PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34944529-8 2021 VEGF, MCP-1 and Il-12 levels in PBMCs supernatants from the glucose-containing medium were higher than those from the standard medium in each of the diabetic groups. Glucose 60-67 C-C motif chemokine ligand 2 Homo sapiens 6-11 34673277-8 2022 In addition, TMAO significantly increased TNF-alpha-induced P-selectin production in mesothelial cells, as well as high glucose-induced TNF-alpha and CCL2 expression in endothelial cells. Glucose 120-127 C-C motif chemokine ligand 2 Homo sapiens 150-154 33655586-9 2021 After high glucose induction, the expression of TNF-alpha, IL-1beta, and IL-6 was increased and the expression of MCP-1, NLPR3, and ASC proteins was also increased (p < .001). Glucose 11-18 C-C motif chemokine ligand 2 Homo sapiens 114-119 34265211-8 2021 Changes in fasting glucose and AUC of OGTT (0-120 min) were positively correlated with changes in MCP-1 and TNF-alpha (p < 0.05). Glucose 19-26 C-C motif chemokine ligand 2 Homo sapiens 98-103 35441585-7 2022 It also suppressed the expression of pro-inflammatory mediators, interleukin-6 (IL-6) and monocyte chemokine protein 1 (MCP-1), against high glucose exposure in hGECs. Glucose 141-148 C-C motif chemokine ligand 2 Homo sapiens 90-118 35441585-7 2022 It also suppressed the expression of pro-inflammatory mediators, interleukin-6 (IL-6) and monocyte chemokine protein 1 (MCP-1), against high glucose exposure in hGECs. Glucose 141-148 C-C motif chemokine ligand 2 Homo sapiens 120-125 35064409-5 2022 Compared with normal-glucose treatment, the expression of microRNA-155 markedly increased in HRGECs treated with high-glucose, as well as the mRNA and protein levels of ETS-1, VCAM-1, MCP-1 and cleaved caspase-3. Glucose 118-125 C-C motif chemokine ligand 2 Homo sapiens 184-189 31594182-34 2019 The expression level of human monocyte chemoattractant protein 1 (MCP-1) in hASCs of AGEs-high glucose combination group showed increasing trend with the prolongation of culture time, while the expression level of growth-regulated oncogene (GRO) on PCD 6 was significantly higher than that on PCD 4 within the same group (P<0.05); the expression levels of MCP-1 and GRO in hASCs of protein-high osmotic pressure combination group showed decreasing trend with the prolongation of culture time. Glucose 95-102 C-C motif chemokine ligand 2 Homo sapiens 30-64 32806763-12 2020 RIH/glucose fluctuations also induced M1 polarization and an inflammatory profile (CD11c, IL-1beta, TNF-alpha, IL-6, and monocyte chemoattractant protein (MCP)-1) in macrophages. Glucose 4-11 C-C motif chemokine ligand 2 Homo sapiens 121-161 32606862-9 2020 In vitro, the mRNA expression of MCP-1 and TNF-alpha was significantly decreased when the generation of alpha1-AT in tubular epithelial cells was inhibited under high glucose stimulation. Glucose 167-174 C-C motif chemokine ligand 2 Homo sapiens 33-38 33228017-9 2020 In vitro, dapagliflozin reduced monocyte chemoattractant protein-1 release under high-glucose conditions in human and murine peritoneal mesothelial cells. Glucose 86-93 C-C motif chemokine ligand 2 Homo sapiens 32-66 31960917-6 2020 Pre-treating ARPE-19 cells with quercetin clearly attenuated high glucose-induced viability loss, apoptosis, MCP-1 and IL-6 overproduction, and ROS generation. Glucose 66-73 C-C motif chemokine ligand 2 Homo sapiens 109-114 31594182-34 2019 The expression level of human monocyte chemoattractant protein 1 (MCP-1) in hASCs of AGEs-high glucose combination group showed increasing trend with the prolongation of culture time, while the expression level of growth-regulated oncogene (GRO) on PCD 6 was significantly higher than that on PCD 4 within the same group (P<0.05); the expression levels of MCP-1 and GRO in hASCs of protein-high osmotic pressure combination group showed decreasing trend with the prolongation of culture time. Glucose 95-102 C-C motif chemokine ligand 2 Homo sapiens 66-71 30372883-6 2018 Vildagliptin potently suppresses high glucose-induced generation of reactive oxygen species (ROS) and production of vascular inflammatory factors including tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8), intercellular cell adhesion molecule-1 (ICAM-1) and monocyte chemotactic protein 1 (MCP-1). Glucose 38-45 C-C motif chemokine ligand 2 Homo sapiens 271-301 31455007-8 2019 The obtained data implies that glucose-induced insulin secretion (GIS) in pancreatic beta cells is significantly attenuated by IH, and that IH increases selenoprotein P, which is one of the hepatokines, as well as TNF-alpha, CCL-2, and resistin, members of adipokines, to induce insulin resistance via direct cellular mechanisms. Glucose 31-38 C-C motif chemokine ligand 2 Homo sapiens 225-230 30988769-1 2019 The present study prospectively investigated the effect of blood glucose level at admission on monocyte chemoattractant protein-1 levels at different time points before and after primary percutaneous coronary intervention, and the postoperative 1-year prognosis of patients with acute ST-segment elevation myocardial infarction. Glucose 65-72 C-C motif chemokine ligand 2 Homo sapiens 95-129 30988769-4 2019 The increase in monocyte chemoattractant protein-1 levels 24 h after percutaneous coronary intervention, compared with those before percutaneous coronary intervention, was significantly correlated with the blood glucose level at admission. Glucose 212-219 C-C motif chemokine ligand 2 Homo sapiens 16-50 31934133-9 2019 High glucose significantly evoked MV generation, which contained increased protein level of IL-6, 8 and MCP-1. Glucose 5-12 C-C motif chemokine ligand 2 Homo sapiens 104-109 31167690-12 2019 Compared with the blank group, the protein levels of NF-kappaBp65, p-IkappaBalpha, IKKalpha, MCP-1 and ICAM-1 increased in the high glucose group, while the protein levels above decreased in the PDTC group compared with the high glucose group. Glucose 132-139 C-C motif chemokine ligand 2 Homo sapiens 93-98 30372883-6 2018 Vildagliptin potently suppresses high glucose-induced generation of reactive oxygen species (ROS) and production of vascular inflammatory factors including tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8), intercellular cell adhesion molecule-1 (ICAM-1) and monocyte chemotactic protein 1 (MCP-1). Glucose 38-45 C-C motif chemokine ligand 2 Homo sapiens 303-308 30237731-6 2018 After stimulation with LPS, we observed an exacerbated increase in TNF-alpha, IL-6, and MCP-1 concentration in the high glucose condition compared to the normal glucose environment. Glucose 120-127 C-C motif chemokine ligand 2 Homo sapiens 88-93 29785210-9 2018 Resistin/RBP4, visfatin/MCP-1 and MCP-1/RBP4 ratios were strongly correlated with the levels of fasting glucose, HbA1c and HOMA-beta. Glucose 104-111 C-C motif chemokine ligand 2 Homo sapiens 34-39 29587203-4 2018 We found that high glucose induced phosphorylation of Btk, MAPKs and NF-kappaB, and the expression of downstream inflammation cytokines monocyte chemo-attractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta). Glucose 19-26 C-C motif chemokine ligand 2 Homo sapiens 136-171 29587203-4 2018 We found that high glucose induced phosphorylation of Btk, MAPKs and NF-kappaB, and the expression of downstream inflammation cytokines monocyte chemo-attractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta). Glucose 19-26 C-C motif chemokine ligand 2 Homo sapiens 173-178 29678838-4 2018 RESULTS: Treatment of human retinal Muller cells with high-glucose induced significant upregulation of ROCK-1, VEGF, and MCP-1/CCL2. Glucose 59-66 C-C motif chemokine ligand 2 Homo sapiens 121-126 29678838-4 2018 RESULTS: Treatment of human retinal Muller cells with high-glucose induced significant upregulation of ROCK-1, VEGF, and MCP-1/CCL2. Glucose 59-66 C-C motif chemokine ligand 2 Homo sapiens 127-131 29166648-11 2017 While the levels of monocyte chemoattractant protein 1 mRNA expressed by hypox-visASCs correlated positively with the body mass index and waist circumference of the subjects, the concentration of vascular endothelial growth factor present in hypox-visASC-conditioned culture medium decreased significantly with increasing plasma glucose. Glucose 329-336 C-C motif chemokine ligand 2 Homo sapiens 20-54 28852907-7 2018 HK-2 cells with high glucose up-regulated IL-6 and MCP-1 in a dose- and time-dependent manner, and SUV39H1 expression was reduced with greater glucose and prolonged stimulation. Glucose 21-28 C-C motif chemokine ligand 2 Homo sapiens 51-56 28598282-9 2017 Also, high glucose increased TRAF6, interleukin (IL)-6, TNF-alpha, and chemical chemokine ligand (CCL) 2 levels, whereas it decreased IL-10 level. Glucose 11-18 C-C motif chemokine ligand 2 Homo sapiens 80-104 28598282-12 2017 Overexpression of miR-126 significantly abrogated high glucose-induced secretion of proinflammatory cytokines such as IL-6, TNF-alpha, and CCL2 and promoted production of IL-10. Glucose 55-62 C-C motif chemokine ligand 2 Homo sapiens 139-143 26583035-8 2015 HK2 cells exposed to high glucose had reduced FXR expression and increased MCP-1, TGF-beta1, fibronectin and collagen IV expression, which was reversed in the presence of GW4064. Glucose 26-33 C-C motif chemokine ligand 2 Homo sapiens 75-80 29340323-8 2018 In human tubular epithelial HK-2 cells, IgG fractions containing anti-EPOR antibodies upregulated the expression of monocyte chemoattractant protein-1 mRNA under a high concentration of glucose. Glucose 186-193 C-C motif chemokine ligand 2 Homo sapiens 116-150 27722989-9 2017 Inhibition of TLR4 attenuated the high-glucose-induced expression of MCP-1 mRNA and protein, MyD88 mRNA, nuclear NF-kappaB p65 protein, TGF-beta, fibronectin, and alpha-SMA mRNA and protein. Glucose 39-46 C-C motif chemokine ligand 2 Homo sapiens 69-74 26924930-4 2016 In present study, agmatine attenuated the cell death and the expression of pro-inflammatory cytokines such as IL-6, TNF-alpha and CCL2 in high glucose in vitro conditions. Glucose 143-150 C-C motif chemokine ligand 2 Homo sapiens 130-134 25817234-0 2015 Puerarin suppresses high glucose-induced MCP-1 expression via modulating histone methylation in cultured endothelial cells. Glucose 25-32 C-C motif chemokine ligand 2 Homo sapiens 41-46 25882815-7 2015 High glucose increased TGF-beta1 mRNA expression, which significantly increased migration inhibitory factor and monocyte chemoattractant protein-1 protein secretion. Glucose 5-12 C-C motif chemokine ligand 2 Homo sapiens 112-146 25958099-9 2015 TGF-beta1 and E-selectin concentrations increased while MCP-1 decreased across quartiles of fasting plasma glucose. Glucose 107-114 C-C motif chemokine ligand 2 Homo sapiens 56-61 25834072-7 2015 CCL2 mRNA expression was upregulated by high concentrations of glucose after 6 h, but, most notably, a concentration-dependent induction of CCL2 was present after 96 h. In human peritoneal biopsies, NFAT5 mRNA levels were increased in uremic patients compared with nonuremic control patients. Glucose 63-70 C-C motif chemokine ligand 2 Homo sapiens 0-4 25817234-2 2015 The purpose of the present study was to investigate the epigenetic mechanism involved in the repression of monocyte chemoattractant protein-1 (MCP-1) expression by puerarin under high glucose (25mM) condition. Glucose 184-191 C-C motif chemokine ligand 2 Homo sapiens 107-141 25817234-2 2015 The purpose of the present study was to investigate the epigenetic mechanism involved in the repression of monocyte chemoattractant protein-1 (MCP-1) expression by puerarin under high glucose (25mM) condition. Glucose 184-191 C-C motif chemokine ligand 2 Homo sapiens 143-148 25817234-4 2015 KEY FINDINGS: Puerarin significantly inhibited high glucose-induced upregulation of H3K4 di- and tri-methylation (H3K4me2/3) on the MCP-1 gene promotor. Glucose 52-59 C-C motif chemokine ligand 2 Homo sapiens 132-137 25817234-5 2015 Additionally, the enrichment of H3K4 histone methyltransferases including MLL, menin and SET7 on the MCP-1 promotor was increased, while the demethylase LSD1 was decreased in EA.hy926 cells following exposure to high glucose. Glucose 217-224 C-C motif chemokine ligand 2 Homo sapiens 101-106 25817234-8 2015 SIGNIFICANCE: Our findings suggested that puerarin plays a critical role in transcriptional repression of high glucose-induced MCP-1 gene expression, at least in part due to alteration of H3K4me2/3 methylation, thus possesses a therapeutic potential in diabetes-induced vascular injuries. Glucose 111-118 C-C motif chemokine ligand 2 Homo sapiens 127-132 24988089-5 2014 Ambient plasma glucose concentration showed a significant positive association with plasma MDA, oxLDL, MCP-1, and VCAM, and a significant inverse association with PON1 and ApoA1 in diabetic patients. Glucose 15-22 C-C motif chemokine ligand 2 Homo sapiens 103-108 24788844-5 2014 Significant differences were found in gender, age, fever days, white blood cell count, C-reactive protein level, blood glucose concentration, and CCL2 level among genotypes of CCL2-2510A/G in EV71-infected patients, but no significant differences were found in alanine aminotransferase, aspartate aminotransferase, or creatine kinase myocardial isozyme levels or in cerebrospinal fluid evaluations (except monocytes) in patients with EV71 encephalitis. Glucose 119-126 C-C motif chemokine ligand 2 Homo sapiens 176-180 24782172-0 2014 Effects of mycophenolate mofetil on the expression of monocyte chemoattractant protein-1 and fibronectin in high glucose cultured human mesangial cells. Glucose 113-120 C-C motif chemokine ligand 2 Homo sapiens 54-88 24782172-1 2014 The effects of high glucose on the expression of monocyte chemoattractant protein-1 (MCP-1) and the main component of the extracellular matrix, fibronectin (FN), were explored in human mesangial cells (HMCs), along with the intervention effects of mycophenolate mofetil (MMF) on these indicators. Glucose 20-27 C-C motif chemokine ligand 2 Homo sapiens 49-83 24782172-1 2014 The effects of high glucose on the expression of monocyte chemoattractant protein-1 (MCP-1) and the main component of the extracellular matrix, fibronectin (FN), were explored in human mesangial cells (HMCs), along with the intervention effects of mycophenolate mofetil (MMF) on these indicators. Glucose 20-27 C-C motif chemokine ligand 2 Homo sapiens 85-90 24782172-4 2014 MCP-1 mRNA and protein expressions and FN secretion significantly increased in HMCs of the high glucose group compared with the normal control group (P < 0.01), with the highest expression observed at 48 h. MMF could reduce the MCP-1 mRNA and protein and FN expression levels (P < 0.01), and the inhibition occurred in a dose- and time-dependent manner (P < 0.05). Glucose 96-103 C-C motif chemokine ligand 2 Homo sapiens 0-5 24782172-4 2014 MCP-1 mRNA and protein expressions and FN secretion significantly increased in HMCs of the high glucose group compared with the normal control group (P < 0.01), with the highest expression observed at 48 h. MMF could reduce the MCP-1 mRNA and protein and FN expression levels (P < 0.01), and the inhibition occurred in a dose- and time-dependent manner (P < 0.05). Glucose 96-103 C-C motif chemokine ligand 2 Homo sapiens 231-236 24586431-8 2014 Activation of PAR-4 by a selective agonist was found to elicit the pro-inflammatory and pro-fibrotic phenotypes in PTEC while blockade of the receptor by specific antagonist attenuated high glucose-induced IL-6, CCL-2, CTGF and collagen IV expression. Glucose 190-197 C-C motif chemokine ligand 2 Homo sapiens 212-217 24600221-6 2014 Consequently, the blood glucose concentration in the MCP-1 group was significantly lower than that in the control group at week 2 post-surgery. Glucose 24-31 C-C motif chemokine ligand 2 Homo sapiens 53-58 23564379-0 2013 CCL2/CCR2 augments the production of transforming growth factor-beta1, type 1 collagen and CCL2 by human CD45-/collagen 1-positive cells under high glucose concentrations. Glucose 148-155 C-C motif chemokine ligand 2 Homo sapiens 0-4 23564379-0 2013 CCL2/CCR2 augments the production of transforming growth factor-beta1, type 1 collagen and CCL2 by human CD45-/collagen 1-positive cells under high glucose concentrations. Glucose 148-155 C-C motif chemokine ligand 2 Homo sapiens 91-95 21997325-9 2013 "In vitro" results demonstrate that glucose directly and significantly induced MCP-1 and IL6 and reduced TLR2 mRNA expression. Glucose 36-43 C-C motif chemokine ligand 2 Homo sapiens 79-84 21997325-10 2013 Insulin at high dose (100 IU/ml) dramatically enhanced the upregulatory effects of glucose on MCP-1 and IL-6 and reduced per se TLR2 mRNA expression. Glucose 83-90 C-C motif chemokine ligand 2 Homo sapiens 94-99 23529237-7 2013 Pretreatment with high glucose significantly promoted LPS-induced NF-kappaB nuclear translocation (P<0.01) and the mRNA expression and secretion of MCP-1 and IL-6. Glucose 23-30 C-C motif chemokine ligand 2 Homo sapiens 151-156 23600826-7 2013 Similarly, co-incubation of fatty acids with glucose diminished secretion of IL-10, IFN-gamma and CCL2 (monocyte chemotactic protein-1), while IL-8 was up-regulated (P < 0 001). Glucose 45-52 C-C motif chemokine ligand 2 Homo sapiens 98-102 23600826-7 2013 Similarly, co-incubation of fatty acids with glucose diminished secretion of IL-10, IFN-gamma and CCL2 (monocyte chemotactic protein-1), while IL-8 was up-regulated (P < 0 001). Glucose 45-52 C-C motif chemokine ligand 2 Homo sapiens 104-134 23529237-6 2013 High glucose promoted NF-kappaB nuclear translocation and significantly enhanced the expression and secretion of both MCP-1 and IL-6 (P<0.01). Glucose 5-12 C-C motif chemokine ligand 2 Homo sapiens 118-123 21975431-9 2012 CONCLUSION: These data suggest that hypomethylation of CpG sites in the MCP-1 promoter region may be affected by blood glucose and TG, which then increase the serum MCP-1 level and may play a role in the vascular complications of Type 2 diabetes. Glucose 119-126 C-C motif chemokine ligand 2 Homo sapiens 72-77 22694757-0 2012 ROCK inhibitor fasudil attenuated high glucose-induced MCP-1 and VCAM-1 expression and monocyte-endothelial cell adhesion. Glucose 39-46 C-C motif chemokine ligand 2 Homo sapiens 55-60 21975431-2 2012 The aim of this study was to investigate the methylation status of CpG sites in the MCP-1 promoter in Type 2 diabetic patients and its correlation to serum MCP- 1 level, and blood glucose level. Glucose 180-187 C-C motif chemokine ligand 2 Homo sapiens 84-89 22469745-0 2012 Quercetin suppresses NF-kappaB and MCP-1 expression in a high glucose-induced human mesangial cell proliferation model. Glucose 62-69 C-C motif chemokine ligand 2 Homo sapiens 35-40 22469745-7 2012 HMCs cultured in high glucose had signficantly greater proliferation, accumulation in the G1 phase, upregulated NF-kappaB and MCP-1 expression. Glucose 22-29 C-C motif chemokine ligand 2 Homo sapiens 126-131 21975431-8 2012 MCP-1 promoter methylation was significantly correlated to serum MCP-1, HbA1c, fasting blood glucose, and triglyceride. Glucose 93-100 C-C motif chemokine ligand 2 Homo sapiens 0-5 21975431-9 2012 CONCLUSION: These data suggest that hypomethylation of CpG sites in the MCP-1 promoter region may be affected by blood glucose and TG, which then increase the serum MCP-1 level and may play a role in the vascular complications of Type 2 diabetes. Glucose 119-126 C-C motif chemokine ligand 2 Homo sapiens 165-170 22095986-3 2012 METHODS AND RESULTS: Chronic exposure of monocytes to diabetic conditions induced by human LDL plus high D-glucose concentrations (LDL+HG) promoted NADPH Oxidase 4 (Nox4) expression, increased intracellular H(2)O(2) formation, stimulated protein S-glutathionylation, and increased chemotaxis in response to MCP-1, platelet-derived growth factor B, and RANTES. Glucose 105-114 C-C motif chemokine ligand 2 Homo sapiens 307-312 22558981-0 2012 [Effect of mycophenolate on expression of MCP-1 and fibronectin in human mesangial cells induced by high glucose]. Glucose 105-112 C-C motif chemokine ligand 2 Homo sapiens 42-47 22169009-9 2012 In cultured podocytes, paricalcitol and calcitriol at concentrations in the physiological and clinically significant range prevented the increase in MCP-1, IL-6, renin, and fibronectin mRNA expression and the secretion of MCP-1 to the culture media induced by high glucose. Glucose 265-272 C-C motif chemokine ligand 2 Homo sapiens 222-227 22558981-5 2012 RESULTS: Compared with the control group, the levels of the MCP-1 and FN in high glucose group were significantly increased with the expression peak at 48 h (P<0.01). Glucose 82-89 C-C motif chemokine ligand 2 Homo sapiens 61-66 22086137-9 2012 Our results show that high glucose concentrations (12 mM and particularly 24 mM) alter the biomineralization process in osteoblastic cells and provoke the following: i) a rise in mineralization, ii) an increase in the mRNA expression of RANKL and a decrease of OPG, iii) an increase in the mRNA expression of osteocalcin, bone sialoprotein and the transcription factor Runx2, iv) a diminished quality of the mineral, and v) an increase in the expression of IL1beta, IL6, IL8, MCP-1 and IL10 mRNAs. Glucose 27-34 C-C motif chemokine ligand 2 Homo sapiens 476-481 22112811-9 2012 Two candidate plasma factors, glucose and the saturated fatty acid palmitic acid, did not affect proliferation or adipocyte differentiation in vitro but were found to increase CCL2 (monocyte chemoattractant protein-1) secretion by adipocytes. Glucose 30-37 C-C motif chemokine ligand 2 Homo sapiens 176-180 22112811-9 2012 Two candidate plasma factors, glucose and the saturated fatty acid palmitic acid, did not affect proliferation or adipocyte differentiation in vitro but were found to increase CCL2 (monocyte chemoattractant protein-1) secretion by adipocytes. Glucose 30-37 C-C motif chemokine ligand 2 Homo sapiens 182-216 20582713-5 2010 RESULTS: Treatment with 50 mmol/L glucose markedly increased the level of IL-1beta, IL-18, TNF-alpha, PGE2, NO, TGF-beta1, MCP-1, MIP-1alpha, and RANTES. Glucose 34-41 C-C motif chemokine ligand 2 Homo sapiens 123-128 22021706-6 2012 In vitro, high glucose induced TLR4 expression via protein kinase C activation in a time- and dose-dependent manner, resulting in upregulation of IL-6 and chemokine (C-C motif) ligand 2 (CCL-2) expression via IkappaB/NF-kappaB activation in human proximal tubular epithelial cells. Glucose 15-22 C-C motif chemokine ligand 2 Homo sapiens 187-192 21855538-8 2011 Furthermore, MCP-1 serum levels were also elevated in patients with ultrasound-diagnosed NAFLD and correlated with the body-mass index and fasting glucose. Glucose 147-154 C-C motif chemokine ligand 2 Homo sapiens 13-18 21956423-3 2011 OBJECTIVE: Our objective was to determine the effects of 10 wk of dietary fructose or glucose consumption on plasma concentrations of monocyte chemoattractant protein-1 (MCP-1), plasminogen activator inhibitor-1 (PAI-1), E-selectin, intercellular adhesion molecule-1, C-reactive protein, and IL-6. Glucose 86-93 C-C motif chemokine ligand 2 Homo sapiens 134-168 20809989-0 2010 Increased levels of CRP and MCP-1 are associated with previously unknown abnormal glucose regulation in patients with acute STEMI: a cohort study. Glucose 82-89 C-C motif chemokine ligand 2 Homo sapiens 28-33 20809989-8 2010 High levels of CRP (>= 75 percentiles (33.13 mg/L)) and MCP-1 (>= 25 percentiles (190 ug/mL)) were associated with abnormal glucose regulation with an adjusted OR of 3.2 (95% CI 1.5, 6.8) and 7.6 (95% CI 1.7, 34.2), respectively. Glucose 130-137 C-C motif chemokine ligand 2 Homo sapiens 59-64 20809989-9 2010 CONCLUSION: Elevated levels of CRP and MCP-1 measured in patients early after an acute STEMI were associated with abnormal glucose regulation classified by an OGTT at three-month follow-up. Glucose 123-130 C-C motif chemokine ligand 2 Homo sapiens 39-44 20505014-6 2010 RT-qPCR and proteome analysis of human islets incubated with 16.7 mM/l glucose revealed a significant decrease in pro-angiogenic factors including vascular endothelial growth factor (VEGF) mRNA by 20% and VEGF protein levels by 42% as well as additional proteins such as fibroblast growth factor-4 by 41%, MMP9 by 18%, monocyte chemoattractant protein-1 by 21%, and prolactin by 25%. Glucose 71-78 C-C motif chemokine ligand 2 Homo sapiens 319-353 20692455-12 2010 CONCLUSIONS: These data show that MCP-1 gene expression regulated by the -2518 G/A polymorphism, is correlated with glucose-stimulated insulin release. Glucose 116-123 C-C motif chemokine ligand 2 Homo sapiens 34-39 18167242-1 2007 OBJECTIVE: To investigate the influence of atorvastatin (ATOR) on the expression of monocyte chemoattractant protein-1 (MCP-1) induced by high concentration glucose in peritoneal mesothelial cells (PMCs) and the possible mechanism thereof. Glucose 157-164 C-C motif chemokine ligand 2 Homo sapiens 84-118 18579703-0 2008 MCP-1/CCR2 system is involved in high glucose-induced fibronectin and type IV collagen expression in cultured mesangial cells. Glucose 38-45 C-C motif chemokine ligand 2 Homo sapiens 0-5 18579703-3 2008 This study was undertaken to investigate the functional role of the MCP-1/CCR2 system in high glucose-induced ECM (fibronectin and type IV collagen) protein expression in cultured mesangial cells (MCs). Glucose 94-101 C-C motif chemokine ligand 2 Homo sapiens 68-73 18493738-9 2008 RESULTS: Physiological concentrations of C-peptide affect high glucose-induced endothelial dysfunction by: (1) decreasing VCAM-1 expression and U-937 cell adherence to HAEC; (2) reducing secretion of IL-8 and MCP-1; and (3) suppressing NF-kappaB activation. Glucose 63-70 C-C motif chemokine ligand 2 Homo sapiens 209-214 17490777-0 2007 Monocyte chemoattractant protein-1 promoter -2518 polymorphism is associated with post-challenge insulin and glucose levels in non-diabetic Japanese subjects. Glucose 109-116 C-C motif chemokine ligand 2 Homo sapiens 0-34 17490777-1 2007 We investigated that the association of MCP-1 polymorphism at position -2518 with insulin sensitivity and insulin secretion by measuring the fasting and post-challenge glucose and insulin levels during 75g OGTT in 409 non-diabetic Japanese subjects. Glucose 168-175 C-C motif chemokine ligand 2 Homo sapiens 40-45 17490777-9 2007 The present study demonstrates that the A/A polymorphism of the MCP-1 gene at position -2518 is associated with insulin resistance during glucose loading in non-diabetic Japanese subjects. Glucose 138-145 C-C motif chemokine ligand 2 Homo sapiens 64-69 18167242-0 2007 [Influence of atorvastatin on the expression of monocyte chemoattractant protein-1 in peritoneal mesothelial cells by high glucose]. Glucose 123-130 C-C motif chemokine ligand 2 Homo sapiens 48-82 19923143-2 2010 METHODS AND RESULTS: High-glucose (HG) super-induced interleukin (IL)-6, CCL-2, transforming growth factor (TGF)-beta, vascular endothelial growth factor (VEGF) and B(2)K receptor (B(2)KR) mRNA in cultured proximal tubular epithelial cells (PTEC), whereas bradykinin (BK) upregulated IL-6, CCL-2 and TGF-beta mRNA. Glucose 26-33 C-C motif chemokine ligand 2 Homo sapiens 73-78 19923143-2 2010 METHODS AND RESULTS: High-glucose (HG) super-induced interleukin (IL)-6, CCL-2, transforming growth factor (TGF)-beta, vascular endothelial growth factor (VEGF) and B(2)K receptor (B(2)KR) mRNA in cultured proximal tubular epithelial cells (PTEC), whereas bradykinin (BK) upregulated IL-6, CCL-2 and TGF-beta mRNA. Glucose 26-33 C-C motif chemokine ligand 2 Homo sapiens 290-295 19850013-4 2009 Exposure of HEC for 48h to AGE-LDL in 5mM glucose induced an increase of RAGE expression (50%), NADPHox activity (107%), p22(phox) and NOX4 mRNA (50% and 188%, respectively) and MCP-1 expression (80%). Glucose 42-49 C-C motif chemokine ligand 2 Homo sapiens 178-183 19850013-6 2009 The addition of 25mM glucose in the culture medium enhanced the effect of AGE-LDL, but also of nLDL, on RAGE, p22(phox), NOX4, p67(phox), and MCP-1 gene expression. Glucose 21-28 C-C motif chemokine ligand 2 Homo sapiens 142-147 19741020-8 2009 High glucose (25 mM) increased TNF-alpha, IL-6, and monocyte chemoattractant protein-1 in mesangial cell conditioned medium. Glucose 5-12 C-C motif chemokine ligand 2 Homo sapiens 52-86 19397838-5 2009 In response to high glucose, several of these transcription factors regulate the gene encoding the profibrotic cytokine transforming growth factor beta, as well as genes for a range of other proteins implicated in inflammation and extracellular matrix turnover, including thrombospondin 1, the chemokine CCL2, osteopontin, fibronectin, decorin, plasminogen activator inhibitor 1 and aldose reductase. Glucose 20-27 C-C motif chemokine ligand 2 Homo sapiens 304-308 19218094-8 2009 Cells cultured in a medium with glucose 30 mmol/L generated more free radicals (+20%, P < 0.05) and released more MCP-1 (+113%, P < 0.001) and IL-6 (+26%, P < 0.05). Glucose 32-39 C-C motif chemokine ligand 2 Homo sapiens 117-122 19756411-3 2009 The aim of this study was to investigate the effect of intermittent high glucose on the expression of IL-18, MCP-1, and PAI-1 and adiponectin in 3T3-L1 adipocytes. Glucose 73-80 C-C motif chemokine ligand 2 Homo sapiens 109-114 19756411-6 2009 Stable high glucose significantly increased expression and secretion of IL-18, MCP-1, and PAI-1, and reduced adiponectin expression and secretion compared to normal glucose conditions.These effects were significantly greater under intermittent high glucose conditions compared to stable high glucose. Glucose 12-19 C-C motif chemokine ligand 2 Homo sapiens 79-84 18688800-5 2008 High glucose-induced MCP-1 and IL-8 mRNA expression levels also decreased by ABO. Glucose 5-12 C-C motif chemokine ligand 2 Homo sapiens 21-26 19132243-0 2008 High glucose conditions induce upregulation of fractalkine and monocyte chemotactic protein-1 in human smooth muscle cells. Glucose 5-12 C-C motif chemokine ligand 2 Homo sapiens 63-93 18758143-5 2008 Consistent with previous reports, exposure of ECV304 cells to high glucose for 24 h caused an increase of intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein 1 (MCP-1), and promoted cell adhesion between monocyte and ECV304 cells. Glucose 67-74 C-C motif chemokine ligand 2 Homo sapiens 153-187 18322021-6 2008 In cultured primary human renal mesangial cells (HMC), the high-glucose medium-induced upregulation of VEGF and MCP-1 was largely blocked by PEDF. Glucose 64-71 C-C motif chemokine ligand 2 Homo sapiens 112-117 18167242-1 2007 OBJECTIVE: To investigate the influence of atorvastatin (ATOR) on the expression of monocyte chemoattractant protein-1 (MCP-1) induced by high concentration glucose in peritoneal mesothelial cells (PMCs) and the possible mechanism thereof. Glucose 157-164 C-C motif chemokine ligand 2 Homo sapiens 120-125 18167242-5 2007 Glucose dose- and time-dependently reduced the protein expression of IkappaBalpha in the PMCs and increased the p65 expression in the nucleus, and accelerated the PMCs to express MCP-1 mRNA and protein (P < 0.05 and P < 0.01). Glucose 0-7 C-C motif chemokine ligand 2 Homo sapiens 179-184 18167242-6 2007 PDTC dose-dependently inhibited the acceleration of expression of MCP-1 mRNA and protein in the PMCs induced by high concentration glucose (P < 0.05 or P < 0.01). Glucose 131-138 C-C motif chemokine ligand 2 Homo sapiens 66-71 18167242-8 2007 CONCLUSION: High concentration glucose induces PMCs to express MCP-1 in a time- and dose-dependent manner. Glucose 31-38 C-C motif chemokine ligand 2 Homo sapiens 63-68 17618604-4 2007 In the disease-specific EC, glucose treatment resulted also in moderately inhibited cell growth by 5-10%, increased basal expression of VCAM-1 by 10-20%, and an enhanced release of monocyte-chemoattractant-protein-1 (MCP-1) by 40-70%. Glucose 28-35 C-C motif chemokine ligand 2 Homo sapiens 181-215 17618604-4 2007 In the disease-specific EC, glucose treatment resulted also in moderately inhibited cell growth by 5-10%, increased basal expression of VCAM-1 by 10-20%, and an enhanced release of monocyte-chemoattractant-protein-1 (MCP-1) by 40-70%. Glucose 28-35 C-C motif chemokine ligand 2 Homo sapiens 217-222 18292825-3 2007 In this study we compared serum MCP-1 concentrations between pregnant women with normal glucose tolerance (NGT), gestational diabetes mellitus (GDM) and non-pregnant healthy women. Glucose 88-95 C-C motif chemokine ligand 2 Homo sapiens 32-37 17097661-0 2007 Short-term high glucose exposure induces monocyte-endothelial cells adhesion and transmigration by increasing VCAM-1 and MCP-1 expression in human aortic endothelial cells. Glucose 16-23 C-C motif chemokine ligand 2 Homo sapiens 121-126 17097661-3 2007 HAECs stimulated with 25mM d(+)glucose (HG) for not more than 12h, exhibited rapid up-regulation of vascular cell adhesion molecule-1 (VCAM-1) and monocyte chemoattractant protein-1 (MCP-1) mRNA and protein. Glucose 27-38 C-C motif chemokine ligand 2 Homo sapiens 147-181 17097661-3 2007 HAECs stimulated with 25mM d(+)glucose (HG) for not more than 12h, exhibited rapid up-regulation of vascular cell adhesion molecule-1 (VCAM-1) and monocyte chemoattractant protein-1 (MCP-1) mRNA and protein. Glucose 27-38 C-C motif chemokine ligand 2 Homo sapiens 183-188 17655880-0 2007 D-Psicose inhibits the expression of MCP-1 induced by high-glucose stimulation in HUVECs. Glucose 59-66 C-C motif chemokine ligand 2 Homo sapiens 37-42 17655880-3 2007 Recent report indicates that MCP-1 is induced by glucose-stimulation, raising the important link between diabetes mellitus and atherosclerosis. Glucose 49-56 C-C motif chemokine ligand 2 Homo sapiens 29-34 17655880-6 2007 Results showed that MCP-1 mRNA and protein were stimulated following exposure to 22.4 mM glucose. Glucose 89-96 C-C motif chemokine ligand 2 Homo sapiens 20-25 17655880-7 2007 Transcriptional activity of MCP-1 promoter paralleled endogenous expression of the gene and this activity was dependent on the dose of d-glucose. Glucose 135-144 C-C motif chemokine ligand 2 Homo sapiens 28-33 17655880-9 2007 Next we used inhibitors of selected signal transduction pathways to show that high-glucose (HG) stimulated MCP-1 promoter activity was sensitive to p38-Mitogen-Activated Protein Kinase (p38-MAPK) pathway inhibitor. Glucose 83-90 C-C motif chemokine ligand 2 Homo sapiens 107-112 17322498-5 2007 RESULTS: The MCP-1 SNP c.-3813C>T exhibited trends for differences between the genotype groups in triglycerides, 2-h glucose and uric acid (P = 0.0084, 0.014, 0.027). Glucose 117-124 C-C motif chemokine ligand 2 Homo sapiens 13-18 18292825-9 2007 Multiple regression analysis revealed that MCP1 concentrations were significantly predicted only by plasma glucose ( beta=0.3489, p=0.00004). Glucose 107-114 C-C motif chemokine ligand 2 Homo sapiens 43-47 16730843-11 2006 In vitro studies demonstrated that glycated albumin or high glucose induces NF-kappaB activation followed by up-regulation of MCP-1 promoter activity and protein production in glial cells. Glucose 60-67 C-C motif chemokine ligand 2 Homo sapiens 126-131 17178597-4 2006 Here, we review the current knowledge on MCP-1 and its regulation by high glucose level in vascular cells involved in diabetes-induced accelerated atherosclerosis. Glucose 74-81 C-C motif chemokine ligand 2 Homo sapiens 41-46 17045117-7 2006 Serum MCP-1 levels were positively correlated with HbA1c and plasma fasting glucose levels. Glucose 76-83 C-C motif chemokine ligand 2 Homo sapiens 6-11 17178597-5 2006 The signalling pathways involved in MCP-1 modulation by high glucose, the proximal signalling events that stimulate downstream effects and the role of this chemokine in the pathophysiology of diabetes and its complications, are discussed. Glucose 61-68 C-C motif chemokine ligand 2 Homo sapiens 36-41 17375405-3 2006 Glucose, glucose metabolites and AGEs alter endothelial cell functions, induce adhesion molecule overexpression (ICAM-1, VCAM), cytokine release (IL-6, MCP-1) and tissue factor production. Glucose 0-7 C-C motif chemokine ligand 2 Homo sapiens 152-157 17375405-3 2006 Glucose, glucose metabolites and AGEs alter endothelial cell functions, induce adhesion molecule overexpression (ICAM-1, VCAM), cytokine release (IL-6, MCP-1) and tissue factor production. Glucose 9-16 C-C motif chemokine ligand 2 Homo sapiens 152-157 16631114-9 2006 Our data suggest that elevated serum MCP-1 levels and increased monocyte CCR2, CD36, CD68 expression correlate with poor blood glucose control and potentially contribute to increased recruitment of monocytes to the vessel wall in diabetes mellitus. Glucose 127-134 C-C motif chemokine ligand 2 Homo sapiens 37-42 16518329-9 2006 Prednisolone increased I-kappaB-alpha expression and inhibited glucose/mannitol-induced NF-kappaB DNA binding and MCP-1 expression without affecting PKC phosphorylation. Glucose 63-70 C-C motif chemokine ligand 2 Homo sapiens 114-119 16600694-0 2006 Aspirin and PPAR-alpha activators inhibit monocyte chemoattractant protein-1 expression induced by high glucose concentration in human endothelial cells. Glucose 104-111 C-C motif chemokine ligand 2 Homo sapiens 42-76 16600694-5 2006 The results showed that (i) aspirin, fenofibrate and clofibrate decrease significantly the MCP-1 expression and secretion in human endothelial cells; (ii) the high glucose up-regulated expression of MCP-1 in endothelial cells was significantly reduced by inhibitors of NF-kB and reactive oxygen species; (iii) all drugs notably decrease the level of the reactive oxygen species and activation of NF-kB and AP-1. Glucose 164-171 C-C motif chemokine ligand 2 Homo sapiens 91-96 16600694-6 2006 Together, the findings indicate that in endothelial cells aspirin and PPAR-alpha activators reduce the high glucose-increased expression of MCP-1 by a mechanism that includes the inhibition of reactive oxygen species, and decrease of AP-1 and NF-kB activation. Glucose 108-115 C-C motif chemokine ligand 2 Homo sapiens 140-145 16439461-6 2006 In addition, MCP-1 significantly reduced insulin-stimulated glucose uptake in the myocytes. Glucose 60-67 C-C motif chemokine ligand 2 Homo sapiens 13-18 16439461-10 2006 Human skeletal muscle cells are highly sensitive toward MCP-1, which impairs insulin signaling and glucose uptake at concentrations even below that found in the circulation. Glucose 99-106 C-C motif chemokine ligand 2 Homo sapiens 56-61 16518329-11 2006 Our results indicate that glucose induces MCP-1 mainly through hyperosmolarity by activating PKC and its downstream NF-kappaB, and that such effect was inhibited by prednisolone, suggesting the efficacy of prednisolone in preventing peritoneal fibrosis in patients on CAPD. Glucose 26-33 C-C motif chemokine ligand 2 Homo sapiens 42-47 16309586-4 2005 Glucose and heme increased both 8-epi-PGF2alpha and MCP-1. Glucose 0-7 C-C motif chemokine ligand 2 Homo sapiens 52-57 16518329-2 2006 We investigated the cellular mechanism of high-glucose-induced expression of monocyte chemoattractant protein-1 (MCP-1), which is important in recruiting monocytes into the peritoneum and progression of peritoneal fibrosis, and examined the inhibitory mechanism of glucocorticoids. Glucose 47-54 C-C motif chemokine ligand 2 Homo sapiens 77-111 16518329-2 2006 We investigated the cellular mechanism of high-glucose-induced expression of monocyte chemoattractant protein-1 (MCP-1), which is important in recruiting monocytes into the peritoneum and progression of peritoneal fibrosis, and examined the inhibitory mechanism of glucocorticoids. Glucose 47-54 C-C motif chemokine ligand 2 Homo sapiens 113-118 16518329-6 2006 High glucose increased MCP-1 mRNA and MCP-1 protein expression. Glucose 5-12 C-C motif chemokine ligand 2 Homo sapiens 23-28 16518329-6 2006 High glucose increased MCP-1 mRNA and MCP-1 protein expression. Glucose 5-12 C-C motif chemokine ligand 2 Homo sapiens 38-43 16518329-7 2006 Although glucose increased phosphorylation of MEK1/2, p42/44 MAPK, p38 MAPK, JNK1/2, and PKC, and DNA-binding activity of NF-kappaB, its effect on MCP-1 expression was suppressed only by PKC and NF-kappaB inhibitors. Glucose 9-16 C-C motif chemokine ligand 2 Homo sapiens 147-152 16143069-4 2005 RESULTS: High concentration of glucose, AGE, high concentration of insulin and H(2)O(2) can activate P38MAPK and increase the expression of MCP-1 in HUVEC. Glucose 31-38 C-C motif chemokine ligand 2 Homo sapiens 140-145 15207092-0 2004 [Expression of monocyte chemoattractant protein-1 in glomerular endothelial cells stimulated by high concentration of glucose]. Glucose 118-125 C-C motif chemokine ligand 2 Homo sapiens 15-49 15677312-8 2005 Combined exposure to both stretch and high glucose further increased MCP-1 production. Glucose 43-50 C-C motif chemokine ligand 2 Homo sapiens 69-74 15113752-12 2004 Exposure to 30 mM D-glucose reduced monocyte chemoattractant protein 1 levels to 78.6 +/- 7.1% (P < 0.05) of control, with the reduction more marked in the presence of either pioglitazone (P < 0.01) or L-805645 (P < 0.01). Glucose 18-27 C-C motif chemokine ligand 2 Homo sapiens 36-70 15349727-5 2004 MCP-1 decreases insulin-stimulated glucose uptake into adipocytes. Glucose 35-42 C-C motif chemokine ligand 2 Homo sapiens 0-5 15207092-1 2004 AIM: To study the expression of monocyte chemoattractant protein-1 (MCP-1) in cultured human glomerular endothelial cells (HUGECs) stimulated by high concentration of glucose. Glucose 167-174 C-C motif chemokine ligand 2 Homo sapiens 32-66 15207092-1 2004 AIM: To study the expression of monocyte chemoattractant protein-1 (MCP-1) in cultured human glomerular endothelial cells (HUGECs) stimulated by high concentration of glucose. Glucose 167-174 C-C motif chemokine ligand 2 Homo sapiens 68-73 15207092-2 2004 METHODS: The effect of high concentration of glucose on the expression of MCP-1mRNA by HUGECs was detected by in situ hybridization and cell ELISA. Glucose 45-52 C-C motif chemokine ligand 2 Homo sapiens 74-79 15207092-5 2004 RESULTS: The MCP-1 mRNA was only weakly expressed in HUGECs cultured under the condition of low concentration of glucose. Glucose 113-120 C-C motif chemokine ligand 2 Homo sapiens 13-18 15207092-6 2004 Following a stimulation of high concentration of glucose (25 mmol/L), MCP-1 mRNA expression was upregulated from the 8th hour and reached the maximum at the 16th hour. Glucose 49-56 C-C motif chemokine ligand 2 Homo sapiens 70-75 15207092-7 2004 Conditioned medium of cultured HUGECs stimulated with high concentration of glucose had marked chemotaxis for monocytes, which was inhibited by anti-MCP-1 antibody. Glucose 76-83 C-C motif chemokine ligand 2 Homo sapiens 149-154 15207092-8 2004 CONCLUSION: HUGEC stimulated by high glucose may highly express MCP-1, and produce chemotatic factors for monocytes. Glucose 37-44 C-C motif chemokine ligand 2 Homo sapiens 64-69 12732205-0 2003 High glucose accelerates MCP-1 production via p38 MAPK in vascular endothelial cells. Glucose 5-12 C-C motif chemokine ligand 2 Homo sapiens 25-30 14605496-7 2003 Monocyte chemoattractant protein-1 synthesis by cells exposed to glucose was increased by 31% (p < 001), and again that effect was prevented by OTZ. Glucose 65-72 C-C motif chemokine ligand 2 Homo sapiens 0-34 12732205-4 2003 Chronic incubation with high glucose increased mRNA expression and production rate of MCP-1 in a time (1-7 days)- and concentration (10-35 mM)-dependent manner. Glucose 29-36 C-C motif chemokine ligand 2 Homo sapiens 86-91 11912248-0 2002 Role of high glucose-induced nuclear factor-kappaB activation in monocyte chemoattractant protein-1 expression by mesangial cells. Glucose 13-20 C-C motif chemokine ligand 2 Homo sapiens 65-99 12399623-0 2002 Differential expression of MCP-1 and its receptor CCR2 in glucose primed human mesangial cells. Glucose 58-65 C-C motif chemokine ligand 2 Homo sapiens 27-32 12399623-3 2002 In the present study, we examined whether the ambient glucose concentration alters the expression of MCP-1 and its receptor CCR2 in primary human mesangial cells (HMC). Glucose 54-61 C-C motif chemokine ligand 2 Homo sapiens 101-106 12399623-7 2002 RESULTS: Exposure of HMC to 30 mM D-glucose led to a 30% increase in MCP-1 mRNA expression as compared to 5 mM D-glucose and osmotic controls while there was no difference in MCP-1 protein production. Glucose 34-43 C-C motif chemokine ligand 2 Homo sapiens 69-74 12399623-9 2002 5 mM D-glucose primed HMC showed a dose-dependent migration towards MCP-1 that was dose-dependently inhibited by pertussis toxin, the broad-spectrum chemokine antagonist vMIP-II as well as the CCR2 receptor antagonist (1-8del)MCP-1--demonstrating functional activity of MCP-1 receptor expression in primary HMC. Glucose 5-14 C-C motif chemokine ligand 2 Homo sapiens 68-73 12399623-9 2002 5 mM D-glucose primed HMC showed a dose-dependent migration towards MCP-1 that was dose-dependently inhibited by pertussis toxin, the broad-spectrum chemokine antagonist vMIP-II as well as the CCR2 receptor antagonist (1-8del)MCP-1--demonstrating functional activity of MCP-1 receptor expression in primary HMC. Glucose 5-14 C-C motif chemokine ligand 2 Homo sapiens 226-231 11835523-9 2002 High glucose may stimulate MCP-1 and/or IL-8 production and their excretion into the urine independently of the phases or pathological lesions of this disease. Glucose 5-12 C-C motif chemokine ligand 2 Homo sapiens 27-32 11422736-0 2001 High glucose induces MCP-1 expression partly via tyrosine kinase-AP-1 pathway in peritoneal mesothelial cells. Glucose 5-12 C-C motif chemokine ligand 2 Homo sapiens 21-26 11422736-4 2001 However, little is known about the effect of high glucose on MCP-1 expression and its signal transduction pathway in human peritoneal mesothelial cells. Glucose 50-57 C-C motif chemokine ligand 2 Homo sapiens 61-66 11422736-9 2001 RESULTS: Glucose induced MCP-1 mRNA expression in a time- and dose-dependent manner. Glucose 9-16 C-C motif chemokine ligand 2 Homo sapiens 25-30 11422736-12 2001 High-glucose-conditioned supernatant possessed an increased chemotactic activity for monocytes, which was neutralized by anti-MCP-1 antibody. Glucose 5-12 C-C motif chemokine ligand 2 Homo sapiens 126-131 11422736-14 2001 Curcumin, an inhibitor of AP-1, dose-dependently suppressed the induction of MCP-1 mRNA by high glucose. Glucose 96-103 C-C motif chemokine ligand 2 Homo sapiens 77-82 11422736-15 2001 Tyrosine kinase inhibitors such as genistein (12.5 to 50 micromol/L) and herbimycin A (0.1 to 1 micromol/L) inhibited the high-glucose-induced MCP-1 mRNA expression in a dose-dependent manner, and also suppressed the high-glucose-induced AP-1 binding activity. Glucose 127-134 C-C motif chemokine ligand 2 Homo sapiens 143-148 11422736-15 2001 Tyrosine kinase inhibitors such as genistein (12.5 to 50 micromol/L) and herbimycin A (0.1 to 1 micromol/L) inhibited the high-glucose-induced MCP-1 mRNA expression in a dose-dependent manner, and also suppressed the high-glucose-induced AP-1 binding activity. Glucose 222-229 C-C motif chemokine ligand 2 Homo sapiens 143-148 11422736-16 2001 CONCLUSIONS: : High glucose induced mesothelial MCP-1 expression partly via the tyrosine kinase-AP-1 pathway. Glucose 20-27 C-C motif chemokine ligand 2 Homo sapiens 48-53 11287779-0 2001 Effect of high glucose concentration on the synthesis of monocyte chemoattractant protein-1 in human peritoneal mesothelial cells: involvement of protein kinase C. Human peritoneal mesothelial cells (HMC) contribute to the activation and control of inflammatory processes in the peritoneum by their potential to produce various inflammatory mediators. Glucose 15-22 C-C motif chemokine ligand 2 Homo sapiens 57-91 11287779-1 2001 The present study was designed to assess the effect of glucose, the osmotic active compound in most commercially available peritoneal dialysis fluids, on the synthesis of the C-C chemokine monocyte chemoattractant protein-1 (MCP-1) in cultured HMC. Glucose 55-62 C-C motif chemokine ligand 2 Homo sapiens 189-223 11287779-1 2001 The present study was designed to assess the effect of glucose, the osmotic active compound in most commercially available peritoneal dialysis fluids, on the synthesis of the C-C chemokine monocyte chemoattractant protein-1 (MCP-1) in cultured HMC. Glucose 55-62 C-C motif chemokine ligand 2 Homo sapiens 225-230 11287779-3 2001 Incubation of HMC with glucose (30-120 mM) resulted in a time- and concentration-dependent increase in MCP-1 protein secretion and mRNA expression. Glucose 23-30 C-C motif chemokine ligand 2 Homo sapiens 103-108 11287779-4 2001 After 24 h the MCP-1 synthesis was increased from 2.8 +/- 0.46 to 4.2 +/- 0.32 ng/10(5) cells (n = 5, p < 0.05) in HMC treated with 60 mM glucose. Glucose 141-148 C-C motif chemokine ligand 2 Homo sapiens 15-20 11287779-6 2001 The stimulating effect of high glucose on MCP-1 expression in HMC was mimicked by activation of protein kinase C (PKC) with the phorbol ester PMA (20 nM). Glucose 31-38 C-C motif chemokine ligand 2 Homo sapiens 42-47 11287779-7 2001 Coincubation of the cells with glucose and the specific PKC inhibitor Ro 31-8220 completely blunted glucose-mediated MCP-1 expression. Glucose 31-38 C-C motif chemokine ligand 2 Homo sapiens 117-122 11287779-7 2001 Coincubation of the cells with glucose and the specific PKC inhibitor Ro 31-8220 completely blunted glucose-mediated MCP-1 expression. Glucose 100-107 C-C motif chemokine ligand 2 Homo sapiens 117-122 11287779-8 2001 In summary, our results indicate that glucose induces MCP-1 synthesis by a PKC-dependent pathway. Glucose 38-45 C-C motif chemokine ligand 2 Homo sapiens 54-59 11730565-4 2001 RESULTS: AGEP-BSA stimulated monocytes to express MCP-1 mRNA in a glucose-concentration-related fashion. Glucose 66-73 C-C motif chemokine ligand 2 Homo sapiens 50-55 11730565-5 2001 The levels of MCP-1 mRNA were increased slightly when monocytes were exposed to AGEP-BSA 200 mg/L (glycosylated with glucose 20 mmol/L), and increased markedly when exposed to AGEP-BSA 200 mg/L (glycosylated with glucose 50 mmol/L), but decreased slightly when exposed to AGEP-BSA 200 mg/L (glycosylated with glucose 80 mmol/L). Glucose 117-124 C-C motif chemokine ligand 2 Homo sapiens 14-19 11730565-5 2001 The levels of MCP-1 mRNA were increased slightly when monocytes were exposed to AGEP-BSA 200 mg/L (glycosylated with glucose 20 mmol/L), and increased markedly when exposed to AGEP-BSA 200 mg/L (glycosylated with glucose 50 mmol/L), but decreased slightly when exposed to AGEP-BSA 200 mg/L (glycosylated with glucose 80 mmol/L). Glucose 213-220 C-C motif chemokine ligand 2 Homo sapiens 14-19 11730565-5 2001 The levels of MCP-1 mRNA were increased slightly when monocytes were exposed to AGEP-BSA 200 mg/L (glycosylated with glucose 20 mmol/L), and increased markedly when exposed to AGEP-BSA 200 mg/L (glycosylated with glucose 50 mmol/L), but decreased slightly when exposed to AGEP-BSA 200 mg/L (glycosylated with glucose 80 mmol/L). Glucose 213-220 C-C motif chemokine ligand 2 Homo sapiens 14-19 9609459-0 1998 A high glucose concentration stimulates the expression of monocyte chemotactic peptide 1 in human mesangial cells. Glucose 7-14 C-C motif chemokine ligand 2 Homo sapiens 58-88 9609459-3 1998 More than a 50% increase in the MCP-1 protein production was observed in MCs cultured in high-glucose medium (450 mg/dl) as compared to normal glucose (100 mg/dl; 1,496 +/- 75 vs. 966 +/- 15 pg/ml after 24 h, 1,910 +/- 93 vs. 1,250 +/- 55 pg/ml after 48 h). Glucose 94-101 C-C motif chemokine ligand 2 Homo sapiens 32-37 9609459-3 1998 More than a 50% increase in the MCP-1 protein production was observed in MCs cultured in high-glucose medium (450 mg/dl) as compared to normal glucose (100 mg/dl; 1,496 +/- 75 vs. 966 +/- 15 pg/ml after 24 h, 1,910 +/- 93 vs. 1,250 +/- 55 pg/ml after 48 h). Glucose 143-150 C-C motif chemokine ligand 2 Homo sapiens 32-37 9609459-7 1998 These findings demonstrate that high glucose can directly increase MCP-1 expression in MCs, which may contribute to monocyte infiltration in diabetic nephropathy, and this is regulated by protein kinase C. Glucose 37-44 C-C motif chemokine ligand 2 Homo sapiens 67-72 8830798-8 1996 High concentrations of glucose (20 mM; 360 mg/dl) increased GHSA-induced hRPE IL-8 and MCP-1 secretion, whereas added insulin (0.5 ng/mL) inhibited IL-8 but not MCP-1 protein secretion and mRNA expression. Glucose 23-30 C-C motif chemokine ligand 2 Homo sapiens 87-92