PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18805504-0 2009 Dynamin-related protein 1 mediates high glucose induced pancreatic beta cell apoptosis. Glucose 40-47 dynamin 1 like Homo sapiens 0-25 21747057-5 2011 In cultured human aortic endothelial cells exposed to 30 mmol/L glucose, we observed a similar loss of mitochondrial networks and increased expression of Fis1 and dynamin-related protein-1 (Drp1), proteins required for mitochondrial fission. Glucose 64-71 dynamin 1 like Homo sapiens 163-188 21747057-5 2011 In cultured human aortic endothelial cells exposed to 30 mmol/L glucose, we observed a similar loss of mitochondrial networks and increased expression of Fis1 and dynamin-related protein-1 (Drp1), proteins required for mitochondrial fission. Glucose 64-71 dynamin 1 like Homo sapiens 190-194 21747057-7 2011 Silencing Fis1 or Drp1 expression with siRNA blunted high glucose-induced alterations in mitochondrial networks, reactive oxygen species production, endothelial nitric oxide synthase activation, and cGMP production. Glucose 58-65 dynamin 1 like Homo sapiens 18-22 18805504-3 2009 In this study, we reported that a mitochondrial fission modulator, Dynamin-related protein 1 (Drp-1), plays an important role in high glucose induced beta cell apoptosis. Glucose 134-141 dynamin 1 like Homo sapiens 67-92 18805504-3 2009 In this study, we reported that a mitochondrial fission modulator, Dynamin-related protein 1 (Drp-1), plays an important role in high glucose induced beta cell apoptosis. Glucose 134-141 dynamin 1 like Homo sapiens 94-99 18805504-5 2009 Induction of Drp-1 expression significantly promoted high glucose induced apoptosis in Drp-1WT (Drp-1 wild type) inducible beta cell line, but not in Drp-1K38A (a dominant negative mutant of Drp1) inducible beta cell line. Glucose 58-65 dynamin 1 like Homo sapiens 13-18 18805504-5 2009 Induction of Drp-1 expression significantly promoted high glucose induced apoptosis in Drp-1WT (Drp-1 wild type) inducible beta cell line, but not in Drp-1K38A (a dominant negative mutant of Drp1) inducible beta cell line. Glucose 58-65 dynamin 1 like Homo sapiens 87-92 18805504-7 2009 These results indicated that Drp-1 mediates high glucose induced pancreatic beta cell apoptosis. Glucose 49-56 dynamin 1 like Homo sapiens 29-34 34888014-11 2021 In JEG3 cells treated with 30 mmol/L glucose, the mRNA and protein expression of p66Shc and Drp1 were increased at 24 h (both P < 0.05), 48 h (both P < 0.01) and 72 h (both P < 0.001). Glucose 37-44 dynamin 1 like Homo sapiens 92-96 35204246-7 2022 Homocysteine exacerbated glucose-induced Drp1 activation and its nitrosylation, mitochondrial fragmentation and cell apoptosis, and further decreased nucleoids and mtDNA transcription. Glucose 25-32 dynamin 1 like Homo sapiens 41-45 35204246-8 2022 Drp1-siRNA or nitric-oxide inhibitor prevented glucose- and homocysteine-induced mitochondrial fission, damage and cell apoptosis. Glucose 47-54 dynamin 1 like Homo sapiens 0-4 32017930-0 2020 Drp1 mediates high glucose-induced mitochondrial dysfunction and epithelial-mesenchymal transition in endometrial cancer cells. Glucose 19-26 dynamin 1 like Homo sapiens 0-4 33904649-10 2021 In conclusion, inhibiting Drp1 with short-term Mdivi-1 administration attenuates the impairment in skeletal muscle insulin signaling and improves whole-body glucose tolerance in the setting of obesity-induced insulin resistance. Glucose 157-164 dynamin 1 like Homo sapiens 26-30 32108342-0 2020 AKAP1 mediates high glucose-induced mitochondrial fission through the phosphorylation of Drp1 in podocytes. Glucose 20-27 dynamin 1 like Homo sapiens 89-93 32304005-9 2020 Besides, high glucose also caused a shift in mitochondrial dynamics towards the appearance of more fused and lesser fragmented mitochondria, with a concomitant decrease in the expression of DRP1, suggesting decreased mitochondrial biogenesis. Glucose 14-21 dynamin 1 like Homo sapiens 190-194 32017930-1 2020 This study aims to clarify the role and molecular mechanism of dynamin-related protein 1 (Drp1)-mediated mitochondrial homeostasis in high glucose (HG)-induced endometrial cancer (EC). Glucose 139-146 dynamin 1 like Homo sapiens 63-88 32017930-1 2020 This study aims to clarify the role and molecular mechanism of dynamin-related protein 1 (Drp1)-mediated mitochondrial homeostasis in high glucose (HG)-induced endometrial cancer (EC). Glucose 139-146 dynamin 1 like Homo sapiens 90-94 30377844-6 2018 DLP-1 was composed of D-(+)-galactose, DL-arabinose, and L-(+)-rhamnose with a molar ratio of 3.21:1.11:0.23, and traces of D-xylose, D-glucose, and D-(+)-mannose. Glucose 134-143 dynamin 1 like Homo sapiens 0-5 31115753-4 2019 RESULTS: DATS treatment significantly inhibited high glucose-induced HUVEC apoptosis by blockage of intracellular and mitochondrial ROS generation, maintenance of the mitochondrial membrane potential, and suppression of high glucose-induced dynamin-related protein 1 (Drp1) expression. Glucose 53-60 dynamin 1 like Homo sapiens 268-272 31115753-4 2019 RESULTS: DATS treatment significantly inhibited high glucose-induced HUVEC apoptosis by blockage of intracellular and mitochondrial ROS generation, maintenance of the mitochondrial membrane potential, and suppression of high glucose-induced dynamin-related protein 1 (Drp1) expression. Glucose 225-232 dynamin 1 like Homo sapiens 241-266 31115753-5 2019 Furthermore, DATS blockage of high glucose-induced mitochondrial fission and apoptosis was through adenosine monophosphate-activated protein kinase (AMPK) activation-inhibited Drp1 expression in HUVECs. Glucose 35-42 dynamin 1 like Homo sapiens 176-180 31115753-6 2019 CONCLUSIONS: DATS demonstrated the ability to inhibit high glucose-induced HUVEC apoptosis via suppression of Drp1-mediated mitochondrial fission in an AMPK-dependent fashion. Glucose 59-66 dynamin 1 like Homo sapiens 110-114 31305892-6 2019 The effect of CSF treatment on the morphology of mitochondria was characterized by phosphorylation of serine 637 on the dynamin-related protein DRP1, a post-translational modification responsible for unopposed mitochondrial fusion in response to low glucose conditions. Glucose 250-257 dynamin 1 like Homo sapiens 144-148 26919426-3 2016 Here, we show that glucose load results in mitochondrial fission and reduced reactive oxygen species in VMH neurons mediated by dynamin-related peptide 1 (DRP1) under the control of uncoupling protein 2 (UCP2). Glucose 19-26 dynamin 1 like Homo sapiens 128-153 28273447-4 2017 Direct inhibition of Drp1 negated high-fat-feeding-induced mitochondrial fission, endoplasmic reticulum (ER) stress, and insulin resistance in the DVC and subsequently restored hepatic glucose production regulation. Glucose 185-192 dynamin 1 like Homo sapiens 21-25 26903301-6 2016 Increased ROS levels induced excessive mitochondrial fission through dynamin-related protein (Drp 1), while Mdivi-1 suppressed the sensitivity of Drp1 to ROS levels, thus inhibiting excessive mitochondrial fission under high-glucose conditions. Glucose 225-232 dynamin 1 like Homo sapiens 146-150 27923790-0 2017 Dynamin-related protein 1 mediates low glucose-induced endothelial dysfunction in human arterioles. Glucose 39-46 dynamin 1 like Homo sapiens 0-25 27923790-11 2017 Disruption of Drp1 and subsequent mitochondrial fragmentation events prevents impaired vascular dilation, restores mitochondrial phenotype, and implicates mitochondrial fission as a primary mediator of LG-induced endothelial dysfunction.NEW & NOTEWORTHY Acute low-glucose exposure induces mitochondrial fragmentation in endothelial cells via Drp1 and is associated with impaired endothelial function in human arterioles. Glucose 268-275 dynamin 1 like Homo sapiens 14-18 26991754-10 2016 Elevated glucose conditions (11 and 25 mM) significantly increased ROS generation, whereas only the 25-mM high glucose condition induced mitochondrial fission and increased the expression of activated dynamin-related protein 1 in iPSC-CMs. Glucose 111-118 dynamin 1 like Homo sapiens 201-226 26919426-3 2016 Here, we show that glucose load results in mitochondrial fission and reduced reactive oxygen species in VMH neurons mediated by dynamin-related peptide 1 (DRP1) under the control of uncoupling protein 2 (UCP2). Glucose 19-26 dynamin 1 like Homo sapiens 155-159 25857570-6 2015 DRP1 expression has increased significantly in glomerular mesangial cell (GMC), which is cultivated in high glucose (HG). Glucose 108-115 dynamin 1 like Homo sapiens 0-4