PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21143598-4 2011 As a general pattern, we observed that pro-inflammatory cytokines increased glucose utilization in astrocytes while the anti-inflammatory cytokines IL-4 and IL-10 decreased astrocytic glucose utilization. Glucose 184-191 interleukin 10 Homo sapiens 157-162 22086137-9 2012 Our results show that high glucose concentrations (12 mM and particularly 24 mM) alter the biomineralization process in osteoblastic cells and provoke the following: i) a rise in mineralization, ii) an increase in the mRNA expression of RANKL and a decrease of OPG, iii) an increase in the mRNA expression of osteocalcin, bone sialoprotein and the transcription factor Runx2, iv) a diminished quality of the mineral, and v) an increase in the expression of IL1beta, IL6, IL8, MCP-1 and IL10 mRNAs. Glucose 27-34 interleukin 10 Homo sapiens 486-490 20206208-11 2010 Measurements of stimulated cytokine production demonstrated (i) that cumulative hypoxia stimulates especially the secretion of IL-1beta, IL-10 and IL-8, and (ii) that lack of glucose results in lower cytokine concentrations. Glucose 175-182 interleukin 10 Homo sapiens 137-142 20454933-13 2010 (4) IL-10 maintained strong correlations with glucose metabolism indices. Glucose 46-53 interleukin 10 Homo sapiens 4-9 20388104-3 2010 Stratifying the data according to IL-10 genotypes, trends for the progressive increase of glucose and neutrophil levels were observed in -1087GG vs. -1087GA vs. -1087AA positive diabetic patients (-1087GG<-1087GA<-1087AA). Glucose 90-97 interleukin 10 Homo sapiens 34-39 20178529-7 2010 While TNFalpha(-308) and IL-6 (-174) genotypes did not influence clinical/laboratory parameters in PE, IL-10 (-1082) A allele carrying genotypes (AG + AA) were associated with higher glucose and lower HDL-cholesterol levels. Glucose 183-190 interleukin 10 Homo sapiens 103-108 18304876-4 2008 Higher FoxP3 expression at diagnosis predicted worse future glycemic control while higher mean numbers of IL-10 cells were associated with better future glucose control. Glucose 153-160 interleukin 10 Homo sapiens 106-111 19643439-8 2009 Glucose indices also correlated with the proinflammatory cytokines interleukin (IL)-2 and IL-12 and inversely with anti-inflammatory cytokines IL-1RA and IL-10. Glucose 0-7 interleukin 10 Homo sapiens 154-159 18304876-5 2008 These data provide an immune phenotype of the honeymoon phase and suggest that analyzing IL-10 and FoxP3 at diagnosis may identify patients that will experience better glucose control. Glucose 168-175 interleukin 10 Homo sapiens 89-94 8811326-0 1996 Elevated glucose levels stimulate transforming growth factor-beta 1 (TGF-beta 1), suppress interleukin IL-2, IL-6 and IL-10 production and DNA synthesis in peripheral blood mononuclear cells. Glucose 9-16 interleukin 10 Homo sapiens 118-123 16556721-5 2006 Regression analysis demonstrated only for the anti-inflammatory parameters adiponectin and IL-10 a significant relationship with the decrease in fasting plasma glucose, whereas changes in IL-6 and CRP were not significantly related to changes in fasting plasma glucose, body fat, maximal oxygen uptake, or insulin sensitivity. Glucose 160-167 interleukin 10 Homo sapiens 91-98 8811326-5 1996 Exposure to elevated glucose levels caused a significant and dose-dependent increase in the production of latent TGF-beta 1 by (PWM)-stimulated PBMC at 24 and 48 h. Production of the cytokines IL-2, IL-6 and IL-10 was suppressed by elevated glucose concentration dose- and time-dependently. Glucose 21-28 interleukin 10 Homo sapiens 208-213 8811326-6 1996 In contrast to the time-dependent decreased effect of glucose-induced TGF-beta 1 production the effects of elevated glucose levels on IL-2, IL-6 and IL-10 production increased with time indicating that TGF-beta 1 production is preceding the reduced IL production. Glucose 116-123 interleukin 10 Homo sapiens 149-154 8811326-8 1996 Our results indicate that high glucose-induced TGF-beta 1 production may suppress immune response by inhibiting the endogenous production of IL-2, IL-6 and IL-10. Glucose 31-38 interleukin 10 Homo sapiens 156-161 8648229-4 1996 CSF glucose levels correlated highly with levels of IL-10, sTNFR-55, and sTNFR-75 and weakly with TNF-alpha and IL-6. Glucose 4-11 interleukin 10 Homo sapiens 52-57 34919670-6 2022 IL-10 inhibits glucose uptake and glycolysis and promotes oxidative phosphorylation with lactate inhibition. Glucose 15-22 interleukin 10 Homo sapiens 0-5 34975473-14 2021 The cytokine analysis showed that the expressions of IL-12p70 and IL-10 were significantly up-regulated after dextrose prolotherapy in IC/BPS patients. Glucose 110-118 interleukin 10 Homo sapiens 66-71 32619466-3 2020 Hepatic gluconeogenesis is then inhibited synergistically by insulin and IL-10 to facilitate glucose clearance. Glucose 93-100 interleukin 10 Homo sapiens 73-78 34909822-8 2021 Moreover, multiple correlations revealed that in active women both IL-10 and TNF-alpha serum levels positively correlate with fasting glucose levels, and were negatively associated with HDL levels. Glucose 134-141 interleukin 10 Homo sapiens 67-72 34517005-4 2022 Here, we report that in contrast to prolonged exposure to high glucose which transforms monocytes proinflammatory, short-term exposure to high glucose causes a rapid monocyte reprograming, manifested by increased expression and secretion of IL-10 which in an autocrine/paracrine fashion, reduces glucose uptake and transforms monocytes into anti-inflammatory phenotype by dampening signaling through toll-like receptors (TLRs). Glucose 63-70 interleukin 10 Homo sapiens 241-246 34517005-4 2022 Here, we report that in contrast to prolonged exposure to high glucose which transforms monocytes proinflammatory, short-term exposure to high glucose causes a rapid monocyte reprograming, manifested by increased expression and secretion of IL-10 which in an autocrine/paracrine fashion, reduces glucose uptake and transforms monocytes into anti-inflammatory phenotype by dampening signaling through toll-like receptors (TLRs). Glucose 143-150 interleukin 10 Homo sapiens 241-246 34517005-4 2022 Here, we report that in contrast to prolonged exposure to high glucose which transforms monocytes proinflammatory, short-term exposure to high glucose causes a rapid monocyte reprograming, manifested by increased expression and secretion of IL-10 which in an autocrine/paracrine fashion, reduces glucose uptake and transforms monocytes into anti-inflammatory phenotype by dampening signaling through toll-like receptors (TLRs). Glucose 296-303 interleukin 10 Homo sapiens 241-246 32056981-7 2020 Our results demonstrated that glucose modulated the macrophage cytokine production, including decreased LPS-induced pro-inflammatory cytokines (i.e., tumor necrosis factor [TNF]alpha and interleukin [IL]-6) and increased anti-inflammatory cytokine (i.e., IL-10), at resting state. Glucose 30-37 interleukin 10 Homo sapiens 255-260 30975555-11 2020 Of the genes studied here, IL10 showed the largest increase in expression throughout all the postprandial curves, particularly after glucose. Glucose 133-140 interleukin 10 Homo sapiens 27-31 31692423-8 2020 RESULTS: The correlation between metabolic and inflammatory markers and healthcare costs demonstrated a positive and significant relationship, adjusted for obesity and HPA, between glucose concentrations and exam costs (r = 0.343, p-value = 0.007) and total cost (r = 261; p-value = 0.043); HOMA index and cost of exams (r = 0.267; p-value = 0.038); and IL-10 and cost of medical consultation (r = 0.297; p-value = 0.020). Glucose 181-188 interleukin 10 Homo sapiens 354-359 31801113-1 2019 As a classic immunoregulatory cytokine, interleukin-10 (IL-10) can provide in vivo and in vitro neuroprotection respectively during cerebral ischemia and after the oxygen-glucose deprivation (OGD)-induced injury. Glucose 171-178 interleukin 10 Homo sapiens 40-54 31801113-1 2019 As a classic immunoregulatory cytokine, interleukin-10 (IL-10) can provide in vivo and in vitro neuroprotection respectively during cerebral ischemia and after the oxygen-glucose deprivation (OGD)-induced injury. Glucose 171-178 interleukin 10 Homo sapiens 56-61 29615317-6 2018 A reduction of plasma interleukin-10 levels significantly correlated with an increase in the mean number of metabolic risk factors such as increased waist circumference, BMI, dyslipidaemia, high blood pressure and glucose intolerance. Glucose 214-221 interleukin 10 Homo sapiens 22-36 31389609-10 2019 High glucose group had clearly increased the content of ROS (p<0.01), LDH (p<0.01), and interleukin-6 (IL-6) (p<0.01), but decreased the content of IL-10 (p<0.01). Glucose 5-12 interleukin 10 Homo sapiens 148-153 30237731-7 2018 THP-1 macrophages in high glucose conditions developed tolerance to IL-10 anti-inflammatory effects (TNF-alpha production) when challenged with LPS. Glucose 26-33 interleukin 10 Homo sapiens 68-73 29225725-1 2017 This study aims to assess the proinflammatory interleukin 1beta (IL-1beta) and anti-inflammatory IL-10 production by monocytes from 38 patients with type 2 diabetes and 31 controls in different glucose concentrations. Glucose 194-201 interleukin 10 Homo sapiens 97-102 28473584-4 2017 Specifically, we show that IL-10 inhibits lipopolysaccharide-induced glucose uptake and glycolysis and promotes oxidative phosphorylation. Glucose 69-76 interleukin 10 Homo sapiens 27-32 28598282-9 2017 Also, high glucose increased TRAF6, interleukin (IL)-6, TNF-alpha, and chemical chemokine ligand (CCL) 2 levels, whereas it decreased IL-10 level. Glucose 11-18 interleukin 10 Homo sapiens 134-139 28598282-12 2017 Overexpression of miR-126 significantly abrogated high glucose-induced secretion of proinflammatory cytokines such as IL-6, TNF-alpha, and CCL2 and promoted production of IL-10. Glucose 55-62 interleukin 10 Homo sapiens 171-176 28316372-7 2017 Anti-inflammatory genes, such as IL10, positively correlated with parameters of glucose, lipid, and periodontal profiles, while proinflammatory genes, such as IFNG, were negatively correlated with these parameters. Glucose 80-87 interleukin 10 Homo sapiens 33-37 27307060-8 2016 Urinary IL-10 levels proved positive correlation with fasting glucose, HbA1c, thrombomodulin and TBARS, while IL-6 plasma levels were positively correlated with HbA1c and albuminuria. Glucose 62-69 interleukin 10 Homo sapiens 8-13 27676159-8 2016 We propose that this IL-10-driven metabolic rheostat maintains metabolic equilibrium during M1 macrophage differentiation and that perturbation of this regulatory loop, either directly by exogenous cellular sources of IL-10 or indirectly via limitations in glucose availability, skews the cellular metabolic program altering the balance between inflammatory and immunosuppressive phenotypes. Glucose 257-264 interleukin 10 Homo sapiens 21-26 26141422-9 2015 The AA genotype of the -1082A/G polymorphism (IL10) was associated with lower glucose levels, while the TC genotype of the 10T/C polymorphism (TGF-beta1) was associated with a lower lipid accumulation product index and higher high-density lipoprotein cholesterol levels in the PCOS group. Glucose 78-85 interleukin 10 Homo sapiens 46-50 26883847-6 2016 These findings were observed in macrophages exposed to high glucose, which demonstrated similar IL10 resistance or hyporesponsiveness. Glucose 60-67 interleukin 10 Homo sapiens 96-100 26883847-8 2016 High glucose was also shown to impair the ability of IL10 to activate STAT3, a downstream signaling protein of IL10. Glucose 5-12 interleukin 10 Homo sapiens 53-57 26883847-8 2016 High glucose was also shown to impair the ability of IL10 to activate STAT3, a downstream signaling protein of IL10. Glucose 5-12 interleukin 10 Homo sapiens 111-115 26366999-0 2015 IL-10 Protects Neurites in Oxygen-Glucose-Deprived Cortical Neurons through the PI3K/Akt Pathway. Glucose 34-41 interleukin 10 Homo sapiens 0-5 26366999-2 2015 Here, we reported that IL-10, in a concentration-dependent manner, reduced neuronal apoptosis and increased neuronal survival in oxygen-glucose-deprived primary cortical neurons, producing an optimal protective effect at 20ng/ml. Glucose 136-143 interleukin 10 Homo sapiens 23-28 26366999-7 2015 These findings suggest that IL-10 provides neuroprotective effects by protecting neurites through PI3K/AKT signaling pathway in oxygen-glucose-deprived primary cortical neurons. Glucose 135-142 interleukin 10 Homo sapiens 28-33 23600826-7 2013 Similarly, co-incubation of fatty acids with glucose diminished secretion of IL-10, IFN-gamma and CCL2 (monocyte chemotactic protein-1), while IL-8 was up-regulated (P < 0 001). Glucose 45-52 interleukin 10 Homo sapiens 77-82