PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2355308-6 1990 These results suggest that danazol is a highly potent inhibitor for several cytochrome P-450-mediated metabolisms of testosterone and xenobiotics in mouse hepatic microsomes. Danazol 27-34 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 76-92 2355308-0 1990 [Inhibition of cytochrome P-450-dependent monoxygenase activities by a synthetic androgen danazol in mouse hepatic microsomes]. Danazol 90-97 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 15-31 2355308-4 1990 Addition of danazol to microsomal preparation resulted in a reverse type I difference spectrum and the spectrophotometric analysis revealed that danazol had a high affinity for cytochrome P-450 with dissociation constants (Ks) of 0.9 and 4.2 microM, which were 2 orders of magnitude lower than those of cimetidine. Danazol 12-19 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 177-193 2355308-4 1990 Addition of danazol to microsomal preparation resulted in a reverse type I difference spectrum and the spectrophotometric analysis revealed that danazol had a high affinity for cytochrome P-450 with dissociation constants (Ks) of 0.9 and 4.2 microM, which were 2 orders of magnitude lower than those of cimetidine. Danazol 145-152 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 177-193