PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33816541-14 2021 The increase in IL-8 was significantly correlated with decreases in total cholesterol (R 2 = 0.24; P = 0.008), LDL-C (R 2 = 0.17; P = 0.031) and glucose (R 2 = 0.44; P = 0.0001). Glucose 145-152 C-X-C motif chemokine ligand 8 Homo sapiens 16-20 8124912-5 1993 However, a correlation was observed between SF levels of IL-8 with those of lactate, LDH, beta 2-microglobulin and glucose. Glucose 115-122 C-X-C motif chemokine ligand 8 Homo sapiens 57-61 2329325-4 1990 The decrease in glucose concentration was less with increasing amounts of NaF but could not be totally abolished. Glucose 16-23 C-X-C motif chemokine ligand 8 Homo sapiens 74-77 1547561-5 1992 When a combination of NaF and mannose was used, the blood glucose concentration was relatively stable but slightly higher than nonpreserved samples for the next 24 h. However, samples containing mannose were unsuitable for electrolyte analysis. Glucose 58-65 C-X-C motif chemokine ligand 8 Homo sapiens 22-25 1547561-6 1992 We conclude that a combination of D-mannose and NaF may be a better preservative for blood glucose than either compound alone. Glucose 91-98 C-X-C motif chemokine ligand 8 Homo sapiens 48-51 1922513-2 1991 When blood was preserved in microtest tubes coated with sodium fluoride (NaF) and measured after 1 hour at room temperature, the glucose level decreased by 7 to 36%. Glucose 129-136 C-X-C motif chemokine ligand 8 Homo sapiens 73-76 35226681-1 2022 INTRODUCTION: Sodium fluoride (NaF) tubes are the recommended tubes for glucose measurements, but these are expensive, have limited number of uses, and are not always available in low resource settings. Glucose 72-79 C-X-C motif chemokine ligand 8 Homo sapiens 31-34 34941711-7 2021 We discovered that lnc-SLC15A1-1 expression was significantly increased upon IS treatment in comparison with high glucose alone, and then cascaded the signal of chemokines CXCL10 and CXCL8 via sponging miR-27b, miR-297, and miR-150b. Glucose 114-121 C-X-C motif chemokine ligand 8 Homo sapiens 183-188 34402375-6 2021 Firstly, we found that Tamsulosin reduced high glucose-induced expressions of TNF-alpha, IL-6, and IL-8. Glucose 47-54 C-X-C motif chemokine ligand 8 Homo sapiens 99-103 34097917-8 2021 High glucose elicits abundant IL-8 secretion in cultured human immortalized podocytes in vitro. Glucose 5-12 C-X-C motif chemokine ligand 8 Homo sapiens 30-34 35226681-6 2022 RESULTS: Rapid decline in glucose concentrations was observed when compared to baseline in serum (declined to 64%) and EDTA-plasma (declined to 77%) after 6 hours when samples were un-centrifuged at room temperature whilst NaF-plasma was stable after 24 hours in the same condition. Glucose 26-33 C-X-C motif chemokine ligand 8 Homo sapiens 223-226 34651203-15 2022 HIF-1 activation increased IL-1beta and IL-8 in human uroepithelial cells treated with high glucose concentration. Glucose 92-99 C-X-C motif chemokine ligand 8 Homo sapiens 40-44 34173106-4 2021 HUVEC cells cultured in the presence of high glucose concentration (30 mmol/ml) and treated with CXCL8 (50 ng/ml) demonstrated more intensive proliferation, migration, and p-ERK/ERK, p-P38/P38, and p-JNK/JNK ratios and significantly lower apoptosis rate than control cells (high glucose, no treatment) and cells treated with CXCL8 and transfected with microRNA-126-mimic. Glucose 45-52 C-X-C motif chemokine ligand 8 Homo sapiens 97-102 33843989-12 2021 Therefore, in a high-glucose environment, IL-8 activated the Akt signaling pathway, promoted paracrine mechanisms of BMSCs, and improved the proliferation and migration of HUVECs. Glucose 21-28 C-X-C motif chemokine ligand 8 Homo sapiens 42-46 33350460-6 2021 RESULTS: Among the 30 samples, the mean decrease in glucose levels was highest in the SSJ tube (0.38 mmol/L), followed by 0.16 mmol/L in Na citrate tube and 0.14 mmol/L in NaF-KOx tube. Glucose 52-59 C-X-C motif chemokine ligand 8 Homo sapiens 172-175 33989405-6 2021 Conditions of 60 mM glucose potentiated secretion of the cytokine IL-8 suggesting that cytokine secretion during hyperglycemia may be a source of tissue inflammation. Glucose 20-27 C-X-C motif chemokine ligand 8 Homo sapiens 66-70 33989405-7 2021 TNFalpha measurably increased secretion of IL-8 and IL-1beta, which was enhanced at 60 mM glucose. Glucose 90-97 C-X-C motif chemokine ligand 8 Homo sapiens 43-47 33176493-8 2021 Besides, we found correlations of interleukin-8 with age, glucose, and lipid profile in the overfat group. Glucose 58-65 C-X-C motif chemokine ligand 8 Homo sapiens 34-47 32608284-0 2020 Up-regulation of miR-20a weakens inflammation and apoptosis in high-glucose-induced renal tubular cell mediating diabetic kidney disease by repressing CXCL8 expression. Glucose 68-75 C-X-C motif chemokine ligand 8 Homo sapiens 151-156 32946851-8 2020 Besides, patients with higher fasting plasma glucose (FPG) had higher IL-6, IL-8, CRP, and mortality. Glucose 45-52 C-X-C motif chemokine ligand 8 Homo sapiens 76-80 32071494-4 2020 The aim is to study the pre-analytical variations on the glucose estimation of using sodium fluoride-disodium EDTA (NaF-Na2EDTA) plasma (glycolysis inhibiting anticoagulant) and determine the fact behind the activity of glycolysis inhibition on the same. Glucose 57-64 C-X-C motif chemokine ligand 8 Homo sapiens 116-119 32056981-8 2020 Moreover, glucose-containing CM reduced the macrophage secretion of TNFalpha and IL-8 but elevated the IL-12 and IL-23 levels, showing an opposite pattern of distinct pro-inflammatory cytokines modulated by cancer glucose metabolites. Glucose 10-17 C-X-C motif chemokine ligand 8 Homo sapiens 81-85 32312819-4 2020 To explore this issue, we analyzed secretomes from glucose-deprived cells, which revealed up-regulation of multiple cytokines and chemokines, including IL-6 and IL-8, in response to starvation stress. Glucose 51-58 C-X-C motif chemokine ligand 8 Homo sapiens 161-165 30871567-12 2019 The levels of TNF-a, IL-6, and IL-8 were positively correlated with increases in BMI, serum glucose and cholesterol levels. Glucose 92-99 C-X-C motif chemokine ligand 8 Homo sapiens 31-35 31705795-2 2020 Using an in vitro model, we previously reported that hyperglycemic levels of glucose induced a pro-inflammatory (IL-1beta, IL-8, RANTES, GRO-alpha), anti-angiogenic (sFlt-1) and anti-migratory profile in a human trophoblast cell line. Glucose 77-84 C-X-C motif chemokine ligand 8 Homo sapiens 123-127 31705795-8 2020 The presence of IL1Ra significantly inhibited excess glucose-induced trophoblast IL-8 and GRO-alpha secretion but had no effect on RANTES or sFlt-1. Glucose 53-60 C-X-C motif chemokine ligand 8 Homo sapiens 81-85 31817562-7 2019 High-glucose conditions increased glucose transporters, glucose influx, ROS, all the high-glucose-induced harmful pathways, TGF-beta1 and IL-8, cell apoptosis, and MMT. Glucose 5-12 C-X-C motif chemokine ligand 8 Homo sapiens 138-142 30843768-5 2020 Treatment with alpha-tocopherol (10, 100, and 1,000 muM) and ascorbic acid (15, 150, and 1,500 muM) at the same time that the dextrose was added reduced IL-1beta, IL-6, and IL-8 levels in culture media from cells maintained at 5.5 mM dextrose but had no effect on IL-1beta, IL-6, and IL-8 levels in cells exposed to 27.5 mM dextrose. Glucose 126-134 C-X-C motif chemokine ligand 8 Homo sapiens 173-177 30843768-5 2020 Treatment with alpha-tocopherol (10, 100, and 1,000 muM) and ascorbic acid (15, 150, and 1,500 muM) at the same time that the dextrose was added reduced IL-1beta, IL-6, and IL-8 levels in culture media from cells maintained at 5.5 mM dextrose but had no effect on IL-1beta, IL-6, and IL-8 levels in cells exposed to 27.5 mM dextrose. Glucose 126-134 C-X-C motif chemokine ligand 8 Homo sapiens 284-288 30902292-3 2019 In addition, the glycated TM by glucose, maltotriose, maltopentaose and maltoheptaose inhibited the proliferation and IL-8 secretion of Caco-2, and the CD63 and CD203c expression, MAPK signaling of KU812 basophils, while the glycated TM by maltose had insignificant suppression on the allergy reactivities of Caco-2 cells and KU812 basophils. Glucose 32-39 C-X-C motif chemokine ligand 8 Homo sapiens 118-122 31158307-0 2019 Human alpha defensins promote the expression of the inflammatory cytokine interleukin-8 under high-glucose conditions: Novel insights into the poor healing of diabetic foot ulcers. Glucose 99-106 C-X-C motif chemokine ligand 8 Homo sapiens 74-87 28976943-9 2017 High glucose-induced secretion of IL-8, TNF-alpha, ICAM-1, and VCAM-1 was reduced, and translocation of the p65 subunit of NF-kappaB to the endothelial cell nucleus was inhibited by EOFAZ. Glucose 5-12 C-X-C motif chemokine ligand 8 Homo sapiens 34-38 30372883-6 2018 Vildagliptin potently suppresses high glucose-induced generation of reactive oxygen species (ROS) and production of vascular inflammatory factors including tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8), intercellular cell adhesion molecule-1 (ICAM-1) and monocyte chemotactic protein 1 (MCP-1). Glucose 38-45 C-X-C motif chemokine ligand 8 Homo sapiens 212-216 30194878-9 2018 RESULTS: Compared to excess glucose alone, combination excess glucose and low-dose aPL (a) further augmented trophoblast inflammatory IL-1beta, inflammasome-associated uric acid and caspase-1, and pro-angiogenic PlGF; (b) dampened trophoblast inflammatory IL-8, anti-angiogenic sEndoglin, and sFlt-1; and (c) further reduced trophoblast migration. Glucose 62-69 C-X-C motif chemokine ligand 8 Homo sapiens 256-260 29312586-9 2017 Thus, glucose affects tamoxifen responsiveness directly modulating CTGF in BC cells, and indirectly promoting IL8 release by adipocytes. Glucose 6-13 C-X-C motif chemokine ligand 8 Homo sapiens 110-113 30305725-6 2019 We also showed that IL-8 stimulation of colon and lung cancer cells-induced glucose uptake and expressions of glucose transporter 3 (GLUT3) and glucosamine fructose-6-phosphate aminotransferase (GFAT), a regulator of glucose flux to the hexosamine biosynthetic pathway, resulting in enhancement of protein O-GlcNAcylation. Glucose 76-83 C-X-C motif chemokine ligand 8 Homo sapiens 20-24 30305725-6 2019 We also showed that IL-8 stimulation of colon and lung cancer cells-induced glucose uptake and expressions of glucose transporter 3 (GLUT3) and glucosamine fructose-6-phosphate aminotransferase (GFAT), a regulator of glucose flux to the hexosamine biosynthetic pathway, resulting in enhancement of protein O-GlcNAcylation. Glucose 110-117 C-X-C motif chemokine ligand 8 Homo sapiens 20-24 30175447-10 2018 RESULTS: Excess glucose triggered a trophoblast sterile inflammatory IL-8 and antimigratory response through HMGB1 activation of TLR4. Glucose 16-23 C-X-C motif chemokine ligand 8 Homo sapiens 69-73 29626212-7 2018 Co-treatment of high glucose with palmitic acid potentiated the expression of several DR-relevant angiogenic and inflammatory targets, including PTGS2 (COX-2) and CXCL8 (IL-8). Glucose 21-28 C-X-C motif chemokine ligand 8 Homo sapiens 163-168 29626212-7 2018 Co-treatment of high glucose with palmitic acid potentiated the expression of several DR-relevant angiogenic and inflammatory targets, including PTGS2 (COX-2) and CXCL8 (IL-8). Glucose 21-28 C-X-C motif chemokine ligand 8 Homo sapiens 170-174 29478513-2 2018 Although glycolysis inhibitors such as sodium fluoride (NaF) in combination with potassium oxalate (KOx) are currently used for overcoming this drawback, their efficacy for stabilizing blood glucose is seemingly limited, and probably lower than that of newer additives such as the citrate buffer. Glucose 191-198 C-X-C motif chemokine ligand 8 Homo sapiens 56-59 27173229-7 2016 In a high-glucose environment, TLR-2/4 expression was significantly upregulated in RGCs (while their viability decreased); additionally, NF-kappaB expression and secretion of TNF-alpha and IL-8 were significantly increased. Glucose 10-17 C-X-C motif chemokine ligand 8 Homo sapiens 189-193 27397896-10 2017 When both LPS and AGE-BSA were present, especially at high concentrations (>= 500 mug/mL of LPS and >= 25 mug/mL of AGE-BSA), a synergistic effect on IL-8 production was found in the high-glucose condition. Glucose 194-201 C-X-C motif chemokine ligand 8 Homo sapiens 156-160 27397896-11 2017 CONCLUSIONS: A synergistic effect of the production of IL-8 could be induced in HGFs with the combination of high glucose, LPS and AGEs. Glucose 114-121 C-X-C motif chemokine ligand 8 Homo sapiens 55-59 28124586-8 2017 RESULTS: High glucose (30.5 mM) increased mRNA expression of interleukin (IL)-6 and secretion of both IL-6 and IL-8 by astrocytes. Glucose 14-21 C-X-C motif chemokine ligand 8 Homo sapiens 111-115 28883755-3 2017 Here, we demonstrate that hypoxia, reactive oxygen species (ROS), and differential concentration of glucose influence the expression of cytokines and chemokines, such as IL-6, IL-8, and IP-10, in human glial cell lines. Glucose 100-107 C-X-C motif chemokine ligand 8 Homo sapiens 176-180 27397896-8 2017 RESULTS: High glucose stimulated a significant increase in the production of IL-6 and IL-8 by HGFs compared with normal glucose. Glucose 14-21 C-X-C motif chemokine ligand 8 Homo sapiens 86-90 27567939-5 2016 RESULTS: The glucose median value was 4.72mmol/L in SST tubes, 4.67mmol/L in lithium-heparin and 4.44mmol/L in NaF-KOx tubes. Glucose 13-20 C-X-C motif chemokine ligand 8 Homo sapiens 111-114 27171647-0 2016 High glucose-induced oxidative stress increases IL-8 production in human gingival epithelial cells. Glucose 5-12 C-X-C motif chemokine ligand 8 Homo sapiens 48-52 26695197-9 2016 The decrease in glucose observed for serum and NaF/KOx tubes was clinically significant at all specified time points while the bias for Glucomedics tubes did not exceed the criteria even with a centrifugation delay of 180 min. Glucose 16-23 C-X-C motif chemokine ligand 8 Homo sapiens 47-50 26537370-8 2016 RESULTS: High glucose levels inhibited PDLSC proliferation and differentiation into osteoblasts but induced NF-kappaB activation and subsequent interleukin (IL)-6 and IL-8 expression. Glucose 14-21 C-X-C motif chemokine ligand 8 Homo sapiens 167-171 26136303-8 2016 The regression equation obtained comparing citrate to NaF/KOx tubes was used to recalculate glucose results retrieved from the laboratory information system. Glucose 92-99 C-X-C motif chemokine ligand 8 Homo sapiens 54-57 26136303-9 2016 RESULTS: Glucose measured in Glucomedics was higher (9.9%; p<0.001), while glucose in NaF/KOx and serum was lower compared to LiH (2.4%; p<0.001 and 3.2%; p<0.001, respectively). Glucose 78-85 C-X-C motif chemokine ligand 8 Homo sapiens 89-92 26136303-15 2016 The replacement of NaF/KOx with Glucomedics tubes substantially impacts glucose results, giving marked rise in diabetes prevalence. Glucose 72-79 C-X-C motif chemokine ligand 8 Homo sapiens 19-22 25751776-5 2015 There were significant differences in gender, age, fever days, white blood cell count, C-reactive protein and blood glucose concentration and IL-8 levels among genotypes of IL-8-251A/T in EV71-infected patients, but no significant differences in alanine or aspartate aminotransferase, creatine kinase-myocardial isozyme and cerebrospinal fluid in patients with EV71 encephalitis. Glucose 116-123 C-X-C motif chemokine ligand 8 Homo sapiens 173-177 27156328-0 2016 Glucose Stability Study: NaF/Citrate Plasma Versus Serum. Glucose 0-7 C-X-C motif chemokine ligand 8 Homo sapiens 25-28 26885173-9 2015 RESULTS: Compared with those in normal glucose condition, IL-6 and IL-8 expression were increased in high glucose condition. Glucose 39-46 C-X-C motif chemokine ligand 8 Homo sapiens 67-71 26885173-9 2015 RESULTS: Compared with those in normal glucose condition, IL-6 and IL-8 expression were increased in high glucose condition. Glucose 106-113 C-X-C motif chemokine ligand 8 Homo sapiens 67-71 25608533-9 2015 EPS-stimulated mRNA expression levels of MYH7, IL-6, and IL-8 correlated negatively with subjects" HbA1c and/or fasting plasma glucose, suggesting an effect linked to the diabetic phenotype. Glucose 127-134 C-X-C motif chemokine ligand 8 Homo sapiens 57-61 25394884-5 2015 RESULTS: Increasing concentrations of glucose significantly increased trophoblast secretion of the inflammatory cytokines/chemokines: IL-1beta, IL-6, IL-8, GRO-alpha, RANTES, and G-CSF; significantly increased trophoblast secretion of the anti-angiogenic factors sFlt-1 and sEndoglin; and significantly decreased trophoblast migration. Glucose 38-45 C-X-C motif chemokine ligand 8 Homo sapiens 150-154 18688800-5 2008 High glucose-induced MCP-1 and IL-8 mRNA expression levels also decreased by ABO. Glucose 5-12 C-X-C motif chemokine ligand 8 Homo sapiens 31-35 24631175-0 2014 Increased plasma glucose levels after change of recommendation from NaF to citrate blood collection tubes. Glucose 17-24 C-X-C motif chemokine ligand 8 Homo sapiens 68-71 24631175-5 2014 CONCLUSIONS: The change from NaF to citrate tubes caused higher glucose values, and consequently more glucose determinations above the decision limit for diabetes. Glucose 64-71 C-X-C motif chemokine ligand 8 Homo sapiens 29-32 24631175-5 2014 CONCLUSIONS: The change from NaF to citrate tubes caused higher glucose values, and consequently more glucose determinations above the decision limit for diabetes. Glucose 102-109 C-X-C motif chemokine ligand 8 Homo sapiens 29-32 23578643-2 2013 Our results demonstrated that high glucose-induced oxidative stress in HUVECs was mainly mediated through activation of reactive oxygen species (ROS), Jun N-kinase 2/3 (JNK2/3) and plasma interleukin-8 (IL-8), and inactivation of phosphorylated protein kinase B (P-Akt). Glucose 35-42 C-X-C motif chemokine ligand 8 Homo sapiens 188-201 23578643-2 2013 Our results demonstrated that high glucose-induced oxidative stress in HUVECs was mainly mediated through activation of reactive oxygen species (ROS), Jun N-kinase 2/3 (JNK2/3) and plasma interleukin-8 (IL-8), and inactivation of phosphorylated protein kinase B (P-Akt). Glucose 35-42 C-X-C motif chemokine ligand 8 Homo sapiens 203-207 23578643-4 2013 Furthermore, 5-HMF rapidly inhibited high glucose-induced activation of IL-8, a downstream activator of P-Akt. Glucose 42-49 C-X-C motif chemokine ligand 8 Homo sapiens 72-76 23333395-6 2013 IL-8 production was significantly induced in 1% O(2), with 5.5 mM glucose (p<0.01). Glucose 66-73 C-X-C motif chemokine ligand 8 Homo sapiens 0-4 21633399-8 2012 The oral glucose challenge was associated with a significant increase in the expression of inflammatory cytokines, including interleukin (IL)-1alpha/beta, IL-6, and IL-8, that may result from ER stress. Glucose 9-16 C-X-C motif chemokine ligand 8 Homo sapiens 165-169 22086137-9 2012 Our results show that high glucose concentrations (12 mM and particularly 24 mM) alter the biomineralization process in osteoblastic cells and provoke the following: i) a rise in mineralization, ii) an increase in the mRNA expression of RANKL and a decrease of OPG, iii) an increase in the mRNA expression of osteocalcin, bone sialoprotein and the transcription factor Runx2, iv) a diminished quality of the mineral, and v) an increase in the expression of IL1beta, IL6, IL8, MCP-1 and IL10 mRNAs. Glucose 27-34 C-X-C motif chemokine ligand 8 Homo sapiens 471-474 21936573-2 2011 Crude MRPs derived from Glu-Lys showed the greatest capacity (P < 0.05) to inhibit nitric oxide (NO) and interleukin 8 (IL-8) production in interferon gamma and phorbol ester-induced Caco-2 cells. Glucose 24-27 C-X-C motif chemokine ligand 8 Homo sapiens 108-121 21936573-2 2011 Crude MRPs derived from Glu-Lys showed the greatest capacity (P < 0.05) to inhibit nitric oxide (NO) and interleukin 8 (IL-8) production in interferon gamma and phorbol ester-induced Caco-2 cells. Glucose 24-27 C-X-C motif chemokine ligand 8 Homo sapiens 123-127 21822181-7 2011 There was a significant negative correlation between levels of IL-8 and pH (r=-0.83, p<0.05), and of IL-8 and glucose in pleural fluid (r=-0.61, p<0.05). Glucose 113-120 C-X-C motif chemokine ligand 8 Homo sapiens 104-108 20578705-8 2010 Incubation of ARPE-19 cells with 33 mM glucose for 9 days significantly induced the accumulation of VEGF, IL-6, IL-8, TGF-beta, and COX-2, activation of PKCbeta, and reduction of Cx43 and GJIC. Glucose 39-46 C-X-C motif chemokine ligand 8 Homo sapiens 112-116 20578705-9 2010 Incubation of ARPE-19 cells with 33 mM glucose in the presence of 0-10 microM trans-resveratrol dose-dependently inhibited VEGF, TGF-beta1, COX-2, IL-6, and IL-8 accumulation, PKCbeta activation, and Cx43 degradation and enhanced GJIC. Glucose 39-46 C-X-C motif chemokine ligand 8 Homo sapiens 157-161 20206208-11 2010 Measurements of stimulated cytokine production demonstrated (i) that cumulative hypoxia stimulates especially the secretion of IL-1beta, IL-10 and IL-8, and (ii) that lack of glucose results in lower cytokine concentrations. Glucose 175-182 C-X-C motif chemokine ligand 8 Homo sapiens 147-151 20019678-7 2010 Fasting glucose related to VAT expression of TNFalpha, MIP, serum amyloid A (SAA), IL-1alpha, IL-1beta, IL-8, and IL-8 receptor. Glucose 8-15 C-X-C motif chemokine ligand 8 Homo sapiens 104-108 20019678-7 2010 Fasting glucose related to VAT expression of TNFalpha, MIP, serum amyloid A (SAA), IL-1alpha, IL-1beta, IL-8, and IL-8 receptor. Glucose 8-15 C-X-C motif chemokine ligand 8 Homo sapiens 114-118 21341456-6 2010 CONCLUSION: The elevated levels of IL-6, IL-16, alpha-TNF, and the chemokine IL-8 with the lower blood content of the cytokine IL-4 were long before the development of DM1 in children with normal blood glucose level in the presence of LIAA, which should be borne in mind while developing the immune mechanisms specifically directed against block, which participate by means of cytokines in beta-cell destruction, as well as methods for preventing the development of T1DM in subjects with LIAA. Glucose 202-209 C-X-C motif chemokine ligand 8 Homo sapiens 77-81 19773182-8 2009 CONCLUSIONS: In adolescents with T1DM and chronic, poor glucose control, increased serum IL-8 is associated with reduced IGF-1 suggesting a pro-inflammatory milieu that may contribute to alterations in the GH/IGF-1 axis. Glucose 56-63 C-X-C motif chemokine ligand 8 Homo sapiens 89-93 25002707-2 2015 Most recent studies on glucose stabilities confirm that the sodium fluoride/potassium oxalate (NaF/KOx) tube is far from the gold standard. Glucose 23-30 C-X-C motif chemokine ligand 8 Homo sapiens 95-98 25002707-4 2015 Greiner has introduced a glucose-specific tube (Glucomedics) containing NaF/KOx, citrate, and EDTA to minimise glycolysis. Glucose 25-32 C-X-C motif chemokine ligand 8 Homo sapiens 72-75 25303153-5 2014 Fluctuating glucose concentrations maximally upregulated TLR4 but not TLR2 expression with increased NF-kB activation, IL-8 and ICAM-1 expression. Glucose 12-19 C-X-C motif chemokine ligand 8 Homo sapiens 119-123 23129725-1 2013 Entrenched in current laboratory protocols for the measurement of plasma glucose is the false belief that sodium fluoride (NaF) is an effective inhibitor of glycolysis. Glucose 73-80 C-X-C motif chemokine ligand 8 Homo sapiens 123-126 23129725-2 2013 The failure of NaF to properly control glycolysis decreases plasma glucose concentrations. Glucose 67-74 C-X-C motif chemokine ligand 8 Homo sapiens 15-18 22219634-9 2011 The result of ELISA also showed that the release of IL-6 and IL-8 can be inhibited by high glucose, but these inhibitions were partly counteracted after pretreatment with anti-TLR2 and/or anti-TLR4 monoclonal antibody. Glucose 91-98 C-X-C motif chemokine ligand 8 Homo sapiens 61-65 20046083-9 2009 NaF glucose showed a negative mean bias of 2.6 mg/dL vs SST glucose but showed high correlation (R=0.9899). Glucose 4-11 C-X-C motif chemokine ligand 8 Homo sapiens 0-3 19638548-5 2009 RESULTS: The mean glucose concentrations for NaF-KOx samples and Li-Heparin samples were 5.7 mmol/l and 6.1 mmol/l, respectively, with a mean difference of 0.39 mmol/l. Glucose 18-25 C-X-C motif chemokine ligand 8 Homo sapiens 45-48 17639599-4 2007 Therefore, we investigated whether high glucose could activate microglia and stimulate IL-8 secretion and if so, the possible mechanisms that were involved. Glucose 40-47 C-X-C motif chemokine ligand 8 Homo sapiens 87-91 18789871-1 2008 Oral glucose uptake alters the function of immune cells and an elevation of systemic CXCL8 was described. Glucose 5-12 C-X-C motif chemokine ligand 8 Homo sapiens 85-90 18789871-2 2008 Monocytes secrete high amounts of CXCL8 and therefore it was analyzed whether glucose or insulin upregulate monocytic CXCL8 release. Glucose 78-85 C-X-C motif chemokine ligand 8 Homo sapiens 118-123 18155175-1 2008 BACKGROUND: In a previous report (Higai K et al., Biol Pharm Bull, 2007), glycated human serum albumin (Glc-HSA) was found to induce interleukin-8 (IL-8) mRNA expression in human monocyte-derived U937 cells through a reactive oxygen species (ROS)-dependent pathway; however, Glc-HSA signaling has not been elucidated in macrophages. Glucose 104-107 C-X-C motif chemokine ligand 8 Homo sapiens 133-146 18155175-1 2008 BACKGROUND: In a previous report (Higai K et al., Biol Pharm Bull, 2007), glycated human serum albumin (Glc-HSA) was found to induce interleukin-8 (IL-8) mRNA expression in human monocyte-derived U937 cells through a reactive oxygen species (ROS)-dependent pathway; however, Glc-HSA signaling has not been elucidated in macrophages. Glucose 104-107 C-X-C motif chemokine ligand 8 Homo sapiens 148-152 17707405-6 2008 RESULTS: The IL-8 production by the HUVECs was significantly higher in the high glucose culture than in the control culture (glucose concentration of 100 mg/dL) (P < 0.05). Glucose 80-87 C-X-C motif chemokine ligand 8 Homo sapiens 13-17 17707405-6 2008 RESULTS: The IL-8 production by the HUVECs was significantly higher in the high glucose culture than in the control culture (glucose concentration of 100 mg/dL) (P < 0.05). Glucose 125-132 C-X-C motif chemokine ligand 8 Homo sapiens 13-17 17707405-7 2008 Moreover, the hyperglycemia associated with elevated TNF-alpha was found to enhance the level of IL-8 production by the HUVECs cultured at all glucose concentrations and over both time courses, compared to the control (P < 0.05). Glucose 143-150 C-X-C motif chemokine ligand 8 Homo sapiens 97-101 17639599-13 2007 High glucose-induced IL-8 production by microglia may contribute to diabetic encephalopathy. Glucose 5-12 C-X-C motif chemokine ligand 8 Homo sapiens 21-25 17917246-4 2007 Furthermore, promoter activity of the IL-8 reporter gene was enhanced approximately 2-fold by stimulation with Glc-HSA and GA-HSA. Glucose 111-114 C-X-C motif chemokine ligand 8 Homo sapiens 38-42 18050667-3 2007 Tubes containing NaF in addition to EDTA, usually used for measurement of plasma glucose and HbA1c in diabetic patients, could be used for the collection of plasma sample. Glucose 81-88 C-X-C motif chemokine ligand 8 Homo sapiens 17-20 18789871-7 2008 CXCL8 was also higher when determined in the cell lysate of leukocytes 2h after glucose uptake whereas plasma CXCL8 levels were significantly reduced. Glucose 80-87 C-X-C motif chemokine ligand 8 Homo sapiens 0-5 18789871-8 2008 In summary, these data indicate that oral glucose uptake in insulin-sensitive adults is associated with elevated monocytic and reduced systemic CXCL8. Glucose 42-49 C-X-C motif chemokine ligand 8 Homo sapiens 144-149 18664535-10 2008 Glucose-induced IL-1beta was biologically active and stimulated IL-8 release. Glucose 0-7 C-X-C motif chemokine ligand 8 Homo sapiens 64-68 18493738-9 2008 RESULTS: Physiological concentrations of C-peptide affect high glucose-induced endothelial dysfunction by: (1) decreasing VCAM-1 expression and U-937 cell adherence to HAEC; (2) reducing secretion of IL-8 and MCP-1; and (3) suppressing NF-kappaB activation. Glucose 63-70 C-X-C motif chemokine ligand 8 Homo sapiens 200-204 17639599-5 2007 ELISA results showed that treatment with high glucose (35 mM) compared with treatment with low glucose (10 mM) time-dependently elevated secretion of GRO (the rat ortholog of human IL-8) in primary cultured rat microglia. Glucose 46-53 C-X-C motif chemokine ligand 8 Homo sapiens 181-185 17639599-5 2007 ELISA results showed that treatment with high glucose (35 mM) compared with treatment with low glucose (10 mM) time-dependently elevated secretion of GRO (the rat ortholog of human IL-8) in primary cultured rat microglia. Glucose 95-102 C-X-C motif chemokine ligand 8 Homo sapiens 181-185 16671497-6 2006 RESULTS: HUVECs cultured at glucose concentrations of 300 and 400 mg/dL produced more (p < 0.01) IL-8 than control cells (200 mg/dL). Glucose 28-35 C-X-C motif chemokine ligand 8 Homo sapiens 100-104 16249253-4 2006 High glucose also increased the specific binding of (125)I-labeled insulin in HAEC accompanied by accelerated production of interleukin (IL)-6 and IL-8. Glucose 5-12 C-X-C motif chemokine ligand 8 Homo sapiens 147-151 16423909-6 2006 RESULTS: We found the following associations with plasma marker concentrations: Age, neutrophil count, and glucose concentration were positively associated with IL-8 concentrations in children and adults, as were smoking and platelet count in adults. Glucose 107-114 C-X-C motif chemokine ligand 8 Homo sapiens 161-165 17003352-7 2006 These findings implicate several factors in the insulin signaling pathway, which may be further dysregulated in HIV+IGT, and support the notion that insulin signaling pathways for glucose and leucine metabolism may be disrupted by increased proinflammatory adipocytokines (IL-8) and increased lipid oxidation. Glucose 180-187 C-X-C motif chemokine ligand 8 Homo sapiens 273-277 16671497-7 2006 HUVECs cultured at glucose concentrations of 300 and 400 mg/dL also produced more (p < 0.01) IL-8 than those cultured in the absence of LPS. Glucose 19-26 C-X-C motif chemokine ligand 8 Homo sapiens 96-100 16183791-5 2005 Utilization of glucose was nearly halted by NaF, whereas that of glutamine was rather enhanced. Glucose 15-22 C-X-C motif chemokine ligand 8 Homo sapiens 44-47 17974147-2 2006 Chronic elevated glucose level in DM increases monocyte adhesion to aortic endothelial cells (ECs) which is mediated primarily through induction of interleukin-8 (IL-8). Glucose 17-24 C-X-C motif chemokine ligand 8 Homo sapiens 148-161 17974147-2 2006 Chronic elevated glucose level in DM increases monocyte adhesion to aortic endothelial cells (ECs) which is mediated primarily through induction of interleukin-8 (IL-8). Glucose 17-24 C-X-C motif chemokine ligand 8 Homo sapiens 163-167 14981920-7 2003 NaF reduced the glucose consumption at early stage, possibly by inhibition of glycolysis, whereas cisplatin and etoposide reduced the glucose consumption at later stage, suggesting that early decline of glucose consumption is rather specific to NaF. Glucose 16-23 C-X-C motif chemokine ligand 8 Homo sapiens 0-3 15230146-8 2004 Furthermore TNF-alpha and IL-8 levels correlated with pleocytosis, and protein and glucose levels, whereas IL-1 beta correlated with pleocytosis and protein level in CSF. Glucose 83-90 C-X-C motif chemokine ligand 8 Homo sapiens 26-30 12600878-0 2003 Glucose regulates monocyte adhesion through endothelial production of interleukin-8. Glucose 0-7 C-X-C motif chemokine ligand 8 Homo sapiens 70-83 14550286-3 2003 Glucose (up to 35mM) increased secretion of PAI-1 (p<0.01) and IL-8 (p<0.01), but not TNF-alpha, in a dose- and time-dependent manner. Glucose 0-7 C-X-C motif chemokine ligand 8 Homo sapiens 66-70 14550286-6 2003 The present data demonstrate that glucose increases PAI-1 and IL-8 secretion. Glucose 34-41 C-X-C motif chemokine ligand 8 Homo sapiens 62-66 12600878-7 2003 Glucose dramatically stimulated IL-8 promoter activity. Glucose 0-7 C-X-C motif chemokine ligand 8 Homo sapiens 32-36 14666669-8 2003 During the cell death induction in human promyelocytic leukemia HL-60 cells by NaF, the consumption of glucose rapidly declined, followed by a decline in the consumption of major amino acids. Glucose 103-110 C-X-C motif chemokine ligand 8 Homo sapiens 79-82 14666669-9 2003 The present study suggests that the cytotoxic activity of NaF is not regulated by the redox mechanism, but rather linked to the rapid decline in glucose consumption at early stage. Glucose 145-152 C-X-C motif chemokine ligand 8 Homo sapiens 58-61 12793907-3 2003 We recently reported that plasma IL-8 is increased in obese subjects with normal glucose tolerance (NGT). Glucose 81-88 C-X-C motif chemokine ligand 8 Homo sapiens 33-37 12793907-12 2003 CONCLUSION: Plasma IL-8 concentrations after glucose load are increased in obese IGT subjects in comparison to normoglycemic weight-matched individuals. Glucose 45-52 C-X-C motif chemokine ligand 8 Homo sapiens 19-23 12793907-13 2003 Increase in plasma IL-8 might be both insulin-mediated (during clamp) and glucose-mediated (during OGTT). Glucose 74-81 C-X-C motif chemokine ligand 8 Homo sapiens 19-23 12600878-8 2003 Using mutated IL-8 promoter constructs and EMSA, we found that the AP-1 element and the glucose-response element were responsible for much of the glucose-mediated activation of IL-8 transcription. Glucose 88-95 C-X-C motif chemokine ligand 8 Homo sapiens 177-181 12600878-8 2003 Using mutated IL-8 promoter constructs and EMSA, we found that the AP-1 element and the glucose-response element were responsible for much of the glucose-mediated activation of IL-8 transcription. Glucose 146-153 C-X-C motif chemokine ligand 8 Homo sapiens 14-18 12600878-2 2003 HAECs cultured for 7 days in 25 mmol/L glucose had a 2-fold elevation in interleukin-8 (IL-8) secretion over control cells cultured in 5.5 mmol/L glucose (P<0.001). Glucose 39-46 C-X-C motif chemokine ligand 8 Homo sapiens 73-86 12600878-8 2003 Using mutated IL-8 promoter constructs and EMSA, we found that the AP-1 element and the glucose-response element were responsible for much of the glucose-mediated activation of IL-8 transcription. Glucose 146-153 C-X-C motif chemokine ligand 8 Homo sapiens 177-181 12600878-9 2003 Interestingly, inhibition of reactive oxygen species (ROS) production through use of pharmacological uncouplers of the mitochondrial electron transport chain significantly reduced glucose-mediated induction of IL-8 expression. Glucose 180-187 C-X-C motif chemokine ligand 8 Homo sapiens 210-214 12600878-2 2003 HAECs cultured for 7 days in 25 mmol/L glucose had a 2-fold elevation in interleukin-8 (IL-8) secretion over control cells cultured in 5.5 mmol/L glucose (P<0.001). Glucose 39-46 C-X-C motif chemokine ligand 8 Homo sapiens 88-92 12600878-10 2003 These data indicate that glucose regulates monocyte:endothelial interactions through stimulation of IL-8 and ROS production and activation of the alpha5beta1 integrin complex on HAECs. Glucose 25-32 C-X-C motif chemokine ligand 8 Homo sapiens 100-104 12600878-3 2003 Use of a neutralizing antibody to IL-8 prevented glucose-mediated monocyte adhesion. Glucose 49-56 C-X-C motif chemokine ligand 8 Homo sapiens 34-38 11972286-0 2002 alpha-Tocopherol Inhibits IL-8 synthesis induced by thrombin and high glucose in endothelial cells. Glucose 70-77 C-X-C motif chemokine ligand 8 Homo sapiens 26-30 11972286-3 2002 Therefore, we examined the effect of alpha-tocopherol on the regulation of IL-8 synthesis induced by high glucose and/or thrombin in endothelial cells. Glucose 106-113 C-X-C motif chemokine ligand 8 Homo sapiens 75-79 11972286-5 2002 Furthermore, high glucose levels and thrombin combined had additive effects on IL-8 synthesis, and alpha-tocopherol diminished their effect; alpha-tocopherol also inhibited the phosphorylation of IkappaB-alpha induced by high glucose levels and/or thrombin. Glucose 18-25 C-X-C motif chemokine ligand 8 Homo sapiens 79-83 11606315-0 2001 Pravastatin suppresses the interleukin-8 production induced by thrombin in human aortic endothelial cells cultured with high glucose by inhibiting the p44/42 mitogen activated protein kinase. Glucose 125-132 C-X-C motif chemokine ligand 8 Homo sapiens 27-40 11835523-9 2002 High glucose may stimulate MCP-1 and/or IL-8 production and their excretion into the urine independently of the phases or pathological lesions of this disease. Glucose 5-12 C-X-C motif chemokine ligand 8 Homo sapiens 40-44 11848444-8 2002 Furthermore, ELISA assays performed on the supernatant of HUVEC culture medium showed a significant increase of IL-8 for cells treated with 25-mM compared to 5-mM glucose. Glucose 163-170 C-X-C motif chemokine ligand 8 Homo sapiens 112-116 9829345-6 1998 Plasma glucose level was determined in NaF preserved plasma using the glucose oxidase method. Glucose 7-14 C-X-C motif chemokine ligand 8 Homo sapiens 39-42 11673649-3 2001 High glucose concentrations increased IL-8 mRNA levels in a MAPK-p38-dependent manner, which was suppressed by shear stress. Glucose 5-12 C-X-C motif chemokine ligand 8 Homo sapiens 38-42 11673649-4 2001 Measurement of IL-8 protein in HUVEC culture media by ELISA demonstrated that IL-8 secretion was also increased by high glucose and suppressed by shear stress. Glucose 120-127 C-X-C motif chemokine ligand 8 Homo sapiens 15-19 11673649-4 2001 Measurement of IL-8 protein in HUVEC culture media by ELISA demonstrated that IL-8 secretion was also increased by high glucose and suppressed by shear stress. Glucose 120-127 C-X-C motif chemokine ligand 8 Homo sapiens 78-82 8830798-8 1996 High concentrations of glucose (20 mM; 360 mg/dl) increased GHSA-induced hRPE IL-8 and MCP-1 secretion, whereas added insulin (0.5 ng/mL) inhibited IL-8 but not MCP-1 protein secretion and mRNA expression. Glucose 23-30 C-X-C motif chemokine ligand 8 Homo sapiens 78-82 9165232-0 1997 High glucose enhances the gene expression of interleukin-8 in human endothelial cells, but not in smooth muscle cells: possible role of interleukin-8 in diabetic macroangiopathy. Glucose 5-12 C-X-C motif chemokine ligand 8 Homo sapiens 45-58 9165232-1 1997 We examined the effect of high glucose concentrations on the production of interleukin(IL)-8, which seems to be important for the development of atherosclerosis, in cultured human aortic endothelial cells (AoEC) and smooth muscle cells (AoSMC). Glucose 31-38 C-X-C motif chemokine ligand 8 Homo sapiens 75-92 9165232-3 1997 After 2 days" culture, 42.5 mmol/l glucose enhanced IL-8 mRNA expression in AoEC, but not in AoSMC, compared to 4 mmol/l glucose. Glucose 35-42 C-X-C motif chemokine ligand 8 Homo sapiens 52-56 9165232-4 1997 After 7 days" culture, the IL-8 concentration in AoEC lysate and the expression of IL-8 mRNA were significantly increased by 20.5 mmol/l glucose, or 42.5 mmol/l glucose compared to 4 mmol/l glucose. Glucose 137-144 C-X-C motif chemokine ligand 8 Homo sapiens 27-31 9165232-4 1997 After 7 days" culture, the IL-8 concentration in AoEC lysate and the expression of IL-8 mRNA were significantly increased by 20.5 mmol/l glucose, or 42.5 mmol/l glucose compared to 4 mmol/l glucose. Glucose 137-144 C-X-C motif chemokine ligand 8 Homo sapiens 83-87 9165232-4 1997 After 7 days" culture, the IL-8 concentration in AoEC lysate and the expression of IL-8 mRNA were significantly increased by 20.5 mmol/l glucose, or 42.5 mmol/l glucose compared to 4 mmol/l glucose. Glucose 161-168 C-X-C motif chemokine ligand 8 Homo sapiens 27-31 9165232-4 1997 After 7 days" culture, the IL-8 concentration in AoEC lysate and the expression of IL-8 mRNA were significantly increased by 20.5 mmol/l glucose, or 42.5 mmol/l glucose compared to 4 mmol/l glucose. Glucose 161-168 C-X-C motif chemokine ligand 8 Homo sapiens 83-87 9165232-4 1997 After 7 days" culture, the IL-8 concentration in AoEC lysate and the expression of IL-8 mRNA were significantly increased by 20.5 mmol/l glucose, or 42.5 mmol/l glucose compared to 4 mmol/l glucose. Glucose 161-168 C-X-C motif chemokine ligand 8 Homo sapiens 27-31 9165232-4 1997 After 7 days" culture, the IL-8 concentration in AoEC lysate and the expression of IL-8 mRNA were significantly increased by 20.5 mmol/l glucose, or 42.5 mmol/l glucose compared to 4 mmol/l glucose. Glucose 161-168 C-X-C motif chemokine ligand 8 Homo sapiens 83-87 9165232-5 1997 On the other hand, the IL-8 concentration in AoSMC lysate was not affected by any glucose concentration and the expression of IL-8 mRNA in AoSMC was diminished by high glucose. Glucose 168-175 C-X-C motif chemokine ligand 8 Homo sapiens 126-130 9165232-6 1997 These results suggest that the chemotactic gradient by IL-8 is established between arterial intima and media in response to high glucose levels in diabetic patients, and that it may be one of the key factors for SMC migration to the intima leading to diabetic macroangiopathy. Glucose 129-136 C-X-C motif chemokine ligand 8 Homo sapiens 55-59 11885079-6 1997 The mouthrinses containing 1% xylitol and 0.1% NaF produced the same results as 1% xylitol alone on oral glucose clearance. Glucose 105-112 C-X-C motif chemokine ligand 8 Homo sapiens 47-50 9010051-4 1996 SF IL-8 levels correlated strongly with CD, lactate, glucose and the lactate to glucose ratio when both disease groups were considered together (P < 0.001). Glucose 53-60 C-X-C motif chemokine ligand 8 Homo sapiens 3-7 9010051-4 1996 SF IL-8 levels correlated strongly with CD, lactate, glucose and the lactate to glucose ratio when both disease groups were considered together (P < 0.001). Glucose 80-87 C-X-C motif chemokine ligand 8 Homo sapiens 3-7 8886829-0 1996 The IL-8 production in endothelial cells is stimulated by high glucose. Glucose 63-70 C-X-C motif chemokine ligand 8 Homo sapiens 4-8 8801091-3 1996 The CSF levels of IL-8 correlated with the levels of tumor necrosis factor-alpha, leukocyte count, neutrophil count, protein level, CSF/blood glucose ratio, and the number of days patients were hospitalized. Glucose 142-149 C-X-C motif chemokine ligand 8 Homo sapiens 18-22