PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32640667-7 2020 In glucose-loaded macrophages, there was cellular induction of IL-4, IL-4 Ralpha, arginase-1, and CD163, indicating that high glucose skewed naive macrophages toward M2 phenotypes via an IL-4-IL-4Ralpha interaction. Glucose 3-10 interleukin 4 Mus musculus 63-67 32640667-7 2020 In glucose-loaded macrophages, there was cellular induction of IL-4, IL-4 Ralpha, arginase-1, and CD163, indicating that high glucose skewed naive macrophages toward M2 phenotypes via an IL-4-IL-4Ralpha interaction. Glucose 3-10 interleukin 4 Mus musculus 69-73 32640667-7 2020 In glucose-loaded macrophages, there was cellular induction of IL-4, IL-4 Ralpha, arginase-1, and CD163, indicating that high glucose skewed naive macrophages toward M2 phenotypes via an IL-4-IL-4Ralpha interaction. Glucose 126-133 interleukin 4 Mus musculus 63-67 32640667-7 2020 In glucose-loaded macrophages, there was cellular induction of IL-4, IL-4 Ralpha, arginase-1, and CD163, indicating that high glucose skewed naive macrophages toward M2 phenotypes via an IL-4-IL-4Ralpha interaction. Glucose 126-133 interleukin 4 Mus musculus 69-73 31814802-5 2019 IL-4 improved GLUT4 translocation and tended to elevate glucose uptake by boosting insulin signaling. Glucose 56-63 interleukin 4 Mus musculus 0-4 32127173-5 2020 Mechanistically, IL-4 treatment increased insulin-stimulated glucose uptake and Akt phosphorylation in skeletal muscle C2C12 cells, and inhibition of IL-4 signaling via ruxolitinib, a Janus kinase (JAK) inhibitor, attenuated IL-4-induced insulin sensitivity. Glucose 61-68 interleukin 4 Mus musculus 17-21 29098499-7 2018 The prolonged secretion of IL-4 was thought to substantially contribute to the improvement of glucose tolerance. Glucose 94-101 interleukin 4 Mus musculus 27-31 11592833-6 2001 We measured glucose levels weekly up to the age of 32 weeks, revealing that co-injection of PAGA-Il4 and PAGA-Il10 plasmids prevented the development of diabetes in 75% of the treated animals. Glucose 12-19 interleukin 4 Mus musculus 97-100 25746764-0 2015 IL4 receptor alpha mediates enhanced glucose and glutamine metabolism to support breast cancer growth. Glucose 37-44 interleukin 4 Mus musculus 0-3 25746764-7 2015 In vitro, IL4-enhanced glucose consumption and lactate production in 4T1 cells was mediated by IL4Ralpha. Glucose 23-30 interleukin 4 Mus musculus 10-13 25746764-11 2015 Our results demonstrate that IL4R mediates enhanced glucose and glutamine metabolism in 4T1 cancer cells, and that IL4-induced growth is supported by IL4/IL4R-enhanced glutamine metabolism in both human and murine mammary cancer cells. Glucose 52-59 interleukin 4 Mus musculus 29-32 21894160-0 2012 Regulation of glucose/lipid metabolism and insulin sensitivity by interleukin-4. Glucose 14-21 interleukin 4 Mus musculus 66-79 21894160-3 2012 In this study, we focused on examining the putative regulation of glucose and lipid metabolism by IL-4. Glucose 66-73 interleukin 4 Mus musculus 98-102 21894160-7 2012 CONCLUSIONS: Our results suggest that IL-4 regulates glucose and lipid metabolism by promoting insulin sensitivity, glucose tolerance and inhibiting lipid deposits. Glucose 53-60 interleukin 4 Mus musculus 38-42 11489328-0 2001 Cell type specific and glucose responsive expression of interleukin-4 by using insulin promoter and water soluble lipopolymer. Glucose 23-30 interleukin 4 Mus musculus 56-69 11489328-3 2001 WSLP-pRIP-IL4 complex was characterized by pancreas beta-cell specific and glucose responsive expression of IL-4. Glucose 75-82 interleukin 4 Mus musculus 108-112 11489328-7 2001 The expression level of IL-4 by pRIP-IL4 increased with increasing concentration of glucose. Glucose 84-91 interleukin 4 Mus musculus 24-28 7479761-2 1995 To investigate the role of PI3-kinase and IRS-1 in insulin-stimulated glucose uptake we examined whether stimulation of insulin-sensitive cells with platelet-derived growth factor (PDGF) or with interleukin 4 (IL-4) stimulates glucose uptake; the activated PDGF receptor (PDGFR) directly binds and activates PI3-kinase, whereas the IL-4 receptor (IL-4R) activates PI3-kinase via IRS-1 or the IRS-1-related molecule 4PS. Glucose 227-234 interleukin 4 Mus musculus 195-208 7479761-2 1995 To investigate the role of PI3-kinase and IRS-1 in insulin-stimulated glucose uptake we examined whether stimulation of insulin-sensitive cells with platelet-derived growth factor (PDGF) or with interleukin 4 (IL-4) stimulates glucose uptake; the activated PDGF receptor (PDGFR) directly binds and activates PI3-kinase, whereas the IL-4 receptor (IL-4R) activates PI3-kinase via IRS-1 or the IRS-1-related molecule 4PS. Glucose 227-234 interleukin 4 Mus musculus 210-214