PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19372209-3	2009	Based on our finding that thiazolidinediones suppress beta-catenin and cyclin D1 by up-regulating the E3 ligase SCF(beta-TrCP), we hypothesized that beta-transducin repeat-containing protein (beta-TrCP) targets Sp1 for proteasomal degradation in response to glucose starvation or OSU-CG12.	Glucose	258-265	beta-transducin repeat containing E3 ubiquitin protein ligase	Homo sapiens	149-190	
19372209-9	2009	The ability of OSU-CG12 to mimic glucose starvation to activate beta-TrCP-mediated Sp1 degradation has translational potential to foster novel strategies for cancer therapy.	Glucose	33-40	beta-transducin repeat containing E3 ubiquitin protein ligase	Homo sapiens	64-73	
18650423-10	2008	Moreover, we obtained evidence that this beta-TrCP-dependent degradation takes part in controlling cyclin D1 turnover when cancer cells undergo glucose starvation, which endows physiological relevance to this novel mechanism.	Glucose	144-151	beta-transducin repeat containing E3 ubiquitin protein ligase	Homo sapiens	41-50	
19372209-0	2009	Thiazolidinediones mimic glucose starvation in facilitating Sp1 degradation through the up-regulation of beta-transducin repeat-containing protein.	Glucose	25-32	beta-transducin repeat containing E3 ubiquitin protein ligase	Homo sapiens	105-146	
19372209-3	2009	Based on our finding that thiazolidinediones suppress beta-catenin and cyclin D1 by up-regulating the E3 ligase SCF(beta-TrCP), we hypothesized that beta-transducin repeat-containing protein (beta-TrCP) targets Sp1 for proteasomal degradation in response to glucose starvation or OSU-CG12.	Glucose	258-265	beta-transducin repeat containing E3 ubiquitin protein ligase	Homo sapiens	116-125