphorylation. Melatonin 95-104 mitogen-activated protein kinase 1 Homo sapiens 127-130 29338098-3 2018 As melatonin has no effect on nonstimulated cells, it is likely that melatonin can counteract ERK activation only downstream of nicotine-induced activation. Melatonin 69-78 mitogen-activated protein kinase 1 Homo sapiens 94-97 29338098-2 2018 Melatonin antagonizes both these effects by inhibiting almost completely ERK phosphorylation. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 73-76 29338098-4 2018 This finding suggests that melatonin hampers ERK phosphorylation presumably by targeting a still unknown intermediate factor that connects nicotine stimulation to ERK phosphorylation. Melatonin 27-36 mitogen-activated protein kinase 1 Homo sapiens 45-48 29338098-4 2018 This finding suggests that melatonin hampers ERK phosphorylation presumably by targeting a still unknown intermediate factor that connects nicotine stimulation to ERK phosphorylation. Melatonin 27-36 mitogen-activated protein kinase 1 Homo sapiens 163-166 28669047-0 2018 Melatonin protected cardiac microvascular endothelial cells against oxidative stress injury via suppression of IP3R-[Ca2+]c/VDAC-[Ca2+]m axis by activation of MAPK/ERK signaling pathway. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 164-167 29338098-5 2018 Furthermore, downstream of ERK activation, melatonin significantly reduces fascin and calpain activation while restoring normal vinculin levels. Melatonin 43-52 mitogen-activated protein kinase 1 Homo sapiens 27-30 29338098-8 2018 Melatonin actions are most likely attributable to ERK inhibition, although melatonin could display other ERK-independent effects, namely through a direct modulation of additional molecular and structural factors, including coronin, cofilin, and cytoskeleton components. Melatonin 0-9 mitogen-activated protein kinase 1 Homo sapiens 50-53 29338098-8 2018 Melatonin actions are most likely attributable to ERK inhibition, although melatonin could display other ERK-independent effects, namely through a direct modulation of additional molecular and structural factors, including coronin, cofilin, and cytoskeleton components. Melatonin 75-84 mitogen-activated protein kinase 1 Homo sapiens 105-108 29330934-7 2018 Meanwhile, BPA-upregulated phosphorylation of ERK and AKT was decreased by melatonin treatment. Melatonin 75-84 mitogen-activated protein kinase 1 Homo sapiens 46-49 29320872-0 2018 Correction to: Bai et al., Melatonin promotes self-renewal of nestin-positive pancreatic stem cells through activation of the MT2/ERK/SMAD/nestin axis. Melatonin 27-36 mitogen-activated protein kinase 1 Homo sapiens 130-133 28669047-6 2018 However, melatonin could protect CMECs against oxidative stress injury via stimulation of MAPK/ERK that inactivated CREB and therefore blocked IP3R/VDAC upregulation and [Ca2+]c/[Ca2+]m overload, sustaining mitochondrial structural and function integrity and ultimately blockading mitochondrial-mediated cellular death. Melatonin 9-18 mitogen-activated protein kinase 1 Homo sapiens 95-98 28500782-11 2017 Further study uncovered that melatonin inhibited the upregulation of p53, ERK and p38 protein expressions in BMSCs with iron overload. Melatonin 29-38 mitogen-activated protein kinase 1 Homo sapiens 74-77 28500782-12 2017 Collectively, melatonin plays a protective role in iron overload-induced osteogenic differentiation dysfunction and senescence through blocking ROS accumulation and p53/ERK/p38 activation. Melatonin 14-23 mitogen-activated protein kinase 1 Homo sapiens 169-172