PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21244482-6	2011	Consistently, combined treatment of melatonin and puromycin reduced the expression of anti-apoptotic proteins, such as bcl-2 and bcl-x(L) , and also induced caspase-3 activation and poly (ADP-ribose) polymerase (PARP) cleavage compared to puromycin treatment alone.	Melatonin	36-45	BCL2 like 1	Homo sapiens	129-137	
33488926-10	2020	Furthermore, melatonin inhibited significantly the expression of proapoptotic protein (Bax) and increased the expression of antiapoptotic proteins (Bcl-2 and Bcl-XL) (P < 0.05).	Melatonin	13-22	BCL2 like 1	Homo sapiens	158-164	
33571963-7	2020	also, expression levels of Bcl-2 and Bcl-xl proteins were significantly increased compared to those in control cells without melatonin or glucose treatments, whereas the Bax protein level decreased.	Melatonin	125-134	BCL2 like 1	Homo sapiens	37-43	
29484412-11	2018	Melatonin also induced upregulation of Bax, downregulation of Bcl-xL, an increase in cleaved caspase-9 level and activation of caspase-3, which confirmed the involvement of the mitochondria in melatonin-induced apoptosis.	Melatonin	0-9	BCL2 like 1	Homo sapiens	62-68	
25000265-7	2014	Melatonin also blocked the hypoxic responses that reduced pro-apoptotic proteins and increased anti-apoptotic proteins including Bcl-2 and Bcl-xL.	Melatonin	0-9	BCL2 like 1	Homo sapiens	139-145	
31735743-7	2020	Mechanism study showed that melatonin significantly reduced the levels of proapoptotic genes p53, Caspase3, and Caspase9 while it upregulated antiapoptotic factors Bcl-2 and Bcl2l1, and antioxidant genes superoxide dismutase 1 and catalase compared with the epirubicin group.	Melatonin	28-37	BCL2 like 1	Homo sapiens	174-180	
23975636-8	2014	Moreover, melatonin increased the Bcl-XL/Bax ratio but reduced the level of cytochrome c, cleavage caspase 9 and 3 proteins.	Melatonin	10-19	BCL2 like 1	Homo sapiens	34-40	
25199820-6	2014	Melatonin-mediated cell death resulted in decreased phosphorylation of EGFR and Akt, leading to attenuated expression of survival proteins, such as Bcl-2, Bcl-xL and survivin, and activated caspase 3 in H1975 cells, but not in HCC827 cells.	Melatonin	0-9	BCL2 like 1	Homo sapiens	155-161	
20964705-6	2011	Antiapoptotic effects of melatonin were related to a reduced expression of Bax and cytosolic cytochrome c release, increased expression of Bcl-2 and Bcl-xL, and inhibition of caspase-9 activity.	Melatonin	25-34	BCL2 like 1	Homo sapiens	149-155	
19220725-5	2009	Melatonin inhibits the important steps of indomethacin-induced activation of mitochondrial pathway of apoptosis such as upregulation of the expression of Bax and Bak, and the downregulation of Bcl-2 and BclxL.	Melatonin	0-9	BCL2 like 1	Homo sapiens	203-208	
12626434-4	2003	High toxic concentration of DA (500 microM), R-APO (50 microM), melatonin (50 microM), and EGCG (50 microM) exhibited a similar profile of proapoptotic gene expression, increasing the level of bax, caspase-6, fas ligand, and the cell-cycle inhibitor gadd45 genes, while decreasing antiapoptotic bcl-2 and bcl-xL.	Melatonin	64-73	BCL2 like 1	Homo sapiens	305-311