PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26546554-9	2016	It was observed that aluminum potentially enhanced protein levels of PERK, EIF2alpha, caspase 9, caspase 3, and inflammatory markers like NF-kappaB, NLRP3, HMGB1, and nitric oxide (NO).	Aluminum	21-29	NLR family pyrin domain containing 3	Homo sapiens	149-154	
21511178-4	2011	(2011) identify NLRP3 inflammasome-independent signaling to be crucial for the Th2 cell response induced by aluminum salts.	Aluminum	108-116	NLR family pyrin domain containing 3	Homo sapiens	16-21	
27150992-4	2016	RESULTS: The expression levels of NLRP3, ASC and AIM2 in plasma of control and AL complete remission groups were significantly higher than those in newly diagnosed and relapsed groups, and were with statistical significance (P < 0.05), but there were no statistical signifirance between ALL and ANLL groups (P > 0.05).	Aluminum	79-81	NLR family pyrin domain containing 3	Homo sapiens	34-39	
24261790-3	2013	Other than being comprised of micrometer-sized aggregates that include nanoscale particulates, Alum lacks specific physicochemical properties to explain activation of the innate immune system, including the mechanism by which aluminum-based adjuvants engage the NLRP3 inflammasome and IL-1beta production.	Aluminum	226-234	NLR family pyrin domain containing 3	Homo sapiens	262-267	
26200133-7	2015	Detailed characterization revealed that increased Ti and Al doping could reduce surface silanol density and expression of three-membered siloxane rings, leading to dose-dependent reduction in hydroxyl radical generation, membrane perturbation, potassium efflux, NLRP3 inflammasome activation, and cytotoxicity in THP-1 cells.	Aluminum	57-59	NLR family pyrin domain containing 3	Homo sapiens	262-267	
25761061-6	2015	We also demonstrated that NLRP3 could activate NF-kappaB and induce cytokines in response to sterile signals, monosodium urate crystals and aluminum adjuvant.	Aluminum	140-148	NLR family pyrin domain containing 3	Homo sapiens	26-31	
19439372-5	2009	Aluminum adjuvants activate NLRP3 by multiple mechanisms such as by causing damage and rupture of the phagolysosomes, generating reactive oxygen species, inducing K(+) efflux and via release from injured tissues of molecules that constitute danger-associated molecular patterns (DAMPs) such as uric acid and ATP.	Aluminum	0-8	NLR family pyrin domain containing 3	Homo sapiens	28-33	
19439372-4	2009	Aluminum adjuvants activate the nucleotide-binding domain and leucine-rich-repeat-containing gene family pyrin-domain-containing 3 (known as NLRP3 or NALP3) inflammasome to activate caspase-1 and to induce proinflammatory cytokines interleukin (IL)-1beta and IL-18 by innate cells.	Aluminum	0-8	NLR family pyrin domain containing 3	Homo sapiens	141-146	
19439372-4	2009	Aluminum adjuvants activate the nucleotide-binding domain and leucine-rich-repeat-containing gene family pyrin-domain-containing 3 (known as NLRP3 or NALP3) inflammasome to activate caspase-1 and to induce proinflammatory cytokines interleukin (IL)-1beta and IL-18 by innate cells.	Aluminum	0-8	NLR family pyrin domain containing 3	Homo sapiens	150-155	
18496530-0	2008	Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants.	Aluminum	79-88	NLR family pyrin domain containing 3	Homo sapiens	21-26	
18496530-4	2008	Here we show that aluminium adjuvants activate an intracellular innate immune response system called the Nalp3 (also known as cryopyrin, CIAS1 or NLRP3) inflammasome.	Aluminum	18-27	NLR family pyrin domain containing 3	Homo sapiens	105-110	
18496530-4	2008	Here we show that aluminium adjuvants activate an intracellular innate immune response system called the Nalp3 (also known as cryopyrin, CIAS1 or NLRP3) inflammasome.	Aluminum	18-27	NLR family pyrin domain containing 3	Homo sapiens	126-135	
18496530-4	2008	Here we show that aluminium adjuvants activate an intracellular innate immune response system called the Nalp3 (also known as cryopyrin, CIAS1 or NLRP3) inflammasome.	Aluminum	18-27	NLR family pyrin domain containing 3	Homo sapiens	137-142	
18496530-4	2008	Here we show that aluminium adjuvants activate an intracellular innate immune response system called the Nalp3 (also known as cryopyrin, CIAS1 or NLRP3) inflammasome.	Aluminum	18-27	NLR family pyrin domain containing 3	Homo sapiens	146-151	
18496530-7	2008	We identify the Nalp3 inflammasome as a crucial element in the adjuvant effect of aluminium adjuvants; in addition, we show that the innate inflammasome pathway can direct a humoral adaptive immune response.	Aluminum	82-91	NLR family pyrin domain containing 3	Homo sapiens	16-21	
19302040-6	2009	Likewise, the NALP3 inflammasome is a crucial element in the adjuvant effect of aluminum and can direct a humoral adaptive immune response.	Aluminum	80-88	NLR family pyrin domain containing 3	Homo sapiens	14-19