PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17475247-0 2007 ArPIKfyve-PIKfyve interaction and role in insulin-regulated GLUT4 translocation and glucose transport in 3T3-L1 adipocytes. Glucose 84-91 VAC14 component of PIKFYVE complex Homo sapiens 0-9 17475247-2 2007 Here we report that an optimal insulin effect on glucose uptake in 3T3-L1 adipocytes is dependent upon expression of both PIKfyve, the sole enzyme for PtdIns 3,5-P(2) biosynthesis, and the PIKfyve activator, ArPIKfyve. Glucose 49-56 VAC14 component of PIKFYVE complex Homo sapiens 208-217 17475247-3 2007 Small-interfering RNAs that selectively ablated PIKfyve or ArPIKfyve in this cell type depleted the PtdIns 3,5-P(2) pool and reduced insulin-activated glucose uptake to a comparable degree. Glucose 151-158 VAC14 component of PIKFYVE complex Homo sapiens 59-68 17475247-8 2007 Together, the data demonstrate for the first time a physical association between functionally related PIKfyve and ArPIKfyve in 3T3-L1 adipocytes and indicate that the novel ArPIKfyve-PIKfyve-PtdIns 3,5-P(2) pathway is physiologically linked to insulin-activated GLUT4 translocation and glucose transport. Glucose 286-293 VAC14 component of PIKFYVE complex Homo sapiens 114-123 17475247-8 2007 Together, the data demonstrate for the first time a physical association between functionally related PIKfyve and ArPIKfyve in 3T3-L1 adipocytes and indicate that the novel ArPIKfyve-PIKfyve-PtdIns 3,5-P(2) pathway is physiologically linked to insulin-activated GLUT4 translocation and glucose transport. Glucose 286-293 VAC14 component of PIKFYVE complex Homo sapiens 173-182 29183809-5 2018 Moreover, the exposure of human islets to 19 mM glucose resulted in significantly altered expression of eight genes (FDR<5%), with five of these (GLRA1, RASD1, VAC14, SLCO5A1, CHRNA5) also exhibiting changes in DNA methylation (p < 0.05). Glucose 48-55 VAC14 component of PIKFYVE complex Homo sapiens 163-168