PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34922004-3 2022 The enzyme soluble epoxide hydrolase (sEH) hydrolyzes EETs to less active diols, and we hypothesized that pharmacologic sEH inhibition would decrease adipose inflammation in obese individuals. eets 54-58 epoxide hydrolase 2 Homo sapiens 11-36 33588415-2 2020 sEH metabolizes biologically highly active and generally cytoprotective epoxyeicosatrienoic acids (EETs), generated from arachidonic acid metabolism by CYP epoxygenases (CYP2C and CYP2J subfamilies), to less active corresponding diols. eets 99-103 epoxide hydrolase 2 Homo sapiens 0-3 34922004-3 2022 The enzyme soluble epoxide hydrolase (sEH) hydrolyzes EETs to less active diols, and we hypothesized that pharmacologic sEH inhibition would decrease adipose inflammation in obese individuals. eets 54-58 epoxide hydrolase 2 Homo sapiens 38-41 34922004-3 2022 The enzyme soluble epoxide hydrolase (sEH) hydrolyzes EETs to less active diols, and we hypothesized that pharmacologic sEH inhibition would decrease adipose inflammation in obese individuals. eets 54-58 epoxide hydrolase 2 Homo sapiens 120-123 34672113-2 2022 Epoxyeicosatrienoic acids (EETs) are endogenous anti-inflammatory mediators, rapidly metabolized by soluble epoxide hydrolase (sEH) to dihydroxyeicosatrienoic acids (DHETs). eets 27-31 epoxide hydrolase 2 Homo sapiens 100-125 34817988-8 2021 This study demonstrates that alkoxy- groups are potent and more metabolically stable bioisostere alternatives to the epoxide within EETs that enable sEH-independent activity. eets 132-136 epoxide hydrolase 2 Homo sapiens 149-152 34672113-2 2022 Epoxyeicosatrienoic acids (EETs) are endogenous anti-inflammatory mediators, rapidly metabolized by soluble epoxide hydrolase (sEH) to dihydroxyeicosatrienoic acids (DHETs). eets 27-31 epoxide hydrolase 2 Homo sapiens 127-130 34672113-3 2022 We hypothesized that sEH driven metabolism of the EETs to DHETs plays a critical role in chronic joint pain associated with OA and provides a new target for treatment. eets 50-54 epoxide hydrolase 2 Homo sapiens 21-24 34672113-4 2022 METHODS: Potential associations between chronic knee pain in people and single nucleotide polymorphisms (SNPs) in the gene encoding sEH and circulating levels of the EETs and DHETs were investigated. eets 166-170 epoxide hydrolase 2 Homo sapiens 132-135 33990688-1 2021 Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid that are rapidly metabolized into diols by soluble epoxide hydrolase (sEH). eets 27-31 epoxide hydrolase 2 Homo sapiens 112-137 34639055-4 2021 EETs are rapidly metabolized primarily via the soluble epoxide hydrolase (sEH) pathway. eets 0-4 epoxide hydrolase 2 Homo sapiens 47-72 34639055-4 2021 EETs are rapidly metabolized primarily via the soluble epoxide hydrolase (sEH) pathway. eets 0-4 epoxide hydrolase 2 Homo sapiens 74-77 35183688-2 2022 Soluble epoxide hydrolase (sEH), encoded by the EPHX2 gene, degrades EETs into less biologically active metabolites. eets 69-73 epoxide hydrolase 2 Homo sapiens 0-25 35183688-2 2022 Soluble epoxide hydrolase (sEH), encoded by the EPHX2 gene, degrades EETs into less biologically active metabolites. eets 69-73 epoxide hydrolase 2 Homo sapiens 27-30 35183688-2 2022 Soluble epoxide hydrolase (sEH), encoded by the EPHX2 gene, degrades EETs into less biologically active metabolites. eets 69-73 epoxide hydrolase 2 Homo sapiens 48-53 34038767-5 2021 We postulated that hyperglycemia-induced elevation in sEH leads to a reduction in its substrates, epoxyeicosatrienoic acids (EETs), and attenuates the function of beta-cells. eets 125-129 epoxide hydrolase 2 Homo sapiens 54-57 34455816-3 2021 We tested the hypothesis that sEH inhibition increases circulating EETs, reduces blood pressure, and improves insulin sensitivity, blood flow, and inflammation in a randomized, double-blind, placebo-controlled crossover study. eets 67-71 epoxide hydrolase 2 Homo sapiens 30-33 35229747-2 2022 The biological activity of EETs is terminated when being metabolized by soluble epoxide hydrolase (sEH), a process that serves as a key regulator of tissue EETs levels. eets 156-160 epoxide hydrolase 2 Homo sapiens 99-102 35229747-3 2022 EETs act through several signaling pathways to mediate various beneficial effects, including anti-inflammation, anti-apoptosis, and anti-oxidation with relieve of endoplasmic reticulum stress, thereby sEH has become a potential therapeutic target in cardiovascular disease and cancer therapy. eets 0-4 epoxide hydrolase 2 Homo sapiens 201-204 35229747-6 2022 Genetic ablation as well as pharmacologic inhibition of sEH has greatly helped to elucidate the physiologic actions of EETs, and maintaining or elevating brain EETs level has been demonstrated beneficial effects in CNS disease models. eets 119-123 epoxide hydrolase 2 Homo sapiens 56-59 35229747-6 2022 Genetic ablation as well as pharmacologic inhibition of sEH has greatly helped to elucidate the physiologic actions of EETs, and maintaining or elevating brain EETs level has been demonstrated beneficial effects in CNS disease models. eets 160-164 epoxide hydrolase 2 Homo sapiens 56-59 35229747-7 2022 Here, we review the literature regarding the studies on the bioactivity of EETs and their metabolic enzyme sEH with special attention paid to their action mechanisms in the CNS, including their modulation of neuronal activity, attenuation of neuroinflammation, regulation of cerebral blood flow, and improvement of neuronal and glial cells survival. eets 75-79 epoxide hydrolase 2 Homo sapiens 107-110 33994786-1 2020 Purpose: Soluble epoxide hydrolase (sEH) and microsomal epoxide hydrolase (mEH) both catalyze the metabolism of epoxyeicosatrienoic acids (EETs), lipid signaling molecules that are protective against ischemic brain injury owing to their participation in the regulation of vascular tone and cerebral blood flow. eets 139-143 epoxide hydrolase 2 Homo sapiens 9-34 33994786-1 2020 Purpose: Soluble epoxide hydrolase (sEH) and microsomal epoxide hydrolase (mEH) both catalyze the metabolism of epoxyeicosatrienoic acids (EETs), lipid signaling molecules that are protective against ischemic brain injury owing to their participation in the regulation of vascular tone and cerebral blood flow. eets 139-143 epoxide hydrolase 2 Homo sapiens 36-39 33990688-1 2021 Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid that are rapidly metabolized into diols by soluble epoxide hydrolase (sEH). eets 27-31 epoxide hydrolase 2 Homo sapiens 139-142 33369424-2 2021 The inhibition of sEH can effectively maintain endogenous epoxyeicosatrienoic acids (EETs) levels and reduce dihydroxyeicosatrienoic acids (DHETs) levels, resulting in therapeutic potentials for cardiovascular, central nervous system, and metabolic diseases. eets 85-89 epoxide hydrolase 2 Homo sapiens 18-21 33788190-6 2021 More detail is provided to introduce a less recognized gene of Ephx2 that encodes soluble epoxide hydrolase (sEH) to degrade epoxyeicosatrienic acids (EETs). eets 151-155 epoxide hydrolase 2 Homo sapiens 63-68 33788190-6 2021 More detail is provided to introduce a less recognized gene of Ephx2 that encodes soluble epoxide hydrolase (sEH) to degrade epoxyeicosatrienic acids (EETs). eets 151-155 epoxide hydrolase 2 Homo sapiens 82-107 33788190-6 2021 More detail is provided to introduce a less recognized gene of Ephx2 that encodes soluble epoxide hydrolase (sEH) to degrade epoxyeicosatrienic acids (EETs). eets 151-155 epoxide hydrolase 2 Homo sapiens 109-112 32903307-1 2020 Soluble epoxide hydrolase (sEH) is responsible for rapid degradation of 14, 15-EET, which is one of the isomers of EETs and plays an important role in cardiovascular diseases. eets 115-119 epoxide hydrolase 2 Homo sapiens 0-25 33255197-2 2020 The substrate-specific hydrolase activity of sEH converts epoxyeicosatrienoic acids (EETs) to less bioactive dihydroxyeicosatrienoic acids. eets 85-89 epoxide hydrolase 2 Homo sapiens 45-48 33239900-3 2020 Giving the importance of epoxyeicosatrienoic acids (EETs) in kidney health, we aimed to study the association between two SNPs in the genes controlling synthesis and degradation of EETs (CYP2J2 rs2280275 and EPHX2 rs751141 respectively) and susceptibility of type 2 diabetes mellitus (T2DM) patients to develop DN. eets 181-185 epoxide hydrolase 2 Homo sapiens 208-213 33312058-2 2020 Soluble epoxide hydrolase (sEH) catalyses the degradation of EETs to less biologically active dihydroxyeicosatrienoic acids. eets 61-65 epoxide hydrolase 2 Homo sapiens 0-25 33312058-2 2020 Soluble epoxide hydrolase (sEH) catalyses the degradation of EETs to less biologically active dihydroxyeicosatrienoic acids. eets 61-65 epoxide hydrolase 2 Homo sapiens 27-30 32903307-1 2020 Soluble epoxide hydrolase (sEH) is responsible for rapid degradation of 14, 15-EET, which is one of the isomers of EETs and plays an important role in cardiovascular diseases. eets 115-119 epoxide hydrolase 2 Homo sapiens 27-30 31622444-1 2019 Cytochrome P450 (CYP) enzymes metabolize arachidonic acid to vasoactive eicosanoids such as epoxyeicosatrienoic acids (EETs) and 20-Hydroxyeicosatetraenoic acid (20-HETE), whilst soluble epoxide hydrolase, encoded by the EPHX2 gene, is in charge of EETs degradation. eets 119-123 epoxide hydrolase 2 Homo sapiens 221-226 31002701-1 2019 Epoxyeicosatrienoic acids (EETs) are signaling lipids produced by cytochrome P450 epoxygenation of arachidonic acid, which are metabolized by EPHX2 (epoxide hydrolase 2, alias soluble epoxide hydrolase or sEH). eets 27-31 epoxide hydrolase 2 Homo sapiens 142-147 31306370-3 2019 Of interest, cytochrome P450 2J (CYP2J) and soluble epoxide hydrolase (sEH) are known to control the maintenance of cardiovascular health through the regulation of cardioprotective epoxyeicosatrienoic acids (EETs) and its less active products, dihydroxyeicosatrienoic acids (DHETs). eets 208-212 epoxide hydrolase 2 Homo sapiens 44-69 31306370-3 2019 Of interest, cytochrome P450 2J (CYP2J) and soluble epoxide hydrolase (sEH) are known to control the maintenance of cardiovascular health through the regulation of cardioprotective epoxyeicosatrienoic acids (EETs) and its less active products, dihydroxyeicosatrienoic acids (DHETs). eets 208-212 epoxide hydrolase 2 Homo sapiens 71-74 31306370-7 2019 The modulation in EETs and DHETs was attributed to the increase of sEH and the decrease of CYP2J. eets 18-22 epoxide hydrolase 2 Homo sapiens 67-70 31002701-1 2019 Epoxyeicosatrienoic acids (EETs) are signaling lipids produced by cytochrome P450 epoxygenation of arachidonic acid, which are metabolized by EPHX2 (epoxide hydrolase 2, alias soluble epoxide hydrolase or sEH). eets 27-31 epoxide hydrolase 2 Homo sapiens 149-168 31002701-1 2019 Epoxyeicosatrienoic acids (EETs) are signaling lipids produced by cytochrome P450 epoxygenation of arachidonic acid, which are metabolized by EPHX2 (epoxide hydrolase 2, alias soluble epoxide hydrolase or sEH). eets 27-31 epoxide hydrolase 2 Homo sapiens 205-208 30716359-3 2019 Recently, enhancing the concentration of epoxyeicosatrienoic acids (EETs) through blocking their hydrolytic degradation by soluble epoxide hydrolase (sEH) has been applied towards reducing the long-term damage associated with central neurologic insults. eets 68-72 epoxide hydrolase 2 Homo sapiens 123-148 30716359-3 2019 Recently, enhancing the concentration of epoxyeicosatrienoic acids (EETs) through blocking their hydrolytic degradation by soluble epoxide hydrolase (sEH) has been applied towards reducing the long-term damage associated with central neurologic insults. eets 68-72 epoxide hydrolase 2 Homo sapiens 150-153 30885203-1 2019 BACKGROUND: This pathophysiological study addressed the hypothesis that soluble epoxide hydrolase (sEH), which metabolizes the vasodilator and anti-inflammatory epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids (DHETs), contributes to conduit artery endothelial dysfunction in type 2 diabetes. eets 188-192 epoxide hydrolase 2 Homo sapiens 72-97 30885203-1 2019 BACKGROUND: This pathophysiological study addressed the hypothesis that soluble epoxide hydrolase (sEH), which metabolizes the vasodilator and anti-inflammatory epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids (DHETs), contributes to conduit artery endothelial dysfunction in type 2 diabetes. eets 188-192 epoxide hydrolase 2 Homo sapiens 99-102 29717935-2 2018 Epoxyeicosatrienoic acids (EETs), which are rapidly metabolized to dihydroxyeicosatrienoic acids by the soluble epoxide hydrolase (sEH), have multiple biological functions, including vasodilation, anti-inflammatory action, and others. eets 27-31 epoxide hydrolase 2 Homo sapiens 104-129 30447256-1 2019 Soluble epoxide hydrolase (sEH) degrades epoxides of fatty acids including epoxyeicosatrienoic acid isomers (EETs), which are produced as metabolites of the cytochrome P450 branch of the arachidonic acid pathway. eets 109-113 epoxide hydrolase 2 Homo sapiens 0-25 30447256-1 2019 Soluble epoxide hydrolase (sEH) degrades epoxides of fatty acids including epoxyeicosatrienoic acid isomers (EETs), which are produced as metabolites of the cytochrome P450 branch of the arachidonic acid pathway. eets 109-113 epoxide hydrolase 2 Homo sapiens 27-30 29717935-2 2018 Epoxyeicosatrienoic acids (EETs), which are rapidly metabolized to dihydroxyeicosatrienoic acids by the soluble epoxide hydrolase (sEH), have multiple biological functions, including vasodilation, anti-inflammatory action, and others. eets 27-31 epoxide hydrolase 2 Homo sapiens 131-134 28839250-2 2017 Whereas the 5-lipoxygenase-activating protein (FLAP) facilitates AA conversion by 5-lipoxygenase (5-LOX) to pro-inflammatory leukotrienes (LTs), the soluble epoxide hydrolase (sEH) degrades anti-inflammatory epoxyeicosatrienoic acids (EETs). eets 235-239 epoxide hydrolase 2 Homo sapiens 149-174 29960002-1 2018 CYP epoxygenases metabolize arachidonic acid into four regioisomers of epoxyeicosatrienoic acids (EETs) which are hydrolysed into their corresponding diols by soluble epoxide hydrolase (sEH). eets 98-102 epoxide hydrolase 2 Homo sapiens 159-184 29960002-1 2018 CYP epoxygenases metabolize arachidonic acid into four regioisomers of epoxyeicosatrienoic acids (EETs) which are hydrolysed into their corresponding diols by soluble epoxide hydrolase (sEH). eets 98-102 epoxide hydrolase 2 Homo sapiens 186-189 29588470-1 2018 Epoxyeicosatrienoic acids (EETs) are produced by cytochrome P450 epoxygenases from arachidonic acid, and their rapid metabolism is mainly through soluble epoxide hydrolase (sEH). eets 27-31 epoxide hydrolase 2 Homo sapiens 146-171 29588470-1 2018 Epoxyeicosatrienoic acids (EETs) are produced by cytochrome P450 epoxygenases from arachidonic acid, and their rapid metabolism is mainly through soluble epoxide hydrolase (sEH). eets 27-31 epoxide hydrolase 2 Homo sapiens 173-176 28958841-1 2017 Cardiac enzymes such as cytochrome P450 2J2 (CYP2J2) metabolize arachidonic acid (AA) to cardioprotective epoxyeicosatrienoic acids (EETs), which in turn are metabolized by soluble epoxide hydrolase (sEH) to dihydroxyeicosatrienoic acids (DHETs). eets 133-137 epoxide hydrolase 2 Homo sapiens 173-198 28958841-1 2017 Cardiac enzymes such as cytochrome P450 2J2 (CYP2J2) metabolize arachidonic acid (AA) to cardioprotective epoxyeicosatrienoic acids (EETs), which in turn are metabolized by soluble epoxide hydrolase (sEH) to dihydroxyeicosatrienoic acids (DHETs). eets 133-137 epoxide hydrolase 2 Homo sapiens 200-203 29908721-2 2018 EETs are rapidly hydrolysed to less active dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH). eets 0-4 epoxide hydrolase 2 Homo sapiens 84-109 29908721-2 2018 EETs are rapidly hydrolysed to less active dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH). eets 0-4 epoxide hydrolase 2 Homo sapiens 111-114 29285425-1 2017 Background: Soluble epoxide hydrolase (sEH) expressed by endothelial cells catalyzes the metabolism of epoxyeicosatrienoic acids (EETs), which are vasoactive agents. eets 130-134 epoxide hydrolase 2 Homo sapiens 12-37 29285425-1 2017 Background: Soluble epoxide hydrolase (sEH) expressed by endothelial cells catalyzes the metabolism of epoxyeicosatrienoic acids (EETs), which are vasoactive agents. eets 130-134 epoxide hydrolase 2 Homo sapiens 39-42 28839250-2 2017 Whereas the 5-lipoxygenase-activating protein (FLAP) facilitates AA conversion by 5-lipoxygenase (5-LOX) to pro-inflammatory leukotrienes (LTs), the soluble epoxide hydrolase (sEH) degrades anti-inflammatory epoxyeicosatrienoic acids (EETs). eets 235-239 epoxide hydrolase 2 Homo sapiens 176-179 27184755-3 2016 EETs can be further metabolized to less active dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH). eets 0-4 epoxide hydrolase 2 Homo sapiens 88-113 29138698-1 2017 Epoxyeicosatrienoic acids (EETs) are derived from arachidonic acid and metabolized by soluble epoxide hydrolase (sEH). eets 27-31 epoxide hydrolase 2 Homo sapiens 86-111 29138698-1 2017 Epoxyeicosatrienoic acids (EETs) are derived from arachidonic acid and metabolized by soluble epoxide hydrolase (sEH). eets 27-31 epoxide hydrolase 2 Homo sapiens 113-116 27924507-3 2016 Inhibition of soluble epoxide hydrolase (sEH) metabolism has been shown to effectively increase the accumulation of epoxyeicosatrienoic acids (EETs), which are cytochrome P450 metabolites of arachidonic acid and have been demonstrated to have neuroprotective effects. eets 143-147 epoxide hydrolase 2 Homo sapiens 14-39 27924507-3 2016 Inhibition of soluble epoxide hydrolase (sEH) metabolism has been shown to effectively increase the accumulation of epoxyeicosatrienoic acids (EETs), which are cytochrome P450 metabolites of arachidonic acid and have been demonstrated to have neuroprotective effects. eets 143-147 epoxide hydrolase 2 Homo sapiens 41-44 28218273-4 2017 The soluble epoxide hydrolase (sEH) converts AA-derived anti-inflammatory epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatetraenoic acids (di-HETEs). eets 101-105 epoxide hydrolase 2 Homo sapiens 4-29 28218273-4 2017 The soluble epoxide hydrolase (sEH) converts AA-derived anti-inflammatory epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatetraenoic acids (di-HETEs). eets 101-105 epoxide hydrolase 2 Homo sapiens 31-34 27184755-3 2016 EETs can be further metabolized to less active dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH). eets 0-4 epoxide hydrolase 2 Homo sapiens 115-118 27372879-6 2016 Therefore, by increasing the half life of endogenous EETs in vivo via inhibition of sEH, its metabolizing enzyme can, therefore, constitutes an important therapeutic strategy in PD. eets 53-57 epoxide hydrolase 2 Homo sapiens 84-87 27092411-1 2016 Soluble epoxide hydrolase (sEH) hydrolyzes epoxyeicosatrienoic acids (EETs) in the metabolic pathway of arachidonic acid and has been considered as an important therapeutic target for chronic diseases such as hypertension, diabetes and inflammation. eets 70-74 epoxide hydrolase 2 Homo sapiens 0-25 27092411-1 2016 Soluble epoxide hydrolase (sEH) hydrolyzes epoxyeicosatrienoic acids (EETs) in the metabolic pathway of arachidonic acid and has been considered as an important therapeutic target for chronic diseases such as hypertension, diabetes and inflammation. eets 70-74 epoxide hydrolase 2 Homo sapiens 27-30 27144772-1 2016 Soluble epoxide hydrolase (sEH) converts highly active epoxyeicosatrienoic acids (EETs) generated by cytochrome P450 (CYP) epoxygenases from arachidonic acid to less active dihydroxyeicosatrienoic acids. eets 82-86 epoxide hydrolase 2 Homo sapiens 0-25 27079253-3 2016 Epoxyecosatrienoic acids (EETs), the products of arachidonic acid metabolism mediated by cytochrome P450 (CYP) 2J, 2C and other isoforms, are regulated by soluble epoxide hydrolase (sEH)-catalyzed conversion into less active diols. eets 26-30 epoxide hydrolase 2 Homo sapiens 155-180 27079253-3 2016 Epoxyecosatrienoic acids (EETs), the products of arachidonic acid metabolism mediated by cytochrome P450 (CYP) 2J, 2C and other isoforms, are regulated by soluble epoxide hydrolase (sEH)-catalyzed conversion into less active diols. eets 26-30 epoxide hydrolase 2 Homo sapiens 182-185 27144772-1 2016 Soluble epoxide hydrolase (sEH) converts highly active epoxyeicosatrienoic acids (EETs) generated by cytochrome P450 (CYP) epoxygenases from arachidonic acid to less active dihydroxyeicosatrienoic acids. eets 82-86 epoxide hydrolase 2 Homo sapiens 27-30 25406731-1 2014 BACKGROUND: Epoxyeicosatrienoic acids (EETs) are derived from arachidonic acid by cytochrome P450 (CYP) and metabolized by soluble epoxide hydrolase (sEH). eets 39-43 epoxide hydrolase 2 Homo sapiens 123-148 26747234-7 2016 Several elegant studies have contributed to defining the importance of stabilizing the levels of epoxyeicosatrienoic acids (EETs), by inhibiting or deleting soluble epoxide hydrolase (sEH), in stroke research. eets 124-128 epoxide hydrolase 2 Homo sapiens 157-182 25406731-1 2014 BACKGROUND: Epoxyeicosatrienoic acids (EETs) are derived from arachidonic acid by cytochrome P450 (CYP) and metabolized by soluble epoxide hydrolase (sEH). eets 39-43 epoxide hydrolase 2 Homo sapiens 150-153 24040964-4 2014 Once formed, EETs are primarily metabolized to their less biologically active metabolites, dihydroxyeicosatrienoic acids, by soluble epoxy hydrolase (sEH) enzyme. eets 13-17 epoxide hydrolase 2 Homo sapiens 125-148 24691274-2 2014 The omega-3 epoxide of DHA, 19, 20-EDP (epoxy docosapentaenoic acid), is metabolized by soluble epoxide hydrolase (sEH), which also metabolizes the anti-inflammatory and antihypertensive arachidonic acid epoxides, epoxyeicosatrienoic acids (EETs). eets 241-245 epoxide hydrolase 2 Homo sapiens 88-113 24691274-2 2014 The omega-3 epoxide of DHA, 19, 20-EDP (epoxy docosapentaenoic acid), is metabolized by soluble epoxide hydrolase (sEH), which also metabolizes the anti-inflammatory and antihypertensive arachidonic acid epoxides, epoxyeicosatrienoic acids (EETs). eets 241-245 epoxide hydrolase 2 Homo sapiens 115-118 25024195-1 2014 Prostaglandins derived from the cyclooxygenase (COX) pathway and epoxyeicosatrienoic acids (EETs) from the cytochrome P450/soluble epoxide hydrolase (sEH) pathway are important eicosanoids that regulate angiogenesis and tumorigenesis. eets 92-96 epoxide hydrolase 2 Homo sapiens 150-153 24040964-4 2014 Once formed, EETs are primarily metabolized to their less biologically active metabolites, dihydroxyeicosatrienoic acids, by soluble epoxy hydrolase (sEH) enzyme. eets 13-17 epoxide hydrolase 2 Homo sapiens 150-153 23237835-2 2013 The inhibition of soluble epoxide hydrolase leads to elevated levels of epoxyeicosatrienoic acids (EETs), and thus inhibitors of sEH represent one of a novel approach to the development of vasodilatory and anti-inflammatory drugs. eets 99-103 epoxide hydrolase 2 Homo sapiens 18-43 23701967-2 2013 sEH readily hydrolyzes lipid signaling molecules, including the epoxyeicosatrienoic acids (EETs), epoxidized lipids produced from arachidonic acid by the action of cytochrome p450s. eets 91-95 epoxide hydrolase 2 Homo sapiens 0-3 22525341-1 2013 BACKGROUND: Epoxyeicosatrienoic acids (EETs) are natural angiogenic mediators regulated by soluble epoxide hydrolase (sEH). eets 39-43 epoxide hydrolase 2 Homo sapiens 118-121 23853671-3 2013 This review discusses the role of soluble epoxide hydrolase (sEH), an enzyme responsible for the degradation of vasoprotective eicosatrienoic acids (EETs), in the context of the cerebral vasculature and its contribution to the sexual dimorphic nature of stroke. eets 149-153 epoxide hydrolase 2 Homo sapiens 34-59 23853671-3 2013 This review discusses the role of soluble epoxide hydrolase (sEH), an enzyme responsible for the degradation of vasoprotective eicosatrienoic acids (EETs), in the context of the cerebral vasculature and its contribution to the sexual dimorphic nature of stroke. eets 149-153 epoxide hydrolase 2 Homo sapiens 61-64 23020295-1 2013 The presence of epoxyeicosatrienoic acids (EETs) in tissues and their metabolism by soluble epoxide hydrolase (sEH) to 1,2-diols were first reported 30 years ago. eets 43-47 epoxide hydrolase 2 Homo sapiens 84-109 23020295-1 2013 The presence of epoxyeicosatrienoic acids (EETs) in tissues and their metabolism by soluble epoxide hydrolase (sEH) to 1,2-diols were first reported 30 years ago. eets 43-47 epoxide hydrolase 2 Homo sapiens 111-114 23237835-2 2013 The inhibition of soluble epoxide hydrolase leads to elevated levels of epoxyeicosatrienoic acids (EETs), and thus inhibitors of sEH represent one of a novel approach to the development of vasodilatory and anti-inflammatory drugs. eets 99-103 epoxide hydrolase 2 Homo sapiens 129-132 22848834-1 2012 Epoxyeicosatrienoic acids (EETs) are generated by the activity of both selective and also more general cytochrome p450 (CYP) enzymes on arachidonic acid and inactivated largely by soluble epoxide hydrolase (sEH), which converts them to their corresponding dihydroxyeicosatrienoic acids (DHETs). eets 27-31 epoxide hydrolase 2 Homo sapiens 180-205 22641086-4 2012 sEH contributes to neuronal cell death by inactivating neuroprotective epoxyeicosatrienoic acids (EETs). eets 98-102 epoxide hydrolase 2 Homo sapiens 0-3 22848834-1 2012 Epoxyeicosatrienoic acids (EETs) are generated by the activity of both selective and also more general cytochrome p450 (CYP) enzymes on arachidonic acid and inactivated largely by soluble epoxide hydrolase (sEH), which converts them to their corresponding dihydroxyeicosatrienoic acids (DHETs). eets 27-31 epoxide hydrolase 2 Homo sapiens 207-210 21519968-1 2011 INTRODUCTION: Cytochrome P450 epoxygenases metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs), which in turn are converted to dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH). eets 101-105 epoxide hydrolase 2 Homo sapiens 180-205 22313298-2 2011 Inhibition of sEH by a highly selective and potent sEH inhibitor (sEHI) elevates the epoxyeicosatrienoic acids (EETs) level in vivo leading to decreased inflammation. eets 112-116 epoxide hydrolase 2 Homo sapiens 14-17 22313298-2 2011 Inhibition of sEH by a highly selective and potent sEH inhibitor (sEHI) elevates the epoxyeicosatrienoic acids (EETs) level in vivo leading to decreased inflammation. eets 112-116 epoxide hydrolase 2 Homo sapiens 51-54 21519968-1 2011 INTRODUCTION: Cytochrome P450 epoxygenases metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs), which in turn are converted to dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH). eets 101-105 epoxide hydrolase 2 Homo sapiens 207-210 19952412-1 2009 Soluble epoxide hydrolase (sEH) is an important pharmacological target because it metabolizes potent bioactive substrates, epoxyeicosatrienoinc acids (EETs) and other lipid epoxide. eets 151-155 epoxide hydrolase 2 Homo sapiens 0-25 21416942-2 2010 Epoxyeicosatrienoic acids (EETs), as metabolites of arachidonic acid, are degraded by sEH. eets 27-31 epoxide hydrolase 2 Homo sapiens 86-89 20008276-1 2010 Soluble epoxide hydrolase (sEH) metabolizes epoxyeicosatrienoic acids (EETs), primarily 14,15-EET. eets 71-75 epoxide hydrolase 2 Homo sapiens 0-25 20008276-1 2010 Soluble epoxide hydrolase (sEH) metabolizes epoxyeicosatrienoic acids (EETs), primarily 14,15-EET. eets 71-75 epoxide hydrolase 2 Homo sapiens 27-30 21757024-6 2011 A recent publication has demonstrated that stabilizing the levels of epoxyeicosatrienoic acids (EETs), CYP eicosanoids, by inhibiting or deleting soluble epoxide hydrolase (sEH) improves beta-cell function and reduces beta-cell apoptosis in diabetes. eets 96-100 epoxide hydrolase 2 Homo sapiens 146-171 21757024-6 2011 A recent publication has demonstrated that stabilizing the levels of epoxyeicosatrienoic acids (EETs), CYP eicosanoids, by inhibiting or deleting soluble epoxide hydrolase (sEH) improves beta-cell function and reduces beta-cell apoptosis in diabetes. eets 96-100 epoxide hydrolase 2 Homo sapiens 173-176 21155804-1 2011 It has recently been reported that soluble epoxide hydrolase (sEH), the major enzyme that metabolizes epoxyeicosatrienoic acids (EETs), is expressed in axons of cortical neurons; however, the functional relevance of axonal sEH localization is unknown. eets 129-133 epoxide hydrolase 2 Homo sapiens 35-60 21155804-1 2011 It has recently been reported that soluble epoxide hydrolase (sEH), the major enzyme that metabolizes epoxyeicosatrienoic acids (EETs), is expressed in axons of cortical neurons; however, the functional relevance of axonal sEH localization is unknown. eets 129-133 epoxide hydrolase 2 Homo sapiens 62-65 21155804-1 2011 It has recently been reported that soluble epoxide hydrolase (sEH), the major enzyme that metabolizes epoxyeicosatrienoic acids (EETs), is expressed in axons of cortical neurons; however, the functional relevance of axonal sEH localization is unknown. eets 129-133 epoxide hydrolase 2 Homo sapiens 223-226 20433684-4 2011 Soluble epoxide hydrolase (sEH) is an enzyme that catalyzes the hydrolysis of epoxyeicosatrienoic acids (EETs), which are lipid mediators derived from arachidonic acid through the cytochrome P450 epoxygenase pathway. eets 105-109 epoxide hydrolase 2 Homo sapiens 0-25 20433684-4 2011 Soluble epoxide hydrolase (sEH) is an enzyme that catalyzes the hydrolysis of epoxyeicosatrienoic acids (EETs), which are lipid mediators derived from arachidonic acid through the cytochrome P450 epoxygenase pathway. eets 105-109 epoxide hydrolase 2 Homo sapiens 27-30 20433684-6 2011 When EETs are hydrolyzed by sEH to corresponding dihydroxyeicosatrienoic acids, their cardioprotective activities become less pronounced. eets 5-9 epoxide hydrolase 2 Homo sapiens 28-31 20733953-3 2010 Soluble epoxide hydrolase (sEH) is an enzyme that converts endogenous anti-inflammatory compounds, the epoxyeicosatrienoic acids (EETs), to the less anti-inflammatory dihydroxyeicosatrienoic acids (DHETs). eets 130-134 epoxide hydrolase 2 Homo sapiens 0-25 20733953-3 2010 Soluble epoxide hydrolase (sEH) is an enzyme that converts endogenous anti-inflammatory compounds, the epoxyeicosatrienoic acids (EETs), to the less anti-inflammatory dihydroxyeicosatrienoic acids (DHETs). eets 130-134 epoxide hydrolase 2 Homo sapiens 27-30 19952412-1 2009 Soluble epoxide hydrolase (sEH) is an important pharmacological target because it metabolizes potent bioactive substrates, epoxyeicosatrienoinc acids (EETs) and other lipid epoxide. eets 151-155 epoxide hydrolase 2 Homo sapiens 27-30 16987999-7 2007 EETs are metabolized primarily by conversion to dihydroxyeicosatrienoic acids (DHETs), a reaction catalyzed by soluble epoxide hydrolase (sEH). eets 0-4 epoxide hydrolase 2 Homo sapiens 111-136 17460077-2 2007 EPHX2 encodes for soluble epoxide hydrolase (sEH), an important enzyme in the metabolic breakdown of arachidonic acid-derived eicosanoids referred to as epoxyeicosatrienoic acids (EETs). eets 180-184 epoxide hydrolase 2 Homo sapiens 0-5 17460077-2 2007 EPHX2 encodes for soluble epoxide hydrolase (sEH), an important enzyme in the metabolic breakdown of arachidonic acid-derived eicosanoids referred to as epoxyeicosatrienoic acids (EETs). eets 180-184 epoxide hydrolase 2 Homo sapiens 18-43 17460077-2 2007 EPHX2 encodes for soluble epoxide hydrolase (sEH), an important enzyme in the metabolic breakdown of arachidonic acid-derived eicosanoids referred to as epoxyeicosatrienoic acids (EETs). eets 180-184 epoxide hydrolase 2 Homo sapiens 45-48 16987999-7 2007 EETs are metabolized primarily by conversion to dihydroxyeicosatrienoic acids (DHETs), a reaction catalyzed by soluble epoxide hydrolase (sEH). eets 0-4 epoxide hydrolase 2 Homo sapiens 138-141 18221075-2 2006 Soluble epoxide hydrolase (sEH, formerly referred to as cytosolic epoxide hydrolase), which is widely distributed in mammalian tissues, is the primary enzyme responsible for the conversion of epoxyeicosatrienoic acids (EETs), the bioactive lipid mediators formed from arachidonic acid by cytochrome P450 epoxygenase, to their corresponding diols. eets 219-223 epoxide hydrolase 2 Homo sapiens 0-25 23045145-3 2007 Early work suggested a role of sEH in detoxifying a wide array of xenobiotic epoxides; however, recent findings clearly implicate the sEH in the regulation of blood pressure, pain, and inflammation through the hydrolysis of endogenous epoxy fatty acids such as epoxyeicosatrienoic acids (EETs). eets 288-292 epoxide hydrolase 2 Homo sapiens 134-137 18221075-2 2006 Soluble epoxide hydrolase (sEH, formerly referred to as cytosolic epoxide hydrolase), which is widely distributed in mammalian tissues, is the primary enzyme responsible for the conversion of epoxyeicosatrienoic acids (EETs), the bioactive lipid mediators formed from arachidonic acid by cytochrome P450 epoxygenase, to their corresponding diols. eets 219-223 epoxide hydrolase 2 Homo sapiens 27-30