PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33765609-4	2021	Herein, by using HT-22 neuronal cells, we found that high glucose decreased the levels of endogenous H2S and its catalytic enzyme, cystathionine-beta-synthase (CBS).	Glucose	58-65	cystathionine beta-synthase	Mus musculus	131-158	
33765609-4	2021	Herein, by using HT-22 neuronal cells, we found that high glucose decreased the levels of endogenous H2S and its catalytic enzyme, cystathionine-beta-synthase (CBS).	Glucose	58-65	cystathionine beta-synthase	Mus musculus	160-163	
33765609-5	2021	The administration of sodium hydrosulfide (NaHS, a H2S donor) or S-adenosylmethionine (SAMe, an allosteric activator of CBS) restored high glucose-induced downregulation of CBS and H2S levels.	Glucose	139-146	cystathionine beta-synthase	Mus musculus	120-123	
33765609-5	2021	The administration of sodium hydrosulfide (NaHS, a H2S donor) or S-adenosylmethionine (SAMe, an allosteric activator of CBS) restored high glucose-induced downregulation of CBS and H2S levels.	Glucose	139-146	cystathionine beta-synthase	Mus musculus	173-176	
33864412-0	2021	Glucose-induced decrease of cystathionine beta-synthase mediates renal injuries.	Glucose	0-7	cystathionine beta-synthase	Mus musculus	28-55	
33864412-4	2021	In cultured mouse PCT cells treated with high glucose, CBS protein and activity was reduced while ubiquitinated CBS was increased, which was abolished by a proteasome inhibitor MG132 at 1 hour; high glucose drove CBS colocalized with proteasome 26S subunit ATPase6, indicating an involvement of ubiquitination proteasome degradation.	Glucose	46-53	cystathionine beta-synthase	Mus musculus	55-58	
33864412-4	2021	In cultured mouse PCT cells treated with high glucose, CBS protein and activity was reduced while ubiquitinated CBS was increased, which was abolished by a proteasome inhibitor MG132 at 1 hour; high glucose drove CBS colocalized with proteasome 26S subunit ATPase6, indicating an involvement of ubiquitination proteasome degradation.	Glucose	199-206	cystathionine beta-synthase	Mus musculus	55-58	
33864412-4	2021	In cultured mouse PCT cells treated with high glucose, CBS protein and activity was reduced while ubiquitinated CBS was increased, which was abolished by a proteasome inhibitor MG132 at 1 hour; high glucose drove CBS colocalized with proteasome 26S subunit ATPase6, indicating an involvement of ubiquitination proteasome degradation.	Glucose	46-53	cystathionine beta-synthase	Mus musculus	112-115	
33864412-4	2021	In cultured mouse PCT cells treated with high glucose, CBS protein and activity was reduced while ubiquitinated CBS was increased, which was abolished by a proteasome inhibitor MG132 at 1 hour; high glucose drove CBS colocalized with proteasome 26S subunit ATPase6, indicating an involvement of ubiquitination proteasome degradation.	Glucose	199-206	cystathionine beta-synthase	Mus musculus	112-115	
33864412-4	2021	In cultured mouse PCT cells treated with high glucose, CBS protein and activity was reduced while ubiquitinated CBS was increased, which was abolished by a proteasome inhibitor MG132 at 1 hour; high glucose drove CBS colocalized with proteasome 26S subunit ATPase6, indicating an involvement of ubiquitination proteasome degradation.	Glucose	46-53	cystathionine beta-synthase	Mus musculus	112-115	
33864412-4	2021	In cultured mouse PCT cells treated with high glucose, CBS protein and activity was reduced while ubiquitinated CBS was increased, which was abolished by a proteasome inhibitor MG132 at 1 hour; high glucose drove CBS colocalized with proteasome 26S subunit ATPase6, indicating an involvement of ubiquitination proteasome degradation.	Glucose	199-206	cystathionine beta-synthase	Mus musculus	112-115	
32591547-6	2020	Furthermore, we determined the role of each regulatory cystathionine-beta-synthase (CBS) domain in the gamma1 subunit in metformin action and found that deletion of either CBS1 or CBS4 negated metformin"s effect on AMPKalpha phosphorylation at T172 and suppression of glucose production in hepatocytes.	Glucose	268-275	cystathionine beta-synthase	Mus musculus	84-87	
33864412-5	2021	At 48 hours, high glucose also selectively decreased CBS protein, concentration-dependently, but increased the ubiquitination of CBS; silence of CBS by siRNA increased nitrotyrosine, a marker for protein oxidative injury.	Glucose	18-25	cystathionine beta-synthase	Mus musculus	53-56	
33864412-5	2021	At 48 hours, high glucose also selectively decreased CBS protein, concentration-dependently, but increased the ubiquitination of CBS; silence of CBS by siRNA increased nitrotyrosine, a marker for protein oxidative injury.	Glucose	18-25	cystathionine beta-synthase	Mus musculus	129-132	
33864412-5	2021	At 48 hours, high glucose also selectively decreased CBS protein, concentration-dependently, but increased the ubiquitination of CBS; silence of CBS by siRNA increased nitrotyrosine, a marker for protein oxidative injury.	Glucose	18-25	cystathionine beta-synthase	Mus musculus	129-132	
29255346-8	2017	Compared with the model group, in which mice received 8 weeks of high-fructose diet and 2 weeks of 0.5% sodium carboxymethyl cellulose, CBS treatment significantly decreased the levels of fasting serum glucose, fasting insulin, triglyceride, and total cholesterol, and increased levels of high-density lipoprotein-cholesterol.	Glucose	202-209	cystathionine beta-synthase	Mus musculus	136-139	
22021075-7	2011	However, Cbs(+/-) mice with diet-induced obesity had greater glucose intolerance and lower total and reduced glutathione levels in the heart, accompanied by lower plasma cysteine levels compared with Cbs(+/+) mice.	Glucose	61-68	cystathionine beta-synthase	Mus musculus	9-12