PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27684496-3	2017	HHEX and PROX1 play significant roles in carbohydrate intolerance and diabetes because these transcription factors may be involved in the regulation of insulin secretion and in glucose and lipid metabolism.	Glucose	177-184	hematopoietically expressed homeobox	Homo sapiens	0-4	
29720110-1	2018	BACKGROUND: Several genome-wide association studies (GWAS) for serum fasting glucose levels have reported HHEX as possibly causal.	Glucose	77-84	hematopoietically expressed homeobox	Homo sapiens	106-110	
29720110-9	2018	CONCLUSIONS: This study clearly demonstrates that a genetic variant in HHEX influences fasting glucose levels in Korean women and male heavy smokers.	Glucose	95-102	hematopoietically expressed homeobox	Homo sapiens	71-75	
23349488-3	2013	The HHEX/IDE T2D locus is associated with decreased insulin secretion in response to oral glucose stimulation in humans.	Glucose	90-97	hematopoietically expressed homeobox	Homo sapiens	4-8	
24112421-8	2014	The rs5015480 SNP near HHEX is significantly associated (in opposite direction to that in Europeans) with a combined fasting glucose (FG) and HbA1c measure (P = 0.00046) and with homeostatic model assessment of beta-cell function (HOMA-B; P = 0.0014).	Glucose	125-132	hematopoietically expressed homeobox	Homo sapiens	23-27	
23512735-9	2013	Notably, rs7100623 in HHEX/IDE was associated with HbA1c (beta = 0.03; P < 0.0001) and type 2 diabetes (beta = 0.326; P = 0.0002), underscoring substantial impact on glucose control.	Glucose	169-176	hematopoietically expressed homeobox	Homo sapiens	22-26	
18039816-0	2008	A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study.	Glucose	75-82	hematopoietically expressed homeobox	Homo sapiens	50-54	
19915463-4	2010	Variants in genes HHEX, CDKN2A/2B, JAZF1, and IGF2BP2 were found to interact with prenatal nutrition in relation to T2D risk and glucose levels in later life.	Glucose	129-136	hematopoietically expressed homeobox	Homo sapiens	18-22	
18039816-3	2008	RESEARCH DESIGN AND METHODS: A total of 854 nondiabetic subjects, collected from five European clinical centers, were genotyped for the HHEX SNPs rs1111875 and rs7923837 and thoroughly characterized by an oral glucose tolerance test (OGTT).	Glucose	210-217	hematopoietically expressed homeobox	Homo sapiens	136-140	
17827400-6	2007	Interestingly, in middle-aged people, the rs1111875 C-allele of HHEX/KIF11/IDE strongly associated with lower acute insulin response during an oral glucose tolerance test (P = 6 x 10(-7)).	Glucose	148-155	hematopoietically expressed homeobox	Homo sapiens	64-68	
17804762-10	2007	CONCLUSIONS: CDKAL1 and HHEX/IDE diabetes-associated alleles are associated with decreased pancreatic beta-cell function, including decreased beta-cell glucose sensitivity that relates insulin secretion to plasma glucose concentration.	Glucose	152-159	hematopoietically expressed homeobox	Homo sapiens	24-28	
17804762-10	2007	CONCLUSIONS: CDKAL1 and HHEX/IDE diabetes-associated alleles are associated with decreased pancreatic beta-cell function, including decreased beta-cell glucose sensitivity that relates insulin secretion to plasma glucose concentration.	Glucose	213-220	hematopoietically expressed homeobox	Homo sapiens	24-28	
17827400-10	2007	Importantly, variations within the HHEX/KIF11/IDE and CDKN2A/B loci confer impaired glucose- and tolbutamide-induced insulin release in middle-aged and young healthy subjects, suggesting a role for these variants in the pathogenesis of pancreatic beta-cell dysfunction.	Glucose	84-91	hematopoietically expressed homeobox	Homo sapiens	35-39	
32944759-9	2021	After correction for multiple testing, glycemia associated SNPs in or near the HHEX and IGF2B2 loci were also associated with beta-cell glucose sensitivity.	Glucose	136-143	hematopoietically expressed homeobox	Homo sapiens	79-83