PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21030485-1 2011 Cytochrome P450 2J2 (CYP2J2) epoxygenase converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EETs) that exert multiple biological effects in the cardiovascular system and in various human solid cancers. eets 116-120 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 0-19 21030485-1 2011 Cytochrome P450 2J2 (CYP2J2) epoxygenase converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EETs) that exert multiple biological effects in the cardiovascular system and in various human solid cancers. eets 116-120 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 21-27 20140850-1 2010 BACKGROUND: Cytochrome P450 (CYP) 2J2 is a regulatory enzyme in the biosynthesis of biologically active CIS-epoxyeicosatrienoic acids (EETs). eets 135-139 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 12-37 17652182-1 2007 CYP2J2 is abundant in cardiac tissue and active in the biosynthesis of eicosanoids such as epoxyeicosatrienoic acids (EETs). eets 118-122 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 0-6 20093140-4 2010 CYP epoxygenases such as CYP1A2, CYP2C, and CYP2J2 metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs) which generally possess vasodilating, anti-inflammatory, anti-apoptotic, anti-thrombotic, natriuretic, and cardioprotective effects. eets 109-113 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 44-50 19944311-2 2009 Cytochrome P-450 (CYP) 2J2 that is expressed in endothelial cells metabolizes arachidonic acids to biologically active epoxyeicosatrienoic acids (EETs) that possess anti-inflammatory and anti-thrombotic effects. eets 146-150 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 0-26 19289568-1 2009 The cytochrome P450 epoxygenase, CYP2J2, converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EETs). eets 116-120 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 33-39 17126841-1 2007 OBJECTIVES: Cytochrome P450 (CYP) 2J2 is expressed in vascular endothelium and metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs), which are potent endogenous vasodilators and inhibitors of vascular inflammation. eets 158-162 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 12-37 15466638-1 2004 BACKGROUND: Cytochrome P450 (CYP) 2J2 is expressed in the vascular endothelium and metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs). eets 162-166 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 12-37 16868033-1 2006 CYP2J2 metabolizes arachidonic acid to 20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids (EETs), which play a critical role in the regulation of renal, pulmonary, cardiac, and vascular function. eets 102-106 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 0-6 15864120-1 2005 CYP2J2 and CYP2C8 metabolize arachidonic acid (AA) to cis-epoxyeicosatrienoic acids (EETs), which play a central role in regulating renal tubular fluid-electrolyte transport and vascular tone. eets 85-89 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 0-6 34044117-1 2021 Extrahepatic CYP2J2 metabolism of arachidonic acid (AA) to bioactive regioisomeric epoxyeicosatrienoic acids (EETs) is implicated in both physiological and pathological conditions. eets 110-114 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 13-19 11455018-1 2001 CYP2J2 is abundant in human heart and its arachidonic acid metabolites, the epoxyeicosatrienoic acids (EETs), have potent vasodilatory, antiinflammatory and cardioprotective properties. eets 103-107 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 0-6 34707002-4 2021 Cytochrome P450 2J2 (CYP2J2) is the main enzyme which mediates arachidonic acid to produce epoxyeicosatrienoic acids (EETs) in human tissues. eets 118-122 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 0-19 34707002-4 2021 Cytochrome P450 2J2 (CYP2J2) is the main enzyme which mediates arachidonic acid to produce epoxyeicosatrienoic acids (EETs) in human tissues. eets 118-122 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 21-27 34707002-5 2021 It has been reported that EETs involve in the development of cancer, while the roles of EETs in PDAC and ferroptosis remain unclear.This study aims to explore the effect of CYP2J2/EETs on ferroptosis of human pancreatic ductal adenocarcinoma cells PANC-1 cells and the underlying mechanisms. eets 88-92 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 173-179 33437370-1 2020 OBJECTIVE: This study aimed to explore the function and mechanism of Cytochrome P450 2J2 (CYP2J2) epoxygenase and epoxyeicosatrienoic acids (EETs) in the malignant development of hepatocellular carcinoma (HCC). eets 141-145 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 69-88 33437370-0 2020 CYP2J2 promotes the development of hepatocellular carcinoma by increasing the EETs production to improve HIF-1alpha stability. eets 78-82 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 0-6 33437370-1 2020 OBJECTIVE: This study aimed to explore the function and mechanism of Cytochrome P450 2J2 (CYP2J2) epoxygenase and epoxyeicosatrienoic acids (EETs) in the malignant development of hepatocellular carcinoma (HCC). eets 141-145 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 90-96 33437370-6 2020 Finally, xenograft experiments were established to investigate the function of CYP2J2-EETs metabolism in HCC tumorigenesis in vivo. eets 86-90 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 79-85 31000184-1 2019 BACKGROUND: The cytochrome P-450 2J2 (CYP2J2) is known to be one of the major enzymes of epoxygenase pathway of arachidonic acid in extrahepatic tissues, which produces series of regioisomeric cis-epoxyeicosatrienoic acids (EETs) such as 5,6-, 8,9-, 11,12-, and 14,15-EETs. eets 224-228 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 16-36 33239900-3 2020 Giving the importance of epoxyeicosatrienoic acids (EETs) in kidney health, we aimed to study the association between two SNPs in the genes controlling synthesis and degradation of EETs (CYP2J2 rs2280275 and EPHX2 rs751141 respectively) and susceptibility of type 2 diabetes mellitus (T2DM) patients to develop DN. eets 52-56 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 187-193 33239900-3 2020 Giving the importance of epoxyeicosatrienoic acids (EETs) in kidney health, we aimed to study the association between two SNPs in the genes controlling synthesis and degradation of EETs (CYP2J2 rs2280275 and EPHX2 rs751141 respectively) and susceptibility of type 2 diabetes mellitus (T2DM) patients to develop DN. eets 181-185 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 187-193 31000184-1 2019 BACKGROUND: The cytochrome P-450 2J2 (CYP2J2) is known to be one of the major enzymes of epoxygenase pathway of arachidonic acid in extrahepatic tissues, which produces series of regioisomeric cis-epoxyeicosatrienoic acids (EETs) such as 5,6-, 8,9-, 11,12-, and 14,15-EETs. eets 224-228 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 38-44 29966295-1 2018 Cytochrome P450 2J2 (CYP2J2) is a known arachidonic acid (AA) epoxygenase that mediates the formation of four bioactive regioisomers of cis-epoxyeicosatrienoic acids (EETs). eets 167-171 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 0-19 29695613-1 2018 Drug-induced cardiotoxicity may be modulated by endogenous arachidonic acid (AA)-derived metabolites known as epoxyeicosatrienoic acids (EETs) synthesized by cytochrome P450 2J2 (CYP2J2). eets 137-141 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 158-177 29695613-1 2018 Drug-induced cardiotoxicity may be modulated by endogenous arachidonic acid (AA)-derived metabolites known as epoxyeicosatrienoic acids (EETs) synthesized by cytochrome P450 2J2 (CYP2J2). eets 137-141 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 179-185 29966295-1 2018 Cytochrome P450 2J2 (CYP2J2) is a known arachidonic acid (AA) epoxygenase that mediates the formation of four bioactive regioisomers of cis-epoxyeicosatrienoic acids (EETs). eets 167-171 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 21-27 25870948-2 2015 The cytochrome P450 epoxygenase 2J2 (CYP2J2) metabolizes arachidonic acid to epoxyeicosatrienoic acids (EETs), which exert an anti-inflammatory effect on the cardiovascular system. eets 104-108 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 4-35 29433675-2 2018 CYP2J2 inhibitors can significantly reduce proliferation, migration and promote apoptosis of tumor cells by inhibiting epoxyeicosatrienoic acids (EETs) biosynthesis. eets 146-150 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 0-6 28958841-1 2017 Cardiac enzymes such as cytochrome P450 2J2 (CYP2J2) metabolize arachidonic acid (AA) to cardioprotective epoxyeicosatrienoic acids (EETs), which in turn are metabolized by soluble epoxide hydrolase (sEH) to dihydroxyeicosatrienoic acids (DHETs). eets 133-137 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 24-43 28958841-1 2017 Cardiac enzymes such as cytochrome P450 2J2 (CYP2J2) metabolize arachidonic acid (AA) to cardioprotective epoxyeicosatrienoic acids (EETs), which in turn are metabolized by soluble epoxide hydrolase (sEH) to dihydroxyeicosatrienoic acids (DHETs). eets 133-137 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 45-51 29911373-2 2017 CYP2J2 can convert arachidonic acid (AA) to expoxyeicosatrienoic acids (EETs), which have various biological effects, implying the important role of CYP2J2 in the regulation of cardiovascular system and promotion of tumor progression and metastasis. eets 72-76 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 0-6 29911373-2 2017 CYP2J2 can convert arachidonic acid (AA) to expoxyeicosatrienoic acids (EETs), which have various biological effects, implying the important role of CYP2J2 in the regulation of cardiovascular system and promotion of tumor progression and metastasis. eets 72-76 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 149-155 25870948-2 2015 The cytochrome P450 epoxygenase 2J2 (CYP2J2) metabolizes arachidonic acid to epoxyeicosatrienoic acids (EETs), which exert an anti-inflammatory effect on the cardiovascular system. eets 104-108 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 37-43 24882266-2 2014 The main human CYP epoxygenases, i.e. CYP2C8, CYP2C9, CYP2C19 and CYP2J2, convert AA to four regioisomer epoxyeicosatrienoic acids (EETs). eets 132-136 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 66-72 25204827-2 2014 Located at the endoplasmic reticulum, CYP2J2 is responsible for epoxidation of endogenous arachidonic acid in cardiac tissue to produce cis-epoxyeicosatrienoic acids (EETs), which have anti-inflammatory and antifibrinolytic properties, and can protect endothelial cells from ischemic or hypoxic injuries. eets 167-171 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 38-44 23474289-1 2013 Cytochrome p450 (CYP)2J2 is an epoxygenase enzyme that metabolises arachidonic acid to epoxyeicosatrienoic acids (EETs). eets 114-118 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 0-24 23647230-2 2013 In cardiac tissues, CYP2J2 can adopt arachidonic acid as a major substrate to produce epoxyeicosatrienoic acids (EETs), which can protect endothelial cells from ischemic or hypoxic injuries and have been implicated in the pathogenesis of coronary artery disease and hypertension. eets 113-117 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 20-26 23684773-1 2013 BACKGROUND: Cytochrome P450 (CYP) 2J2 is expressed in the vascular endothelium and metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs). eets 162-166 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 12-37 23283969-2 2013 Roles for the arachidonic acid epoxygenase metabolites, the epoxyeicosatrienoic acids (EETs), in ENaC activity have been identified; however, their mechanisms of action remain unknown. eets 87-91 cytochrome P450 family 2 subfamily J member 2 Homo sapiens 14-42