PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32631996-8	2020	In AML12 hepatocytes, cyclin D1 depletion led to increased glucose uptake, which was negated if HNF4alpha was depleted simultaneously, and markedly elevated glycogen synthesis.	Glucose	59-66	cyclin D1	Homo sapiens	22-31	
34029286-9	2021	Furthermore, high glucose also caused SH-SY5Y cells arrest in G2 phase and apoptosis, accompanied by decreasing cyclin D1 and E2, and upregulating Bax and cleaved caspase-3.	Glucose	18-25	cyclin D1	Homo sapiens	112-121	
30090655-8	2018	Consistently, high glucose decreased cyclin D1 and D3 expression.	Glucose	19-26	cyclin D1	Homo sapiens	37-46	
31797547-7	2020	In addition, treatment of HeLa cells with PGG significantly reduced the protein levels of cyclin D1, Bcl-2 and STAT3 phosphorylation.	Glucose	42-45	cyclin D1	Homo sapiens	90-99	
32010625-5	2019	We found that both endogenous, glucose-derived lactate and exogenous, lactate supplementation significantly affected the transcription of key oncogenes (MYC, RAS, and PI3KCA), transcription factors (HIF1A and E2F1), tumor suppressors (BRCA1, BRCA2) as well as cell cycle and proliferation genes involved in breast cancer (AKT1, ATM, CCND1, CDK4, CDKN1A, CDK2B) (0.001 < p < 0.05 for all genes).	Glucose	31-38	cyclin D1	Homo sapiens	333-338	
25840567-8	2016	We showed that high glucose activates GSK3beta but suppresses CXCR-4, beta-catenin, LEF-1, and cyclin D1.	Glucose	20-27	cyclin D1	Homo sapiens	95-104	
25840567-10	2016	Our data indicate that GSK3beta plays an important role in regulating the proliferation and migration of BMSCs by inhibiting cyclin D1 and CXCR-4 under high glucose conditions.	Glucose	157-164	cyclin D1	Homo sapiens	125-134	
26615000-8	2015	In comparison with Human umbilical vein endothelial cells in the control group, high glucose level increased the levels of TXNIP expression and ROS level in cells, but reduced cell proliferation as well as migration capability and expression levels of beta-catenin, Cyclin D1 and C-myc; the difference was statistically significant (P < 0.05).	Glucose	85-92	cyclin D1	Homo sapiens	266-275	
21448924-8	2012	We show that high levels of glucose regulate mRNA and protein expression of GSK3beta, and consequently higher levels of activated beta-catenin protein, which locates to the nucleus and is associated with increased levels of cyclin D1 expression.	Glucose	28-35	cyclin D1	Homo sapiens	224-233	
25249644-0	2014	The proliferative gene cyclin D1 and gluconeogenesis--could suppressing glucose production also promote cancer?	Glucose	72-79	cyclin D1	Homo sapiens	23-32	
23690508-4	2013	The high-glucose condition led to increased expression of cyclin D1, de-phosphorylation of p38, and increased phosphorylation of ERK in MDA-MB-231 cells but not in MCF-7 cells.	Glucose	9-16	cyclin D1	Homo sapiens	58-67	
20232305-0	2010	High glucose regulates cyclin D1/E of human mesenchymal stem cells through TGF-beta1 expression via Ca2+/PKC/MAPKs and PI3K/Akt/mTOR signal pathways.	Glucose	5-12	cyclin D1	Homo sapiens	23-32	
22468037-0	2011	Influence of Bcl-1 Gene Polymorphism of Glucocorticoid Receptor Gene (NR3C1, rs41423247) on Blood Pressure, Glucose in Northern Indians.	Glucose	108-115	cyclin D1	Homo sapiens	13-18	
12401721-6	2002	In vivo and in cultured mesangial cells, high glucose resulted in persistent partial phosphorylation of RB, an event catalyzed specifically by cyclin D1-cdk4.	Glucose	46-53	cyclin D1	Homo sapiens	143-157	
20394812-8	2010	Interestingly, suppression in cyclin D1 accumulation was associated with an increase in cellular glucose consumption, and hexokinase II and pyruvate kinase protein levels.	Glucose	97-104	cyclin D1	Homo sapiens	30-39	
19136653-6	2009	Human islets transduced with cdk-6 and cyclin D1 were transplanted into diabetic NOD-SCID mice and markedly outperformed native human islets in vivo, maintaining glucose control for the entire 6 weeks of the study.	Glucose	162-169	cyclin D1	Homo sapiens	39-48	
18650423-10	2008	Moreover, we obtained evidence that this beta-TrCP-dependent degradation takes part in controlling cyclin D1 turnover when cancer cells undergo glucose starvation, which endows physiological relevance to this novel mechanism.	Glucose	144-151	cyclin D1	Homo sapiens	99-108	
26743134-5	2016	Increased nuclear STAT3, p-STAT3 and its downstream target proteins, cyclin D1, vimentin and MMP2, were shown to be underling mechanisms of high glucose stimulation.	Glucose	145-152	cyclin D1	Homo sapiens	69-78	
9000144-0	1996	Glucose-regulated stresses cause decreased expression of cyclin D1 and hypophosphorylation of retinoblastoma protein in human cancer cells.	Glucose	0-7	cyclin D1	Homo sapiens	57-66	
12379472-4	2002	In MCF-7 cells, leptin and high glucose stimulated cell proliferation as demonstrated by the increases in DNA synthesis and expression of cdk2 and cyclin D1.	Glucose	32-39	cyclin D1	Homo sapiens	147-156