PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22021075-7 2011 However, Cbs(+/-) mice with diet-induced obesity had greater glucose intolerance and lower total and reduced glutathione levels in the heart, accompanied by lower plasma cysteine levels compared with Cbs(+/+) mice. Glucose 61-68 cystathionine beta-synthase Mus musculus 9-12 33864412-0 2021 Glucose-induced decrease of cystathionine beta-synthase mediates renal injuries. Glucose 0-7 cystathionine beta-synthase Mus musculus 28-55 33765609-4 2021 Herein, by using HT-22 neuronal cells, we found that high glucose decreased the levels of endogenous H2S and its catalytic enzyme, cystathionine-beta-synthase (CBS). Glucose 58-65 cystathionine beta-synthase Mus musculus 131-158 33765609-4 2021 Herein, by using HT-22 neuronal cells, we found that high glucose decreased the levels of endogenous H2S and its catalytic enzyme, cystathionine-beta-synthase (CBS). Glucose 58-65 cystathionine beta-synthase Mus musculus 160-163 33765609-5 2021 The administration of sodium hydrosulfide (NaHS, a H2S donor) or S-adenosylmethionine (SAMe, an allosteric activator of CBS) restored high glucose-induced downregulation of CBS and H2S levels. Glucose 139-146 cystathionine beta-synthase Mus musculus 120-123 33765609-5 2021 The administration of sodium hydrosulfide (NaHS, a H2S donor) or S-adenosylmethionine (SAMe, an allosteric activator of CBS) restored high glucose-induced downregulation of CBS and H2S levels. Glucose 139-146 cystathionine beta-synthase Mus musculus 173-176 33864412-4 2021 In cultured mouse PCT cells treated with high glucose, CBS protein and activity was reduced while ubiquitinated CBS was increased, which was abolished by a proteasome inhibitor MG132 at 1 hour; high glucose drove CBS colocalized with proteasome 26S subunit ATPase6, indicating an involvement of ubiquitination proteasome degradation. Glucose 199-206 cystathionine beta-synthase Mus musculus 55-58 33864412-4 2021 In cultured mouse PCT cells treated with high glucose, CBS protein and activity was reduced while ubiquitinated CBS was increased, which was abolished by a proteasome inhibitor MG132 at 1 hour; high glucose drove CBS colocalized with proteasome 26S subunit ATPase6, indicating an involvement of ubiquitination proteasome degradation. Glucose 199-206 cystathionine beta-synthase Mus musculus 112-115 33864412-4 2021 In cultured mouse PCT cells treated with high glucose, CBS protein and activity was reduced while ubiquitinated CBS was increased, which was abolished by a proteasome inhibitor MG132 at 1 hour; high glucose drove CBS colocalized with proteasome 26S subunit ATPase6, indicating an involvement of ubiquitination proteasome degradation. Glucose 199-206 cystathionine beta-synthase Mus musculus 112-115 33864412-5 2021 At 48 hours, high glucose also selectively decreased CBS protein, concentration-dependently, but increased the ubiquitination of CBS; silence of CBS by siRNA increased nitrotyrosine, a marker for protein oxidative injury. Glucose 18-25 cystathionine beta-synthase Mus musculus 53-56 33864412-5 2021 At 48 hours, high glucose also selectively decreased CBS protein, concentration-dependently, but increased the ubiquitination of CBS; silence of CBS by siRNA increased nitrotyrosine, a marker for protein oxidative injury. Glucose 18-25 cystathionine beta-synthase Mus musculus 129-132 33864412-5 2021 At 48 hours, high glucose also selectively decreased CBS protein, concentration-dependently, but increased the ubiquitination of CBS; silence of CBS by siRNA increased nitrotyrosine, a marker for protein oxidative injury. Glucose 18-25 cystathionine beta-synthase Mus musculus 129-132 33864412-4 2021 In cultured mouse PCT cells treated with high glucose, CBS protein and activity was reduced while ubiquitinated CBS was increased, which was abolished by a proteasome inhibitor MG132 at 1 hour; high glucose drove CBS colocalized with proteasome 26S subunit ATPase6, indicating an involvement of ubiquitination proteasome degradation. Glucose 46-53 cystathionine beta-synthase Mus musculus 55-58 33864412-4 2021 In cultured mouse PCT cells treated with high glucose, CBS protein and activity was reduced while ubiquitinated CBS was increased, which was abolished by a proteasome inhibitor MG132 at 1 hour; high glucose drove CBS colocalized with proteasome 26S subunit ATPase6, indicating an involvement of ubiquitination proteasome degradation. Glucose 46-53 cystathionine beta-synthase Mus musculus 112-115 33864412-4 2021 In cultured mouse PCT cells treated with high glucose, CBS protein and activity was reduced while ubiquitinated CBS was increased, which was abolished by a proteasome inhibitor MG132 at 1 hour; high glucose drove CBS colocalized with proteasome 26S subunit ATPase6, indicating an involvement of ubiquitination proteasome degradation. Glucose 46-53 cystathionine beta-synthase Mus musculus 112-115 32591547-6 2020 Furthermore, we determined the role of each regulatory cystathionine-beta-synthase (CBS) domain in the gamma1 subunit in metformin action and found that deletion of either CBS1 or CBS4 negated metformin"s effect on AMPKalpha phosphorylation at T172 and suppression of glucose production in hepatocytes. Glucose 268-275 cystathionine beta-synthase Mus musculus 84-87 29255346-8 2017 Compared with the model group, in which mice received 8 weeks of high-fructose diet and 2 weeks of 0.5% sodium carboxymethyl cellulose, CBS treatment significantly decreased the levels of fasting serum glucose, fasting insulin, triglyceride, and total cholesterol, and increased levels of high-density lipoprotein-cholesterol. Glucose 202-209 cystathionine beta-synthase Mus musculus 136-139