PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8576053-0 1996 CWH41 encodes a novel endoplasmic reticulum membrane N-glycoprotein involved in beta 1,6-glucan assembly. beta-1,6-glucan 80-95 mannosyl-oligosaccharide glucosidase Homo sapiens 0-5 8576053-2 1996 Disruption of the CWH41 gene leads to a K1 killer toxin-resistant phenotype and a 50% reduction in the cell wall beta 1,6-glucan level. beta-1,6-glucan 113-128 mannosyl-oligosaccharide glucosidase Homo sapiens 18-23 8576053-3 1996 CWH41 also displays strong genetic interactions with KRE1 and KRE6, two genes known to be involved in the beta 1,6-glucan biosynthetic pathway. beta-1,6-glucan 106-121 mannosyl-oligosaccharide glucosidase Homo sapiens 0-5 8576053-4 1996 The cwh41 delta kre6 delta double mutant is nonviable; and the cwh41 delta kre1 delta double mutation results in strong synergistic defects, with a severely slow-growth phenotype, a 75% reduction in beta 1,6-glucan level, and the secretion of a cell wall glucomannoprotein, Cwp1p. beta-1,6-glucan 199-214 mannosyl-oligosaccharide glucosidase Homo sapiens 63-68 8576053-5 1996 These results provide strong genetic evidence indicating that Cwh41p plays a functional role, possibly as a new synthetic component, in the assembly of cell wall beta 1,6-glucan. beta-1,6-glucan 162-177 mannosyl-oligosaccharide glucosidase Homo sapiens 62-68