PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22733815-1	2012	FGFs 19, 21, and 23 are hormones that regulate in a Klotho co-receptor-dependent fashion major metabolic processes such as glucose and lipid metabolism (FGF21) and phosphate and vitamin D homeostasis (FGF23).	Glucose	123-130	klotho	Homo sapiens	52-58	
23941507-9	2013	Plasma alpha-klotho levels had a significantly negative correlation with fasting glucose levels (r=-0.216, p=0.018) and mean IMT (r=-0.258, p=0.004) in multiple stepwise regression analyses.	Glucose	81-88	klotho	Homo sapiens	13-19	
29884183-14	2018	CONCLUSIONS: Taken together, KL is a negative regulator of aerobic glycolysis and KL inhibited glucose metabolism transformation via the ERK/ HIF1alpha axis.	Glucose	95-102	klotho	Homo sapiens	82-84	
21695423-2	2012	KL participates to the regulation of a number of intracellular biochemical pathways, including lipid profile and glucose metabolism.	Glucose	113-120	klotho	Homo sapiens	0-2	
21695423-6	2012	Gender-segregated analyses confirmed these associations, and suggested that the associations of KL genotypes with HDL-C, fasting glucose and fasting insulin levels may be driven by the female gender, while the association with serum levels of hemoglobin may be driven by the male gender.	Glucose	129-136	klotho	Homo sapiens	96-98	
21695423-8	2012	The genetic risk score (GRS) models further confirmed significant associations among KL SNPs and hemoglobin, total cholesterol, and HDL-C. Gender-segregated analyses with the GRS-tagged approach confirmed the associations with HDL-C, fasting glucose, and fasting insulin levels in females, and with hemoglobin and LC in males.	Glucose	242-249	klotho	Homo sapiens	85-87	
21695423-9	2012	Our findings suggested that KL locus may influence quantitative traits such as serum levels of lipid, fasting glucose, albumin and hemoglobin in hospitalized older patients, with some gender differences suggested for creatinine, IGF-1 levels, and LC, thus being one of the genetic factors possibly contributing to age-related diseases and longevity.	Glucose	110-117	klotho	Homo sapiens	28-30	
34967938-8	2021	Glucose uptake and lactate production in the cardiomyocytes subjected to I/R were normalized after Klotho supplementation.	Glucose	0-7	klotho	Homo sapiens	99-105	
30697600-10	2019	Moreover, an oral glucose tolerance test revealed that soluble Klotho levels decreased, whereas a paradoxical GH peak was observed after glucose intake in a patient with GHoma.	Glucose	18-25	klotho	Homo sapiens	63-69	
30042059-6	2018	Moreover, decreases in alpha-Klotho and beta-Klotho levels in the high glucose-exposed cell culture model, which was dependent on glucose exposure time, were confirmed.	Glucose	71-78	klotho	Homo sapiens	29-35	
30042059-6	2018	Moreover, decreases in alpha-Klotho and beta-Klotho levels in the high glucose-exposed cell culture model, which was dependent on glucose exposure time, were confirmed.	Glucose	130-137	klotho	Homo sapiens	29-35	
29884183-8	2018	The impact of KL on glucose metabolism and its mechanisms were further validated in vitro and in vivo.	Glucose	20-27	klotho	Homo sapiens	14-16	
30620382-5	2018	Because FGF23/Klotho system affects glucose metabolism and gene expression of antioxidant enzymes, changes in its concentration may be a marker of chronic complications of diabetes or a treatment option.	Glucose	36-43	klotho	Homo sapiens	14-20	
27916483-7	2017	Multiple linear regression analyses revealed that alpha-Klotho and beta-Klotho levels were positively correlated with the creatinine clearance rate, and negatively correlated with the urinary albumin to creatinine ratio and randomly sampled serum levels of creatinine, blood urea nitrogen, and blood glucose.	Glucose	300-307	klotho	Homo sapiens	56-62	
28411025-0	2017	Klotho down-regulates Egr-1 by inhibiting TGF-beta1/Smad3 signaling in high glucose treated human mesangial cells.	Glucose	76-83	klotho	Homo sapiens	0-6	
28411025-8	2017	High glucose time-dependently down-regulated Klotho mRNA and protein expression in cultured human MCs.	Glucose	5-12	klotho	Homo sapiens	45-51	
28411025-12	2017	Klotho overexpression can prevent mesangial ECM production in high-glucose-treated human MCs, an effect that has been partially attributed to Egr-1 down-regulation facilitated by TGF-beta1/Smad3 signaling inhibition.	Glucose	67-74	klotho	Homo sapiens	0-6	
26806457-0	2016	Effect of systemically increasing human full-length Klotho on glucose metabolism in db/db mice.	Glucose	62-69	klotho	Homo sapiens	52-58	
26806457-3	2016	Increasing the full-length human Klotho levels has a positive effect on blood glucose through increasing insulin secretion.	Glucose	78-85	klotho	Homo sapiens	33-39