PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22696302-5	2012	Their cytotoxicity was decreased by antioxidants and inhibitors of cytochromes P-450, alpha-naphthoflavone and isoniazide, and increased by an inhibitor of catechol-O-methyltransferase, 3,5-dinitrocatechol.	OR486	186-205	catechol-O-methyltransferase	Homo sapiens	156-184	
27981425-0	2017	1H, 15N, 13C backbone resonance assignments of human soluble catechol O-methyltransferase in complex with S-adenosyl-L-methionine and 3,5-dinitrocatechol.	OR486	134-153	catechol-O-methyltransferase	Homo sapiens	61-89	
27981425-4	2017	Here we report the backbone 1H, 15N and 13C chemical shift assignments of S-COMT in complex with S-adenosyl-L-methionine, 3,5-dinitrocatechol and Mg2+.	OR486	122-141	catechol-O-methyltransferase	Homo sapiens	76-80	
17560937-6	2007	From the effect of 3,5-dinitrocatechol, an inhibitor of catechol-O-methyltransferase (COMT), on HUVEC it is concluded that (-)-epicatechin serves as "prodrug" for conversion to apocynin-like NADPH oxidase inhibitors.	OR486	19-38	catechol-O-methyltransferase	Homo sapiens	56-84	
18486144-6	2008	Here we describe the crystal structures of the 108V and 108M variants of the soluble form of human COMT bound with S-adenosylmethionine (SAM) and a substrate analog, 3,5-dinitrocatechol.	OR486	166-185	catechol-O-methyltransferase	Homo sapiens	99-103	
17560937-6	2007	From the effect of 3,5-dinitrocatechol, an inhibitor of catechol-O-methyltransferase (COMT), on HUVEC it is concluded that (-)-epicatechin serves as "prodrug" for conversion to apocynin-like NADPH oxidase inhibitors.	OR486	19-38	catechol-O-methyltransferase	Homo sapiens	86-90	
16111645-4	2005	Inhibitors of cytochromes P-450, alpha-naphthoflavone and izoniazide, decreased the cytotoxicity of several polyphenols, whereas 3,5-dinitrocatechol, an inhibitor of catechol-o-methyltransferase (COMT), increased it.	OR486	129-148	catechol-O-methyltransferase	Homo sapiens	166-194	
15292328-4	2004	Norepinephrine, epinephrine, isoproterenol, and OR486 (COMT inhibitor) abrogated the inhibitory effects of estradiol on SMC growth and ERK1/2 phosphorylation.	OR486	48-53	catechol-O-methyltransferase	Homo sapiens	55-59	
15507517-5	2005	OR486 (COMT inhibitor) also blocked the antimitogenic effects of estradiol in both the presence and absence of the CYP450 inducers.	OR486	0-5	catechol-O-methyltransferase	Homo sapiens	7-11	
12624000-4	2003	The inhibitory effects of estradiol were blocked by the COMT inhibitors OR486 and quercetin.	OR486	72-77	catechol-O-methyltransferase	Homo sapiens	56-60	
10064789-5	1999	As for tolcapone, 3,5-dinitrocatechol was more potent against MB- than against S-COMT when a fixed amount of total protein was used, but showed the same potency when a fixed concentration of COMT was used.	OR486	18-37	catechol-O-methyltransferase	Homo sapiens	81-85	
11967242-6	2002	Moreover, the inhibitory effects of estradiol were blocked in the presence of the CYP450 inhibitor 1-aminobenzotriazole and the catechol-O-methyltransferase inhibitors quercetin and OR486.	OR486	182-187	catechol-O-methyltransferase	Homo sapiens	128-156	
11882582-5	2002	Moreover, the inhibitory effects of estradiol were blocked by the CYP450 inhibitor 1-aminobenzotriazole (10 micromol/L) and the COMT inhibitors quercetin (10 micromol/L) and OR486 (10 micromol/L).	OR486	174-179	catechol-O-methyltransferase	Homo sapiens	128-132	
11882582-8	2002	The abrogating effects of quercetin and OR486 on the metabolism and antimitogenic effects of 2-hydroxyestradiol were mimicked by 20 micromol/L norepinephrine and isoproterenol, substrates for COMT.	OR486	40-45	catechol-O-methyltransferase	Homo sapiens	192-196	
11882583-9	2002	The growth inhibitory effects of 2-hydroxyestradiol were abrogated by quercetin and OR486 (two structurally dissimilar catechol-O-methyltransferase inhibitors), but not by ICI182780.	OR486	84-89	catechol-O-methyltransferase	Homo sapiens	119-147	
10064789-5	1999	As for tolcapone, 3,5-dinitrocatechol was more potent against MB- than against S-COMT when a fixed amount of total protein was used, but showed the same potency when a fixed concentration of COMT was used.	OR486	18-37	catechol-O-methyltransferase	Homo sapiens	191-195	
10064789-6	1999	Tropolone, a competitive inhibitor, was much less potent than tolcapone and 3,5-dinitrocatechol in inhibiting S- and MB-COMT from both brain and liver and its potency was found not to depend on enzyme concentration.	OR486	76-95	catechol-O-methyltransferase	Homo sapiens	120-124