PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29181127-6	2017	These results demonstrate that melatonin ameliorates OS in MS patients supporting the view that combined administration of interferon beta-1b and melatonin can be more effective in reducing OS in MS patients than interferon beta-1b alone.	Melatonin	31-40	interferon beta 1	Homo sapiens	123-138	
29181127-6	2017	These results demonstrate that melatonin ameliorates OS in MS patients supporting the view that combined administration of interferon beta-1b and melatonin can be more effective in reducing OS in MS patients than interferon beta-1b alone.	Melatonin	31-40	interferon beta 1	Homo sapiens	213-228	
29181127-6	2017	These results demonstrate that melatonin ameliorates OS in MS patients supporting the view that combined administration of interferon beta-1b and melatonin can be more effective in reducing OS in MS patients than interferon beta-1b alone.	Melatonin	146-155	interferon beta 1	Homo sapiens	213-228	
23665342-2	2013	Both vitamin D and melatonin are essential mediators of the effect of sunlight in health, and as such are candidates to play a key role in MS. We hypothesized that vitamin D and melatonin may have related influences in patients with MS. METHODS: In a randomized, double blind study of 40 IFN-beta treated MS patients, 21 patients were assigned to 800 IU of vitamin D3 per day (low dose), while 19 patients received 4,370 IU vitamin D3 per day (high dose) for one year.	Melatonin	178-187	interferon beta 1	Homo sapiens	288-296	
23665342-8	2013	CONCLUSIONS: Melatonin secretion is negatively correlated with alterations in serum 25-OH-D in IFN-beta treated patients with MS.	Melatonin	13-22	interferon beta 1	Homo sapiens	95-103	
22137446-4	2012	OBJECTIVE: To assess the influence of IFN-beta treatment on melatonin secretion, fatigue and sleep characteristics in patients with MS. METHODS: 13 MS patients and 12 healthy controls participated.	Melatonin	60-69	interferon beta 1	Homo sapiens	38-46	
22137446-8	2012	CONCLUSION: Our findings suggest dysregulation of Melatonin secretion in MS, which may be influenced by IFN-beta treatment.	Melatonin	50-59	interferon beta 1	Homo sapiens	104-112