PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35275988-6	2022	In vitro, silencing of NOX5 in human mesangial cells attenuated high glucose induced upregulation of EGR1, PKC-alpha, and TXNIP as well as markers of inflammation (TLR4 and MCP-1) and fibrosis (CTGF and collagens I and III) via reduction in ROS formation.	Glucose	69-76	NADPH oxidase 5	Homo sapiens	23-27	
32012145-0	2020	Inhibition of NADPH Oxidase 5 (NOX5) Suppresses High Glucose-Induced Oxidative Stress, Inflammation and Extracellular Matrix Accumulation in Human Glomerular Mesangial Cells.	Glucose	53-60	NADPH oxidase 5	Homo sapiens	14-29	
31931619-5	2020	In cultures of dispersed islets NOX5 protein was observed in somatostatin-positive (delta) cells in basal (2.8mM glucose) conditions.	Glucose	113-120	NADPH oxidase 5	Homo sapiens	32-36	
31931619-6	2020	siRNA-mediated knock-down of NOX5 in human islets cultured in basal glucose concentrations resulted in diminished glucose-induced insulin secretion in vitro.	Glucose	68-75	NADPH oxidase 5	Homo sapiens	29-33	
31931619-6	2020	siRNA-mediated knock-down of NOX5 in human islets cultured in basal glucose concentrations resulted in diminished glucose-induced insulin secretion in vitro.	Glucose	114-121	NADPH oxidase 5	Homo sapiens	29-33	
31931619-7	2020	However, when islets were preincubated in high (16.7mM) glucose media for 12 hours, NOX5 appeared also in insulin-positive (beta) cells.	Glucose	56-63	NADPH oxidase 5	Homo sapiens	84-88	
31931619-8	2020	In vivo, mice with beta-cell NOX5 expression developed aggravated impairment of glucose-induced insulin secretion compared to control mice when challenged with 14 weeks of high-fat diet.	Glucose	80-87	NADPH oxidase 5	Homo sapiens	29-33	
32012145-0	2020	Inhibition of NADPH Oxidase 5 (NOX5) Suppresses High Glucose-Induced Oxidative Stress, Inflammation and Extracellular Matrix Accumulation in Human Glomerular Mesangial Cells.	Glucose	53-60	NADPH oxidase 5	Homo sapiens	31-35	
32012145-1	2020	BACKGROUND The aim of this study was to explore the effects of NADPH oxidase 5 (NOX5) in high glucose-stimulated human glomerular mesangial cells (HMCs).	Glucose	94-101	NADPH oxidase 5	Homo sapiens	63-78	
32012145-1	2020	BACKGROUND The aim of this study was to explore the effects of NADPH oxidase 5 (NOX5) in high glucose-stimulated human glomerular mesangial cells (HMCs).	Glucose	94-101	NADPH oxidase 5	Homo sapiens	80-84	
24505490-11	2014	Exposure of endothelial cells to high glucose significantly increased PKCalpha activation, and enhanced Nox5 derived superoxide in a manner that was in prevented by a PKCalpha inhibitor, Go 6976.	Glucose	38-45	NADPH oxidase 5	Homo sapiens	104-108