PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31931619-5 2020 In cultures of dispersed islets NOX5 protein was observed in somatostatin-positive (delta) cells in basal (2.8mM glucose) conditions. Glucose 113-120 NADPH oxidase 5 Homo sapiens 32-36 35275988-6 2022 In vitro, silencing of NOX5 in human mesangial cells attenuated high glucose induced upregulation of EGR1, PKC-alpha, and TXNIP as well as markers of inflammation (TLR4 and MCP-1) and fibrosis (CTGF and collagens I and III) via reduction in ROS formation. Glucose 69-76 NADPH oxidase 5 Homo sapiens 23-27 31931619-6 2020 siRNA-mediated knock-down of NOX5 in human islets cultured in basal glucose concentrations resulted in diminished glucose-induced insulin secretion in vitro. Glucose 68-75 NADPH oxidase 5 Homo sapiens 29-33 31931619-6 2020 siRNA-mediated knock-down of NOX5 in human islets cultured in basal glucose concentrations resulted in diminished glucose-induced insulin secretion in vitro. Glucose 114-121 NADPH oxidase 5 Homo sapiens 29-33 31931619-7 2020 However, when islets were preincubated in high (16.7mM) glucose media for 12 hours, NOX5 appeared also in insulin-positive (beta) cells. Glucose 56-63 NADPH oxidase 5 Homo sapiens 84-88 31931619-8 2020 In vivo, mice with beta-cell NOX5 expression developed aggravated impairment of glucose-induced insulin secretion compared to control mice when challenged with 14 weeks of high-fat diet. Glucose 80-87 NADPH oxidase 5 Homo sapiens 29-33 24505490-11 2014 Exposure of endothelial cells to high glucose significantly increased PKCalpha activation, and enhanced Nox5 derived superoxide in a manner that was in prevented by a PKCalpha inhibitor, Go 6976. Glucose 38-45 NADPH oxidase 5 Homo sapiens 104-108 32012145-0 2020 Inhibition of NADPH Oxidase 5 (NOX5) Suppresses High Glucose-Induced Oxidative Stress, Inflammation and Extracellular Matrix Accumulation in Human Glomerular Mesangial Cells. Glucose 53-60 NADPH oxidase 5 Homo sapiens 14-29 32012145-0 2020 Inhibition of NADPH Oxidase 5 (NOX5) Suppresses High Glucose-Induced Oxidative Stress, Inflammation and Extracellular Matrix Accumulation in Human Glomerular Mesangial Cells. Glucose 53-60 NADPH oxidase 5 Homo sapiens 31-35 32012145-1 2020 BACKGROUND The aim of this study was to explore the effects of NADPH oxidase 5 (NOX5) in high glucose-stimulated human glomerular mesangial cells (HMCs). Glucose 94-101 NADPH oxidase 5 Homo sapiens 63-78 32012145-1 2020 BACKGROUND The aim of this study was to explore the effects of NADPH oxidase 5 (NOX5) in high glucose-stimulated human glomerular mesangial cells (HMCs). Glucose 94-101 NADPH oxidase 5 Homo sapiens 80-84