PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12966366-8	2003	Maximal plasma concentrations of diclofenac after oral administration of aceclofenac (0.39 micromol/L) or diclofenac (1.28 micromol/L) were sufficient for a greater than 97% inhibition of COX-2 (50% inhibitory concentration, 0.024 micromol/L) and a 46% (aceclofenac treatment) or 82% inhibition (diclofenac treatment) of COX-1 (50% inhibitory concentration, 0.43 micromol/L).	aceclofenac	73-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	188-193	
12966366-11	2003	Although 100 mg aceclofenac yielded diclofenac concentrations substantially lower than 75 mg diclofenac, these were sufficient for a sustained block of COX-2 but caused a minor and shorter inhibition of COX-1 than 75 mg diclofenac.	aceclofenac	16-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157	
12966366-12	2003	In conclusion, both COX-1-sparing and COX-2-inhibitory actions of aceclofenac may rest in its limited but sustained biotransformation to diclofenac.	aceclofenac	66-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43	
11556519-13	2001	In the whole blood test, aceclofenac and 4"-hydroxyaceclofenac weakly inhibited COX-1 with IC50 values superior to 100 microM, but decreased by 50% COX-2 activity at the concentration of 0.77 and 36 microM, respectively.	aceclofenac	25-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153	
22171305-1	2011	Aceclofenac has been shown to have potent analgesic and anti-inflammatory activities similar to indomethacin and diclofenac, and due to its preferential Cox-2 blockade, it has a better safety than conventional Non steroidal anti-inflammatory drug (NSAIDs) with respect to adverse effect on gastrointestinal and cardiovascular systems.	aceclofenac	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-158	
22171305-2	2011	Aceclofenac is superior from other NSAIDs as it has selectivity for Cox-2, a beneficial Cox inhibitor is well tolerated, has better Gastrointestinal (GI) tolerability and improved cardiovascular safety when compared with other selective Cox-2 inhibitor.	aceclofenac	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73	
22171305-2	2011	Aceclofenac is superior from other NSAIDs as it has selectivity for Cox-2, a beneficial Cox inhibitor is well tolerated, has better Gastrointestinal (GI) tolerability and improved cardiovascular safety when compared with other selective Cox-2 inhibitor.	aceclofenac	0-11	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	237-242