PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7951534-4 1993 During the danazol therapy, serum testosterone (T), cortisol (F), and sex-hormone binding globulin (SHBG) significantly decreased (P < 0.05); but serum dehydroepiandrosterone-sulfate (DHEAS) and FAI increased (P < 0.05). Danazol 11-18 sex hormone binding globulin Homo sapiens 70-98 9408086-8 1997 A decrease of intracellular SHBG caused by high-dose danazol or progesterone might partly contribute to the abolition of the intracellular estrogen-dominant milieu, and be related to the inhibition of estrogen-dependent growth of some endometrial cancer cells. Danazol 53-60 sex hormone binding globulin Homo sapiens 28-32 9408086-0 1997 Effects of danazol and progesterone on sex hormone-binding globulin mRNA expression in human endometrial cancer cell line Ishikawa. Danazol 11-18 sex hormone binding globulin Homo sapiens 39-67 9408086-3 1997 Danazol and progesterone significantly (P < 0.05) suppressed the expression of SHBG mRNA dose-dependently starting at a concentration of 10(-6) and 10(-8) M, respectively. Danazol 0-7 sex hormone binding globulin Homo sapiens 82-86 9408086-6 1997 The time course study showed the time-dependent decrease of SHBG mRNA level by danazol and progesterone (10[-6] M) with or without E2 (10[-8] M), except for a temporal increase by progesterone. Danazol 79-86 sex hormone binding globulin Homo sapiens 60-64 9408086-7 1997 These findings suggest that danazol and progesterone in a superphysiological milieu down-regulate the intracellular SHBG-related steroidal actions, and that progesterone in a physiological milieu with estrogen up-regulates it in a hormone-dependent cell line. Danazol 28-35 sex hormone binding globulin Homo sapiens 116-120 7951534-4 1993 During the danazol therapy, serum testosterone (T), cortisol (F), and sex-hormone binding globulin (SHBG) significantly decreased (P < 0.05); but serum dehydroepiandrosterone-sulfate (DHEAS) and FAI increased (P < 0.05). Danazol 11-18 sex hormone binding globulin Homo sapiens 100-104 4040541-0 1985 [Changes in % free testosterone and sex-hormone binding globulin during danazol administration]. Danazol 72-79 sex hormone binding globulin Homo sapiens 36-64 8462828-0 1993 [SHBG serum level in women with endometriosis before, during and after long-term danazol therapy]. Danazol 81-88 sex hormone binding globulin Homo sapiens 1-5 3641693-0 1986 A comparison of the effects of danazol and gestrinone on testosterone binding to sex hormone binding globulin in vitro and in vivo. Danazol 31-38 sex hormone binding globulin Homo sapiens 81-109 3641693-4 1986 The mean SHBG binding capacity in patients treated with danazol (400 mg/d, n = 7) and gestrinone (5 mg/week, n = 7) fell from 66.9 and 56.4 nmol/l to 36.1 and 28.1 nmol/l, after 1 week"s treatment and to 11.1 and 7.1 nmol/l after 4 weeks respectively. Danazol 56-63 sex hormone binding globulin Homo sapiens 9-13 3641693-5 1986 Despite the similarity between the falls in SHBG binding capacity there was a significantly greater increase in % free testosterone in plasma samples from patients treated with danazol than in those from patients treated with gestrinone at 1 week. Danazol 177-184 sex hormone binding globulin Homo sapiens 44-48 3641693-6 1986 Experiments in vitro suggest that this was largely due to ethisterone (a major metabolite of danazol) competing with testosterone for SHBG binding sites. Danazol 93-100 sex hormone binding globulin Homo sapiens 134-138 3029159-1 1987 The secretion of sex hormone-binding globulin (SHBG) by the human hepatocarcinoma cell line Hep G2 was increased significantly not only by estradiol (E2) but also by testosterone (T), dihydrotestosterone, and the synthetic androgen danazol in the presence, but not the absence, of fetal calf serum. Danazol 232-239 sex hormone binding globulin Homo sapiens 17-45 3029159-1 1987 The secretion of sex hormone-binding globulin (SHBG) by the human hepatocarcinoma cell line Hep G2 was increased significantly not only by estradiol (E2) but also by testosterone (T), dihydrotestosterone, and the synthetic androgen danazol in the presence, but not the absence, of fetal calf serum. Danazol 232-239 sex hormone binding globulin Homo sapiens 47-51 3331377-5 1987 (2) Danazol is a progestagen with high affinity for sex steroid-binding protein (SBP); when given in high dosages in normal males, it increased rapidly the dialyzable fraction (percent protein unbound or free fraction) of T. This suggests that by interacting with the binding sites of SBP, danazol and/or its metabolites displace the fraction of T bound to SBP. Danazol 4-11 sex hormone binding globulin Homo sapiens 52-79 3304725-0 1986 Dosage-related effects of danazol on sex hormone binding globulin and free and total androgen levels. Danazol 26-33 sex hormone binding globulin Homo sapiens 37-65 3304725-1 1986 Danazol is known to cause marked suppression of sex hormone binding globulin (SHBG) levels in plasma and to increase the proportion of plasma testosterone unbound to protein but the effect on the concentration of total and free testosterone is unclear. Danazol 0-7 sex hormone binding globulin Homo sapiens 48-76 3304725-1 1986 Danazol is known to cause marked suppression of sex hormone binding globulin (SHBG) levels in plasma and to increase the proportion of plasma testosterone unbound to protein but the effect on the concentration of total and free testosterone is unclear. Danazol 0-7 sex hormone binding globulin Homo sapiens 78-82 4040541-1 1985 To clarify the androgen balance on the administration of danazol a study was conducted on the levels of % free testosterone (% free T) and sex-hormone-binding globulin (SHBG) during the therapy and the binding properties of danazol to SHBG and androgen receptor. Danazol 224-231 sex hormone binding globulin Homo sapiens 139-167 4040541-2 1985 It was found that danazol displaced testosterone (T) from SHBG and R1881 from androgen receptor, in vitro. Danazol 18-25 sex hormone binding globulin Homo sapiens 58-62 4040541-3 1985 During treatment with danazol, levels of % free T were increased about three fold, but in contrast the SHBG concentration were significantly decreased. Danazol 22-29 sex hormone binding globulin Homo sapiens 103-107 4040541-5 1985 These data suggest that the androgenic effects of danazol were the results of increased free T levels by the T-displacing ability of danazol from SHBG. Danazol 50-57 sex hormone binding globulin Homo sapiens 146-150 4040541-5 1985 These data suggest that the androgenic effects of danazol were the results of increased free T levels by the T-displacing ability of danazol from SHBG. Danazol 133-140 sex hormone binding globulin Homo sapiens 146-150 6538094-1 1984 The effects of danazol therapy on circulating gonadotrophins, oestradiol and sex hormone-binding globulin (SHBG) binding capacity have been studied in eight patients with endometriosis. Danazol 15-22 sex hormone binding globulin Homo sapiens 77-105 6538094-1 1984 The effects of danazol therapy on circulating gonadotrophins, oestradiol and sex hormone-binding globulin (SHBG) binding capacity have been studied in eight patients with endometriosis. Danazol 15-22 sex hormone binding globulin Homo sapiens 107-111 6538094-4 1984 It is concluded that danazol is not "anti-gonadotrophic" as frequently claimed and that its therapeutic actions, side effects and the endocrine changes could be explained by an effect on SHBG production. Danazol 21-28 sex hormone binding globulin Homo sapiens 187-191 6594001-0 1984 Changes in the SHBG concentration during danazol treatment. Danazol 41-48 sex hormone binding globulin Homo sapiens 15-19 6594001-6 1984 After approximately one month of treatment, the SHBG concentrations began to approach a new steady state at a level of approximately 20-30% of the original concentration, depending on the dose of danazol. Danazol 196-203 sex hormone binding globulin Homo sapiens 48-52 6594001-7 1984 The proportional suppression of SHBG was significantly greater following 600 or 800 mg of danazol daily than following 200 or 400 mg. Danazol 90-97 sex hormone binding globulin Homo sapiens 32-36 6594001-10 1984 The findings of the present investigation suggest that danazol exerts a direct inhibitory effect on the hepatic synthesis of SHBG, which is dependent of the dose of danazol, independent of estrogen concentration, but possibly accentuated by endogenous androgens. Danazol 55-62 sex hormone binding globulin Homo sapiens 125-129 6594001-10 1984 The findings of the present investigation suggest that danazol exerts a direct inhibitory effect on the hepatic synthesis of SHBG, which is dependent of the dose of danazol, independent of estrogen concentration, but possibly accentuated by endogenous androgens. Danazol 165-172 sex hormone binding globulin Homo sapiens 125-129 6350956-4 1983 Sex hormone binding globulin was markedly suppressed (P less than .001) throughout danazol treatment, resulting in a threefold elevation (P less than .01) of free testosterone. Danazol 83-90 sex hormone binding globulin Homo sapiens 0-28 6682051-3 1983 Previously it was demonstrated that danazol can displace T from sex-hormone-binding globulin (SHBG). Danazol 36-43 sex hormone binding globulin Homo sapiens 64-92 6682051-3 1983 Previously it was demonstrated that danazol can displace T from sex-hormone-binding globulin (SHBG). Danazol 36-43 sex hormone binding globulin Homo sapiens 94-98 6682051-4 1983 The binding properties of danazol to SHBG and albumin were studied with the use of labeled danazol in an aqueous two-phase equilibrium partition system. Danazol 26-33 sex hormone binding globulin Homo sapiens 37-41 7195405-4 1981 Computer simulation predicted that by interacting with TeBG, therapeutic levels of danazol, methyltestosterone, fluoxymesterone, and norgestrel could displace 83%, 48%, 43%, and 16%, respectively, of the concentration of testosterone bound to TeBG in a normal man. Danazol 83-90 sex hormone binding globulin Homo sapiens 55-59 7201414-2 1982 The interaction of danazol with T binding to sex-hormone-binding globulin (SHBG) was studied with the use of an aqueous two-phase system with polyethylene glycol (PEG) and dextran for equilibrium partition. Danazol 19-26 sex hormone binding globulin Homo sapiens 75-79 7201414-5 1982 The low values for SHBG binding capacity that were found during danazol therapy mainly reflect occupation of binding sites by danazol and to a lesser degree a real decrease in protein concentration. Danazol 64-71 sex hormone binding globulin Homo sapiens 19-23 7201414-5 1982 The low values for SHBG binding capacity that were found during danazol therapy mainly reflect occupation of binding sites by danazol and to a lesser degree a real decrease in protein concentration. Danazol 126-133 sex hormone binding globulin Homo sapiens 19-23 7201414-7 1982 Therapeutic danazol serum levels are 1000 times those of normal female total T levels; and since the affinity to SHBG for danazol was found to be 1/20 that to T one should conclude an almost total occupation of binding sites. Danazol 122-129 sex hormone binding globulin Homo sapiens 113-117 7195405-4 1981 Computer simulation predicted that by interacting with TeBG, therapeutic levels of danazol, methyltestosterone, fluoxymesterone, and norgestrel could displace 83%, 48%, 43%, and 16%, respectively, of the concentration of testosterone bound to TeBG in a normal man. Danazol 83-90 sex hormone binding globulin Homo sapiens 243-247 6794961-4 1981 In all patients, however, both sex hormone binding globulin and thyroxine binding globulin concentrations were considerably suppressed during Danazol therapy. Danazol 142-149 sex hormone binding globulin Homo sapiens 31-59 489712-9 1979 5) The concentrations of T4-binding globulin, pregnancy zone protein, and sex hormone-binding globulin more than doubled in pregnancy, and all three decreased to one third or less on administration of danazol. Danazol 201-208 sex hormone binding globulin Homo sapiens 74-102